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Design and performance evaluation of a large field-of-view dual-particle time-encoded imager based on a depth-of-interaction detector

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Nuclear Science and Techniques 2024年第4期35卷 1-14页

作者： Dong Zhao Xu-Wen Liang Ping-Kun Cai Wei Cheng Wen-bao jia Da-Qian Hei Qing Shan Yong-Sheng Ling Chao Shi Department of Nuclear Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 211106China Collaborative Innovation Center of Radiation Medicine of jiangsu Higher Education Institutions Suzhou 215000China School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China

Time-encoded imaging is useful for identifying potential special nuclear materials and other radioactive sources at a *** this study,a large field-of-view time-encoded imager was developed for gamma-ray and neutron source hotspot imaging based on a depth-of-interaction(DOI)*** imager primarily consists of a DOI detector system and a rotary dual-layer cylindrical coded *** EJ276 plastic scintillator coupled with two SiPMs was designed as the DOI detector to increase the field of view and improve the imager *** difference in signal time at both ends and the log of the signal amplitude ratio were used to calculate the interaction position *** position resolution of the DOI detector was calibrated using a collimated Cs-137 source,and the full width at half maximum of the reconstruction position of the Gaussian fitting curve was approximately 4.4 *** DOI detector can be arbitrarily divided into several units to independently reconstruct the source distribution *** unit length was optimized via Am-Be source-location experiments.A multidetector filtering method is proposed for image *** method can effectively reduce image noise caused by poor DOI detector position *** vertical field of view of the imager was(-55°,55°)when the detector was placed in the center of the coded mask.A DT neutron source at 20 m standoff could be located within 2400 s with an angular resolution of 3.5°.

关键词： Time-encoded imager Depth-of-interaction detector Dual-particle imaging Hotspot imaging

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Microstructure,interfacial reaction behavior,and mechanical properties of Ti_3AlC_(2)reinforced Al6061 composites

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Transactions of Nonferrous Metals Society of China 2024年第9期34卷 2756-2771页

作者： Zhi-bin LIU jia-bao bao Wen-jie HU Hong YAN School of Advanced Manufacturing Nanchang UniversityNanchang 330031China jiangxi Vocational and Technical College of Communications Nanchang 330013China

The interfacial reaction behavior of Al and Ti_3AlC_(2)at different pouring temperatures and its effect on the microstructure and mechanical properties of the composites were *** results show that the addition of3.0 wt.%Ti_3AlC_(2)refines the average grain size ofα(Al)in the composite by 50.1%compared to Al6061 *** analyses indicate that an in-situ Al_(3Ti)transition layer of-180 nm in thickness is generated around the edge of Ti_3AlC_(2)at 720℃,forming a well-bonded Al-Al_(3Ti)*** this processing temperature,the ultimate tensile strength of A16061-3.0 wt.%Ti_3AlC_(2)composite is 199.2 MPa,an improvement of 41.5%over the Al6061 *** analyses further elucidate that 720℃is favourable for forming the nano-sized transition layer at the Ti_3AlC_(2)***,the thermal mismatch strengthening plays a dominant role in this state,with a strengthening contribution of about 74.8%.

关键词： Al6061 composites Ti3AlC2 microstructure interfacial reaction tensile mechanical properties

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Global trends in publications regarding macrophages-related diabetic foot ulcers in the last two decades

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World Journal of Diabetes 2024年第7期15卷 1627-1644页

作者： jian-Ping Wen Shuan-Ji Ou jia-bao Liu Wei Zhang Yu-Dun Qu jia-Xuan Li Chang-Liang Xia Yang Yang Yong Qi Chang-Peng Xu Department of Orthopaedics The Affiliated Guangdong Second Provincial General Hospital of Jinan UniversityGuangzhou 510000Guangdong ProvinceChina The Second School of Clinical Medicine Southern Medical UniversityGuangzhou 510000Guangdong ProvinceChina

BACKGROUND Diabetic foot ulcers(DFUs)are one of the most severe and popular complications of *** persistent non-healing of DFUs is the leading cause of amputation,which causes significant mental and financial stress to patients and their *** are critical cells in wound healing and perform essential roles in all phases of wound ***,no studies have been carried out to systematically illustrate this area from a scientometric point of *** there have been some bibliometric studies on diabetes,reports focusing on the investigation of macrophages in DFUs are *** To perform a bibliometric analysis to systematically assess the current state of research on macrophage-related *** The publications of macrophage-related DFUs from January 1,2004,to December 31,2023,were retrieved from the Web of Science Core Collection on January 9,*** different analytical tools:VOSviewer(v1.6.19),CiteSpace(v6.2.R4),HistCite(v12.03.07),and Excel 2021 were used for the scientometric *** A total of 330 articles on macrophage-related DFUs were *** most published countries,institutions,journals,and authors in this field were China,Shanghai jiao Tong University of China,Wound Repair and Regeneration,and Aristidis *** the analysis of keyword co-occurrence networks,historical direct citation networks,thematic maps,and trend topics maps,we synthesized the prevailing research hotspots and emerging trends in this *** Our bibliometric analysis provides a comprehensive overview of macrophage-related DFUs research and insights into promising upcoming research.

关键词： Diabetic foot ulcers Macrophage Macrophage polarization Bibliometrics Wound healing Inflammation

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The evolution and functional divergence of 10 Apolipoprotein D-like genes in Nilaparvata lugens

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Insect Science 2024年第1期31卷 91-105页

作者： jia-bao Lu Peng-Peng Ren Qiao Li Fang He Zhong-Tian Xu Sai-Nan Wang jian-Ping Chen Jun-Min Li Chuan-Xi Zhang Citrus Research Institute Southwest University/Chinese Academy of Agricultural SciencesNational Engineering Research Center for CitrusChongqingChina Technology Center of Wuhan Customs District HubeiChina Institute of Insect Science Zhejiang UniversityHangzhouChina

Apolipoprotein D(ApoD),a member of the lipocalin superfamily of proteins,is involved in lipid transport and stress *** only a single copy of the ApoD gene is found in humans and some other vertebrates,there are typically several ApoD-like genes in *** date,there have been relatively few studies that have examined the evolution and functional differentiation of ApoD-like genes in insects,particularly hemi-metabolous *** this study,we identified 10 ApoD-like genes(NlApoD1−10)with distinct spatiotemporal expression patterns in Nilaparvata lugens(BPH),which is an important pest of ***1−10 were found to be distributed on 3 chromosomes in a tandem array of NlApoD1/2,NlApoD3−5,and NlApoD7/8,and show sequence and gene structural divergence in the coding regions,indicating that multiple gene duplication events occurred during *** analysis revealed that NlApoD1−10 can be clustered into 5 clades,with NlApoD3−5 and NlApoD7/8 potentially evolving exclusively in the Delphacidae *** screening using an RNA interference approach revealed that only NlApoD2 was essential for BPH development and survival,whereas NlApoD4/5 are highly expressed in testes,and might play roles in ***,stress response analysis revealed that NlApoD3−5/9,NlApoD3−5,and NlApoD9 were up-regulated after treatment with lipopolysaccharide,H2O2,and ultraviolet-C,respectively,indicating their potential roles in stress resistance.

关键词： Apolipoprotein D BPH evolution functional divergence gene duplication NIApoD

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The effect of jiangan Xiaozhi Formula on oxidative stress and inflammatory factors in patients with non-alcoholic fatty liver disease

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Clinical Research Communications 2024年第2期7卷 23-26页

作者： Si Wang jia Zhu Ning Wang jia-bao Liao Yunnan University of Chinese Medicine Kunming 650599China Department of Emergency Jiaxing Hospital of Traditional Chinese MedicineJiaxing 314001China.

Objective:To investigate the effects of jiangan Xiaozhi Formula(JGXZ)on oxidative stress and inflammatory factors in patients with non-alcoholic fatty liver disease(NAFLD).Methods:Between September 2022 and December 2023,our hospital admitted a total of 58 patients with *** patients were split into two groups at random:one for experimentation and the other for *** were 27 patients in the experimental group at the end,compared to 26 in the control group,reasonable exercise,weight management,lipid regulation,and oral polyene phosphatidylcholine capsules(PPC).The experimental group received JGXZ in addition to the above treatments for 12 consecutive *** in Traditional Chinese Medicine(TCM)syndrome scores,blood lipids,liver function indicators,the levels of oxidative stress markers,such as malondialdehyde(MDA),glutathione peroxidase(GSH-Px),and superoxide dismutase(SOD),as well as serum inflammatory factors,such as interleukin-6(IL-6),interleukin-8(IL-8),and tumor necrosis factor-α(TNF-α),were measured both before and after ***:After treatment,both groups showed significant reductions in TCM syndrome scores(P<0.05)and improvements in blood lipids,liver function indicators,inflammatory factors,and oxidative stress markers(P<0.05).Improvements were noticeably better in the experimental group than in the control group.(P<0.05).Conclusion:JGXZ can significantly improve clinical symptoms,regulate blood lipids,and protect liver function in patients with *** mechanism may be related to inhibiting inflammatory responses and regulating the balance of the oxidation-antioxidation system.

关键词： jiangan Xiaozhi Formula non-alcoholic fatty liver disease oxidative stress response inflammatory factors

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Role of gut microbiota in Crohn’s disease pathogenesis:Insights from fecal microbiota transplantation in mouse model

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World Journal of Gastroenterology 2024年第31期30卷 3689-3704页

作者： Qiang Wu Lian-Wen Yuan Li-Chao Yang Ya-Wei Zhang Heng-Chang Yao Liang-Xin Peng bao-jia Yao Zhi-Xian jiang Geriatric Surgery of Department of General Surgery The Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina

BACKGROUND Inflammatory bowel disease,particularly Crohn’s disease(CD),has been associated with alterations in mesenteric adipose tissue(MAT)and the phenomenon termed“creeping fat”.Histopathological evaluations showed that MAT and intestinal tissues were significantly altered in patients with CD,with these tissues characterized by inflammation and *** To evaluate the complex interplay among MAT,creeping fat,inflammation,and gut microbiota in *** Intestinal tissue and MAT were collected from 12 patients with *** manifestations and protein expression levels were analyzed to determine lesion *** samples were collected from five recently treated CD patients and five control subjects and transplanted into *** intestinal and mesenteric lesions in these mice,as well as their systemic inflammatory status,were assessed and compared in mice transplanted with fecal samples from CD patients and control *** Pathological examination of MAT showed significant differences between CDaffected and unaffected colons,including significant differences in gut microbiota *** microbiota transplantation(FMT)from clinically healthy donors into mice with 2,4,6-trinitrobenzene sulfonic acid(TNBS)-induced CD ameliorated CD symptoms,whereas FMT from CD patients into these mice exacerbated CD ***,FMT influenced intestinal permeability,barrier function,and levels of proinflammatory factors and ***,FMT from CD patients intensified fibrotic changes in the colon tissues of mice with TNBS-induced *** Gut microbiota play a critical role in the histopathology of *** MAT and creeping fat may therefore have potential in the treatment of patients with CD.

关键词： Mesenteric adipose tissue Crohn’s disease Fecal microbiota transplantation Intestinal fibrosis Intestinal barrier

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Artificial intelligence-driven radiomics study in cancer:the role of feature engineering and modeling

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Military Medical Research 2024年第1期11卷 115-147页

作者： Yuan-Peng Zhang Xin-Yun Zhang Yu-Ting Cheng Bing Li Xin-Zhi Teng jiang Zhang Saikit Lam Ta Zhou Zong-Rui Ma jia-bao Sheng Victor CWTam Shara WYLee Hong Ge Jing Cai Department of Medical Informatics Nantong UniversityNantong 226001JiangsuChina Department of Health Technology and Informatics the Hong Kong Polytechnic UniversityHong Kong 999077China The Hong Kong Polytechnic University Shenzhen Research Institute Shenzhen 518000GuangdongChina Department of Radiation Oncology the Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer HospitalZhengzhou 450008China

Modern medicine is reliant on various medical imaging technologies for non-invasively observing patients’***,the interpretation of medical images can be highly subjective and dependent on the expertise of ***,some potentially useful quantitative information in medical images,especially that which is not visible to the naked eye,is often ignored during clinical *** contrast,radiomics performs high-throughput feature extraction from medical images,which enables quantitative analysis of medical images and prediction of various clinical *** have reported that radiomics exhibits promising performance in diagnosis and predicting treatment responses and prognosis,demonstrating its potential to be a non-invasive auxiliary tool for personalized ***,radiomics remains in a developmental phase as numerous technical challenges have yet to be solved,especially in feature engineering and statistical *** this review,we introduce the current utility of radiomics by summarizing research on its application in the diagnosis,prognosis,and prediction of treatment responses in patients with *** focus on machine learning approaches,for feature extraction and selection during feature engineering and for imbalanced datasets and multi-modality fusion during statistical ***,we introduce the stability,reproducibility,and interpretability of features,and the generalizability and interpretability of ***,we offer possible solutions to current challenges in radiomics research.

关键词： Artificial intelligence Radiomics Feature extraction Feature selection Modeling Interpretability Multimodalities Head and neck cancer

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基于变分模态分解的采空区“三带”微震信号能量衰减规律

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岩土力学 2024年第4期45卷 991-1002页

作者：贾宝新郑克楠周琳力辽宁工程技术大学土木工程学院辽宁阜新123000 辽宁工程技术大学辽宁省矿山沉陷灾害防治重点实验室辽宁阜新123000

为探明微震信号能量在采空区“三带”结构中的衰减规律,拟开展采空区覆岩相似模型试验,采集人工激发微震波经由采空区结构传播的微震信号,通过变分模态分解(variational mode decomposition,VMD)处理微震信号,获取各频率下模态分量。针... 详细信息

为探明微震信号能量在采空区“三带”结构中的衰减规律,拟开展采空区覆岩相似模型试验,采集人工激发微震波经由采空区结构传播的微震信号,通过变分模态分解(variational mode decomposition,VMD)处理微震信号,获取各频率下模态分量。针对采空区微震信号在VMD下各模态分量中心频率与能量之间的关系展开分析。根据中心频率法确定微震信号最佳模态数量,并计算微震信号欠分解状态、最佳分解状态、过分解状态下各分量能量;对各震源下信号最佳分解状态时各模态分量能量与中心频率分布关系进行拟合,分析在“三带”结构中,微震信号不同传播状态下各结构层对信号能量影响作用。研究结果表明:(1)在VMD过程中,人工激发震动信号有效模态数量在6~11范围内,微震信号能量随模态数量变化明显。(2)采用幂函数可实现对微震信号模态能量与频率关系的拟合,且拟合状态良好(决定系数大于0.9),其中低频模态分量包含能量占信号总能量近50%;采用高斯函数可以拟合震源各分量能量在频域上的分布表现,拟合状态较好,且表现出高斯单峰特征。(3)微震信号穿越采空区“三带”结构,微震信号能量随震源位置与传感器距离增加而减小,同时信号能量随震源位置到达传感器穿越岩层数量增加而减小,信号能量在经由垮落带时,能量变化明显,相较于裂隙带和弯曲下沉带,垮落带对信号能量衰减作用明显。

关键词：变分模态分解(VMD) 微震信号信号频率特征信号能量衰减采空区“三带”结构

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焦化厂蒸氨废水中氨氮快速检测方法的研究

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现代化工 2024年第10期44卷 232-236页

作者：黄家伟赵敏鲍彦舟胡杰颜家保武汉科技大学化学与化工学院煤转化与新型炭材料湖北省重点实验室湖北武汉430081 武汉科技大学信息科学与工程学院湖北武汉430081 武汉轻工大学化学与环境工程学院湖北武汉430023

蒸氨废水中存在较高浓度的S^(2-),严重影响离子选择性电极法测定结果的准确性,因此,焦化厂蒸氨废水中氨氮的检测一般采用纳氏试剂比色法,但该方法操作过程烦琐、测定时间长,分析结果滞后。鉴于此,研制了全固态铵离子选择性电极,通过向... 详细信息

蒸氨废水中存在较高浓度的S^(2-),严重影响离子选择性电极法测定结果的准确性,因此,焦化厂蒸氨废水中氨氮的检测一般采用纳氏试剂比色法,但该方法操作过程烦琐、测定时间长,分析结果滞后。鉴于此,研制了全固态铵离子选择性电极,通过向废水中加入适量的醋酸锌消除S^(2-)的干扰,进而建立一种适用于蒸氨废水中氨氮快速检测的电化学分析方法。调节水样的pH至4~7,加入适量的醋酸锌,测量铵离子选择性电极与Ag/AgCl参比电极间的电位差,通过标准曲线即可快速获得水样中氨氮的浓度。该方法对氨氮的检测线性范围为0.14~1400 mg/L,检出限为0.011 mg/L,相对标准偏差RSD为1.14%~3.02%,加标回收率为99.85%~104.18%。该方法操作简便,测定时间短,可快速分析焦化厂蒸氨废水中的氨氮,并具有开发氨氮在线监测装置的良好应用前景。

关键词：蒸氨废水氨氮快速测定离子选择性电极纳氏试剂比色法硫离子

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英语学界“历史中的《易》”学派的形成与发展

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周易研究 2024年第3期 78-86页

作者：韩子奇王嘉宝北京师范大学人文和社会科学高等研究院广东珠海519087 北京师范大学-香港浸会大学联合国际学院人文社科学院广东珠海519087 北京师范大学-香港浸会大学联合国际学院通识教育学院广东珠海519087

20世纪80年代以来,英语学界对《周易》的认识从“智慧之书”向“历史中的《易》”解易范式转变,逐渐形成了“历史中的《易》”学派。该学派不欲探求《周易》的本来面貌或掌握作者意图,而是运用伽达默尔诠释学方法,关注文本、时代与读者... 详细信息

20世纪80年代以来,英语学界对《周易》的认识从“智慧之书”向“历史中的《易》”解易范式转变,逐渐形成了“历史中的《易》”学派。该学派不欲探求《周易》的本来面貌或掌握作者意图,而是运用伽达默尔诠释学方法,关注文本、时代与读者三个要素的“视域融合”关系,即《周易》文本在历史流变的过程中不断展开,与不同时间的读者或占者不断进行“视域融合”,最后产生出“一人一经”甚至“一瞬一经”的易学新解。“历史中的《易》”学派的易学研究可分为三个阶段:范式初始阶段,以1990年出版的《宋代对〈易经〉的运用》为标志;范式发展阶段,以2005年出版的《〈易经〉与中国政治——经典诠释学与北宋士人的行动主义》为标志;范式开新阶段,以何茂康的《伊川易传》英文全译本(2019)和艾周思的《周易本义》英文全译本(2020)为标志。三十年来,“历史中的《易》”学派推出了一系列重要易学著作的首个英文全译本,围绕易学的核心问题展开了细致讨论,不断加深和推进对中国易学的理解,也不断拓展着易学的海外传播。

关键词：历史中的《易》艾周思苏德恺林理彰何茂康

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