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Synthesis and Properties of Symmetrical Aryl Linked BODIPY Dyads

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Chemical Research in Chinese Universities 2013年第6期29卷 1129-1133页

作者： WANG bang-ying zhao Hong-bin LIAO Jun-xu XU Yong-jun College of Chemistry and Environmental Engineering Dongguan University of Technology Dongguan 523808 P.R.China

Three novel symmetrical 4.4＇-difluoro-4-bora-3a,4a-diaza-sindacene（BODIPY） derivatives were synthesized via a general and efficient protocol. These BODIPY dyads bear a diverse aryl linker bridge in the middle and two BODIPY units at the termini. The photophysical properties of these dyads were investigated by ultravioletvisible（UV-Vis） absorption and emission spectroscopy. And their electrochemical properties were studied by cyclic voltammetry. The absorption of these dyads showed slightly blue shift and the intramolecular charge transfer（ICT） state under,vent ultrafast direct surface crossing to the ground state with high degree of rotational freedom. The results will be useful for the further functionalization of these novel symmetrical BODIPY derivatives.

关键词： 4,4'-Difluoro-4-bora-3a,4a-diaza-sindacene(BODIPY) dyad Bis(dipyrromethane) Symmetrical Photophysical property

Redundant prepuce increases the odds of chronic prostatitis/chronic pelvic pain syndrome （CP/CPPS）

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Asian Journal of Andrology 2014年第5期16卷 774-777,I0011页

作者： Yu-Yang zhao Dong-Liang Xu Fu-Jun zhao bang-Min Han Yi Shao Wei zhao Shu-Jie Xia Department of Urology Shanghai First People's Hospital Institute of Urology Shanghai Jiao Tong University Shanghai China

Some published evidence has revealed that the dendritic cells can interact with pathogens that exist in the inner foreskin. This information provides a new vision that pathogens could play a role through the redundant prepuce; numerous studies have failed to find pathogens in prostates of patients who had chronic prostatitis/chronic pelvic pain syndrome （CP/CPPS）. However, no studies have reported an association between foreskin length and CP/CPPS. Hence, we conducted a retrospective case-control study of clinical data from 322 CP/CPPS patients （case group） and 341 nonCP/CPPS patients （control group）. Demographic characteristics, lifestyle factors, and foreskin lengths were collected and analyzed. Multivariate logistic regression was adopted to calculate the odds of foreskin length for CP/CPPS. According to the multivariate logistic regression results, when the foreskin length covered up more than half of the glans penis, the odds for CP/CPPS were higher with an increased foreskin （odds ratio （OR）： 1.66, 95% confidence interval （CI）： 1.04-2.66）. In comparison, when the glans penis was completely covered by the foreskin, the OR value increased to 1.86 （95% CI, 1.2-2.88）. The study results showed an association between foreskin length and the odds of CP/CPPS. When the foreskin length covered up more than half of the glans penis, there were greater odds for CP/CPPS. This possible mechanism might result from interaction between pathogens and DCs in the inner foreskin, consequently activating T-cells to mediate allergic inflammation in the prostate and producing the autoimmunizations causing CP/CPPS.

关键词： case control study chronic pelvic pain syndrome chronic prostatitis, prepuce

Synthesis and Electrochemical Behavior of Electroactive Bistetrathiafulvalene-attached Thiacalix[4]arene Assemblies

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Chemical Research in Chinese Universities 2012年第5期28卷 828-832页

作者： zhao bang-tun LI Jia-jia ZHOU Zhen YAN Zhen-ning ZHU Wei-min College of Chemistry and Chemical Engineering Luoyang Normal UniversityLuoyang 471022P R.China Department of Chemistry Zhengzhou UniversityZhengzhou 450001P R.China

Tetrabromoalkylthiacalix[4]arenes（1a and 1b） reacted with excess bis（tetraethylammonium）-bis（1,3- dithiole-2-thione-4,5-dithiol）zincate（2） to give thiacalix[4]arene-thiones（3a and 3b） in the presence of Na2S. Two novel bistetrathiafulvalene-attached thiacalix[4]arene assemblies（5a and 5b） formed via triethyl phosphite-mediated cross-coupling of thiacalix[4]arene-thiones（3a and 3b） and 4,5-biscyanoethylthio-1,3-dithiole-2-one（4）. All the four new compounds were characterized by 1H NMR, 13C NMR, IR, MS spectra and elemental analysis. Meanwhile, the structures of thiacalix[4]arene-thiones（3a and 3b） were identified by X-ray analysis. In addition, the cyclic voltammograms of the resulting thiacalix[4]arenes containing electroactive TTF units（5a and 5b） were provided.

关键词： Thiacalixarene Tetrathiafulvalene X-Ray diffraction Cyclic voltammetry

Advance in quality assessment of Chinese materia medica using microscopic and morphological methods

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Chinese Journal of Natural Medicines 2017年第9期15卷 653-663页

作者： MIAO Xiao-Su CUI Qing-Yu WANG zhao-Yi LIU Xiao-Na zhao An-bang QIAO Yan-Jiang WU Zhi-Sheng Beijing University of Chinese Medicine Beijing 100102 China Key Laboratory of Traditional Chinese Medicine of information Engineering of State Administration Beijing 100102 China Binzhou Medical University Yantai 256603 China

Quality evaluation plays a vital role in ensuring safety and effectiveness of Chinese materia medica(CMM). Microscopic and morphological technologies can be used to distinguish CMM's characteristics, such as shape, size, texture, section, and smell, for authenticity and quality control of CMM. The microscopic and morphological applications of novel micro-technology, colorimeter, and texture analyzer for CMM identification are summarized and the future prospect is discussed in this paper. Various styles and complex sources of CMM are systemically reviewed, including cormophyte medicinal materials, fruit and seeds, pollen grain, and spore materials.

关键词： Chinese materia medica Micro-technology Colorimeter Texture analyzer

Synthesis, Structure and Decarboxylative Behavior of a Nitro-coordinated Potassium Compound

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Chinese Journal of Structural Chemistry 2019年第3期38卷 362-368页

作者： LI Dong-Mi CUI Jia-Jia YAO Jia-Xin LI zhao-Hao zhao bang-Tun College of Chemistry and Chemical Engineering and Henan Key Laboratory of Function-oriented Porous Materials Luoyang Normal University

A novel nitro-coordinated potassium compound [K(Htdc)(H_2O)]_n(tdc = 3-nitro-thiophene-2,5-dicarboxylate), has been synthesized and characterized. The complex with a two-dimensional(2D) layer structure contains an infinite K-O ladder-shaped chain, which is connected through carboxyl and unusual nitro-coordination of Htdc– anion. Then the 2D layers are further extended by intermolecular hydrogen-bonding to form a three-dimensional(3D) supramoleculalr network. Variable temperature powder X-ray diffractions, thermogravimetric analysis and nuclear magnetic resonance studies exhibit that the compound has a thermal-induced decarboxylative behavior.

关键词： crystal structure coordination mode two-dimensional compound decarboxylative behaviour

Novel clicked tetrathiafulvalene-calix[4]arene assemblies:Synthesis and intermolecular electron transfer toward p-chloranil

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Chinese Chemical Letters 2013年第7期24卷 573-577页

作者： bang-Tun zhao Xiao-Min Zhu Xiu-Hua Chen Zhen-Ning Yan Wei-Min Zhu College of Chemistry and Chemical Engineering Luoyang Normal University College of Chemistry and Molecular Engineering Zhengzhou University

Two tetrathiafulvalene-calix[4]arene assemblies （TTF-calix-1 and TFF-calix-2） have been synthesized by the click reaction. Both their cyclic voltammograms show, as expected, two one-electron quasi- reversible redox behavior. The UV-vis absorption spectra studies show that these two assemblies undergo progressive oxidation at the TFF moiety in presence of increasing amounts of Cu2＋ or Hg2＋. Moreover, the absorption studies show intermolecular electron transfer between compounds TrF-calix- I or TI＇F-calix-2 and p-chloranil may be promoted by specific metal ions such as Pb2＋, Sc3＋ etc.

关键词： Tetrathiafulvalene Calixarene Click reaction Chloranil lntermolecular electron transfer

Surgical management of Zollinger-Ellison syndrome: Classical considerations and current controversies

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World Journal of Gastroenterology 2019年第32期25卷 4673-4681页

作者： Qian-Qian Shao bang-Bo zhao Liang-Bo Dong Hong-Tao Cao Wei-Bin Wang Department of General Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences/Peking Union Medical College

Zollinger-Ellison syndrome(ZES)is characterized by gastric acid hypersecretion causing severe recurrent acid-related peptic *** secretion of gastrin can now be effectively controlled with powerful proton pump inhibitors,but surgical management to control gastrinoma itself remains *** on a thorough literature review,we design a surgical algorithm for ZES and list some significant consensus findings and recommendations:(1)For sporadic ZES,surgery should be routinely undertaken as early as possible not only for patients with a precisely localized diagnosis but also for those with negative imaging *** surgical approach for sporadic ZES depends on the lesion location(including the duodenum,pancreas,lymph nodes,hepatobiliary tract,stomach,and some extremely rare sites such as the ovaries,heart,omentum,and jejunum).Intraoperative liver exploration and lymphadenectomy should be routinely performed;(2)For multiple endocrine neoplasia type 1-related ZES(MEN1/ZES),surgery should not be performed routinely except for lesions>2 *** attempt to perform radical resection(pancreaticoduodenectomy followed by lymphadenectomy)can be *** ameliorating effect of parathyroid surgery should be considered,and parathyroidectomy should be performed first before any abdominal surgery for ZES;and(3)For hepatic metastatic disease,hepatic resection should be routinely ***,liver transplantation is still considered an investigational therapeutic approach for ***-designed prospective studies are desperately needed to further verify and modify the current considerations.

关键词： Zollinger-Ellison syndrome Sporadic gastrinomas Multiple endocrine neoplasia type 1 Hepatic metastatic disease Surgical treatment

Correlation between synaptic protein expression and synaptic reorganization in the hippocampal CA3 region in a rat model of post-traumatic epilepsy

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Neural Regeneration Research 2010年第15期5卷 1156-1160页

作者： Gaolian Zhang Jianmin Huang bang zhao Haineng Huang Yuanyang Deng HuadongHuang Qirong He Jianping Liang Department of Neurosurgery First Affiliated Hospital Guangxi Traditional Chinese Medicine University Nanning 530023 Guangxi Zhuang Autonomous Region China Department of Neurology Hospital Affiliated to Youjiang Medical University for Nationafities Baise 533000 Guangxi Zhuang Autonomous Region China Department of Neurosurgery Hospital Affiliated to Youjiang Medical University for Nationalities Baise 533000 Guangxi Zhuang Autonomous Region China

Postsynaptic density protein-95 and synaptophysin participate in synaptic reorganization in the forebrain of epilepsy models. However, the time-effect relationship between dynamic synapsin expression in hippocampus and synaptic reorganization in the post-traumatic epilepsy model remains unclear. FeCI2 was injected into the hippocampal CA3 region of the right forebrain in rats to induce post-traumatic epilepsy. Postsynaptic density protein-95 and synaptophysin expression was detected using immunohistochemistry. Epileptiform discharge induced by FeCI2 injection was determined in rat forebrain neurons, revealing decreased postsynaptic density protein-95 expression at 24 hours and lowest levels at 7 days. Synaptophysin expression was markedly reduced at 24 hours, but increased at 7 days. Postsynaptic density protein-95 and synaptophysin expression was consistent with abnormal mossy fiber sprouting and synaptic reorganization following neuronal injury in the hippocampal CA3 region of FeCI2-induced epilepsy models.

关键词： post-traumatic epilepsy hippocampus FeCI2 forebrain postsynaptic density protein-95 synaptophysin brain injury neural regeneration

Effect of quantitative consciousness index on seizure parameters during electroconvulsive therapy in patients with major depressive disorder

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World Journal of Psychiatry 2024年第9期14卷 1375-1385页

作者： bang-Shu zhao Bi Deng Qi-Bin Chen Xiao Li You Yang Su Min Department of Anesthesiology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Anesthesiology The First Clinical College of Chongqing Medical UniversityChongqing 400016China Department of Psychiatry The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Electroconvulsive therapy(ECT)is both an effective treatment for patients with major depressive disorder(MDD)and a noxious *** some studies have explored the effect of sedation depth on seizure parameters in ECT,there is little research on the noxious stimulation response to *** this study,we used two electroencephalography(EEG)-derived indices,the quantitative consci-ousness(qCON)index and quantitative nociceptive(qNOX)index,to monitor sedation,hypnosis,and noxious stimulation response in patients with MDD undergoing acute *** Patients with MDD(n=24)underwent acute bilateral temporal ECT under propofol *** ECT,the patients were randomly divided into three groups according to qCON scores(qCON60-70,qCON50-60,and qCON40-50).Continuous qCON monitoring was performed 3 minutes before and during ECT,and the qCON,qNOX,vital signs,EEG seizure parameters,and complications during the recovery period were *** 24-item Hamilton Rating Scale for Depression,Zung’s Self-rating Depression Scale,and Montreal Cognitive Asse-ssment scores were evaluated before the first ECT session,after the fourth ECT session,and after the full course of *** A total of 193 ECT sessions were performed on 24 *** qCON index significantly affected the EEG seizure duration,peak mid-ictal amplitude,and maximum heart rate during ECT(P0.05).CONCLUSION Electrical stimulation at a qCON index of 60-70 resulted in better EEG seizure parameters without increasing complications in patients with MDD undergoing b

关键词： Electroconvulsive therapy Propofol Nociception Depression Electroencephalogram