Salvia ceratophylla L. from South of Jordan: new insights on chemical composition and biological activities
作者机构：Department of Basic and Applied SciencesAl-Balqa Applied UniversityAl-Salt 19117Jordan National Center for Natural Products ResearchSchool of PharmacyUniversity of MississippiUniversityMS 38677USA Coimbra Institute for Clinical and Biomedical Research(iCBR)Faculty of MedicineUniversity of Coimbra3000-548 CoimbraPortugal Center for Innovative Biomedicine and Biotechnology(CIBB)University of Coimbra3000-548 CoimbraPortugal Centre for Functional EcologyDepartment of Life SciencesUniversity of CoimbraCalçada Martim de Freitas3000-456 CoimbraPortugal School of GeosciencesUniversity of Edinburgh219 Crew BuildingKing’s BuildingsEdinburgh EH93FFUK CIEPQPF/Faculty of PharmacyUniversity of CoimbraHealth Sciences CampusAzinhaga de S.Comba3000-548 CoimbraPortugal Department of Pharmaceutical BiologyInstitute of Pharmaceutical and Biocmedical SciencesJohannes Gutenberg UniversityStaudinger Weg 555128 MainzGermany
出 版 物：《Natural Products and Bioprospecting》 (应用天然产物（英文）)
年 卷 期：2020年第10卷第5期
页 面：307-316页
学科分类：0710[理学-生物学] 0832[工学-食品科学与工程（可授工学、农学学位）] 1007[医学-药学(可授医学、理学学位)] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 07[理学] 1001[医学-基础医学(可授医学、理学学位)] 070303[理学-有机化学] 0703[理学-化学] 0901[农学-作物学] 0902[农学-园艺学]
基 金：supported by Foundation for Science and Technology(FCT) Portugal(Strategic Projects UID/NEU/04539/2013,and UID/NEU/04539/2019,UIDB/04539/2020 and UIDP/04539/2020(CIBB)).
主 题：Lamiaceae Essential oil Chemical composition Cytotoxicity Anti-inflammatory activity Neglected diseases
摘 要：In Jordan,Salvia ceratophylla L.is traditionally used in the treatment of cancer,microbial infections,and urinary disorders.This study aimed:(1)to chemically characterize S.ceratophylla essential oil(EO)from South Jordan,by gas chromatography(GC)and gas chromatography-mass spectrometry(GC-MS);and(2)to evaluate in vitro the cytotoxic,anti-inflammatory,and antiprotozoal activities of the EO,it’s predominant components,and the hexane(A),ethyl acetate(B),methanol(C)and crude-methanol extracts(D).The analysis revealed that the EO has 71 compounds,with linalool(54.8%)as main constitu-ent.Only the hexane extract(A)showed some cytotoxic activity against SK-MEL,KB,BT-549,SK-OV-3,LLC-PK1 and VERO cells lines with IC50 between 60 and100μg/mL.The EO inhibited NO production(IC5090μg/mL)and NF-κB activity(IC5038μg/mL).The extracts A,B,and D inhibited NO production and NF-κB activity with IC50 between 32 and 150μg/mL.Linalool considerably inhibited NO production(IC5018μg/mL).The extracts tested did not exhibit antileish-manial activity.Regarding antitrypanosomal activity,the EO exhibited significant results with IC502.65μg/mL.In conclu-sion,Jordan S.ceratophylla EO represents a rich source of linalool and bears a promising therapeutic potential for further antitrypanosomal drug development.
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