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The Smoothness of Scatter.ng Op.r.tor. for.Sinh-Gor.on and Nonlinear.Schr.dinger.Equations

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Acta Mathematica Sinica,English Ser.es 2002年第3期18卷 549-564页

作者： bao xiang wang department of mathematics, hebei university. baoding 071002. p. r. china department of mathematics Hebei University Baoding 071002 P. R. China

We show that the scatter.ng op.r.tor.car.ies a band in H^s (r.n)×H^(s-1)(r.n) into H^s (r.n)× H^(s-1)(r.n) for.the sinh-Gor.on equation and an analogous r.sult also holds tr.e for.the nonlinear.Schr.inger.equation with an exp.nential nonlinear.ty, wher. s≥n/2 is ar.itr.r. and n≥2. Ther.for., the scatter.ng op.r.tor. ar. infinitely smooth for.the above two equations.

关键词： Sinh-Gor.on equation Nolinear.Schr.dinger.equation The smoothness of scatter.ng op.r.tor

p.ecise p.anar.Twisted Molecular.Engineer.ng to Constr.ct Semiconducting p.lymer. with Balanced Absor.0}ion and Quantum Yield for.Efficient p.otother.nostics

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r.sear.h 2024年第2期2023卷 227-238页

作者： xiang Su Zhir.ng bao Wei Xie Deliang wang Ting Han Dong wang Ben Zhong Tang Center.for.AIE r.sear.h Shenzhen Key Laboratory of Polymer Science and TechnologyGuangdong Research Center for Interfacial Engineering of Functional MaterialsCollege of Materials Science and EngineeringShenzhen UniversityShenzhen 518060China School of Biomedical and p.ar.aceutical Sciences Guangdong University of TechnologyGuangzhou 510006China department of r.diation and Medical Oncology Hubei Key Laboratory of Tumor Biological BehaviorsHubei Cancer Clinical Study CenterZhongnan Hospital of Wuhan UniversityWuhan 430071China department of Mater.als Chemistr. Huzhou UniversityHuzhou 313000China School of Science and Engineer.ng Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhenGuangdong 518172China

Semiconducting p.lymer.(Sp.)have shown gr.at feasibility as candidates for.near.infr.r.d-II(NIr.Ⅱ)fluor.scence imaging-navigated p.otother.al ther.p. due to their.str.ng light-har.esting ability and flexible ***,the fluor.scence signal of tr.ditional Sp. tends to quench in their.aggr.gate states owing to the str.ngπ-πstacking,which can lead to the r.diative decay p.thway shutting *** addr.ss this issue,aggr.gation-induced emission effect has been used as a r.tional tactic to boost the aggr.gate-state fluor.scence of NIr.Ⅱ*** this contr.bution,we develop.d a p.ecise molecular.engineer.ng tactic based on the block cop.lymer.zations that integr.te p.anar.and twisted segments into one conjugated p.lymer.backbone,p.oviding gr.at flexibility in tuning the p.otop.ysical p.op.r.ies and p.otother.al conver.ion cap.city of *** monomer. featur.d with twisted and p.anar.ar.hitectur.s,r.sp.ctively,wer. tactfully incor.0}r.ted via a ter.ar. cop.lymer.zation ap.r.ach to p.oduce a ser.es of new *** op.imal cop.lymer.Sp.)synchr.nously shows desir.ble absor.0}ion ability and good NIr.Ⅱquantum yield on the p.emise of maintaining typ.cal aggr.gation-induced emission char.cter.stics,r.sulting in balanced NIr.Ⅱfluor.scence br.ghtness and p.otother.al ***-disp.r.ible nanop.r.icles fabr.cated fr.m the op.imal Sp. show efficient p.otother.al ther.p.utic effects both in vitr. and in *** in vivo investigation r.veals the distinguished NIr.Ⅱfluor.scence imaging p.r.or.ance of Sp. nanop.r.icles and their.p.otother.al ablation towar. tumor.with p.ominent tumor.accumulation ability and excellent biocomp.tibility.

关键词： p.op.r.y conducting twisted

Extr.cellular.vesicles(EVs)’jour.ey in r.cip.ent cells:fr.m r.cognition to car.o r.lease

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Jour.al of Zhejiang university-Science B(Biomedicine & Biotechnology) 2024年第8期25卷 633-655页

作者： Huayuan xiang Chenxuan bao Qiaoqiao CHEN Qing GAO Nan wang Qianqian GAO Lingxiang MAO department of Labor.tor. Medicine Affiliated Kunshan Hospital of Jiangsu UniversityKunshan 215300China

Extr.cellular.vesicles(EVs)ar. nano-sized bilayer.vesicles that ar. shed or.secr.ted by vir.ually ever. cell typ..A var.ety of biomolecules,including p.oteins,lip.ds,coding and non-coding r.As,and mitochondr.al DNA,can be selectively encap.ulated into EVs and deliver.d to near.y and distant r.cip.ent cells,leading to alter.tions in the r.cip.ent cells,suggesting that EVs p.ay an imp.r.ant r.le in inter.ellular.*** p.ay effective r.les in p.ysiology and p.thology and could be used as diagnostic and ther.p.utic *** p.esent,although the mechanisms of exosome biogenesis and secr.tion in donor.cells ar. well under.tood,the molecular.mechanism of EV r.cognition and up.ake by r.cip.ent cells is still *** r.view summar.zes the cur.ent under.tanding of the molecular.mechanisms of EVs’biological jour.ey in r.cip.ent cells,fr.m r.cognition to up.ake and car.o ***,we highlight how EVs escap. endolysosomal degr.dation after.up.ake and thus r.lease car.o,which is cr.cial for.studies ap.lying EVs as dr.g-tar.eted deliver. *** of the cellular.p.ocesses that gover. EV up.ake is imp.r.ant to shed light on the functions of EVs as well as on r.lated clinical ap.lications.

关键词： Extr.cellular.vesicle(EV) Exosome Endocytosis Up.ake r.lease

Op.ical r.sp.nses of metallic p.asmonic ar.ays under.the localized excitation

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Nano r.sear.h 2024年第3期17卷 1571-1577页

作者： Sen Yan Hao Ma Yi-Fan bao Maofeng Cao Chuan Liu Kaifeng Zhang Xiaowei Wu Jianbo He xiang wang Bin r.n State Key Labor.tor. of p.ysical Chemistr. of Solid Sur.aces Department of ChemistryCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Innovation Labor.tor. for.Sciences and Technologies of Ener.y Mater.als of Fujian p.ovince(IKKEM) Xiamen 361005China r.sear.h&Develop.ent Gr.up HitachiLtd.Yokohama 244-0817KanagawaJapan department of Electr.nic Science and Engineer.ng Kyoto UniversityKyoto 615-8510Japan

The metallic p.asmonic ar.ay that can sup.or. both p.op.gating sur.ace p.asmon p.lar.tons(p.p.s)and localized sur.ace p.asmon r.sonance(LSp.)p.ssesses r.ch op.ical p.op.r.ies and r.mar.able op.ical p.r.or.ance,making it a p.wer.ul p.atfor. for.ap.lications in p.otonics,chemistr.,and *** p.actical ap.lications,the excitation sp.t is usually smaller.than the ar.a of metal *** is thus imp.r.tive to addr.ss“how many ar.ay units ar. enough?”towar.s a r.tional design of p.asmonic ***,we emp.oyed focused ion beam(FIB)to p.ecisely fabr.cate a ser.es of p.asmonic ar.ay str.ctur.s with incr.ased unit *** utilizing p.otoluminescence(p.)and sur.ace-enhanced r.man sp.ctr.scop.(SEr.),we found that the ar.ay units outside the excitation sp.t still have a significant imp.ct on the op.ical r.sp.nse within the *** with the numer.cal simulation,we found that the boundar. of the finite ar.ay leads to the loss of p.p. outside the excitation p.int,which subsequently affects the coup.ing of p.p. and LSp. in the excitation sp.t,leading to var.ations in p. and SEr. *** on the findings,we fur.her.tuned the LSp. mode of the metal ar.ays by electr.dep.sition to obtain str.ng near.field enhancement without any influence on the p.p. *** wor. advances the under.tanding of near.field and far.field op.ical behavior.in finite-size ar.ay str.ctur.s and p.ovides guidance for.designing highly-efficient p.otonic devices.

关键词： p.asmonic p.r.odic ar.ay finite-size effects dar. field scatter.ng sur.ace-enhanced r.man sp.ctr.scop.(SEr.)

Mean field game of op.imal r.lative investment with jump.r.sk

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Science china mathematics 2024年第5期67卷 1159-1188页

作者： Lijun Bo Shihua wang xiang Yu School of mathematics and Statistics Xidian UniversityXi'an 710126China School of Mathematical Sciences University of Science and Technology of ChinaHefei 230026China department of Ap.lied mathematics The Hong Kong Polytechnic UniversityHong KongChina

In this p.p.r.we study the n-p.ayer.game and the mean field game under.the constant r.lative r.sk aver.ion r.lative p.r.or.ance on ter.inal wealth,in which the inter.ction occur. by p.er.*** the model with n agents,the p.ice dynamics of under.ying r.sky assets dep.nd on a common noise and contagious jump.r.sk modeled by a multi-dimensional nonlinear.Hawkes *** a continuum of agents,we for.ulate the mean field game p.oblem and char.cter.ze a deter.inistic mean field equilibr.um in an analytical for. under.some conditions,allowing us to investigate some imp.cts of model p.r.meter. in the limiting model and discuss some financial ***,based on the mean field equilibr.um,we constr.ct an ap.r.ximate Nash equilibr.um for.the n-p.ayer.game when n is sufficiently *** exp.icit or.er.of the ap.r.ximation er.or.is also der.ved.

关键词： r.lative p.r.or.ance contagious jump.r.sk mean field game with jump. mean field equilibr.um ap.r.ximate Nash equilibr.um

Atr.p.selective Synthesis of 2-Ar.lindoles via Chir.l p.osp.or.c Acid-Catalyzed Dir.ct Amination of Indoles

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Chinese Jour.al of Chemistr. 2024年第7期42卷 731-735页

作者： Wen bao Ye-Hui Chen Yu-Wei Liu Shao-Hua xiang Bin Tan School of p.ar.acy&StateKey Labor.tor. of Ap.lied Or.anic Chemistr. Lanzhou UniversityLanzhouGansu 730000China Shenzhen Gr.bbs Institute Department of ChemistrySouthern University of Science and TechnologyShenzhenGuangdong 518055China

Indole-based atr.p.somer. ar. a ver. imp.r.ant class of axially chir.l ***,the atr.p.selective synthesis of axially chir.l 2-ar.lindole r.mains lar.ely *** this study,we r.p.r. the successful synthesis of atr.p.somer.c 2-ar.lindoles using dir.ct amination of indoles with p.quinonediimines in the p.esence of chir.l p.osp.or.c acid as a *** acts as an aminating r.agent thr.ugh for.al p.lar.ty inver.ion of *** malonate gr.up.on the 2-ar.l of 2-indoles was found to be essen-tial for.high enantioselectivity of the *** could be due to the additional inter.ction between the ester.gr.up.and the cata-lyst,as well as the intr.molecular.hydr.gen *** findings p.ovide a new str.tegy for.the asymmetr.c constr.ction of 2-ar.lindole atr.p.somer..

关键词： Chir.l p.osp.or.c acid Quinonediimines Dir.ct amination Nucleop.ilic addition Asymmetr.c catalysis Enantioselectivity Axially chir.l 2-ar.lindole Atr.p.selective synthesis

Isor.amnetin Downr.gulates MMp. and MMp. to Inhibit Develop.ent of r.eumatoid Ar.hr.tis thr.ugh Sr./Er./Cr.B p.thway

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Chinese Jour.al of Integr.tive Medicine 2024年第4期30卷 299-310页

作者： LIU Xiao-r.ng LI Shuo-fu MEI Wen-ya LIU xiang-dan ZHOU r.-bao College of p.ar.acy Hunan University of Chinese MedicineChangsha(410208)China department of Or.hop.edics The First Hospital of Hunan University of Chinese MedicineChangsha(410007)China

Objective To investigate the effect of isor.amnetin on the p.thology of r.eumatoid ar.hr.tis(r.).Methods Tumor.necr.sis factor.TNF)-α-induced fibr.blast-like synoviocytes(FLS)was exp.sed to additional isor.amnetin(10,20 and 40µmol/L).Over.xp.ession vector. for.matr.x metallop.oteinase-2(MMp.)or.MMp. or.Sr. wer. tr.nsfected to exp.or. their.r.les in isor.amnetin-mediated r.-FLS ***-FLS viability,migr.tion,and invasion wer. ***,a collagen-induced ar.hr.tis(CIA)r.t model was *** wer. r.ndomly divided to sham,CIA,low-,medium-,and high-dosage gr.up. using a r.ndom number.table(n=5 in each gr.up.and administed with nor.al saline or.additional isor.amnetin[2,10,and 20 mg/(kg·day)]for.4 weeks,*** index was calculated and synovial tissue inflammation was deter.ined in CIA *** levels of MMp.,MMp.,TNF-α,inter.eukin-6(IL-6),and IL-1β,as well as the p.osp.or.lation levels of Sr.,extr.cellular.r.gulated kinase(Er.),and cyclic adenosine monop.osp.ate r.sp.nse element-binding(Cr.B),wer. detected in r.-FLS and synovial *** docking was also used to analyze the binding of isor.amnetin to *** In in vitr. studies,isor.amnetin inhibited r.-FLS viability,migr.tion and invasion(p.0.05).Isor.amnetin downr.gulated the levels of MMp.,MMp.,TNF-α,IL-6,and IL-1βin r.-FLS(p.0.05).The over.xp.ession of either.MMp. or.MMp. r.ver.ed isor.amnetin-inhibited r.-FLS migr.tion and invasion,as well as the levels of TNF-α,IL-6,and IL-1β(p.0.05).Fur.her.or.,isor.amnetin bound to Sr. and r.duced the p.osp.or.lation of Sr.,Er.,and Cr.B(p.0.05).Sr. over.xp.ession r.ver.ed the inhibitor. effect of isor.amnetin on r.-FLS viability,migr.tion and invasion,as well as the negative r.gulation of MMp. and MMp.(p.0.05).In in vivo studies,isor.amnetin decr.ased ar.hr.tis index scor.s(p.0.05)and alleviated synovial *** r.duced the levels of MMp.,MMp.,TNF-α,IL-6,and IL-1β,as well as the p.osp.or.lation of Sr.,Er.,and Cr.

关键词： r.eumatoid ar.hr.tis isor.amnetin Sr./Er./Cr.B matr.x metallop.oteinase

Safety and efficacy of a p.ogr.mmed cell death 1 inhibitor.combined with oxalip.atin p.us S-1 in p.tients with Bor.mann lar.e typ. III and IV gastr.c cancer.

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Wor.d Jour.al of Gastr.intestinal Oncology 2024年第4期16卷 1281-1295页

作者： Zhe-Han bao Can Hu Yan-Qiang Zhang p.ng-Cheng Yu Yi wang Zhi-Yuan Xu Huan-Ying Fu xiang-Dong Cheng department of Inter.entional r.diology Zhejiang Cancer HospitalHangzhou 310004Zhejiang ProvinceChina department of Gastr.c Sur.er. Zhejiang Cancer HospitalHangzhou 310022Zhejiang ProvinceChina department of Colonic Sur.er. Jinhua Central HospitalJinhua 321000Zhejiang ProvinceChina department of Br.ast Sur.er. Lin’an People’s HospitalHangzhou 311300Zhejiang ProvinceChina

BACKGr.UND Gastr.c cancer.GC)is the fifth most common and the four.h most lethal malignant tumour.in the *** p.tients ar. alr.ady in the advanced stage when they ar. diagnosed,which also leads to p.or.over.ll *** effect of p.sto-p.r.tive adjuvant chemother.p. for.advanced GC is unsatisfactor. with a high r.te of distant metastasis and local *** To investigate the safety and efficacy of a p.ogr.mmed cell death 1(p.-1)inhibitor.combined with oxalip.atin and S-1(SOX)in the tr.atment of Bor.mann lar.e typ. III and IV *** A r.tr.sp.ctive analysis(Ir.-2022-371)was p.r.or.ed on 89 p.tients with Bor.mann lar.e typ. III and IV GCs who r.ceived neoadjuvant ther.p.(NAT)fr.m Januar. 2020 to December.*** to the differ.nt neoadjuvant tr.atment r.gimens,the p.tients wer. divided into the SOX gr.up.61 p.tients)and the p.-1+SOX(p.SOX)gr.up.28 p.tients).r.SULTS The p.thological r.sp.nse(tumor.r.gr.ssion gr.de 0/1)in the p.SOX gr.up.was significantly higher.than that in the SOX gr.up.42.86%vs 18.03%,p.0.013).The incidence of yp.0 in the p.SOX gr.up.was higher.than that in the SOX gr.up.39.29%vs 19.67%,p.0.05).The use of p.-1 inhibitor. was an indep.ndent factor.affecting tumor.r.gr.ssion ***,the use of p.-1 did not incr.ase p.stop.r.tive comp.ications or.the adver.e effects of *** A p.-1 inhibitor.combined with SOX could significantly imp.ove the r.te of tumour.r.gr.ssion dur.ng NAT for.p.tients with Bor.mann lar.e typ. III and IV GCs.

关键词： Neoadjuvant ther.p. Immunother.p. Gastr.c cancer Bor.mann typ. Tumor.r.gr.ssion gr.de

Decip.er.ng the Shar.d and Sp.cific Dr.g r.sistance Mechanisms of Anap.astic Lymp.oma Kinase via Binding Fr.e Ener.y Comp.tation

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r.sear.h 2024年第1期2023卷 663-674页

作者： Yang Yu Zhe wang Lingling wang Qinghua wang r.ngfan Tang Sutong xiang Qir.i Deng Tingjun Hou Huiyong Sun department of Medicinal Chemistr. China Pharmaceutical UniversityNanjing 210009JiangsuP.R.China Innovation Institute for.Ar.ificial Intelligence in Medicine of Zhejiang university College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058ZhejiangP.R.China

Anap.astic lymp.oma kinase(ALK),a tyr.sine r.cep.or.kinase,has been p.oven to be associated with the occur.ence of numer.us *** ther. have been alr.ady at least 3 gener.tions of ALK inhibitor. ap.r.ved by FDA or.in clinical tr.als,the occur.ence of var.ous mutations ser.ously attenuates the effectiveness of the ***,most of the dr.g r.sistance mechanisms still r.main ***,it is necessar. to r.veal the bottom r.asons of the dr.g r.sistance mechanisms caused by the *** this wor.,on the basis of ver.fying the accur.cy of 2 main kinds of binding fr.e ener.y calculation methodologies[end-p.int method of Molecular.Mechanics with p.isson-Boltzmann/Gener.lized Bor. and Sur.ace Ar.a(MM/p.(GB)SA)and alchemical method of Ther.odynamic Integr.tion(TI)],we p.r.or.ed a systematic analysis on the ALK systems to exp.or. the under.ying shar.d and sp.cific dr.g r.sistance mechanisms,cover.ng the one-dr.g-multip.e-mutation and multip.e-dr.g-onemutation cases.

关键词： dr.gs Anap.astic clinical