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Autophagy: novel insights into therapeutic target of electroacupuncture against cerebral ischemia/reperfusion injury

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Neural Regeneration Research 2019年第6期14卷 954-961页

作者： Ya-Guang Huang Wei Tao song-bai yang Jin-Feng Wang Zhi-Gang Mei Zhi-Tao Feng Medical College of China Three Gorges University Yichang Hospital of Traditional Chinese Medicine Clinical Medical College of Traditional Chinese MedicineChina Three Gorges University

Electroacupuncture is known as an effective adjuvant therapy in ischemic cerebrovascular disease. However, its underlying mechanisms remain unclear. Studies suggest that autophagy, which is essential for cell survival and cell death, is involved in cerebral ischemia reperfusion injury and might be modulate by electroacupuncture therapy in key ways. This paper aims to provide novel insights into a therapeutic target of electroacupuncture against cerebral ischemia/reperfusion injury from the perspective of autophagy. Here we review recent studies on electroacupuncture regulation of autophagy-related markers such as UNC-51-like kinase-1 complex, Beclin1, microtubule-associated protein-1 light chain 3, p62, and autophagosomes for treating cerebral ischemia/reperfusion injury. The results of these studies show that electroacupuncture may affect the initiation of autophagy, vesicle nucleation, expansion and maturation of autophagosomes, as well as fusion and degradation of autophagolysosomes. Moreover, studies indicate that electroacupuncture probably modulates autophagy by activating the mammalian target of the rapamycin signaling *** review thus indicates that autophagy is a therapeutic target of electroacupuncture treatment against ischemic cerebrovascular diseases.

关键词： nerve regeneration autophagy electroacupuncture cerebral ischemia/reperfusion injury mTOR LC3 Beclin1 p62 neuroprotection neural regeneration

High-lattice-adapted surface modifying Na_(4)MnV(PO_(4))_(3) for better sodium storage

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Nano Research 2024年第4期17卷 2728-2735页

作者： Chongran song Shiyu Li Ying bai International Joint Research Laboratory of New Energy Materials and Devices of Henan Province School of Physics and ElectronicsAcademy for Advanced Interdisciplinary StudiesHenan UniversityKaifeng 475004China

Sodium-ion batteries(SIBs)are required to possess long cycle life when used for large-scale energy *** polyanionic Na_(4)MnV(PO_(4))_(3)(NMVP)reveals good cyclic stability due to its unique three-dimensional(3D)frame structure,but it still faces the challenge of interfacial degradation in practical *** this work,NASICON-type Na_(1.3)Al_(0.7)Ti_(1.3)(PO_(4))_(3)(NATP)was deposited on the surface of NMVP to promote interface stability by surface modification and gradient *** a result,the optimized NMVP@2%NATP released a capacity retention of 44.8%after 1000 cycles at 5 C,much higher than that of the initial NMVP(28.9%).The enhanced electrochemical performance was mainly attributed to NATP coating acting as a fast ion transport carrier and physical barrier,significantly facilitating the Na^(+)diffusion and isolating side reaction at the electrode/electrolyte *** the other hand,Ti_(4)^(+)and Al^(3+)cations from the NATP were partially doped inside the NMVP surface to boost the transport of Na^(+),and the perfect lattice matching of NVMP and NATP improved the interface and structural stability accompanying long *** work demonstrated the effectiveness of surface modification with high lattice match material and provided new perspectives for high energy density solid-state SIBs.

关键词： high-lattice-adapted cathode surface modification sodium-ion batteries

Additive manufactured osseointegrated screws with hierarchical design

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Bio-Design and Manufacturing 2024年第2期7卷 206-235页

作者： Wenbo yang Hao Chen Haotian bai Yifu Sun Aobo Zhang yang Liu Yuchao song Qing Han Jincheng Wang Department of Orthopedics Second Hospital of Jilin UniversityChangchun 130022China College of Biological and Agricultural Engineering Jilin UniversityChangchun 130022China School of Materials Science and Engineering Jilin UniversityChangchun 130022China

Bone screws are devices used to fix implants or bones to ***,conventional screws are mechanically fixed with thread and often face long-term failure due to poor *** improve osseointegration,screws are evolving from solid and smooth to porous and *** manufacturing(AM)offers a high degree of manufacturing freedom,enabling the preparation of predesigned screws that are porous and *** paper provides an overview of the problems currently faced by bone screws:long-term loosening and screw ***,advances in osseointegrated screws are summarized hierarchically(sub-micro,micro,and macro).At the sub-microscale level,we describe surface-modification techniques for enhancing *** the micro level,we summarize the micro-design parameters that affect the mechanical and biological properties of porous osseointegrated screws,including porosity,pore size,and pore *** addition,we highlight three promising pore shapes:triply periodic minimal surface,auxetic structure with negative Poisson ratio,and the Voronoi *** the macro level,we outline the strategies of graded design,gradient design,and topology optimization design to improve the mechanical strength of porous osseointegrated ***,this paper outlines advances in AM technology for enhancing the mechanical properties of porous osseointegrated *** osseointegrated screws with hierarchical design are expected to provide excellent long-term fixation and the required mechanical strength.

关键词： Bone screws Additive manufacturing Architecture design Surface modification

Puerarin protects rat brain against ischemia/reperfusion injury by suppressing autophagy via the AMPK-mT OR-ULK1 signaling pathway

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Neural Regeneration Research 2018年第6期13卷 989-998页

作者： Jin-Feng Wang Zhi-Gang Mei yang Fu song-bai yang Shi-Zhong Zhang Wei-Feng Huang Li Xiong Hua-Jun Zhou Wei Tao Zhi-Tao Feng Third-Grade Pharmacological Laboratory on Chinese Medicine Approved by State Administration of Traditional Chinese Medicine Medical College of China Three Gorges University Yichang Hubei Province China Xiangyang Hospital of Traditional Chinese Medicine Xiangyang Hubei Province China Yichang Hospital of Traditional Chinese Medicine Clinical Medical College of Traditional Chinese Medicine China Three Gorges UniversityYichang Hubei Province China Department of Medicine and Therapeutics the Chinese University of Hong Kong Hong Kong Special Administrative Region China The Institute of Neurology the First College of Clinical Medical Sciences China Three Gorges University Yichang Hubei Province China

Puerarin suppresses autophagy to alleviate cerebral ischemia/reperfusion injury, and accumulating evidence indicates that the AMPKm TOR signaling pathway regulates the activation of the autophagy pathway through the coordinated phosphorylation of ULK1. In this study, we investigated the mechanisms underlying the neuroprotective effect of puerarin and its role in modulating autophagy via the AMPK-m TOR-ULK1 signaling pathway in the rat middle cerebral artery occlusion model of cerebral ischemia/reperfusion injury. Rats were intraperitoneally injected with puerarin, 50 or 100 mg/kg, daily for 7 days. Then, 30 minutes after the final administration, rats were subjected to transient middle cerebral artery occlusion for 90 minutes. Then, after 24 hours of reperfusion, the Longa score and infarct volume were evaluated in each group. Autophagosome formation was observed by transmission electron microscopy. LC3, Beclin-1 p62, AMPK, m TOR and ULK1 protein expression levels were examined by immunofluorescence and western blot assay. Puerarin substantially reduced the Longa score and infarct volume, and it lessened autophagosome formation in the hippocampal CA1 area following cerebral ischemia/reperfusion injury in a dose-dependent manner. Pretreatment with puerarin（50 or 100 mg/kg） reduced Beclin-1 expression and the LC3-II/LC3-I ratio, as well as p-AMPK and p S317-ULK1 levels. In comparison, it increased p62 expression. Furthermore, puerarin at 100 mg/kg dramatically increased the levels of p-m TOR and p S757-ULK1 in the hippocampus on the ischemic side. Our findings suggest that puerarin alleviates autophagy by activating the APMK-m TOR-ULK1 signaling pathway. Thus, puerarin might have therapeutic potential for treating cerebral ischemia/reperfusion injury.

关键词： nerve regeneration puerarin autophagy cerebral ischemia/reperfusion AMPK-m TOR-ULK1 signaling pathway light chain 3 p62 ischemic stroke AMPK/m TOR traditional Chinese medicine middle cerebral artery occlusion neural regeneration

Automatic velocity picking based on optimal key points tracking algorithm

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Petroleum Science 2024年第2期21卷 903-917页

作者： Yong-Hao Wang Wen-Kai Lu song-bai Jin yang Li Yu-Xuan Li Xiao-Feng Gu The Institute for Artificial Intelligence(THUAI) Tsinghua UniversityBeijing100084China State Key Laboratory of Intelligent Technology and Systems Tsinghua UniversityBeijing100084China Beijing National Research Center for Information Science and Technology(BNRist) Beijing100084China The Department of Automation Tsinghua UniversityBeijing100084China

Picking velocities from semblances manually is laborious and necessitates experience. Although various methods for automatic velocity picking have been developed, there remains a challenge in efficiently incorporating information from nearby gathers to ensure picked velocity aligns with seismic horizons while also improving picking accuracy. The conventional method of velocity picking from a semblance volume is computationally demanding, highlighting a need for a more efficient strategy. In this study, we introduce a novel method for automatic velocity picking based on multi-object tracking. This dynamic tracking process across different semblance panels can integrate information from nearby gathers effectively while maintaining computational efficiency. First, we employ accelerated density clustering on the velocity spectrum to discern cluster centers without the requirement for prior knowledge regarding the number of clusters. These cluster centers embody the maximum likelihood velocities of the main subsurface structures. Second, our proposed method tracks key points within the semblance volume. Kalman filter is adopted to adjust the tracking process, followed by interpolation on these tracked points to construct the final velocity model. Our synthetic data example demonstrates that our proposed algorithm can effectively rectify the picking errors of the clustering algorithm. We further compare the performances of the clustering method(CM), the proposed tracking method(TM), and the variational method(VM) on a field dataset from the Gulf of Mexico. The results attest that our method offers superior accuracy than CM, achieves comparable accuracy with VM, and benefits from a reduced computational cost.

关键词： Velocity picking Multi-object tracking Density clustering Kalman filter

Hematuria after nocturnal exercise of a man: A case report

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World Journal of Clinical Cases 2024年第5期12卷 1025-1028页

作者： Ming-Jian bai song-Tao yang Xue-Kai Liu Department of Clinical Laboratory Aerospace Center HospitalBeijing 100049China Department of Nephrology Aerospace Center HospitalBeijing 100049China

BACKGROUND A man experienced multiple episodes of macroscopic hematuria following nocturnal *** stones and tumors were considered the two most likely *** patient had two hobbies:Consuming health care products in large quantities and engaging in late-night *** SUMMARY Health care products contain a large amount of calcium phosphate,and we hypothesize that this could induce the formation of small phosphate *** exercise,the urinary system is abraded,resulting in *** patient was advised to stop using the health care ***,the aforementioned symptoms disappeared ***,the patient resumed the above two habits one year later;correspondingly,the macroscopic hematuria *** This finding further confirmed the above inference and allowed for a new avenue to determine the cause of the patient’s hematuria.

关键词： Hematuria Health care products Exercise Case report

Boundary Behaviors for a Continuous-state Nonlinear Neveu’s Branching Process

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Acta Mathematica Sinica,English Series 2024年第8期40卷 2005-2016页

作者： Lin Yu bai Xu yang School of Mathematics and Information Science North Minzu UniversityYinchuan 750021P.R.China

By generalizing a criterion of Mufa Chen for Markov jump processes,we establish the necessary and sufficient conditions for the extinction,explosion and coming down from infinity of a continuous-state nonlinear Neveu... 详细信息

关键词： Continuous-state branching process nonlinear branching Neveu’s branching extinction explosion coming down from infinity

Response of runoff and its components to climate change in the Manas River of the Tian Shan Mountains

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Advances in Climate Change Research 2024年第1期15卷 62-74页

作者： Ze-Long yang Peng bai Key Laboratory of Water Cycle and Related Land Surface Processes Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 10010lChina University of Chinese Academy of Sciences Beijing 100049China

A warming-wetting climate trend has led to increased runoff in most watersheds in the Tian Shan Mountains over the past few ***,it remains unclear how runoff components,that is,rainfall runoff(Rrain),snowmelt runoff(Rsnow),and glacier meltwater(Rglacier),responded to historical climate change and how they will evolve under future climate change ***,we used a modified Hydrologiska Byrans Vattenbalansavdelning(HBV)model and a detrending method to quantify the impact of precipitation and temperature changes on runoff components in the largest river(Manas River)on the northern slope of the Tian Shan Mountains from 1982 to 2015.A multivariate calibration strategy,including snow cover,glacier area,and runoff was implemented to constrain model parameters associated with runoff *** downscaled outputs of 12 general circulation models(GCMs)from the Sixth Coupled Model Intercomparison Project(CMIP6)were also used to force the modified HBV model to project the response of runoff and its components to future(2016-2100)climate change under three common socio-economic pathways(SSP126,SSP245,and SSP585).The results indicate that Rrain dominates mean annual runoff with a proportion of 42%,followed by Rsnow(37%)and Rglacier(21%).In terms of inter-annual variation,Rrain and Rsnow show increasing trends(0.93(p0.05)mm per year),while Rglacier exhibits an insignificant(p>0.05)decreasing trend(-0.12 mm per year),leading to an increasing trend in total runoff(1.12 mm per year,p>0.05).The attribution analysis indicates that changes in precipitation and temperature contribute 8.16 and 10.37 mm,respectively,to the increase in runoff at the mean annual *** wetting(increased precipitation)increases Rrain(5.03 mm)and Rsnow(3.19 mm)but has a limited effect on Rglacier(-0.06 mm),while warming increases Rrain(10.69 mm)and Rglacier(5.79 mm)but decreases Rsnow(-6.12 mm).The negative effect of glacier shrinkage on Rglacier has outweighed the

关键词： Tian Shan Rainfall runoff Snowmelt runoff Glacier meltwater Warming-wetting Tipping point

Infrared radiation characteristics of dagger-type hypersonic missile

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Chinese Journal of Aeronautics 2024年第4期37卷 137-150页

作者： Xubo DU Qingzhen yang Haoqi yang Jin bai Yongqiang SHI School of Power and Energy Northwestern Polytechnical UniversityXi’an 710129China

Hypersonic vehicles emit strong infrared radiation from their high-temperature exhaust plume and body, which is critical for infrared early warning, tracking, and guidance. In this work, a comprehensive analysis is conducted on the factors involved in air dissociation reaction within the shock layer of hypersonic missile heads, as well as the multi-component afterburning effect of the exhaust plume. A novel Reverse Monte Carlo Method(RMCM) is proposed for infrared radiation calculation, which utilizes two-dimensional Low-Discrepancy Sequences(LDS) to improve computational accuracy. The numerical calculations for a dagger-type missile show that afterburning reactions increase the temperature on the centerline of the outlet exhaust plume by about 1000 K. The total infrared radiation intensity of the missile is the highest in the 1–3 μm band, with the hightemperature wall of the nozzle being the primary source of solid radiation, and gas radiation primarily coming from H_(2)O. The radiation intensity of the missile exhaust plume in the 3–5 μm band is the highest, with radiation sources primarily coming from CO_(2), CO, and HCl. Afterburning reactions of the exhaust plume increase the total infrared radiation intensity of the missile by about 0.7times. These results can provide reference for the detection and guidance of hypersonic missiles.

关键词： Hypersonic vehicles Infrared radiation Monte Carlo methods Low-discrepancy sequences Exhaust plume Afterburning