Correlation between synaptic protein expression and synaptic reorganization in the hippocampal CA3 region in a rat model of post-traumatic epilepsy

作     者：Gaolian Zhang Jianmin Huang Bang Zhao Haineng Huang Yuanyang Deng HuadongHuang Qirong He Jianping Liang 

作者机构：Department of Neurosurgery First Affiliated Hospital Guangxi Traditional Chinese Medicine University Nanning 530023 Guangxi Zhuang Autonomous Region China Department of Neurology Hospital Affiliated to Youjiang Medical University for Nationafities Baise 533000 Guangxi Zhuang Autonomous Region China Department of Neurosurgery Hospital Affiliated to Youjiang Medical University for Nationalities Baise 533000 Guangxi Zhuang Autonomous Region China 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2010年第5卷第15期

页      面：1156-1160页

核心收录：

学科分类：0710[理学-生物学] 090603[农学-临床兽医学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 09[农学] 0906[农学-兽医学] 071006[理学-神经生物学] 

基　　金：the General Program of Department of Education of Guangxi Zhuang Autonomous Region No.Guijiaokeyan34 

主　　题：post-traumatic epilepsy hippocampus FeCI2 forebrain postsynaptic density protein-95 synaptophysin brain injury neural regeneration 

摘      要：Postsynaptic density protein-95 and synaptophysin participate in synaptic reorganization in the forebrain of epilepsy models. However, the time-effect relationship between dynamic synapsin expression in hippocampus and synaptic reorganization in the post-traumatic epilepsy model remains unclear. FeCI2 was injected into the hippocampal CA3 region of the right forebrain in rats to induce post-traumatic epilepsy. Postsynaptic density protein-95 and synaptophysin expression was detected using immunohistochemistry. Epileptiform discharge induced by FeCI2 injection was determined in rat forebrain neurons, revealing decreased postsynaptic density protein-95 expression at 24 hours and lowest levels at 7 days. Synaptophysin expression was markedly reduced at 24 hours, but increased at 7 days. Postsynaptic density protein-95 and synaptophysin expression was consistent with abnormal mossy fiber sprouting and synaptic reorganization following neuronal injury in the hippocampal CA3 region of FeCI2-induced epilepsy models.