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Computational pharmacokinetics and in vitro-in vivo correlation of anti-diabetic synergistic phyto-composite blend

World Journal of Diabetes 2015年第11期6卷 1179-1185页

作者： baishakhi de Koushik Bhandari Nishant Chakravorty Ranjan Mukherjee Rohit Gundamaraju Rajeev K Singla Prakash Katakam Shanta K Adiki Biswajoy Ghosh Analava Mitra School of Medical Science and Technology IIT Kharagpur 721302 India department of Medical Microbiology Faculty of Medicine University of Malaya Division of Biotechnology Netaji Subhas Institute of Technology Faculty of Pharmacy University of Zawiya Nirmala College of Pharmacy

despite tremendous strides in modern medicine stringent control over insulin resistance or restoration of normoglycemia has not yet been achieved.With the growth of molecular biology,omics technologies,docking studies,and in silico pharmacology,modulators of enzymes and receptors affecting the molecular pathogenesis of the disease are being considered as the latest targets for anti-diabetic therapy.Therapeutic molecular targets are now being developed basing on the up or down regulation of different signaling pathways affecting the disease.Phytosynergistic antidiabetic therapy is in vogue both with classical and non-classical medicinal systems.However its chemoprofiling,structural and pharmacokinetic validation awaits providing recognition to such formulations for international acceptance.Translational health research with its focus on benchside product development and its sequential transition to patient bedside puts the pharma RDs to a challenge to develop bio-waiver protocols.Pharmacokinetic simulation models and establishment of in vitro-in vivo correlation can help to replace in vivo bioavailability studies and provide means of quality control for scale up and post approval modification.Thisreview attempts to bring different shades highlighting phyto-synergy,molecular targeting of antidiabetic agents via different signaling pathways and bio-waiver studies under a single umbrella.

关键词： In silico pharmacology Phytosynergistic Anti-diabe

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In vitro–in vivo studies of the quantitative effect of calcium,multivitamins and milk on single dose ciprofloxacin bioavailability

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Journal of Pharmaceutical Analysis 2015年第6期5卷 389-395页

作者： baishakhi dey Prakash Katakam Fathi H.Assaleh Babu Rao Chandu Shanta Kumari Adiki Analava Mitra School of Medical Science and Technology Faculty of Pharmacy University of Zawia department of Pharmaceutical Analysis Nirmala College of Pharmacy

Ciprofioxacin, commonly used in India as an anti-microbial for prolonged use in chronic and non-specific indications, may affect the bioavailability of the drug. The drug prescribed is commonly taken with multivitamins, calcium and milk. A simple and reliable analytical methodology obtaining a correlation with in vivo urinary excretion studies using UV and HPLC and in vitro dissolution studies （IVIVC） has shown a significant increase in elimination rate of ciprofloxacin co-administered with multivitamins, calcium and milk. Appreciable IVlVC results proved that dissolution studies could serve as an alternative to in vivo bioavailability and also support bio-waivers.

关键词： CiprofloxacinAnalytical methodologyBioavailabilityBio-waiverDissolution study

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Structural Characterization of Borate Glasses Containing Zinc and Manganese Oxides

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Journal of Modern Physics 2011年第9期2卷 1062-1066页

作者： Manisha Pal baishakhi Roy Mrinal Pal 不详

We have investigated the effect of inclusion of two transition metal ions (TMI) on structure and optical properties of borate glass system having composition xMnO2 – yZnO – (100 – x – y) B2O3 (9 ≤ x ≤ 12, 36 ≤y ≤ 48) prepared by melt quenched route. Thermal study by using a differential scanning calorimeter (DSC) reveals that the glass transition temperature (Tg) and crystallization temperature (Tc) of the glasses increases with the increase of borate content in the system. Fourier transform infrared (FTIR) spectra indicate that inclusion of TMI produces BO3 and BO4 structural units by breaking the boroxol (B3O6) ring. The optical band gap energy estimated from ultraviolet-visible spectra shows a decreasing tendency when TMI are incorporated in the borate structure.

关键词： Borate Glass Differential Thermal Analysis (DTA) Infrared (IR) Spectroscopy Optical Band Gap

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Chemo-profiling of eucalyptus and study of its hypoglycemic potential

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World Journal of Diabetes 2013年第5期4卷 170-176页

作者： baishakhi dey Analava Mitra School of Medical Science and Technology

Constant escalations in the number of diabetics worldwide and the failure of conventional therapy to restore normoglycemia without adverse effects,in spite of tremendous strides in modern medicine,calls for naturopathy and alternative medicine.Because diabetes is multi-factorial and has secondary complications,prevention of hyperglycemia is the central dogma for its management.To date,no oral hypoglycemic exists which can achieve tight glycemic control without side effects.Dietary adjuncts,lifestyle interventions and a resurgence of interest in phyto-therapy have consequently gained ground.Natural hypoglycemics have attracted attention due to ease of incorporation in everyday diet,affordability,less adverse effects,and long term safety.Ethno botanical literature reports more than 800 anti-diabetic plants species.Eucalyptus is well represented in the Aboriginal Pharmacopoeias for its various pharmacological activities.Its hot aqueous decoction has been used as a hypoglycemic in various regions of world.This editorial attempts to summarize the data on the hypoglycemic potential of the different eucalyptus species,highlight the value of its natural biomolecules for the prophylaxis and treatment of type2 diabetes,describe their mechanistic actions,shed light on the posology and safety aspects of eucalyptusand assess its applicability as a reinforcement to currently used therapy.

关键词： Normoglycemia Escalations Eucalyptus Central dogma Dietary adjuncts Aboriginal Pharmacopoeias Natural biomolecules Prophylaxis Posology

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Exploration of natural enzyme inhibitors with hypoglycemic potentials amongst Eucalyptus Spp. by in vitro assays

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World Journal of Diabetes 2014年第2期5卷 209-218页

作者： baishakhi dey Analava Mitra Prakash Katakam Rajeev K Singla School of Medical Science and Technology Faculty of Pharmacy University of Zawiya Division of Biotechnology Netaji Subhas Institute of Technology

AIM: To investigate the presence and potency of natural enzyme inhibitors with hypoglycemic potentials amongst Eucalyptus Spp. by in vitro assays.METHODS: The leaf extracts of the three different Eucalyptus species [E. globulus(EG), E. citriodora(EC), E. camaldulensis(ECA)] were subjected to in vitro assay procedures to explore the prevalence of natural enzyme inhibitors(NEIs) after preliminary qualitative and quantitative phytochemical evaluations, to study their inhibitory actions against the enzymes like α-amylase, α-glucosidase, aldose reductase, angiotensin converting enzyme and dipeptidyl peptidase 4 playing pathogenic roles in type 2 diabetes. The antioxidant potential and total antioxidant capacity of the species were also evaluated.RESULTS: Major bioactive compounds like polyphenols(341.75 ± 3.63 to 496.85 ± 3.98) and flavonoids(4.89 ± 0.01 to 7.15 ± 0.02) were found in appreciable quantity in three species. Based on the IC50 values of the extracts under investigation, in all assays the effectivity was in the order of EG > ECA > EC. The results of the ferric reducing antioxidant power assay showed that the reducing ability of the species was also in the order of EG > ECA > EC. A strong correlation(R2 = 0.81-0.99) was found between the phenolic contents and the inhibitory potentials of the extracts against the targeted enzymes.CONCLUSION: These results show immense hypoglycemic potentiality of the Eucalyptus Spp. and a remarkable source of NEIs for a future phytotherapeutic approach in Type 2 diabetes.

关键词： Natural enzyme inhibitors Hypoglycemic Eucalyptus In vitro assays Pathogenic Polyphenols Flavonoids

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在类型 2 糖尿病的生活方式干预的机械学的研究

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World Journal of Diabetes 2012年第12期3卷 201-207页

作者： Analava Mitra debasis dewanjee baishakhi dey School of Medical Science and Technology IIT Kharagpur 721302India

AIM:To investigate the effect of lifestyle interventions in the non-pharmacological management of type 2 diabetes via a mechanistic approach.METHODS:A randomized controlled trial was carried out on 60 type 2 diabetic male and female volunteers that fulfilled the inclusion criteria,with their proper consent and permission of the International Electrotechnical Commission for 1 year.30 patients were included in the test group and 30 patients in the control group.demographic details,anthropometrical status,physical activity,food habits and blood glucose lipid profile of the volunteers were recorded at baseline,the test group was directed for lifestyle intervention and final blood glucose lipid data were collected at the end of one year of patient follow-up.RESULTS:After 1 year,the test group who had a lifestyle intervention was found to show a significant improvement in blood glucose lipid profile.The fasting plasma glucose level(FPG),postprandial plasma glucose level(PPG),glycosylated hemoglobin(HbA1c) and body mass index(BMI) values of the test group were reduced significantly,up to 145 ± 2.52,174 ± 2.59,6.3 ± 0.32 and 25 ± 0.41 respectively at the end of the study period,in comparison to the control group whereFPG,PPG,HbA1c and BMI values were 193 ± 3.36,249 ± 4.24,7.2 ± 0.42 and 26 ± 0.65 respectively.Improvement in the total cholesterol(TC),triglyceride(TG),high-density lipoproteins(HDL) and low-density lipoproteins(LDL) values of the test group was also remarkable in comparison to the control group.The TC,TG,HDL and LDL values of the test group were reduced significantly,up to 149 ± 3.32,124 ± 2.16,58 ± 0.62 and 118 ± 2.31,respectively.CONCLUSION:The significant improvement in the blood glucose lipid profile of the test group after 1 year signifies the value of non-pharmacological management of type 2 diabetes via lifestyle intervention strategies.

关键词： Metabolic Unconventional Therapeutic Interventions Non-pharmacological Sedentary Lifestyle Counseling

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