In vitro–in vivo studies of the quantitative effect of calcium,multivitamins and milk on single dose ciprofloxacin bioavailability

作     者：Baishakhi Dey Prakash Katakam Fathi H.Assaleh Babu Rao Chandu Shanta Kumari Adiki Analava Mitra 

作者机构：School of Medical Science and Technology Faculty of Pharmacy University of Zawia Department of Pharmaceutical AnalysisNirmala College of Pharmacy 

出 版 物：《Journal of Pharmaceutical Analysis》 (药物分析学报（英文版）)

年 卷 期：2015年第5卷第6期

页      面：389-395页

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

主　　题：CiprofloxacinAnalytical methodologyBioavailabilityBio waiverDissolution study 

摘      要：Ciprofioxacin, commonly used in India as an anti-microbial for prolonged use in chronic and non-specific indications, may affect the bioavailability of the drug. The drug prescribed is commonly taken with multivitamins, calcium and milk. A simple and reliable analytical methodology obtaining a correlation with in vivo urinary excretion studies using UV and HPLC and in vitro dissolution studies （IVIVC） has shown a significant increase in elimination rate of ciprofloxacin co-administered with multivitamins, calcium and milk. Appreciable IVlVC results proved that dissolution studies could serve as an alternative to in vivo bioavailability and also support bio-waivers.