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新时代公安标准化高质量发展问题与对策研究——以法庭科学领域为例

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公安研究 2024年第1期 98-104页

作者：孙宝良公安部鉴定中心

标准化是新时代推动公安工作高质量发展的重要支撑。本文试从法庭科学领域入手,在考察组织体系、标准水平、工作机制的基础上,一方面,将标准文本质量分解为五个要素进行检视;另一方面,对标准实践应用方面的困境进行剖析;同时,将标准文... 详细信息

标准化是新时代推动公安工作高质量发展的重要支撑。本文试从法庭科学领域入手,在考察组织体系、标准水平、工作机制的基础上,一方面,将标准文本质量分解为五个要素进行检视;另一方面,对标准实践应用方面的困境进行剖析;同时,将标准文本和标准应用中的问题溯源至标准化工作中深挖细研。其后,针对发现的问题,从宏观层面提出推动形成高质量的协商共治,并就治理框架、特质、手段、生态和基础进行了逐一分析;从标准层面提出构建高质量的标准系统,并分别从“制标导向型向应用导向型转变、层次结构型向模块组合型转变、数量规模型向质量效益型转变、单一共识型向分级适用型转变、被动维护型向主动管理型转变”五个方面阐述了思路;从实施层面提出强化高质量的价值实现,并从监督合力、宣导形式、辐射效应、融合发展、迭代改进五个方面给出了具体建议,以期进一步推动法庭科学标准化工作的高质量发展。

关键词：公安标准化高质量发展法庭科学应用导向质量效益

卒中后认知障碍炎症代谢类生物标志物研究进展

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神经损伤与功能重建 2024年第5期19卷 291-295页

作者：曹敏董梁袁慧孙保亮山东第一医科大学(山东省医学科学院)研究生部济南250117 山东第一医科大学第二附属医院神经内科山东泰安271000 山东第一医科大学第二附属医院脑微循环实验室山东泰安271000

卒中后认知障碍(Post-stroke cognitive impairment,PSCI)是卒中后的主要并发症之一,是指因卒中引起的由轻度认知功能障碍至痴呆程度的各种综合征。科学研究表明,PSCI是可逆的,通过检测患者PSCI相关生物标志物可早期预测及发现PSCI并进... 详细信息

卒中后认知障碍(Post-stroke cognitive impairment,PSCI)是卒中后的主要并发症之一,是指因卒中引起的由轻度认知功能障碍至痴呆程度的各种综合征。科学研究表明,PSCI是可逆的,通过检测患者PSCI相关生物标志物可早期预测及发现PSCI并进行干预,文章中总结了近年来对PSCI潜在生物标志物的研究进展。

关键词：卒中后认知障碍生物标志物诊断

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血红蛋白类氧载体的研究进展及应用前景

临床输血与检验 2024年第2期26卷 282-288页

作者：李洋杨明峰王莹张坚刘嘉馨孙保亮山东第一医科大学(山东省医学科学院)第二附属医院山东泰安271000 山东第一医科大学(山东省医学科学院)脑科学与类脑研究院山东济南250117 中国医学科学院微循环研究所北京100005 中国医学科学院输血研究所四川成都610052

红细胞输注已广泛应用于创伤救治、外科手术、输血治疗以及战伤急救等多个方面,但依然存在血液资源紧缺、储存期短、输前需交叉配型、可能经血传播病原体等问题。血红蛋白氧载体(hemoglobin-based oxygen carriers,HBOCs)是一类由无基... 详细信息

红细胞输注已广泛应用于创伤救治、外科手术、输血治疗以及战伤急救等多个方面,但依然存在血液资源紧缺、储存期短、输前需交叉配型、可能经血传播病原体等问题。血红蛋白氧载体(hemoglobin-based oxygen carriers,HBOCs)是一类由无基质血红蛋白通过化学修饰等方法制备的可溶性纳米级具有携释氧功能的氧载体,能代替红细胞为体内各器官、组织输送氧气,且具有无血型和病毒传播风险、储存长,即时可用的特点,也称为红细胞代用品。本文旨在综述HBOCs研究的进展,同时探讨其在除替代红细胞输血治疗以外,针对其他如器官保存、脑缺血、肿瘤等治疗中的应用前景。

关键词：红细胞代用品血红蛋白氧载体创伤贫血器官保存脑缺血肿瘤

Unique recovery stage of reef communities after F/F event in a huge coral reef of Carboniferous, Southern Guizhou,China

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Science China Earth Sciences 2004年第5期47卷 412-418页

作者： GONG Enpu YANG Hongying GUAN Changqing sun baoliang YAO Yuzeng Department of Geology Northeastern University Shenyang 110004 China Department of Geology Northeastern University Shenyang 110004 China Department of Geology Northeastern University Shenyang 110004 China Department of Geology Northeastern University Shenyang 110004 China Department of Geology Northeastern University Shenyang 110004 China

A huge coral reef occurring in the Triticites belt of the Maping Formation, in Bianping Village, about 4 km west of Houchang Town from Ziyun County, Southern Guizhou, China is described. The coral reef has been well studied and some significant characteristics were dis-covered: the composition of reef-building community is very monotonous; there are only one or two builders in each reef-building stage; the dwellers are also poor in variety; the reef-building process is very simple; the reef has been separately built by various reef-building mechanisms, and there have been few parts built by two coexisting building mechanisms; the process of reef building is often discontinuous and lacks transition. All these characteristics are considered to be unique to the recovery stage of reef communities after F/F event and are representative of a process that reef communities must undergo post the catastrophe.

关键词： Houchang Town, Southern Guizhou, Carboniferous, coral reef, community recovery.

Infant guinea pig retina model of glutamate toxicity and intervention of basic fibroblast growth factor

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Neural Regeneration Research 2011年第7期6卷 534-541页

作者： Yunzhi Shi Lihua Wei Mingshan Song Min Chen Changqing Du baoliang sun Department of Histology and Embryology Taishan Medical College Taian 271000 Shandong Province China Department of Urology Taian Central Hospital Taian 271000 Shandong Province China Department of Foreign Language Taishan Medical College Taian 271000 Shandong Province China Key Laboratory of Cerebral Microcirculation at the Universities of Shandong Department of Neurology Affiliated Hospital of Taishan MedicalCollege Taian 271000 Shandong Province China

Impaired vision with oligemic ophthalmopathy is a result of excitotoxicity caused by excitatory amino acids, resulting in pathological changes, such as loss of retinal neurons and in particular retinal ganglionic cells. The present study utilized infant guinea pigs, aged 45-50 days, to establish injury models via intraperitoneal injection of fixed sodium glutamate doses. Results from hematoxylin- eosin staining revealed significantly reduced retinal ganglionic cell numbers and retinal damage at 10 days after 7 consecutive days of 3 g/kg sodium glutamate treatment; these animals served as the injury model group. In addition, models of moderate injury （glutamate 3 g/kg daily, for 7 consecutive days） were intraperitoneally pretreated with basic fibroblast growth factor （800 U/kg daily）. Immunohistochemistry results confirmed reduced anti-apoptotic gene bcl-2 expression in the ganglion cell layer of glutamate-injured guinea pigs. Expression of the pro-apoptotic gene caspase-3 was increased in the ganglion cell layer and inner plexiform layer. Somatostatin expression was primarily distributed in the ganglion cell layer and inner nuclear layer. Expression of the presynaptic element synaptophysin was weak. However, following basic fibroblast growth factor injection, expressions of the above-described bioactive molecules were reversed, which suggested that basic fibroblast growth factor exerted protective effects on sodium glutamate-induced retinal injury in infant guinea pigs by regulating expression of synaptophysin, somatostatin, Bcl-2, and caspase-3.

关键词： synaptophysin somatostatin apoptosis-related genes basic fibroblast growth factor glutamate retina

Paleoecology of Late Carboniferous Phylloid Algae in Southern Guizhou,SW China

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Acta Geologica Sinica(English Edition) 2007年第4期81卷 566-572页

作者： GONG Enpu ZHANG Yonglil GUAN Changqing Elias SAMANKASSOU sun baoliang Department of Geology Northeastern University Shenyang 110004 China Institute of Geology and Paleontology University of Fribourg Switzerland

Phylloid algae arc important rcef-builders in the late Carboniferous. This paper focuses on the paleoecology of phylloid algae in the Late Carboniferous on well-exposed reefs in Ziyun County, Guizhou Province. Phylloid algae growing closely packed arc attached via holdfast or similar structure to substrate. They were growing in environments such as shallow water, photic zone and below the wave base with medium energy currents. They have a variety of morphological forms, such as single cup-shaped, cabbage-shaped and clustering cup-shaped. The thalli arc of certain tenacity and intensity. In the areas dominated by phylloid algae, other marine orgam＇sms arc relatively scarce. Obviously, phylloid algae arc stronger competitors for living space than other co-occurring organisms.

关键词： Late Carboniferous phylloid algae characteristics of paleoecology

Changes of dynamical balance of free radicals induced by levodopa in rat glia-containing mesencephalic culture fluid

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Neural Regeneration Research 2006年第5期1卷 401-404页

作者： Wenxia Li Shenggang sun Jingru Wang baoliang sun Yanbo Zhang Deparlment of Neurology Affiliated Hospital of Taishan Medical University Taian 271000Shandong Province China Department of Neurology Union Hospital Tongji Medical College Huazhong University of Science and TechnologyWuhan 430022 Hubei Province. China

BACKGROUND ： Parkinson disease is neurodegenerative disorders, characterized by a progressive and selective degeneration of nigrostdatal dopaminergic pathway. Its main clinical symptoms include bradykinesia, dgidity, rest tremor and disturbances in balance. Levodopa （L-DOPA） is the ＂gold standard＂ for the symptomatic treatment of Parkinson disease, but L-DOPA is toxic to dopaminergic neurons and the chronic administration of L-DOPA often causes the side effects of motor such as ＂on-off ＂, etc., and its mechanism still has not been completely clarified. OBJECTIVE ： To observe the changes of the content of glutathione （GSH）, activities of glutathione peroxidase （GSH-Px） and superoxide dismutase （SOD） and content of malondialdehyde （MDA） in gila-containing mesencephalic culture fluid after L-DOPA of different concentrations were added. DESIGN： A comparative observation. SETTINGS ： Department of Neurology, Affiliated Hospital of Taishan Medical University; Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology. MATERIALS ： The experiment was carried out in the Basic Research Institute, Taishan Medical University from December 2003 to September 2004. Ten postnatal newborn SD rats （within 2 days） were selected, either male or female. Fetal bovine serum （DMEM/F12） was from Gibco Company; L-DOPA and glial fibrillary acidic protein （GFAP） from Sigma Company. Kits for determination of GSH, GSH-Px, SOD and MDA were purchased from Nanjing Jiancheng Bioengineering Research Institute. METHODS ： Gila-containing mesencephalic culture fluid were placed in 24-well culture plate, and L-DOPA of 50, 100 and 500 μmot/L was added to each group, the blank control group was also set. The glia-containing mesencephalic culture fluid selected at 4, 24, 48 and 72 hours respectively to determine the GSH content with colorimetdc quantitative technique, GSH-Px activity with colorimetdc method, SOD activity with xanthine oxidase meth

关键词： free radicals Parkinson disease neurodegenerative disorders Science and Technology glutathione peroxidase superoxide dismutase dopaminergic neurons colorimetric method dynamical balance xanthine oxidase determination of Basic Research acidic protein side effects time point

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阿尔茨海默病与铁死亡相关性的研究进展

神经损伤与功能重建 2024年第2期19卷 105-108页

作者：张洪铭冯丽娜孙保亮山东中医药大学济南250355 山东第一医科大学(山东省医学科学院)第二附属医院山东泰安271099 山东第一医科大学(山东省医学科学院)临床与基础医学院山东泰安271016

阿尔茨海默病(Alzheimer’s disease,AD)是最常见的痴呆类型,是以进行性认知功能障碍为主要表现的神经系统退行性病变。调节性细胞死亡是基因决定的细胞主动有序的死亡,普遍存在于在生命体发育过程中,对调节生命稳态至关重要。随着调节... 详细信息

阿尔茨海默病(Alzheimer’s disease,AD)是最常见的痴呆类型,是以进行性认知功能障碍为主要表现的神经系统退行性病变。调节性细胞死亡是基因决定的细胞主动有序的死亡,普遍存在于在生命体发育过程中,对调节生命稳态至关重要。随着调节性细胞死亡在AD的广泛研究,越来越多的证据揭示铁死亡与AD的发生、发展以及转归密切相关。本文将对铁死亡的分子机制及其在AD中的调控作用进行综述,为AD的发病机制和治疗探索潜在治疗靶点。

关键词：阿尔茨海默病铁死亡铁代谢紊乱脂质过氧化综述

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Fossil Equidae in the Linxia Basin with Biostratigraphic and Paleozoogeographic Significance

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Acta Geologica Sinica(English Edition) 2024年第1期98卷 1-9页

作者： sun Boyang Key Laboratory of Vertebrate Evolution and Human Origins of the Chinese Academy of Sciences Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of SciencesBeijing 100044China

The Linxia Basin is characterized by an abundance of Cenozoic sediments,that contain exceptionally rich fossil *** are abundant in the Linxia Basin,the fossil record of equids in this region including 16 species that represent 10 *** comparison to other classic late Cenozoic areas in China,the Linxia Basin stands out,because the fauna and chronological data accompanying Linxia equids render them remarkably useful for *** anchitheriines in the region,such as Anchitherium and Sinohippus,represent early equids that appeared in the late stages of the middle and late Miocene,*** the equines,most species of Chinese hipparions have been identified in the Linxia Basin and some species of the genera Hipparion and Hippotherium have FAD records for ***,Equus eisenmannae is one of the earliest known species of Equus in the Old World and is well-represented at the Longdan *** species with precise geohistorical distributions can serve as standards for high-resolution chronological units within this *** at the eastern margin of the Tibetan Plateau and subject to considerable uplift,the Linxia Basin has served as a biogeographic transition area for equids throughout the late Cenozoic.

关键词： Equidae Cenozoic biostratigraphy paleozoogeography Linxia Basin