The Role of Cytokine Interleukin-2, Transcription Factor of FoxP3 in the Immunological Regulation of Allergic Rhinitis
The Role of Cytokine Interleukin-2, Transcription Factor of FoxP3 in the Immunological Regulation of Allergic Rhinitis作者机构：Department of Ear Nose and Throat Faculty of Medicine Indonesia Christian University of Jakarta Jakarta Indonesia Molecular Biology and Immunology Laboratory for Infection Diseases Faculty of Medicine University of Hasanuddin Makassar Indonesia Department of Anesthesiology Faculty of Medicine Indonesia Christian University of Jakarta Jakarta Indonesia Department of Ear Nose and Throat Faculty of Medicine University of Hasanuddin Makassar Indonesia Department of Microbiology Faculty of Medicine University of Hasanuddin Makassar Indonesia
出 版 物：《International Journal of Otolaryngology and Head & Neck Surgery》 (耳鼻喉（英文）)
年 卷 期：2018年第7卷第1期
页 面：7-19页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Allergic Rhinitis Interleukin-2 FoxP3
摘 要：Allergic rhinitis (AR) is the inflammation of nasal mucosa due to the type 1 hypersensitivity reactions mediated by immunoglobulin E (IgE) and triggered by certain allergens. The latest concept in allergic disease is the role of regulatory T cells (Treg). Interleukin-2 enhances the function and survival of Treg to perform its function as a controller of effector for forming a tolerant system by suppressing and regulating the homeostasis system. Treg has a transcription factor FoxP3 which plays a role in developing major function of Treg and progression to produce IL-10 and TGF-?. The atopic diseases are caused by a deficiency of Treg. The new perspective is low-dose IL-2 therapy towards autoimmune disease and allergic inflammation. Low-dose IL-2 therapy requires further clinical studies to optimize the dose, time, and the schedule of the IL-2 treatment. FoxP3 has the potential to assist in evaluating the active process of immunological process, which cannot be evaluated by Th1 and Th2 markers, and FoxP3 can be a successful immunotherapy marker.
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