Phenolic Constituents with Antioxidative,Tyrosinase Inhibitory and Anti‑aging Activities from Dendrobium loddigesii Rolfe

作     者：Rui-Jing Ma Liu Yang Xue Bai Jin-Yu Li Ming-Yan Yuan Ya-Qin Wang Yong Xie Jiang-Miao Hu Jun Zhou 

作者机构：State Key Laboratory of Phytochemistry and Plant Resources in West ChinaKunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China College of PharmacyGuilin Medical UniversityGuilin 541004People’s Republic of China R&D Center of Dr.PlantKunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China 

出 版 物：《Natural Products and Bioprospecting》 (应用天然产物（英文）)

年 卷 期：2019年第9卷第5期

页      面：329-336页

学科分类：0202[经济学-应用经济学] 02[经济学] 020205[经济学-产业经济学] 

基　　金：This project was supported financially by the Yunnan Provincial Science and Technology Department(Nos.2017ZF003-04 2015HB093 and 2019HA001).Authors are grateful to the staff of the analytical group of the State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences for measurements of all spectra 

主　　题：Dendrobium loddigesii Phenolic constituents Antioxidative Tyrosinase inhibitory Anti-aging 

摘      要：Aqueous ethanol extracts of powdered stems of Dendrobium loddigesii afforded three new phenolics including threo-7-Oethyl-9-O-(4-hydroxyphenyl)propionyl-guaiacylglycerol(1),(R)-4,5,4ʹ-trihydroxy-3,3ʹ,α-trimethoxybibenzyl(2)and(S)-5,5′,7-trihydroxy-3′,4′-dimethoxyflavanone(3),together with eleven known *** structures were determined by extensive spectroscopic *** identify natural antioxidants,whitening,and anti-aging agents,the abilities of these phenolics were assessed to scavenge the 1,2-diphenyl-2-picrylhydrazyl(DPPH)radical,their abilities to inhibit tyrosinase production,and their abilities to stimulate collagen production by human dermal fibroblasts-adult(HDFa)*** was found that compounds 1,4-8,13 and 14 exhibited significant DPPH radical scavenging activities,compound 10 exhibited tyrosinase inhibitory activity(IC_(50)37.904μg/mL),and compound 9 showed significant collagen production with an EC_(50)value of 3.182μg/*** results suggest that phenolic constituents from *** may be candidate antioxidants,skin-whitening and/or anti-aging agents.