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Innovative development path of ethnomedicines： an overview of ethnomedicines in China

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Frontiers of Medicine 2016年第2期10卷 166-177页

作者： Zhaoyun zhu Ting Wang Dehuan Fu Yali Gui Jingkun Wang Tao Cui Yunnan Institute of Materia Medica Innovation and R & D Center of Yunnan Baiyao Group Co. Ltd. and Yunnan Province Company KeyLaboratory for New Drug Research and Development of TCM and Ethnomedicines Kunming 650111 China

In the long history of disease prevention and treatment, ancestral populations worldwide have gained knowledge and experiences in traditional medicines. For instance, ethnomedicines of Chinese ethnic minorities constitute an important part of traditional medicines. In our study, we firstly clarified the concept of ethnomedicines and the connotations of ethnopharmacology. The particularity of ethnomedicine research were then summed up, and the development profiles of the ethnomedicines of Chinese ethnic minorities were discussed by investigating the current status and existing problems. On this basis, we abstracted the innovative development path of ethnomedicines for the first time, which was found to follows：resource study -, standardized development research -~ industrialization of the achievements and efforts for internationalization. We found that platform establishment and team training are keys to achieving innovative development. Hence, this study provided a basis for ethnomedicine development.

关键词： traditional medicines ethnomedicines Chinese ethnic minorities ethnopharmacology research mode innovative development path

循经穴位贴敷联合云南白药气雾剂对骨质疏松性胸腰椎压缩性骨折患者术后疗效的影响

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黑龙江医学 2024年第16期48卷 1926-1928页

作者：朱丽梅赖玲娥曾国华潘奇林饶欣赣州市人民医院江西赣州341000

目的:探讨骨质疏松性胸腰椎压缩性骨折患者术后应用循经穴位贴敷联合云南白药气雾剂的治疗效果。方法:选取2021年6月—2022年6月赣州市人民医院脊柱外科收治的骨质疏松性胸腰椎压缩性骨折行经皮球囊扩张椎体后凸成形术的82例患者作为研... 详细信息

目的:探讨骨质疏松性胸腰椎压缩性骨折患者术后应用循经穴位贴敷联合云南白药气雾剂的治疗效果。方法:选取2021年6月—2022年6月赣州市人民医院脊柱外科收治的骨质疏松性胸腰椎压缩性骨折行经皮球囊扩张椎体后凸成形术的82例患者作为研究对象,随机分为研究组和对照组,每组各41例。对照组采用常规综合护理,研究组在常规综合护理的基础上给予循经穴位贴敷联合云南白药气雾剂外用,比较两组患者疼痛评分和骨折愈合指标。结果:术后1周、术后1个月时,两组患者视觉模拟评分法(VAS)评分均明显降低,且研究组的VAS评分均明显低于对照组,差异均有统计学意义(t=-4.662、-5.054,P<0.05);术后1个月,两组患者Cobb角较术前明显降低、椎体前缘高度和骨钙素均较术前明显升高,且研究组Cobb角明显低于对照组、椎体前缘高度和骨钙素明显高于对照组,差异均有统计学意义(t=-21.40、19.29、-10.17,P<0.05)。结论:在经皮球囊扩张椎体后凸成形术后给予循经穴位贴敷联合云南白药气雾剂治疗,可有效改善胸腰椎压缩性骨折患者的疼痛情况,促进骨折愈合。

关键词：循经穴位贴敷云南白药气雾剂骨质疏松性胸腰椎压缩性骨折临床疗效

Innovative development path of ethnomedicines： a case study

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Frontiers of Medicine 2017年第2期11卷 297-305页

作者： Zhaoyun zhu Yali Gui Li Wang Ting Wang Yang Yang Yunzhuang Niu Dehuan Fu Jingkun Wang Tao Cui Yunnan Institute of Materia Medica Innovation and R & D Center of Yunnan Baiyao Group Co. Ltd. and Yunnan Province Company KeyLaboratory for New Drug Research and Development of TCM and Ethnomedicines Kunming 650111 China

Innovative development extends the vitality of ethnomedicines. Developing ethnomedicines is not only beneficial to the public but also to the related industry and transforms economic growth, driving local social and economic development further. Its economic benefit can be used to optimize and promote the hardware and software of the platform, as well as support the sustainable development of ethnomedicines. Apart from research and discussion on the innovative development of ethnomedicines on the basis of theory and regulations, this series of articles also summarizes cases that are conducive to the overall understanding of the necessity and feasibility of the innovative development. In terms of industrial development, large enterprises and products, such as Yunnan baiyao, Guizhou Miao ethnomedicines, Cheezheng Tibetan Medicine, products developed from Dengzhanhua （Erigeron breviscapus）, the Gold series of Yi ethnomedicines, and products developed from Sanqi （Panax notoginseng）, in China are introduced and summarized, focusing on resource superiority, sustainable innovation, standard research and development, and production, as well as intellectual property protection.

关键词： ethnomedicine industry resource advantages continuous innovation standardized development research intellectual property protection

Innovative development path of ethnomedicines： the interpretation of the path

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Frontiers of Medicine 2017年第1期11卷 32-47页

作者： Zhaoyun zhu Dehuan Fu Yali Gui Tao Cui Jingkun Wang Ting Wang Zhizhong Yang Yanfei Niu Zhennan She Li Wang Yunnan Institute of Materia Medica Innovation and R & D Center of Yunnan Baiyao Group Co. Ltd. and Yunnan Province Company Key Laboratory for New Drug Research and Development of TCM and Ethnomedicines Kunming 650111 China

One of the primary purposes of the innovative development of ethnomedicines is to use their excellent safety and significant efficacy to serve a broader population. To achieve this purpose, modern scientific and technological means should be referenced, and relevant national laws and regulations as well as technical guides should be strictly followed to develop standards and to perform systemic research in producing ethnomedicines. Finally, ethnomedicines, which are applied to a limited extent in ethnic areas, can be transformed into safe, effective, and quality-controllable medical products to relieve the pain of more patients. The innovative development path of ethnomedicines includes the following three primary stages： resource study, standardized development research, and industrialization of the achievements and efforts for internationalization. The implementation of this path is always guaranteed by the research and development platform and the talent team. This article is based on the accumulation of long-term practice and is combined with the relevant disciplines, laws and regulations, and technical guidance from the research and development of ethnomedicines. The intention is to perform an in-depth analysis and explanation of the major research thinking, methods, contents, and technical paths involved in all stages of the innovative development path of ethnomedicines to provide useful references for the development of proper ethnomedicine use.

关键词： ethnomedicines innovative development path resource study standardized development research industrialization internationalization

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远程监管在药品监管和企业管理的作用与实践

中国医药导刊 2024年第7期26卷 643-649页

作者：唐竹刘勤缪锦辉丛薇方东来马馥娟李劲云南白药集团股份有限公司云南昆明650500 云南省食品药品监督检验研究院云南昆明650101 云南省药品监督管理局云南昆明650106

当前,信息技术与监管业务不断融合,数字化监管、移动化监管等创新监管方式的作用不断凸显。远程监管能够通过智能分析风险点准确制定监管策略,从而提高监管效率并确保药品安全。云南省药品监督管理局“以点带面”,推行“药监慧眼”工程... 详细信息

当前,信息技术与监管业务不断融合,数字化监管、移动化监管等创新监管方式的作用不断凸显。远程监管能够通过智能分析风险点准确制定监管策略,从而提高监管效率并确保药品安全。云南省药品监督管理局“以点带面”,推行“药监慧眼”工程试点,实现药品生产安全远程监管。在试点过程中,云南白药集团及其子公司通过“技术先行”“数据赋能”解决了信息化程度不同企业的数据收集、上传、预警问题,为探索药品生产智慧监管提供了新思路。“药监慧眼”工程试点的实施不但促进了企业自身信息化建设,推进质量管理系统的整合,更重要的是将生产过程可识别化,为智慧监管打通了关键一环,是药品全生命周期风险管控的有效手段。本研究总结试点项目的实施和成效,并对实现药品生产全过程可追溯、推进药品生产企业信息化建设、构建监管大数据的应用场景进行了思考,建议通过鼓励医药产业信息化、打通中药原料的追溯和监管、建立信息安全防护体系、构建智能化数据分析等措施,推动药品安全治理的网络化、智慧化、高效化。

关键词：远程监管 “药监慧眼”工程 “数据湖” 信息化建设药品监管智慧化

基于网络药理学和分子对接的白药子抗口腔鳞癌作用机制研究

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肇庆学院学报 2024年第2期45卷 1-8页

作者：曾鹏朱培亮黄俊章张晓晴廖玉梅赵钿邓雪儿肇庆学院食品与制药工程学院广东肇庆526061

为利用网络药理学及分子对接技术探究白药子有效成分对应靶基因治疗口腔鳞癌的作用机制.采用TCMSP、PubChem、GeneCards、David、STRING 11.5、SwissTargetPrediction、中国知网等数据库进行文献挖掘获取中药活性成分及疾病相关靶标,并... 详细信息

为利用网络药理学及分子对接技术探究白药子有效成分对应靶基因治疗口腔鳞癌的作用机制.采用TCMSP、PubChem、GeneCards、David、STRING 11.5、SwissTargetPrediction、中国知网等数据库进行文献挖掘获取中药活性成分及疾病相关靶标,并对其进行条件筛选.运用Cytoscape3.7.2绘制白药子的“药物-活性成分-靶点-疾病”网络图,运用Venny 2.1.0网站绘制白药子有效成分-口腔鳞癌交集靶点的韦恩图,利用STRING 11.5网站,将置信度设为0.400,其他设置保持默认,提取交集基因制作蛋白互作(PPI)关系网络图,依据相互关系筛选核心靶标.制作“中药-成分-靶点-疾病”核心靶标互作网络模型.基于David数据库进行功能分析及通路富集分析,再用微生信网站(http://***/)进行可视化分析.结果得到白药子活性成分25个,筛选出有效活性成分6个,筛选出有效基因靶点155个、口腔鳞癌相关基因靶点3450个,获取相关交集靶点90个,得到20条主要KEGG通路.本研究通过网络药理学研究分析,构造白药子治疗口腔鳞癌“化合物、靶点及其途径”的互作网络,为研究白药子治疗口腔鳞癌临床应用提供理论基础.

关键词：网络药理学分子对接白药子活性成分口腔鳞癌

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从湿热中阻论治慢性乙型肝炎研究进展

西部中医药 2023年第2期36卷 133-136页

作者：陈泽山朱文琳陈柏尧王淼东文彬邓鑫广西中医药大学广西南宁530001 广西中医药大学附属瑞康医院广西南宁530000

从湿热中阻证为切入点,认为慢性乙型肝炎湿热中阻证的病因主要有外感邪气、饮食所伤、情志不遂、胆腑郁热等,湿热中阻证与肝组织病理、血清转氨酶、乙型肝炎病毒DNA、肝纤4项都有一定关联性。中医药治疗慢性乙型肝炎有独特的优势,如:经... 详细信息

从湿热中阻证为切入点,认为慢性乙型肝炎湿热中阻证的病因主要有外感邪气、饮食所伤、情志不遂、胆腑郁热等,湿热中阻证与肝组织病理、血清转氨酶、乙型肝炎病毒DNA、肝纤4项都有一定关联性。中医药治疗慢性乙型肝炎有独特的优势,如:经方茵陈蒿汤、龙胆泻肝汤等,中成药当飞利肝宁胶囊、乙肝清热解毒胶囊、护肝胶囊等,均对该病有较好疗效;此外,中药金线莲及穴位贴敷对该病也有一定治疗作用。

关键词：肝炎乙型慢性湿热中阻证文献综述

Colorectal Adenocarcinoma Post-Operative Treatment with Chinese Herbs

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Yangtze Medicine 2018年第1期2卷 46-50页

作者： Jihe zhu Blagica Arsovska Kristina Kozovska Faculty of Medical Sciences Goce Delcev University of Stip Stip Republic of Macedonia Institute of Biology Faculty of Natural Sciences and Mathematics Skopje Republic of Macedonia

Colorectal cancer is malignancy of the colon or rectum. Adenocarcinoma is the most common colorectal cancer. These malignant cancer cells grow inside the colon and the rectum. Large clusters of these cells form structures known as tumors. Our treated patient is a 48 year old male who has undergone colorectal adenocarcinoma surgery in stage IIIB. During the surgery he was resected part of the colon with a total length of 57 cm. We started the treatment with Chinese herbs immediately after the surgery with no additional chemotherapy and radiotherapy. Herbs used in the treatment are Cordyceps sinensis, Ganoderma broken spores (Reishi) and Yunnan baiyao. Before the surgery the patient was pale, exhausted, with abdominal pain on the left side under the ribs, Iron (Fe) was very low—7, tumor marker (CEA) was high—39.64 ng/mL, hematochezia was present and with insulin intake of 34 units (the patient is diabetic). Two months after using the herbs daily, the patient blood analysis was improved, Iron (Fe) is elevated, no hematochezia is detected, organs are with normal findings, normal color of the face is restored, post-operative scar healed very well and quickly and insulin intake is reduced from 34 to 6 units. After 6 months of treatment the results are amazing, the patient is in excellent health condition, the treatment is completed and is no longer taking any medications. With the herbal treatment we succeeded to keep the patient in good health, boost the immune system and improve the Qi energy flow.

关键词： Treatment Traditional Chinese Medicine Cancer Adenocarcinoma Colon

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三七花啤酒的研制

云南中医学院学报 2018年第6期41卷 19-21页

作者：朱卓朱虹江云南省药物研究所/云南白药集团创新研发中心云南省中药和民族药新药创制企业重点实验室云南昆明650111 云南中医学院第一附属医院云南昆明650031

2016年5月13日,云南省卫生计生委正式批复同意将三七花、茎叶作为普通地方特色食品原料进行管理,开发具有云南地方特色的三七花啤酒可在满足市场需求的同时促进消费者的身体健康。本文采用传统啤酒生产工艺酿造三七花啤酒,并对产品的感... 详细信息

2016年5月13日,云南省卫生计生委正式批复同意将三七花、茎叶作为普通地方特色食品原料进行管理,开发具有云南地方特色的三七花啤酒可在满足市场需求的同时促进消费者的身体健康。本文采用传统啤酒生产工艺酿造三七花啤酒,并对产品的感官、理化和微生物等指标进行了检测和评定,产品各项指标均符合产品国家标准的规定。

关键词：三七花啤酒工艺质量