检索结果-南通市图书馆

A smart dual-drug nanosystem based on coassembly of plant and food-derived natural products for synergistic HCC immunotherapy

引用

Acta Pharmaceutica Sinica B 2021年第1期11卷 246-257页

作者： Bingchen Zhang Jiali Jiang Pengyu Wu Junjie Zou Jingqing Le Juanfang Lin Chao Li Bangyue Luo Yongjie Zhang Rui Huang Jingwei Shao Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy College of ChemistryFuzhou UniversityFuzhou 350116China Institute of Oceanography Minjiang UniversityFuzhou 350108China

Nanotechnology has emerged as an ideal approach for achieving the efficient chemo agent delivery.However,the potential toxicity and unclear internal metabolism of most nano-carriers was still a major obstacle for the clinical application.Herein,a novel"core-shell"co-assembly carrier-free nanosystem was constructed based on natural sources of ursolic acid(UA)and polyphenol(EGCG)with the EpCAM-aptamer modification for hepatocellular carcinoma(HCC)synergistic treatment.As the nature products derived from food-plant,UA and EGCG had good anticancer activities and low toxicity.With the simple and"green"method,the nanodrugs had the advantages of good stability,p H-responsive and strong penetration of tumor tissues,which was expected to increase tumor cellular uptake,long circulation and effectively avoid the potential defects of traditional carriers.The nanocomplex exhibited the low cytotoxicity in the normal cells in vitro,good biosafety of organic tissues and efficient tumor accumulation in vivo.Importantly,UA combined with EGCG showed the immunotherapy by activating the innate immunity and acquired immunity resulting in significant synergistic therapeutic effect.The research could provide new ideas for the research and development of self-assembly delivery system in the future,and offer effective intervention strategies for clinical HCC treatment.

关键词： Natural product Ursolic acid EGCG Aptamer Co-assembly Nanodrug HCC Synergistic treatment Immunotherapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

漓渚铁矿深部找矿的设想及实践

引用

金属矿山 2006年第7期35卷 51-53,76页

作者：罗邦月浙江漓铁集团有限公司

漓渚铁矿利用历年积累的地质资料,开展成矿规律的深度研究,对该矿床深部、近外围找矿进行了探讨和预测,并通过适量探矿工程验证,取得了一定成效,为该矿下一步找矿工作指明了方向。对其它资源不足,需寻找接替资源的类似矿山具有借鉴作用。

关键词：危机矿山找矿接替资源预测

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

“一带一路”倡议下中国与东盟区域移动支付发展研究

引用

金融科技时代 2021年第3期29卷 82-87页

作者：罗永宣罗婕尹刘邦月罗昀芳中国人民银行河池市中心支行中国人民银行南丹县支行

互联网技术和跨界电商的飞速发展推动了移动支付市场需求的全球化趋势。在“一带一路”倡议背景下,作为沿线重要区域的东盟与中国的区域金融合作日益深化,为移动支付在东盟支付市场的发展提供了新的机遇。同时,我国移动支付技术上的成... 详细信息

互联网技术和跨界电商的飞速发展推动了移动支付市场需求的全球化趋势。在“一带一路”倡议背景下,作为沿线重要区域的东盟与中国的区域金融合作日益深化,为移动支付在东盟支付市场的发展提供了新的机遇。同时,我国移动支付技术上的成功经验和“走出去”的战略尝试为东盟金融欠发达国带去了移动支付快速成长的契机。本文通过对东盟国家移动支付发展现状进行分析,指出“一带一路”倡议下区域移动支付的发展优势与挑战,提出深化中国-东盟区域金融合作的创新路径,为我国移动支付产业参与全球市场竞争助力。

关键词： “一带一路”倡议移动支付东盟

来源：

维普期刊数据库

同方期刊数据库评论