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The Role of Cytokine Interleukin-2, Transcription Factor of FoxP3 in the Immunological Regulation of Allergic Rhinitis

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International Journal of Otolaryngology and Head & Neck Surgery 2018年第1期7卷 7-19页

作者： bambang suprayogi resi utomo Mochammad Hatta Robert H. Sirait Sutji Pratiwi Muhammad Nasrum Massi Department of Ear Nose and Throat Faculty of Medicine Indonesia Christian University of Jakarta Jakarta Indonesia Molecular Biology and Immunology Laboratory for Infection Diseases Faculty of Medicine University of Hasanuddin Makassar Indonesia Department of Anesthesiology Faculty of Medicine Indonesia Christian University of Jakarta Jakarta Indonesia Department of Ear Nose and Throat Faculty of Medicine University of Hasanuddin Makassar Indonesia Department of Microbiology Faculty of Medicine University of Hasanuddin Makassar Indonesia

Allergic rhinitis (AR) is the inflammation of nasal mucosa due to the type 1 hypersensitivity reactions mediated by immunoglobulin E (IgE) and triggered by certain allergens. The latest concept in allergic disease is the role of regulatory T cells (Treg). Interleukin-2 enhances the function and survival of Treg to perform its function as a controller of effector for forming a tolerant system by suppressing and regulating the homeostasis system. Treg has a transcription factor FoxP3 which plays a role in developing major function of Treg and progression to produce IL-10 and TGF-?. The atopic diseases are caused by a deficiency of Treg. The new perspective is low-dose IL-2 therapy towards autoimmune disease and allergic inflammation. Low-dose IL-2 therapy requires further clinical studies to optimize the dose, time, and the schedule of the IL-2 treatment. FoxP3 has the potential to assist in evaluating the active process of immunological process, which cannot be evaluated by Th1 and Th2 markers, and FoxP3 can be a successful immunotherapy marker.

关键词： Allergic Rhinitis Interleukin-2 FoxP3

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Analysis of Forkhead Box Protein-3 (Foxp3) in Allergic Rhinitis Patients

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International Journal of Otolaryngology and Head & Neck Surgery 2018年第4期7卷 228-236页

作者： bambang suprayogi resi utomo Mochammad Hatta Sutji Pratiwi Muhammad Nasrum Massi Lina Marlina Erica Gilda Minawati Simanjuntak Department of Ear Nose and Throat Faculty of Medicine Indonesia Christian University of Jakarta Jakarta Indonesia Molecular Biology and Immunology Laboratory for Infection Diseases Faculty of Medicine University of Hasanuddin Makassar Indonesia Department of Ear Nose and Throat Faculty of Medicine University of Hasanuddin Makassar Indonesia Department of Microbiology Faculty of Medicine University of Hasanuddin Makassar Indonesia Department of Anesthesiology Faculty of Medicine Indonesia Christian University of Jakarta Jakarta Indonesia

Background: A new concept in understanding allergic diseases is regulatory T cells (Tregs), which control the immune reaction caused by Th2 cytokine production. Forkhead Box Protein 3 (FoxP3) is a marker that has a critical role in the development and function of Tregs. Some studies found differences in FoxP3 level and in Tregs capacity to control immune reactions in allergic diseases. The aim of this study was to investigate FoxP3 level in Allergic rhinitis (AR) patients compared to atopic and healthy/normal persons in Jakarta. Methodology: This study used observation to analyze the level of FoxP3 in AR, atopic and healthy/normal persons, and used ELISA to measure the FoxP3 level. Results: The study had sixty participants divided into three groups: 21 in the Normal group, 16 in the Atopic group, and 23 in the AR group. The mean FoxP3 levels were 0.81 ± 0.35 in the normal group, 3.42 ± 0.15 in the atopic group, and 3.40 ± 0.13 in the AR group. Statistical analysis with Mann-Whitney tests indicated significant differences, with AR and atopic groups having higher FoxP3 levels than the normal group, (p = 0.001), and no statistically significant differences between the AR and atopic groups, (p = 0.92). Conclusion: Our study results suggested that FoxP3 was active in the control of inflammatory processes due to allergies, and decrease level of FoxP3 indicated severe AR, but suggested another mechanism caused differences in the clinical phenotypes of AR and atopic patients, despite them having equally high levels of FoxP3.

关键词： Allergic Rhinitis Atopic Regulator T Cells FoxP3 ELISA

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The Analysis of the Effective Systemic Lidocaine Dosage on the Expression of HMGB1 mRNA on Mice with Sterile Musculoskeletal Injury

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Open Journal of Anesthesiology 2017年第2期7卷 35-41页

作者： Robert Hotman Sirait Mochammad Hatta Muhammad Ramli Tigor Peniel Simanjuntak bambang suprayogi Andi Asadul Islam Syafrie Kamsul Arief Department of Anesthesiology Faculty of Medicine Christian University of Indonesia Jakarta Indonesia Molecular Biology and Immunology Laboratory Faculty of Medicine University of Hasanuddin Makassar Indonesia Department of Anesthesiology Faculty of Medicine University of Hasanuddin Makassar Indonesia Department of Obstetric and Gynecology Faculty of Medicine Christian University of Indonesia Jakarta Indonesia Department of Otorhinolaryngology Faculty of Medicine Christian University of Indonesia Jakarta Indonesia Department of Surgery Faculty of Medicine University of Hasanuddin Makassar Indonesia

A severe injury can trigger an inflammation response and excessive response can cause multiple organ failure. HMGB1 is an early inflammation mediator in sterile injury and a late inflammation mediator in infection. It is an important mediator in severe sepsis and always associated with the severity of organ failure. Previous studies showed that the administration of systemic lidocaine could inhibit the expression of HMGB1 on septic mice with musculoskeletal injury. Nine male adult Balb/c mice were grouped by simple random sampling method into three groups of intravenous lidocaine injection dosages: 2 mg/kg, 3 mg/kg, 4 mg/kg. Musculoskeletal injury was done by breaking the left femoral bone in a close manner. Peripheral blood sampling was done 4 hours after injury and 2 hours after lidocaine therap. To evaluate the expression level of HMGB1 mRNA, RT-PCR was used. The result of our study showed that intravenous lidoaine administration on the 3 groups could decrease the level of HMGB1. In conclusion, lidocaine hold an important role in clinical diseases by inhibiting HMGB1.

关键词： High Mobility Group Box 1 Lidocaine Musculoskeletal Injury

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