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Natural Products and Bioprospecting 2019年第5期9卷 329-336页

作者： Rui-Jing Ma Liu Yang Xue bai Jin-Yu Li Ming-Yan Yuan Ya-Qin Wang Yong Xie Jiang-Miao Hu Jun Zhou State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China College of Pharmacy Guilin Medical UniversityGuilin 541004People’s Republic of China R&D Center of Dr.Plant Kunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China

Aqueous ethanol extracts of powdered stems of Dendrobium loddigesii afforded three new phenolics including threo-7-Oethyl-9-O-(4-hydroxyphenyl)propionyl-guaiacylglycerol(1),(R)-4,5,4ʹ-trihydroxy-3,3ʹ,α-trimethoxybibenzyl(2.and(S)-5,5′,7-trihydroxy-3′,4′-dimethoxyflavanone(3),together with eleven known *** structures were determined by extensive spectroscopic *** identify natural antioxidants,whitening,and anti-aging agents,the abilities of these phenolics were assessed to scavenge the 1,2.diphenyl-2.picrylhydrazyl(DPPH)radical,their abilities to inhibit tyrosinase production,and their abilities to stimulate collagen production by human dermal fibroblasts-adult(HDFa)*** was found that compounds 1,4-8,13 and 14 exhibited significant DPPH radical scavenging activities,compound 10 exhibited tyrosinase inhibitory activity(IC_(50)37.904μg/mL),and compound 9 showed significant collagen production with an EC_(50)value of 3.182.g/*** results suggest that phenolic constituents from *** may be candidate antioxidants,skin-whitening and/or anti-aging agents.

关键词： Dendrobium loddigesii Phenolic constituents Antioxidative Tyrosinase inhibitory Anti-aging

Characterization of flgK gene and FlgK protein required for H pylori Colonization-from cloning to clinical relevance

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World Journal of Gastroenterology 2006年第25期12卷 3989-3993页

作者： Jiunn-Jong Wu Bor-Shyang Sheu Ay-Huey Huang Shin-Ting Lin Hsiao-bai Yang departments of Medical Technology National Cheng Kung university Hospital 138 Sheng Li RoadTainan 70428TaiwanChina department of Internal Medicine National Cheng Kung university Hospital 138 Sheng Li RoadTainan 70428TaiwanChina departments of Pathology National Cheng Kung university Hospital 138 Sheng Li RoadTainan 70428TaiwanChina Institutes of Microbiology and and immunity National Cheng Kung university Hospital 138 Sheng Li RoadTainan 70428TaiwanChina

AIM： To characterize the role of flgK and its protein product in Hpylori colonization. METHODS： The PCR cloning method identified the flgK gene. An isogenic flgK mutant was constructed by gene replacement and confirmed by Southern blot analysis and PCR analysis. The recombinant FlgK protein （r-FlgK） was purified. Electron microscopy （EM） was applied to demonstrate the flagella of H pylori. An in vitro motility test was assessed in semisolid medium. The densities of H pylori colonization with either the wild-type strain or its flgK mutant were compared among BALB/c mice with or without pre-immunization with r-FlgK. The serological responses to r-FlgK were analyzed for 70 clinical patients with different densities of H pylori colonization. RESULTS： From a duodenal ulcer strain, the flgK gene was cloned and it contained 182. bp, with a 95.7% identity to the published sequences. No flagella were observed under EM for the mutant strain, which had a loss of motility. Hpylori density was lower in the BALB/c mice inoculated by the mutant or with pre-immunization with r-FlgK compared to unimmunized mice or mice inoculated by the wild-type strain （P 〈 0.05）. In the H pylori-infected patients, the serological responses to r-FlgK were uniformly low in titer.CONCLUSION： FlgK encoded by flgK is important for flagella formation and H pylori motility. Deficiency in FlgK or an enhanced serological response to r-FlgK can interfere with Hpylori colonization. FlgK of Hpylori could be a novel target for vaccination.

关键词： H pylori Colonization Isogenic mutant BALB/c mice Flagella Vaccine.

Environmental Monitoring of A Laboratory for New Coronavirus Nucleic Acid Testing

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Biomedical and Environmental Sciences 2020年第10期33卷 771-774页

作者： NING Pei Yong YU Ai Ping WANG Yuan GUO Li Ru SHAN Dan KONG Mei YU Ling Qi LYU Li Kun ZOU Ming SU Xu FEI Chun Nan ZHOU Yu Hui WANG bai Qi Tianjin Centers for Disease Control and Prevention-Institute of Pathogen Biology Tianjin 300011China department of Occupational and Environmental Health School of Public HealthTianjin Medical UniversityTianjin 300070China ZYUNICON(Tianjin)Science&Technology Co.Ltd. Tianjin 300402China Tianjin Key Laboratory of Environment Nutrition and Public HealthTianjin 300070China National Demonstration Center for Experimental Preventive Medicine Education(Tianjin Medical university) Tianjin 300070China

The coronavirus disease 2.19(COVID-19) is an infection of the respiratory tract which first broke out in Wuhan, China, in December 2.19. The etiologic agent of this disease was identified as a betacoronavirus related to severe acute respiratory syndrome coronavirus(SARS-CoV). Thus, the International Committee on Virus Classification named the new coronavirus severe acute respiratory syndrome coronavirus-2.SARS-CoV-2.[1].

关键词： respiratory acute infection

Prognostic risk model construction and prognostic biomarkers identification in esophageal adenocarcinoma based on immune-related long noncoding RNA

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Oncology and Translational Medicine 2020年第3期6卷 109-115页

作者： Kai Qin Yi Cheng Jing Zhang Xianglin Yuan Jianhua Wang Jian bai department of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China department of Obstetrics and Gynecology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective The aim of this study was to construct a prognostic model of esophageal adenocarcinoma(EAC)based on immune-related long noncoding RNAs(immune-related lncRNAs)and identify prognostic biomarkers using the Cancer Genome Atlas(TCGA)*** Whole genomic mRNA expression and clinical data of esophageal adenocarcinoma were obtained from the TCGA *** software Strawberry Perl,R and R packets were used to identify the immune-related genes and lncRNAs of esophageal adenocarcinoma,and for data processing and *** differentially expressed lncRNAs were detected while comparing esophageal adenocarcinoma and normal tissue *** key immune-related lncRNAs were screened using lasso regression analysis and univariate cox regression analysis,and used to construct the prognostic model using multivariate cox regression *** evaluate the accuracy of the risk prognostic model,all esophageal adenocarcinomas were divided into high-risk and low-risk groups according to the median risk score,after which Kaplan-Meier(K-M)survival curves,operating characteristic(ROC)curve and independent prognostic analysis of clinical traits were *** addition,statistically significant immune-related lncRNAs and potential prognostic biomarkers were identified using the prognostic model and multifactor cox regression analysis for k-m survival *** A total of 132. differentially expressed immune-related lncRNAs were identified,2. of which were associated with prognosis via univariate cox regression *** addition,K-M survival analysis showed that the total survival time of the higher risk group was significantly shorter than that of the lower risk group(P=1.063e-10).The area under the ROC curve of 5-year total survival rate was *** risk score showed independent prognostic risk for esophageal adenocarcinoma via single factor and multifactorial independent prognostic *** addition,the HR and 95%CI of each key immune-related lncRNA

关键词： immune-related Cancer Genome Atlas(lncRNA) prognostic model prognostic biomarker esophageal adenocarcinoma(EAC) Cancer Genome Atlas(TCGA)database

人工心脏瓣膜患者华法林抗凝质量影响因素分析及预测模型构建

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中南药学 2024年第5期22卷 1379-1384页

作者：史金平梁凯云张琰唐亚娟白娟洪术霞路小寒王立珍西安国际医学中心医院药学部西安710100 西安外事学院医学院西安710100

目的研究人工心脏瓣膜患者华法林抗凝质量的影响因素,构建华法林抗凝质量预测模型,甄别低/中水平华法林抗凝质量人群,提高其抗凝质量。方法回顾性调取2.2.年1月—2.2.年5月至某院就诊的人工心脏瓣膜患者,以治疗范围内时间百分比为指标... 详细信息

目的研究人工心脏瓣膜患者华法林抗凝质量的影响因素,构建华法林抗凝质量预测模型,甄别低/中水平华法林抗凝质量人群,提高其抗凝质量。方法回顾性调取2.2.年1月—2.2.年5月至某院就诊的人工心脏瓣膜患者,以治疗范围内时间百分比为指标,评价华法林的抗凝质量,采用Logistic回归方程分析华法林抗凝质量的影响因素,构建人工心脏瓣膜患者华法林抗凝质量列线图预测模型,并对该模型进行内部验证。结果共纳入2.6例患者,其中高抗凝质量组60例,低/中抗凝质量组176例,Logistic回归分析结果提示:合并心肌梗死/缺血性脑卒中病史[Exp(B)=0.14,95%CI:0.02.0.87,P=0.04]、焦虑/抑郁状态[Exp(B)=0.06,95%CI:0.08~0.89,P=0.01]是人工心脏瓣膜患者华法林高抗凝质量的危险因素;高白蛋白水平[Exp(B)=1.13,95%CI:1.02.1.2.,P=0.02.、高INR监测频率[Exp(B)=10.92.95%CI:5.11~2..32.P<0.01]是人工心脏瓣膜患者华法林高抗凝质量的保护因素,以此构建的列线图预测模型C-index 指数为0.940。结论构建的人工心脏瓣膜患者华法林抗凝质量列线图预测模型的区分度及一致性良好,具有较高的临床应用价值,可甄别低/中水平华法林抗凝质量,有针对性地开展药学监护,提高患者抗凝质量。

关键词：人工心脏瓣膜华法林抗凝质量治疗范围内时间百分比影响因素列线图预测模型

Expectant management of heterotopic cesarean scar pregnancy

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Chinese Medical Journal 2012年第7期125卷 1341-1344页

作者： bai Xiao-xia GAO Hui-juan YANG Xiao-fu DONG Ming-yue ZHU Yi-min department of Reproductive Endocrinology Women’s HospitalSchool of MedicineZhejiang UniversityHangzhouZhejiang 310006China

Background Heterotopic cesarean scar pregnancy （HCSP） is a very rare but life-threatening entity and there is no optimal management strategy. Here we report a successfully managed case of HCSP with expectant treatment in a tertiary referral hospital. Methods A woman with HCSP after in vitro fertilization-embryo transfer opted for expectant treatment after five days of mild bleeding and ultrasound demonstrated cardiac activity disappearance of the scar pregnancy at 8＋4 weeks of gestation. Results The patient had mild to moderate bleeding during close monitoring. Three days later, speculum examination revealed the gestational mass was partly protruding at the os of the cervix and it was removed with forceps without massive hemorrhage. A healthy male baby was delivered by cesarean section at gestational age of 36＋4 weeks. Conclusions The expectant method might be an alternative option for a HCSP with loss of cardiac activity of the scar pregnancy, when applied under supportive management and with available emergency surgery facilities.

关键词： cesarean scar heterotopic pregnancy expectant treatment in vitro fertilization-embryo transfer

Simulation Studying Effects of Multiple Primary Aberrations on Donut-shaped Gaussian Beam

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Optics and Photonics Journal 2013年第2期3卷 1-5页

作者： Chen Zhang Kaige Wang Jintao bai Yong Liu Guiren Wang department of Mechanical Engineering University of South Carolina Columbia United States Institute of Photonics & Photo-Technology Northwest University Xi’an China

In this paper, we demonstrate the variation of donut-shaped depletion pattern which influenced by multiple primary aberrations. The simulation is base on a common stimulation emission of depletion (STED) system composed by Gaussian laser and vortex phase plate. The simulation results are helpful guidelines for analyzing the aberration of depletion patterns in real situations.

关键词： Donut Shaped Depletion Pattern Primary Aberration Gaussian Laser Phase Plate

Early warning study of color doppler ultrasound in children with thyroid nodules and thyroid cancer

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Journal of Hainan Medical university 2019年第9期25卷 66-69页

作者： Li Yang Wen-Qi Ma bai-Ling Liu Qi Zhou Ultrasound department of Xi'an Children's Hospital Xi'an710003Shaanxi ProvinceChina Ultrasound department Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'an710003Shaanxi ProvinceChina

Objective: To study the diagnostic value of color doppler ultrasound in children with thyroid nodules and thyroid cancer. Methods: A total of sixty children with thyroid nodules treated in our hospital from March 2.17 to March 2.18 were selected for study. All patients underwent color Doppler ultrasound diagnosis. According to the diagnostic data, benign thyroid nodules and thyroid cancer were analyzed. The nodule nature was grouped into benign nodules group and malignant nodules group. The aspect ratio and boundary of the two groups were compared in blurring, calcification, blood flow signal classification, etc. Results: A total of 95 nodules were diagnosed by color doppler ultrasonography in 60 cases of thyroid nodules. 49 cases were benign nodules. There were 80 nodules, accounting for 82.11%, 11 cases of thyroid cancer, and 15 nodules. Accounted for 15.79%. Biopsy puncture pathology confirmed 77 benign nodules and 18 malignant nodules. The pathological results were gold standard. The specificity of color Doppler ultrasound was 90%, the sensitivity was 66.67%, and the accuracy of ultrasound diagnosis was 86.32..The two nodules were statistically significant in terms of boundary, aspect ratio, calcification, echo, and resistance index (P0.05).Conclusion: Color Doppler ultrasound has the advantages of simple operation, high accuracy, non-invasive and painless, and reproducible detection. The high-frequency probe can clearly display changes such as minute lesions, blood flow signals, echoes, calcifications, etc., and can diagnose thyroid cancer in time. It provides a favorable basis for clinical treatment and has important clinical warning value, especially for children with thyroid examination.

关键词： Thyroid nodules Color doppler ultrasound Pediatric Thyroid cancer Early warning

Sputtered MoN nanolayer as a multifunctional polysulfide catalyst for high-performance lithium–sulfur batteries

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eScience 2022年第3期2卷 329-338页

作者： Xin-Yang Yue Jing Zhang Jian Bao Yi-Fan bai Xun-Lu Li Si-Yu Yang Zheng-Wen Fu Zhen-Hua Wang Yong-Ning Zhou department of Materials Science Fudan UniversityShanghai200433China Beijing Key Laboratory for Chemical Power Source and Green Catalysis School of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing100081China Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing100084China department of Chemistry Fudan UniversityShanghai200433China

Two major obstacles for the practical application of lithium–sulfur batteries are sluggish redox kinetics and the shuttle effect of lithium polysulfides(LiPSs).Herein,MoN nanolayer-decorated multilayer graphene is fabricated via magnetron sputtering then serves as a multifunctional interlayer in Li–S batteries to suppress the shuttle effect and enhance redox *** is revealed that after the initial discharge process,the MoN layers break up into independent microreaction units consisting of MoN bodies and MoS_(2. edges,forming a heterogeneous composite catalyst in *** MoN bodies not only have high sulfur affinity to trap LiPSs but also enhance their redox *** the same time,the MoS_(2. edge weakens the mobility of LiPSs via the anchoring *** a result,Li–S cells using the interlayer present superior cycling stability under a high sulfur loading of 4.8 mg cm^(-2..This work may open a new avenue for developing high-performance Li–S batteries.

关键词： Li–S batteries Polysulfide Barrier interlayer MoN Magnetron sputtering

Role of Kasai procedure in surgery of hilar bile duct strictures

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World Journal of Gastroenterology 2011年第37期17卷 4231-4234页

作者： Jin-Bo Gao Li-Shan bai Zhi-Jian Hu Jun-Wei Wu Xin-Qun Chai department of Hepatobiliary Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 Hubei Province China

AIM:To assess the application of the Kasai procedure in the surgical management of hilar bile duct ***:Ten consecutive patients between 2.05 and 2.11 with hilar bile duct strictures who underwent the Kasai procedure were retrospectively *** portoenterostomy with the placement of biliary stents was performed in all *** characteristics,postoperative complications,and long-term outcomes were *** patients were followed up for 2.60 mo ***:Patients were classified according to the Bismuth classification of biliary *** were two Bismuth Ⅲ and eight Bismuth Ⅳ *** lesions were benign and four were *** the benign lesions,three were due to post-cholecystectomy injury,one to trauma,one to inflammation,and one to inflammatory *** the malignant lesions,four were due to hilar *** patients underwent Kasai portoenterostomy with the placement of biliary *** were no perioperative *** patient experienced anastomotic leak and was managed *** other complications occurred *** the follow-up period,all patients reported a good quality of ***:The Kasai procedure combined with biliary stents may be appropriate for patients with hilar biliary stricture that cannot be managed by standard surgical methods.

关键词： Kasai procedure Hilar bile duct Stricture Surgery