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Improvement of inflammatory response and gastrointestinal function in perioperative of cholelithiasis by Modified Xiao-Cheng-Qi decoction

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World Journal of Clinical Cases 2023年第4期11卷 830-843页

作者： bao-fang sun Fan Zhang Qiang-Pu Chen Qiang Wei Wen-Tao Zhu Hai-Bin Ji Xing-Yuan Zhang Department of Hepatobiliary Surgery Binzhou Medical University HospitalBinzhou 256603Shandong ProvinceChina

BACKGROUND In the perioperative period of biliary surgery,various factors can induce the release of a large number of inflammatory factors,leading to an imbalance in proinflammatory and anti-inflammatory responses and resulting in gastrointestinal(GI)*** Recovery After Surgery protocols in biliary surgery have been shown to reduce the stress response and accelerate postoperative *** is crucial to reduce the inflammatory response and promote the recovery of GI function after biliary surgery,both of which are the basis and key for perioperative care and postoperative *** To better understand the effects of Modified Xiao-Cheng-Qi decoction(MXD)on inflammatory response and GI function in the perioperative management of cholelithiasis and their *** This was a prospective randomized placebo-controlled trial,in which 162 patients who received biliary tract surgery were randomly assigned to three groups:MXD group,XD group,and placebo-control *** observed parameters included frequency of bowel sounds,time of first flatus and defecation,time of diet,and amount of activity after *** serum levels of C-reactive protein(CRP),interleukin(IL)-6,IL-10,serum amyloid A protein(SAA),and substance P were measured by the enzyme-linked immunosorbent ***,the spearman correlation coefficient was used to analyze the relationship between the indicators of GI function and *** Compared to the placebo-control,improvements in GI function were observed in the MXD groups including reduced incidence of nausea,vomiting,and bloating;and earlier first exhaust time,first defecation time,and feeding time after surgery(P<0.05).On the 1st and 2nd d after surgery,IL-6,CRP and SAA levels in MXD group were lower than that in placebo control,but substance P level was higher,compared to the control(P<0.05).Functional diarrhea occurred in both MXD and XD groups without any other adverse effects,toxic reactions,and allergic re

关键词： Modified Xiao-cheng-qi Decoction Cholelithiasis Inflammatory response Gastrointestinal function Enhanced Recovery After Surgery Perioperative

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腹部外科围手术期过度炎症反应的调控

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世界华人消化杂志 2017年第8期25卷 709-715页

作者：孙宝房陈强谱滨州医学院附属医院肝胆外科滨州医学院附属医院临床营养中心山东省临床营养与代谢重点实验室山东省滨州市256600

腹部外科围手术期过度炎症反应是由围手术期各种诱发因素引起的,以炎细胞活化、细胞因子及炎性介质异常表达、促炎-抗炎网络体系失衡为基础,导致各器官功能障碍的一系列病理生理学过程.围手术期过度炎症反应是阻碍腹部外科患者康复的重... 详细信息

腹部外科围手术期过度炎症反应是由围手术期各种诱发因素引起的,以炎细胞活化、细胞因子及炎性介质异常表达、促炎-抗炎网络体系失衡为基础,导致各器官功能障碍的一系列病理生理学过程.围手术期过度炎症反应是阻碍腹部外科患者康复的重要因素.因此,对围手术期过度炎症反应积极进行调控,控制应激反应,抑制过度炎症反应及其所造成的不良反应,可以减少并发症发病率和死亡率,保护重要器官功能,从而加速患者的康复.但目前对围手术期过度炎症反应的病理生理过程及调控措施的认识尚处初级阶段.本文对腹部外科围手术期过度炎症反应的调控措施进行系统介绍.

关键词：腹部外科围手术期炎症反应应激反应调控

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天津汇金中心基桩测试数据与基础沉降数据分析

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建筑结构 2017年第18期47卷 75-78页

作者：王媛鲍蕾方云飞孙宏伟北京市建筑设计研究院有限公司北京100045

天津汇金中心由超高层塔楼及附属裙房组成,采用变刚度调平桩筏基础设计,主塔楼及部分裙房南侧紧邻地铁深基坑。通过分析工程检验桩数据、对比上部结构-基础-地基共同作用的沉降变形数值计算结果和实测结果以及对地铁深基坑与主塔楼的相... 详细信息

天津汇金中心由超高层塔楼及附属裙房组成,采用变刚度调平桩筏基础设计,主塔楼及部分裙房南侧紧邻地铁深基坑。通过分析工程检验桩数据、对比上部结构-基础-地基共同作用的沉降变形数值计算结果和实测结果以及对地铁深基坑与主塔楼的相互影响的数值分析,证明了变刚度调平桩筏基础设计的合理性以及采用有限元计算软件Zsoil进行上部结构-基础-桩-土共同工作的数值计算分析的可靠性。

关键词：天津汇金中心桩筏基础变刚度调平设计检验桩沉降分析

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腹部外科围手术期过度炎症反应机制及对机体的影响

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世界华人消化杂志 2017年第2期25卷 178-184页

作者：孙宝房陈强谱滨州医学院附属医院肝胆外科滨州医学院附属医院临床营养中心山东省临床营养与代谢重点实验室山东省滨州市256600

炎症反应是腹部手术创伤的重要病理生理变化,适度炎症反应对创伤愈合起到积极作用,但过度炎症反应对机体有害,是术后各种并发症的主要原因,是发展至多器官障碍综合征的共同通路.因此,对围手术期过度炎症反应积极进行干预,可以减少术后... 详细信息

炎症反应是腹部手术创伤的重要病理生理变化,适度炎症反应对创伤愈合起到积极作用,但过度炎症反应对机体有害,是术后各种并发症的主要原因,是发展至多器官障碍综合征的共同通路.因此,对围手术期过度炎症反应积极进行干预,可以减少术后并发症发病率和死亡率.但目前对围手术期过度炎症反应的病理生理过程的认识尚处初级阶段.本文对腹部外科围手术期过度炎症反应的诱发因素、发生机制、病理生理变化及对机体的危害和影响进行系统介绍.

关键词：腹部外科围手术期过度炎症反应多器官功能障

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The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

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Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-Yan sun Lingyun Nie Jing Zhang Xue fang Hongmei Luo Chuanhai Fu Zhiyi Wei Ai-Hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

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Recent Advances in Fibrous Materials for Hydroelectricity Generation

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Nano-Micro Letters 2025年第2期17卷 109-133页

作者： Can Ge Duo Xu Xiao Feng Xing Yang Zheheng Song Yuhang Song Jingyu Chen Yingcun Liu Chong Gao Yong Du Zhe sun Weilin Xu Jian fang College of Textile and Clothing Engineering Soochow UniversitySuzhou 215123People’s Republic of China National Engineering Laboratory for Modern Silk Soochow UniversitySuzhou 215123People’s Republic of China State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200People’s Republic of China Institute of Functional Nano&Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123People’s Republic of China Department of Electrical and Computer Engineering University of MassachusettsAmherstMA 01003USA Department of Materials Imperial College LondonSouth Kensington CampusLondon SW72AZUK College of Textile Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310018People’s Republic of China School of Materials Science and Engineering Shanghai Institute of Technology100 Haiquan RoadShanghai 201418People’s Republic of China

Depleting fossil energy sources and conventional polluting power generation pose a threat to sustainable *** generation from ubiquitous and spontaneous phase transitions between liquid and gaseous water has been considered a promising strategy for mitigating the energy *** materials with unique flexibility,processability,multifunctionality,and practicability have been widely applied for fibrous materials-based hydroelectricity generation(FHG).In this review,the power generation mechanisms,design principles,and electricity enhancement factors of FHG are first ***,the fabrication strategies and characteristics of varied constructions including 1D fiber,1D yarn,2D fabric,2D membrane,3D fibrous framework,and 3D fibrous gel are ***,the advanced functions of FHG during water harvesting,proton dissociation,ion separation,and charge accumulation processes are analyzed in ***,the potential applications including power supply,energy storage,electrical sensor,and information expression are also ***,some existing challenges are considered and prospects for future development are sincerely proposed.

关键词： Hydroelectricity Fibrous material Streaming potential Ion diffusion

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加速康复外科对消化道肿瘤患者长期生存率影响的Meta分析

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世界华人消化杂志 2019年第7期27卷 442-449页

作者：冀海斌陈强谱张帆朱文涛赵宝磊魏强孙宝房杨祯王霄霄滨州医学院附属医院肝胆外科山东省滨州市256603

背景加速康复外科(enhanced recovery after surgery, ERAS)是指在围手术期通过多学科协作模式采取一系列基于循证医学证据的最优化措施,降低围手术期应激反应,加快患者术后各器官功能恢复. ERAS已在多个学科得到推广,并被证实可以提高... 详细信息

背景加速康复外科(enhanced recovery after surgery, ERAS)是指在围手术期通过多学科协作模式采取一系列基于循证医学证据的最优化措施,降低围手术期应激反应,加快患者术后各器官功能恢复. ERAS已在多个学科得到推广,并被证实可以提高患者近期预后,而针对患者远期预后的研究正在初步进行.目的评价围手术期应用ERAS对消化道肿瘤患者生存率的影响.方法应用计算机检索1995-01/2018-11万方、CNKI、维普、PubMed、Cochrane Library、EMBASE数据库有关消化道肿瘤患者围手术期应用ERAS的随机对照试验、病例对照研究,由两名研究者分别对符合纳入标准的研究进行质量评价和数据提取,采用Rev Man5.3.5软件进行Meta分析.结果共纳入10篇研究进行Meta分析,共计2477例患者,其中ERAS组751例,对照组(采取传统围手术期管理)1726例.与对照组相比, ERAS组术后3年生存率提高(OR=0.48, 95%CI:0.30-0.78, P0.05),术后2年生存率差异无统计学意义(OR=1.19, 95%CI:0.38-3.73, P>0.05).结论消化道肿瘤手术围手术期实施ERAS可以改善预后,3年生存率, 5年生存率.

关键词：加速康复外科生存率肿瘤预后 Meta分析

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Design and offline testing of a resonant stripline beam position monitor for the IRFEL project at NSRL

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Nuclear Science and Techniques 2020年第7期31卷 76-84页

作者： Xiao-Yu Liu fang-fang Wu Tian-Yu Zhou Ping Lu bao-Gen sun National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230029China

A 476 MHz resonant stripline beam position monitor(BPM)is planned to be installed in an infrared free electron laser machine at National Synchrotron Radiation *** type of BPM was developed based on a standard stripline BPM by moving the coupling feedthrough closer to the short end downstream,which introduces a resonance and therefore a capability for higher resolution compared with broadband *** design and offline measurement results of the prototype are shown in this *** design goal is the optimization of the central frequencies and corresponding quality factors of the three intrinsic transverse electromagnetic modes to roughly476 MHz and 30,respectively,the fulfillment of which is demonstrated by a transmission parameter test via a network *** voltage signal modeling and an estimation of the position resolution of the designed BPM are shown in ***,a calibration test of the prototype using the stretched wire method is presented,including a description of the test stand and the evaluation of position sensitivities.

关键词： beam testing closer

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Optimal investment with transaction costs based on exponential utility function:a parabolic double obstacle problem

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Applied Mathematics(A Journal of Chinese Universities) 2011年第4期26卷 483-492页

作者： bao Qun-fang YANG Jing-yang sun Chao LI Sheng-hong Department of Mathematics Zhejiang University Hangzhou 310027 China Jingdezhen Ceramic Institute Jiangxi 333403 China

This paper concerns optimal investment problem with proportional transaction costs and finite time horizon based on exponential utility function. Using a partial differential equation approach, we reveal that the problem is equivalent to a parabolic double obstacle problem involving two free boundaries that correspond to the optimal buying and selling policies. Numerical examples are obtained by the binomial method.

关键词： Optimal investment transaction costs double obstacle problem stochastic control exponential utility function.

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The slanting property of semi-diurnal internal tide propagation in the Pacific Ocean at 1°45′S,156°E

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Acta Oceanologica Sinica 2006年第4期25卷 143-145页

作者： bao Xianwen ZHANG Yijun sun Li DU Tao fang Xinhua Physical Oceanography Laboratory Ocean University of China Qingdao 266003 China National Marine Data ＆ Information Service Tianjin 300171 China

By analyzing a data set collected using a moored instrument array and CTD during TOGA-COARE, it is found that there exist remarkable internal tides in the western equatorial Pacific Ocean around 1°45′S, 156°E, whose horizontal wavenumber （wavelength）, vertical wavenumber, h 156° orizontal propagation speed and vertical propagation speed are 3.3×10^-2 km^-1 （210 km）, - 1.6×10^-3m, 2.0 m/s and -3.8 cm/s, respectively, that is, the waveform propagates downwards slantingly. Moreover, the propagating direction rotates statistically clockwise as the depth increases and its cause is unclear.

关键词： internal waves internal tides western equatorial Pacific Ocean TOGA-COARE

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