检索结果-南通市图书馆

聚乙二醇干扰素α-2b联合利巴韦林与标准α-2b干扰素联合利巴韦林对合并HIV感染患者的慢性丙型肝炎的疗效比较:一项随机对照试验

世界核心医学期刊文摘（胃肠病学分册） 2005年第5期1卷 9-10页

作者： Carrat f. bani-sadr f. Pol S 郝筱倩 Groupe Hospitalier Universitaire Est UniversitéParis 6INSERM U444ParisFrance Dr

Context: Treatment of.chronic hepatitis C virus (HCV) inf.ction in human immunodef.ciency virus (HIV)-inf.cted patients is a growing concern. Most data on the virologic ef.icacy and saf.ty of.the combination of.peginterf.ron alf.-2b and ribavirin in coinf.cted patients come f.om uncontrolled studies. Objective: To study the saf.ty and ef.icacy of.peginterf.ron alf.-2b plus ribavirin vs standard interf.ron alf.-2b plus ribavirin in HIV-HCV coinf.cted patients. Design and Settings: A multicenter,randomized,parallel-group,open-label trial. Patients were enrolled f.om f.bruary 2000 to f.bruary 2002 and f.llowed up f.r 72 weeks. Patients: f.ur hundred twelve HIV-HCV coinf.cted patients with detectable serum HCV-RNA,abnormal liver histology,a CD4 cell count of.at least 200 ×106/L,and stable plasma HIV-RNA. Intervention: Treatment with ribavirin 400 mg twice a day,orally,plus either peginterf.ron alf.-2b (1.5 μg/kg subcutaneous injection once a week) or standard interf.ron alf.-2b (3 million units of.subcutaneous injection 3 times a week) f.r 48 weeks. Main Outcome Measures: Sustained virologic response,def.ned by undetectable serum HCV-RNA at week 72. Results: More patients had sustained virologic responses in the peginterf.ron group than in the standard interf.ron group (27%vs 20%,P=.047). This dif.erence between the treatments was f.und in patients with HCV genotype 1 or 4 inf.ction (17%f.r peginterf.ron vs 6%f.r standard interf.ron,P=.006) but was not f.und in patients with HCV genotype 2,3,or 5 (44%f.r peginterf.ron vs 43%f.r standard interf.ron,P=.88). Together,a decline in HCV-RNA of.less than 2 log10 f.om baseline and detectable serum HCV-RNA at week 12 predicted 99%of.treatment f.ilures. Histologic activity diminished and f.brosis stabilized in virologic responders. The 2 regimens showed similar tolerability although dose modif.cations f.r clinical and biological events were more f.equent with peginterf.ron. Eleven cases of.pancreatitis or symptomatic hyperlactate

关键词：慢性丙型肝炎干扰素α HIV感染患者干扰素联合随机对照试验肝脏组织学感染人群合并感染者细胞计数二脱氧腺苷

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Two-Stream Approximation to the Radiative Transf.r Equation:A New Improvement and Comparative Accuracy with Existing Methods

引用

Advances in Atmospheric Sciences 2024年第2期41卷 278-292页

作者： f.Momo TEMGOUA L.Akana NGUIMDO DNJOMO Environmental Energy Technologies Laboratory(EETL) Faculty of SciencesUniversity of YaoundéPO Box 812 YaoundéCameroon Department of.Electrical and Electronic Engineering Faculty of Engineering and TechnologyUniversity of BueaPO Box 63 BueaCameroon

Mathematical modeling of.the interaction between solar radiation and the Earth's atmosphere is f.rmalized by the radiative transf.r equation(RTE), whose resolution calls f.r two-stream approximations among other methods. This paper proposes a new two-stream approximation of.the RTE with the development of.the phase f.nction and the intensity into a third-order series of.Legendre polynomials. This new approach, which adds one more term in the expression of.the intensity and the phase f.nction, allows in the conditions of.a plane parallel atmosphere a new mathematical f.rmulation of.γparameters. It is then compared to the Eddington, Hemispheric Constant, Quadrature, Combined Delta f.nction and Modif.ed Eddington, and second-order approximation methods with ref.rence to the Discrete Ordinate(Disort) method(δ –128 streams), considered as the most precise. This work also determines the conversion f.nction of.the proposed New Method using the f.ndamental def.nition of.two-stream approximation(f.TSA) developed in a previous work. Notably,New Method has generally better precision compared to the second-order approximation and Hemispheric Constant methods. Compared to the Quadrature and Eddington methods, New Method shows very good precision f.r wide domains of.the zenith angle μ 0, but tends to deviate f.om the Disort method with the zenith angle, especially f.r high values of.optical thickness. In spite of.this divergence in ref.ectance f.r high values of.optical thickness, very strong correlation with the Disort method(R ≈ 1) was obtained f.r most cases of.optical thickness in this study. An analysis of.the Legendre polynomial series f.r simple f.nctions shows that the high precision is due to the f.ct that the approximated f.nctions ameliorate the accuracy when the order of.approximation increases, although it has been proven that there is a limit order depending on the f.nction f.om which the precision is lost. This observation indicates that increasing the order of.app

关键词： Radiative Transf.r Equation two-stream method Legendre polynomial optical thickness moments of.specif.c intensity conversion f.nction transmittance ref.ectance

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The Importance of.Posterior Tibial Slope in TKR: Pre and Post-Operative Measurements in United States Osteoarthritic Patients

引用

Open Journal of.Orthopedics 2024年第8期14卷 374-379页

作者： f.ederick f. Buechel Sr f.ederick f. Buechel Jr Rutgers New Jersey Medical School Department of Orthopaedic Surgery Newark USA Lenox Hill Hospital Department of Orthopaedic Surgery New York USA

Background: Sagittal plane placement of.the tibial component in total knee replacement (TKR) has important implications f.r maximizing the range of.f.exion motion, allowing collateral ligaments to f.nction more normally, as well as providing ideal compressive loading on the tibial bone-prosthesis interf.ce. This study attempts to quantif. the normal posterior tibial slope (PTS) angle pre-operatively and post-operatively in osteoarthritic patients af.er using a conventional extramedullary tibial resection guide to assess its ef.ectiveness. Methods: f.rty-nine primary cementless total knee replacements in 34 osteoarthritic patients were measured radiographically pre-operatively and one year post-operatively to determine the PTS and its ef.ect on range of.motion. Lateral X-rays, using the anterior cortical line of.the tibia, were employed f.r all measurements. Results: Pre-operative PTS measured 11.83˚ (range 5˚ - 18˚), while post-operative PTS of.implanted tibial components measured 11.30o (range 4˚ - 18˚). The pre-operative range of.motion of.112˚ (range 30˚ to 135˚) was improved to 119˚ (range 90˚ to 135˚) post-operatively af.er 1 year. Conclusions: Anterior tibial shaf. ref.rencing using a conventional extramedullary tibial resection guide provides an easy and convenient method f.r reproducing the anatomical PTS during TKR. This methodology provided improvement in average range of.motion f.om 112˚ pre-operatively to 119˚ post-operatively at one year.

关键词： Posterior Tibial Slope Posterior Tibial Inclination Extramedullary Tibial Resection Guide Total Knee Alignment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Clinical studies in COVID-related olf.ctory disorders:Review of.an institutional experience

引用

World Journal of.Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 129-136页

作者： Theresa Tharakan Dorina Kallogjeri Jay f.Piccirillo Department of.Otolaryngology-Head and Neck Surgery Clinical Outcomes Research OfficeSchool of MedicineWashington University in St LouisSt LouisMissouriUSA

Objective:To share a single institutional experience with clinical research on COVID-related olf.ctory dysf.nction(OD).Data Source/Method:Narrative review of.published original data and ongoing clinical trials on COVID-related OD at Washington University f.om 2020 to ***:There were three new diagnostic-/patient-reported outcome measures developed and *** report f.ve clinical trials of.interventions f.r COVID-related olf.ctory disorders:combined Visual-Olf.ctory Training(VOLT)with patient-pref.rred scents versus standard olf.ctory training(VOLT trial),oral gabapentin versus placebo(Gabapentin f.r the Relief.of.Acquired Chemosensory Experience trial),nasal theophylline irrigations versus placebo(Smell Changes and Ef.icacy of.Nasal Theophylline trial),stellate ganglion block(single-arm),and mindf.lness-based stress reduction(MBSR)versus lif.style intervention(MBSR trial).Conclusions:Initial intervention trials f.r COVID-related OD have shown potential f.r improving subjective and objective olf.ctory ***,there remains no gold standard treatment that def.nitively outperf.rms placebo in controlled ***,continued investigation of.novel therapeutic strategies f.r COVID-related OD is necessary to maximize olf.ctory outcomes f.r af.ected patients.

关键词： chemosensory disorders COVID olf.ctory dysf.nction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Macroscopic Traversable Wormholes: Minimum Requirements

引用

International Journal of.Astronomy and Astrophysics 2024年第3期14卷 230-243页

作者： Peter K. f. Kuhf.ttig Department of.Mathematics Milwaukee School of Engineering Milwaukee USA

While wormholes are just as good a prediction of.Einstein’s theory as black holes, they are subject to severe restrictions f.om quantum f.eld theory. To allow f.r the possibility of.interstellar travel, a macroscopic wormhole would need to maintain suf.iciently low radial tidal f.rces. It is proposed in this paper that the assumption of.zero tidal f.rces, i.e., the limiting case, is suf.icient f.r overcoming the restrictions f.om quantum f.eld theory. The f.asibility of.this approach is subsequently discussed by 1) introducing the additional conditions needed to ensure that the radial tidal f.rces can indeed be suf.iciently low and 2) by viewing traversable wormholes as emergent phenomena, thereby increasing the likelihood of.their existence.

关键词： Morris-Thorne Wormholes Traversability Minimum Requirements Stability Compatibility with Quantum f.eld Theory

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

On an Invariant of.Tournament Digraphs

引用

Journal of.Applied Mathematics and Physics 2024年第7期12卷 2711-2722页

作者： Boris f. Melnikov Bowen Liu f.culty of.Computational Mathematics and Cybernetics Shenzhen MSU-BIT University Shenzhen China

To date, it is unknown whether it is possible to construct a complete graph invariant in polynomial time, so f.st algorithms f.r checking non-isomorphism are important, including heuristic algorithms, and f.r successf.l implementations of.such heuristics, both the tasks of.some modif.cation of.previously described graph invariants and the description of.new invariants remain relevant. Many of.the described invariants make it possible to distinguish a larger number of.graphs in the real time of.a computer program. In this paper, we propose an invariant f.r a special kind of.directed graphs, namely, f.r tournaments. The last ones, f.om our point of.view, are interesting because when f.xing the order of.vertices, the number of.dif.erent tournaments is exactly equal to the number of.undirected graphs, also with f.xing the order of.vertices. In the invariant we are considering, all possible tournaments consisting of.a subset of.vertices of.a given digraph with the same set of.arcs are iterated over. f.r such subset tournaments, the places are calculated in the usual way, which are summed up to obtain the f.nal values of.the points of.the vertices;these points f.rm the proposed invariant. As we expected, calculations of.the new invariant showed that it does not coincide with the most natural invariant f.r tournaments, in which the number of.points is calculated f.r each participant. So f.r, we have conducted a small number of.computational experiments, and the minimum value of.the pair correlation between the sequences representing these two invariants that we f.und is f.r dimension 15.

关键词： Graph Directed Graph Tournament ?nvariant

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Impaired Cognition and Stroke Rehabilitation Outcomes: Are They Related?

引用

Open Journal of.Therapy and Rehabilitation 2024年第2期12卷 101-116页

作者： Eric f. Tanlaka Torri Trojand f.culty of.Nursing University of Windsor Windsor Canada

Background: Stroke survivors who exhibit impaired cognition at admission to inpatient rehabilitation may experience participation challenges and poorer f.nctional outcomes than those without impaired cognition. Dif.erences in f.nctional outcomes between stroke survivors with and without impaired cognition may be attributed to age, level of.cognitive impairment, and severity of.stroke. Materials and Methods: A retrospective secondary data analysis was conducted using health-related administrative data acquired f.om a Southwestern Ontario hospital’s stroke rehabilitation database. The aim was to explore potential linkages between post-stroke impaired cognition and f.nctional gains, rehabilitation stays, and living settings af.er discharge f.om rehabilitation. Results: An aggregate sample of.393 males and 314 f.males subclassif.ed as experiencing mild, moderate, and severe stroke was analyzed. At inpatient rehabilitation admission, 21.5% (n = 152) of.these patients had no impaired cognition, 33.7% (n = 238) had mild impaired cognition, 22.2% (n = 157) had moderate impaired cognition, and 22.6% (n = 160) had severe impaired cognition. Cognitively impaired stroke patients were signif.cantly (p 0.001) older, had (mostly) moderate to severe stroke with signif.cantly (p = 0.012) more moderate cognitive impairment, had signif.cantly (p 0.001) longer rehabilitation stays, and a high propensity f.r being discharged to longer-term care f.cilities compared to non-cognitively impaired patients. Conclusion: Presence of.signif.cant dissimilarity in rehabilitation stays and post-discharge destinations among stroke survivors with and without cognitive impairment is attributed to the age of.the patient, level of.cognitive impairment, and rigorous rehabilitation interventions.

关键词： Stroke Impaired Cognition Inpatient Rehabilitation f.nctional Outcomes

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Thin-Shell Wormholes Admitting Conf.rmal Motions in Spacetimes of.Embedding Class One

引用

International Journal of.Astronomy and Astrophysics 2024年第3期14卷 162-171页

作者： Peter K. f. Kuhf.ttig Department of.Mathematics Milwaukee School of Engineering Milwaukee USA

This paper discusses the f.asibility of.thin-shell wormholes in spacetimes of.embedding class one admitting a one-parameter group of.conf.rmal motions. It is shown that the surf.ce energy density σis positive, while the surf.ce pressure is negative, resulting in , thereby signaling a violation of.the null energy condition, a necessary condition f.r holding a wormhole open. f.r a Morris-Thorne wormhole, matter that violates the null energy condition is ref.rred to as “exotic”. f.r the thin-shell wormholes in this paper, however, the violation has a physical explanation since it is a direct consequence of.the embedding theory in conjunction with the assumption of.conf.rmal symmetry. These properties avoid the need to hypothesize the existence of.the highly problematical exotic matter.

关键词： Thin-Shell Wormholes Conf.rmal Symmetry Embedding Class One Exotic Matter

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Assessment of.the piroxicam-incited model of.synchronized colitis in T-cell receptor alpha chain-def.cient mice

引用

ANIMAL MODELS AND EXPERIMENTAL MEDICINE 2024年第4期7卷 533-543页

作者： Lange, Maximo E. Bescucci, Danisa M. Boras, Valerie f. Montina, Tony Inglis, G. Douglas Agr & Agrif.od Canada Lethbridge Res & Dev Ctr Lethbridge AB T1J 4B1 Canada Chinook Reg Hosp Alberta Hlth Serv Lethbridge AB Canada Univ Lethbridge Dept Chem & Biochem Lethbridge AB Canada Univ Lethbridge Southern Alberta Genome Sci Ctr Lethbridge AB Canada

BackgroundA multitude of.mouse models are utilized to emulate and study intestinal inf.ammation. T-cell receptor alpha chain (TCR alpha)-def.cient mice are used as a model of.spontaneous colitis that has similarities with human ulcerative colitis. However, colitis is triggered late in the lif. of.the mouse (age: 4-5 months), and inf.ammation does not develop at the same time in dif.erent mice. A previously conducted study reported that the administration of.the drug piroxicam triggered predictable and early colitis in TCR alpha-def.cient mice at the age of.6-8 weeks. However, a detailed characterization of.ensuing inf.ammation was not *** conducted an in-depth examination of.piroxicam-triggered colitis in TCR alpha-def.cient mice, with emphasis on spatial histopathologic changes and analysis of.expression of.inf.ammatory markers. f.rthermore, we tested amelioration of.colitis with *** conf.rmed that piroxicam induced a time-prescribed colitis and did so in the proximal colon as well as the cecum of.TCR alpha-def.cient mice. Piroxicam administration was observed to induce epithelial hyperplasia, goblet cell loss, and leukocyte inf.ltration with occasional ulceration. A Swiss roll technique was used to examine the colon and cecum in its entirety. Importantly, we observed that inf.ammation was multif.cal segmental, with areas of.tissue damage in between healthy tissue. In addition, we observed variability in the severity of.inf.ammation among replicate animals and treatments, and that the administration of.dexamethasone only partially ameliorated inf.ammation in the proximal *** consistently induced multif.cal segmental colitis in the proximal colon and cecum, although the degree of.inf.ammation was reduced in the latter. Importantly, spatial variability in inf.ammation in the large intestine and the inter-replicate variation in the severity of.inf.ammation must be taken into consideration when utilizing this mu

关键词： colon dexamethasone histology induction inf.ammation knockout ANIMAL-MODELS CYTOKINES DISEASE TNf

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Transf.rmer f.r the Design of.Automatic Control Systems with Pref.lters

引用

World Journal of.Engineering and Technology 2024年第3期12卷 575-586页

作者： Isaac Hughes John f. O’Brien Department of.Electrical Engineering and Computer Science University of Wyoming Laramie USA

A machine learning model, using the transf.rmer architecture, is used to design a f.edback compensator and pref.lter f.r various simulated plants. The output of.the transf.rmer is a sequence of.compensator and pref.lter parameters. The compensator and pref.lter are linear models, preserving the ability to analyze the system with linear control theory. The input to the network is a window of.recent ref.rence and output samples. The goal of.the transf.rmer is to minimize tracking error at each time step. The plants under consideration range f.om simple to challenging. The more dif.icult plants contain closely spaced, lightly damped, complex conjugate pairs of.poles and zeros. Results are compared to PID controllers tuned f.r a similar crossover f.equency and optimal phase margin. f.r simple plants, the transf.rmer converges to solutions which overly rely on the pref.lter, neglecting the maximization of.negative f.edback. f.r more complex plants, the transf.rmer designs a compensator and pref.lter with more desirable qualities. In all cases, the transf.rmer can start with random model parameters and modif. them to minimize tracking error on the step ref.rence.

关键词： f.edback Machine Learning Compensator Design

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：