检索结果-南通市图书馆

MiRNA-145-5p inhibits gastric cancer progression via the serpin family E member 1-extracellular signal-regulated kinase-1/2 axis

引用

World Journal of Gastrointestinal Oncology 2024年第5期16卷 2123-2140页

作者： Hong-Xia bai Xue-Mei Qiu Chun-Hong Xu Jian-qiang Guo Department of Gastroenterology The Second Hospital of Shandong UniversityJinan 250000Shandong ProvinceChina Department of Gastroenterology Liaocheng People’s HospitalLiaocheng 252000Shandong ProvinceChina Department of Reproductive Center Zaozhuang Maternal and Child Health Care HospitalZaozhuang 277000Shandong ProvinceChina

BACKGROUND MicroRNAs(miRNAs)regulate gene expression and play a critical role in cancer ***,there is still a limited understanding of the function and regulatory mechanism of miRNAs in gastric cancer(GC).AIM To investigate the role and molecular mechanism of miRNA-145-5p(miR145-5p)in the progression of *** Real-time polymerase chain reaction(RT-PCR)was used to detect miRNA expression in human GC tissues and *** ability of cancer cells to migrate and invade was assessed using wound-healing and transwell assays,*** proliferation was measured using cell counting kit-8 and colony formation assays,and apoptosis was evaluated using flow *** of the epithelial-mesenchymal transition(EMT)-associated protein was determined by Western *** of miR-145-5p were predicated using bioinformatics analysis and verified using a dual-luciferase reporter *** family E member 1(SERPINE1)expression in GC tissues and cells was evaluated using RT-PCR and immunohistochemical *** correlation between SERPINE1 expression and overall patient survival was determined using Kaplan-Meier plot *** association between SERPINE1 and GC progression was also tested.A rescue experiment of SERPINE1 overexpression was conducted to verify the relationship between this protein and *** mechanism by which miR-145-5p influences GC progression was further explored by assessing tumor formation in nude *** GC tissues and cells had reduced miR-145-5p expression and SERPINE1 was identified as a direct target of this *** of miR-145-5p was associated with decreased GC cell proliferation,invasion,migration,and EMT,and these effects were reversed by forcing SERPINE1 ***-Meier plot analysis revealed that patients with higher SERPINE1 expression had a shorter survival rate than those with lower SERPINE1 *** mouse tumorigenesis experiments confirmed that miR-145-5p target

关键词： Gastric cancer MicroRNA-145-5p Serpin family E member 1 Epithelial-mesenchymal transition Proliferation Extracellular signal-regulated kinase-1/2

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A comparative study of organic agriculture development between China and South Korea

引用

Ecological Economy 2010年第1期6卷 96-104页

作者： qiang bai-fa HUANG Tian-zhu College of Humanities. Northwest A＆F University Yangling 712100. P. R China School of Management Shaanxi University of Science and Technology Xi＇an 710021. P R. China

Human activities including modern agriculture have caused environmental pollution, so people begin to pay attentton to safe food. As a result, organic agriculture has emerged. Organic agriculture in South Korea （hereinafter referred as Korea） and China has developed rapidly since the appearance of organic agriculture in 1970s and 1980s respectively. Organic agriculture in China and Korea has developed steadily through agricultural support policies, certification management, institutions construction etc. In the development of organtc agriculture, China and Korea are now facing some technical and extension problems. In general however the development of organic agriculture in China lags behind Korea. China can learn from the experience about the development of organic agriculture in Korea to solve contradiction between development of organic agriculture and food safety, to strengthen the organic food certification, to introduce a system of agricultural direct payment and other positive measures, thus will guarantee steady and healthy development of organic agriculture in China.

关键词： South Korea Organic agriculture China Comparison

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Economic analysis in admitted patients with acute exacerbation of chronic obstructive pulmonary disease

引用

Chinese Medical Journal 2008年第7期121卷 587-591页

作者： CHEN Ya-hong YAO Wan-zhen CAI bai-qiang WANG Hong DENG Xiao-mei GAO Hui-li HUANG Jia-sheng WANG Xin-mao Department of Respiratory Medicine Peking University ThirdHospital Beijing 100083 China Department of Respiratory Medicine Peking Union MedicalCollege Hospital Beijing 100730 China Department of Respiratory Medicine Sixth Peking HospitalBeijing 100007 China Department of Respiratory Medicine Beijing Haidian HospitalBeijing 100080 China

Background The socio-economic burden of acute exacerbation of chronic obstructive pulmonary disease （AECOPD） in Beijing is not fully understood. The study investigated the hospitalization cost in patients with AECOPD and the associated factors. Methods A multi-center, retrospective study was conducted in the four hospitals in Beijing including two level III hospitals and two level II hospitals. Patients with AECOPD admitted to the hospitals between January and December in 2006 were enrolled. The hospitalization cost and its relationship with disease severity and treatment were analyzed. Results Totally 439 patients were enrolled with 294 men （67.0%） and a mean age 73.4 years. The mean hospital stay was 20.7 days. A total of 204 patients （46.5%） had respiratory failure, 153 （34.9%） with cor pulmonale, 123 （28.0%） with coronary artery disease, 231 （52.6%） with hypertension, 70 （15.9%） with cerebrovascular disease and 32 （7.3%） with renal failure. The percentage of drug cost to total cost was the highest （71.2%）, followed by laboratory cost （16.7%）, therapy cost （9.7%）, oxygen cost （7.3%）, radiology cost （4.5%）, examination cost （4.5%）, bed cost （4.1%）. Correlation analysis showed that cost was positively correlated with age, hospitalization days, co-morbidities such as respiratory failure and cor pulmonale, hypertension. Three hundred and twenty-one patients were further analyzed. The hospitalization cost increased in patients with non-invasive ventilation （P〈0.01）, invasive mechanical ventilation （P〈0.01）, ICU stay （P〈0.01）, antibiotics （P〈0.05）, systemic steroids （P〈0.01）, and poor prognosis （P〈0.05）. Correlation analysis showed that the hospitalization cost was negatively correlated with percentage forced expiratory volume in 1 second （FEV1%）（r=-0.149, P〈0.05）, pH （r=-0.258, P〈0.01）, and PaO2 （r=-0.131, P〈0.05）, positively correlated with PaCO2 （r=0.319, P〈0.01）, non-invasive positive pressure ventilation （r=0.375, P〈0.01） and duration （r=0.463, P〈0.01）, invasive

关键词： chronic obstructive pulmonary disease acute exacerbation cost analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Experimental study on shock interaction control of double wedge in high-enthalpy hypersonic flow subject to plasma synthetic jet

引用

Chinese Journal of Aeronautics 2024年第4期37卷 151-165页

作者： Xuzhen XIE qiang LIU Yan ZHOU Zhenbing LUO Wei XIE Guanghui bai Kai LUO Qiu WANG Jianjun WU College of Aerospace Science and Engineering National University of Defense TechnologyChangsha 410073China China Academy of Launch Vehicle Technology Beijing 100076China Institute of Mechanics Chinese Academy of SciencesBeijing 100190China

The hypersonic shock-shock interaction flow field at double-wedge geometries controlled by plasma synthetic jet actuator is experimentally studied in a Ma = 8 high-enthalpy shock tunnel with the purpose of exploring a novel technique for reducing surface heat flux in a real flight environment. The results demonstrate that increasing the discharge energy is advantageous in eliminating the shock wave, shifting the shock wave interaction point, and shortening the control response time. The oblique shock wave can be completely removed when the actuator's discharge energy grows from 0.4 J to 11.5 J, and the displacement of the shock wave interaction point increases by 124.56%, while the controlled response time is shortened by 30 μs. Besides, the reduction in diameter of the jet exit is firstly proved to have a negative impact on energy deposition in a working environment with incoming flow, which reduces the discharge energy and hence decreases the control effect. The shock wave control response time lengthens when the jet exits away from the second wedge. Along with comparing the change in wall heat flux at the second wedge over time, the control effect of plasma synthetic jet actuator with and without inflation is also analyzed. When plasma synthetic jet works in inflatable mode, both the ability to eliminate shock waves and the shifting effect of the shock wave interaction point are increased significantly, and the wall heat flux is also reduced.

关键词： Hypersonic flow High-enthalpy flow Plasma synthetic jet Shock wave Flow control

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Intercostal artery damage and massive hemothorax after thoracocentesis by central venous catheter： A case report

引用

Chinese Journal of Traumatology 2017年第5期20卷 305-307页

作者： bai-qiang Li Bo Ye Fa-Xi Chen Lu Ke Zhi-Hui Tong Jie-Shou Li Wei-Qin Li Department of General Surgery SICU Jinling Hospital Medical School of Nanjing University Nanjing 210002 China

Central venous catheters （CVCs） are widely used in various puncture and drainage operations in intensive care units （ICUs） in recent years. Compared to conventional operating devices, CVC was welcomed by clinicians because of the advantages of easy use, less damage to the body and convenient fixation pro- cess. We came across a patient with severe acute pancreatitis （SAP） who developed cardiac arrest due to thoracic cavity massive bleeding 24 h after thoracoceotesis with CVC. Thoracotomy surgery was carried out immediately, which confirmed an intercostal artery injury. The patient was discharged from hospital without any neurological complications two months later. Here we report this case to remind all the emergency department and ICU physicians to pay more attention to the complication of thoracic cavity bleeding following thoracocentesis conducted by CVC.

关键词： Central venous catheters Thoracentesis Hemothorax

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ginsenoside Rk3 modulates gut microbiota and regulates immune response of group 3 innate lymphoid cells to against colorectal tumorigenesis

引用

Journal of Pharmaceutical Analysis 2024年第2期14卷 259-275页

作者： Xue bai Rongzhan Fu Yannan Liu Jianjun Deng qiang Fei Zhiguang Duan Chenhui Zhu Daidi Fan Shaanxi Key Laboratory of Degradable Biomedical Materials School of Chemical EngineeringNorthwest UniversityXi'an710069China Biotech&Biomed Research Institute Northwest UniversityXi'an710069China School of Chemical Engineering and Technology Xi'an Jiaotong UniversityXi'an710069China

The gut microbiota plays a pivotal role in the immunomodulatory and protumorigenic microenvironment of colorectal cancer(CRC).However,the effect of ginsenoside Rk3(Rk3)on CRC and gut microbiota remains ***,the purpose of this study is to explore the potential effect of Rk3 on CRC from the perspective of gut microbiota and immune *** results reveal that treatment with Rk3 significantly suppresses the formation of colon tumors,repairs intestinal barrier damage,and regulates the gut microbiota imbalance caused by CRC,including enrichment of probiotics such as Akkermansia muciniphila and Barnesiella intestinihominis,and clearance of pathogenic *** metabolomics data demonstrate that Rk3 can modulate the metabolism of amino acids and bile acids,particularly by upregulating glutamine,which has the potential to regulate the immune ***,we elucidate the regulatory effects of Rk3 on chemokines and inflammatory factors associated with group 3 innate lymphoid cells(ILC3s)and T helper 17(Th17)signaling pathways,which inhibits the hyperactivation of the Janus kinase-signal transducer and activator of transcription 3(JAK-STAT3)signaling *** results indicate that Rk3 modulates gut microbiota,regulates ILC3s immune response,and inhibits the JAK-STAT3 signaling pathway to suppress the development of colon *** importantly,the results of fecal microbiota transplantation suggest that the inhibitory effect of Rk3 on colon tumors and its regulation of ILC3 immune responses are mediated by the gut *** summary,these findings emphasize that Rk3 can be utilized as a regulator of the gut microbiota for the prevention and treatment of CRC.

关键词： Colorectal cancer Ginsenoside Immune cells Gut microbiota

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

大学生科技创新能力培养机制研究——哈佛大学的经验与启示

引用

重庆大学学报（社会科学版） 2012年第6期18卷 170-175页

作者：白强重庆大学生命科学学院重庆400045

大学生科技创新能力是国家未来创新能力的基础。加强大学生科技创新能力培养需要构建科学而完善的长效机制。在考察美国哈佛大学学生科技创新能力培养机制成功经验的基础上,分析中国大学生科技创新能力培养机制的基本现状,建议结合中国... 详细信息

大学生科技创新能力是国家未来创新能力的基础。加强大学生科技创新能力培养需要构建科学而完善的长效机制。在考察美国哈佛大学学生科技创新能力培养机制成功经验的基础上,分析中国大学生科技创新能力培养机制的基本现状,建议结合中国实际,借鉴哈佛大学的成功经验,从创新教育理念、深化教育教学改革、加强教师队伍建设、重视科技创新实践、培养学生创新人格和建设校园创新文化等方面进一步完善中国大学生科技创新能力培养机制。

关键词：大学生科技创新培养机制

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于知识生产模式Ⅲ的高校学科高质量发展研究

引用

科学管理研究 2023年第4期41卷 41-47页

作者：白强铜仁学院教育学院贵州铜仁554300 重庆大学公共管理学院重庆400044

知识生产模式Ⅲ正在深刻影响学科发展样态。深入分析知识生产模式Ⅲ的特征及其对高校学科高质量发展的影响,进而探究顺应知识生产模式Ⅲ的高校学科高质量发展动力、逻辑与策略,具有重要现实意义。分析发现:知识生产模式Ⅲ给高校学科发... 详细信息

知识生产模式Ⅲ正在深刻影响学科发展样态。深入分析知识生产模式Ⅲ的特征及其对高校学科高质量发展的影响,进而探究顺应知识生产模式Ⅲ的高校学科高质量发展动力、逻辑与策略,具有重要现实意义。分析发现:知识生产模式Ⅲ给高校学科发出了在问题解决、多元融合、开放情境、共建共创共治中走向高质量发展的重要信号。但现实中,驱动高校学科高质量发展的政府推力、市场拉力、社会引力、学科内在动力之间仍然存在着逻辑冲突,需要遵循问题导向的知识统一逻辑、多维协同的知识创新逻辑、生态和谐的知识共生逻辑、开放发展的知识吸纳逻辑,形成推动高校学科高质量发展的驱动合力,并优化建设策略,从单一追求转向双重并重、从离散发展转向协同发展、从封闭发展转向开放发展、从碎片发展转向整体发展、从跟跑发展转向领跑发展,进而提升高校学科的服务力、合成力、包容力、综合力和引领力,有助于推动高校学科高质量发展。

关键词：知识生产模式Ⅲ 学科高质量发展动力冲突逻辑遵循策略优化

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

知识生产模式变革下一流学科建设的逻辑转向与机制建构

引用

大学教育科学 2022年第5期 14-22页

作者：白强铜仁学院教育学院铜仁554300 重庆大学

学科建设的根本是知识生产,知识生产模式深刻影响学科建设质量。当前,知识生产模式变革方兴未艾,把握知识生产模式变革下学科的发展趋势、揭示一流学科建设的逻辑走向、建构顺应知识生产模式变革的一流学科建设机制是“双一流”建设的... 详细信息

学科建设的根本是知识生产,知识生产模式深刻影响学科建设质量。当前,知识生产模式变革方兴未艾,把握知识生产模式变革下学科的发展趋势、揭示一流学科建设的逻辑走向、建构顺应知识生产模式变革的一流学科建设机制是“双一流”建设的紧要议题。知识生产组织结构走向高度聚合、价值取向更加强调应用、场域跨界特征更加显著、生产方式更加注重协同的学科发展趋势,给一流学科建设发出了从知识增长到问题解决、从线性发展到螺旋上升、从学者推动到多元协同、从理论创新到应用创新的逻辑转向信号。反思我国一流学科建设实践,仍然存在着政策制度“盲点”、发展动力“难点”、学科组织“痛点”、学科治理“卡点”、学科评价“堵点”,需要坚持学科建设的底线思维与发展思维相结合、学术逻辑与社会逻辑相统一,通过建构服务导向的政策引领机制、问题牵引的发展动力机制、聚合效应的学科组织机制、分类共治的学科治理机制、多元综合的学科评价机制,推动一流学科创新发展、高质发展。

关键词：知识生产模式一流学科建设学科趋势逻辑转向机制建构

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

大学生科技创新非智力因素培养研究——以教育联动为视角

引用

重庆大学学报（社会科学版） 2014年第6期20卷 206-211页

作者：白强南京大学教育研究院江苏南京210093

科技创新是智力与非智力因素共同作用的结果。调查发现,中国大学生科技创新非智力因素总体状况不容乐观,原因在于各级教育缺乏衔接联动。培养大学生科技创新非智力因素,应当建立一体化的人才培养机制,实现大中小学各教育阶段的有机衔接... 详细信息

科技创新是智力与非智力因素共同作用的结果。调查发现,中国大学生科技创新非智力因素总体状况不容乐观,原因在于各级教育缺乏衔接联动。培养大学生科技创新非智力因素,应当建立一体化的人才培养机制,实现大中小学各教育阶段的有机衔接。建议高度重视非智力因素,把非智力因素教育纳入各级学校教育教学体系;改革传统人才培养方式,各级学校要大力开展个性化和多元化人才培养;各教育阶段衔接联动,构建大中小学一体化创新人才培养机制;深化教育体制改革,着力优化各级教育人才考试评价招生制度;加强各级学校思想政治教育,培育学生科技创新使命感和责任感。

关键词：科技创新非智力因素教育联动

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：