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PREPARATION　AND　CHARACTERIZATION　OF　A　NEW　COENZYME　B_（12）　ANALOGUE　CONTAINING　2＇，3＇－　DIDEOXYURIDINE

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Chinese Chemical Letters 1996年第6期7卷 503-504页

作者： bao hua zhu Hong YAN Lai Bin LUO Ze hua LIU Hui Lan CHEN(Department of Chemistru,Coordination Chemistry Institute and Coordination Chemistry State Key Laboratory,Nanjing University,Nanjing,210093) NANJING UNIV DEPT CHEMINST COORDINAT CHEMNANJING 210093PEOPLES R CHINA NANJING UNIV STATE KEY LAB COORDINAT CHEMNANJING 210093PEOPLES R CHINA

Anew kind of coenzyme B12 analogue 2',3' ,5' -trideoxyuridinyl-cobalamin(ddUCbl) wasfirst synthesized by an improved method in which 5'-O-toluenesulfonyl-2',3'-dideoxyuridilne wasfirst transormed into 5'-iodo-2',3'-dideoxyuridine and then reacted with reducdhydroxocobalamin. The new analogue was characterized by UV-yis and1 HNMR spectroscopy

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SEFormer:A Lightweight CNN-Transformer Based on Separable Multiscale Depthwise Convolution and Efficient Self-Attention for Rotating Machinery Fault Diagnosis

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Computers, Materials & Continua 2025年第1期82卷 1417-1437页

作者： Hongxing Wang Xilai Ju hua zhu huafeng Li State Key Laboratory of Mechanics and Control for Aerospace Structures Nanjing University of Aeronautics and AstronauticsNanjing210016China School of Computer Science and Engineering Nanyang Technological UniversitySingapore639798Singapore

Traditional data-driven fault diagnosis methods depend on expert experience to manually extract effective fault features of signals,which has certain ***,deep learning techniques have gained prominence as a central focus of research in the field of fault diagnosis by strong fault feature extraction ability and end-to-end fault diagnosis ***,utilizing the respective advantages of convolution neural network(CNN)and Transformer in local and global feature extraction,research on cooperating the two have demonstrated promise in the field of fault ***,the cross-channel convolution mechanism in CNN and the self-attention calculations in Transformer contribute to excessive complexity in the cooperative *** complexity results in high computational costs and limited industrial *** tackle the above challenges,this paper proposes a lightweight CNN-Transformer named as SEFormer for rotating machinery fault ***,a separable multiscale depthwise convolution block is designed to extract and integrate multiscale feature information from different channel dimensions of vibration ***,an efficient self-attention block is developed to capture critical fine-grained features of the signal from a global ***,experimental results on the planetary gearbox dataset and themotor roller bearing dataset prove that the proposed framework can balance the advantages of robustness,generalization and lightweight compared to recent state-of-the-art fault diagnosis models based on CNN and *** study presents a feasible strategy for developing a lightweight rotating machinery fault diagnosis framework aimed at economical deployment.

关键词： CNN-Transformer separable multiscale depthwise convolution efficient self-attention fault diagnosis

Effects of antisense oligonucleotides of PKC-α on proliferation and apoptosis of HepG₂ in vitro

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Hepatobiliary & Pancreatic Diseases International 2005年第1期4卷 75-79页

作者： bao-hua zhu Zhen-Xiang Yao Shao-Jun Luo Li-Ming Jiang Jiang-Wei Xiao Sheng-Chun Liu Jin-Biao Liu Jian-Ming Sun Zhi-Yuan Pei Department of Hepatobiliary Surgery First Affiliated Hospital Chongqing University of Medical Sciences Chongqing 400016 China. baohuazhu@***

BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most common malignancies in China. The long-term survival rate of patients with HCC after prevention and management remains unsatisfactory. In order to provide a novel strategy to cure HCC, we investigated the effects of antisense oligonucleotides of PKC-alpha on proliferation and apoptosis of human hepatoma cell line HepG2 in vitro.METHODS: The human hepatocellular carcinoma cell line HepG2 was cultured and subcultured in RPMI1640 medium in vitro. PKC-alpha antisense oligonucleotides(asODN) of different concentrations with a random sequence as a control were transfected into HepG2 cells by lipofectin(LP). The cell growth index (GI) and the clone formation rate of HepG2 were detected by MTT colorimetric assay and soft agar assay, respectively. The apoptosis rate of HepG2 treated with PKC-alpha asODN was assayed by flow cytometry(FCM). The results were analyzed by SPSS 10.0 software.RESULTS: The GI of HepG2 transfected by PKC-alpha asODN with concentrations ranging from 0.10 micromol to 1.00 micromol were lower significantly than those of control groups (P<0.05). The clone formation rates of HepG2 transfected by PKC-alpha asODN from 0.05 micromol to 1.00 micromol were lower significantly than those of the control groups (P<0.01), and there was a dose-dependent relationship among them. The apoptosis rates of HepG2 treated with PKC-alpha asODN from 0.50 micromol to 1.00 micromol were significantly higher than those of the control groups.CONCLUSION: PKC-alpha asODN could inhibit the growth and proliferation of HepG2 and induce its apoptosis by blocking the cell signal transduction related to PKC-alpha in vitro, and may be potentially used in the prevention and management of recurrent and metastatic HCC.

关键词： hepatocellular carcinoma HepG2 PKC-α asODN

SYNTHESIS　AND　CHARACTERIZATION　OF　COBINAMIDES　CONTAINING　2′－DEOXYNUCLEOSIDES──A　NEW　KIND　OF　VITAMIN　B_（12）　COENZYME　ANALOGUES

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Chinese Chemical Letters 1994年第5期5卷 377-378页

作者： Hui Lan CHEN Zheng WU Lai Bin LUO bao hua zhu (Deparment of Chemistry, Nanjing University, Nanjing, 210093)Hong YAN Wen Xia TANG (Coordination Chemisty State key Laboratory, Nanjing, 210093)

A new kind of vitamin B(12) coenzyme analogues-2', 5' dideoxycyticobinamide (2' dAdoCbi), 5'-deoxythmidylcobinamide (ThyCbi) and 2', 5' -dideoxycytidylcobinamide (2' dCytCbi) were synthesized by a new route in which deoxynucleosidylcobalamins directly reacted with freshly prepared Ce (OH)3 to remove the di -methylbezimidazole (DBZM) nucleotide. All cobinamides containing 2'-deoxynucleosides were character lied by UV-Vis and 1H NMR spectroscopy.

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中国旅游业对外直接投资特征及其关联因素分析

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商业研究 2017年第7期 173-177页

作者：包富华朱美宁咸阳师范学院经济与管理学院陕西咸阳712000 陕西师范大学旅游与环境学院西安710062 陕西国际商贸学院商学院陕西咸阳712000

当前中国旅游业OFDI不断增长,认识和把握其时空特征及关联因素,对于国家进行相应的宏观管理和中国旅游企业制订具体投资战略具有参考价值。本文利用2004-2015年中国旅游业OFDI的流量、存量数据分析中国旅游业OFDI的特征及关联因素。时... 详细信息

当前中国旅游业OFDI不断增长,认识和把握其时空特征及关联因素,对于国家进行相应的宏观管理和中国旅游企业制订具体投资战略具有参考价值。本文利用2004-2015年中国旅游业OFDI的流量、存量数据分析中国旅游业OFDI的特征及关联因素。时间序列分析表明中国旅游业OFDI流量和存量整体呈增长趋势,且二者的增长均呈现"乘幂"型特征;空间分布分析表明中国主要的对外投资国家(地区)大致跟随出境旅游国家(地区),"资金流"和"人流"之间存在较好的伴随状态;灰色关联度分析表明人均GDP、出境旅游人数和入境旅游人数分别是影响中国旅游业OFDI的前三大因素,其中,人均GDP是其基础,出境旅游人数是其载体,入境旅游是其重要保障。

关键词：对外直接投资灰色关联度出境旅游旅游业

Deciphering Water Oxidation Catalysts:The Dominant Role of Surface Chemistry over Reconstruction Degree in Activity Promotion

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Nano-Micro Letters 2025年第3期17卷 340-354页

作者： Li An Jianyi Li Yuanmiao Sun Jiamin zhu Justin zhu Yeow Seow Hong Zhang Nan Zhang Pinxian Xi * Zhichuan JXu Chun‑hua Yan State Key Laboratory of Applied Organic Chemistry Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu ProvinceFrontiers Science Center for Rare IsotopesCollege of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000People’s Republic of China School of Materials Science and Engineering Nanyang Technological UniversitySingapore 639798Singapore Faculty of Materials Science and Energy Engineering Institute of Technology for Carbon NeutralityShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055People’s Republic of China Key Laboratory of Electromagnetic Materials and Devices National Center for International Research On Photoelectric and Energy MaterialsSchool of Materials and EnergyElectron Microscopy CenterYunnan UniversityKunming 650091People’s Republic of China State Key Laboratory of Baiyunobo Rare Earth Resource Researches and Comprehensive Utilization Baotou Research Institute of Rare EarthsBaotou 014030People’s Republic of China Beijing National Laboratory for Molecular Sciences State Key Laboratory of Rare Earth Materials Chemistry and ApplicationsPKU‑HKU Joint Laboratory in Rare Earth Materials and Bioinorganic ChemistryPeking UniversityBeijing 100871People’s Republic of China

Water splitting hinges crucially on the availability of electrocatalysts for the oxygen evolution *** surface reconstruction has been widely observed in perovskite catalysts,and the reconstruction degree has been often correlated with the activity ***,a systematic study on the roles of Fe substitution in activation of perovskite LaNiO_(3)is *** substituting Fe content influences both current change tendency and surface reconstruction ***_(0.9)Fe_(0.1)O_(3)is found exhibiting a volcano-peak intrinsic activity in both pristine and reconstructed among all substituted perovskites in the LaNi_(1-x)Fe_(x)O_(3)(x=0.00,0.10,0.25,0.50,0.75,1.00)*** reconstructed LaNi_(0.9)Fe_(0.1)O_(3)shows a higher intrinsic activity than most reported NiFe-based ***,density functional theory calculations reveal that Fe substitution can lower the O 2p level,which thus stabilize lattice oxygen in LaNi0.9Fe0.1O3 and ensure its long-term ***,it is vital interesting that activity of the reconstructed catalysts relied more on the surface chemistry rather than the reconstruction *** effect of Fe on the degree of surface reconstruction of the perovskite is decoupled from that on its activity enhancement after surface *** finding showcases the importance to customize the surface chemistry of reconstructed catalysts for water oxidation.

关键词： Oxygen evolution reaction Perovskite oxides Doping Activation and reconstruction

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应用信任函数的容错区间估计融合方法

四川大学学报（自然科学版） 2003年第3期40卷 419-422页

作者：李保华朱允民四川大学数学学院成都610064

传感器网络是在动态的、具有不确定性的环境里运作的,所以网络设计时容错就成为一个很重要的问题.作者利用信任函数理论提出了一种新的容错区间融合函数,它根据先验信息和对融合结果的要求得到与之相应的输出区间及其信任度,可以缩短Mar... 详细信息

传感器网络是在动态的、具有不确定性的环境里运作的,所以网络设计时容错就成为一个很重要的问题.作者利用信任函数理论提出了一种新的容错区间融合函数,它根据先验信息和对融合结果的要求得到与之相应的输出区间及其信任度,可以缩短Marzullo函数的输出区间,而且其输出结果比过去有关作者提出的函数的输出结果更为可靠.

关键词：容错区间融合函数基本概率赋值信任函数

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膜生物反应器处理轻工废水研究进展

安徽化工 2016年第6期42卷 12-17页

作者：许宝华朱桂生黄诚江苏索普(集团)有限公司江苏镇江212006

阐述了膜生物反应器的工艺特点和国内外研究状况,介绍了近几年国内外利用膜生物反应器处理轻工业废水的应用实例。在此基础上分析了膜生物反应器存在的问题,并对膜生物反应器应用于轻工业废水处理进行了展望。

关键词：膜生物反应器工业废水膜污染研究进展

Synthesis and Cystal Sructure of the Custer [Fe2（CO）4（μ,η~2-COC6H5）（μ4,η~3-CH3C（CH2PPh（CH2PPh2）2））]

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Synthesis and Cystal Sructure of the Custer [Fe2（CO）4（μ,...