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Salvia ceratophylla L. from South of Jordan: new insights on chemical composition and biological activities

Natural Products and Bioprospecting 2020年第5期10卷 307-316页

作者： Mohammad Sanad Abu-Darwish Célia Cabral Zulfigar Ali Mei Wang Shabana IKhan Melissa RJacob Surendra KJain Babu LTekwani Fazila Zulfiqar Ikhlas AKhan Hatem Taifour Lígia Salgueiro Thomas Efferth Department of Basic and Applied Sciences Al-Balqa Applied UniversityAl-Salt 19117Jordan National Center for Natural Products Research School of PharmacyUniversity of MississippiUniversityMS 38677USA Coimbra Institute for Clinical and Biomedical Research(iCBR) Faculty of MedicineUniversity of Coimbra3000-548 CoimbraPortugal Center for Innovative Biomedicine and Biotechnology(CIBB) University of Coimbra3000-548 CoimbraPortugal Centre for Functional Ecology Department of Life SciencesUniversity of CoimbraCalçada Martim de Freitas3000-456 CoimbraPortugal School of Geosciences University of Edinburgh219 Crew BuildingKing’s BuildingsEdinburgh EH93FFUK CIEPQPF/Faculty of Pharmacy University of CoimbraHealth Sciences CampusAzinhaga de S.Comba3000-548 CoimbraPortugal Department of Pharmaceutical Biology Institute of Pharmaceutical and Biocmedical SciencesJohannes Gutenberg UniversityStaudinger Weg 555128 MainzGermany

In Jordan,Salvia ceratophylla L.is traditionally used in the treatment of cancer,microbial infections,and urinary disorders.This study aimed:(1)to chemically characterize S.ceratophylla essential oil(EO)from South Jordan,by gas chromatography(GC)and gas chromatography-mass spectrometry(GC-MS);and(2)to evaluate in vitro the cytotoxic,anti-inflammatory,and antiprotozoal activities of the EO,it’s predominant components,and the hexane(A),ethyl acetate(B),methanol(C)and crude-methanol extracts(D).The analysis revealed that the EO has 71 compounds,with linalool(54.8%)as main constitu-ent.Only the hexane extract(A)showed some cytotoxic activity against SK-MEL,KB,BT-549,SK-OV-3,LLC-PK1 and VERO cells lines with IC50 between 60 and>100μg/mL.The EO inhibited NO production(IC5090μg/mL)and NF-κB activity(IC5038μg/mL).The extracts A,B,and D inhibited NO production and NF-κB activity with IC50 between 32 and 150μg/mL.Linalool considerably inhibited NO production(IC5018μg/mL).The extracts tested did not exhibit antileish-manial activity.Regarding antitrypanosomal activity,the EO exhibited significant results with IC502.65μg/mL.In conclu-sion,Jordan S.ceratophylla EO represents a rich source of linalool and bears a promising therapeutic potential for further antitrypanosomal drug development.

关键词： Lamiaceae Essential oil Chemical composition Cytotoxicity Anti-inflammatory activity Neglected diseases

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