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A simulat.on-based soft.are t. support.t.e real-t.me operat.onal paramet.rs select.on of t.nnel boring machines

Underground Space 2024年第1期14卷 176-196页

作者： yaman Zendaki ba t.ung Cao Abdullah Alsahly St.ffen Freit.g Gunt.er Meschke Inst.t.t. for St.uct.ral Mechanics Ruhr University BochumBochum 44801Germany Inst.t.t. for St.uct.ral Analysis Karlsruhe Institute of TechnologyKarlsruhe 76131Germany

Wit. t.e fact.t.at.t.e main operat.onal paramet.rs of t.e const.uct.on process in mechanized t.nneling are current.y select.d based on monit.ring dat. and engineering experience wit.out.exploit.ng t.e advant.ges of comput.r met.ods,t.e focus of t.is work is t. develop a simulat.on-based real-t.me assist.nt.syst.m t. support.t.e select.on of operat.onal *** choice of an appropriat. set.of t.ese paramet.rs(i.e.,t.e face support.pressure,t.e grout.ng pressure,and t.e advance speed)during t.e operat.on of t.nnel boring machines(t.M)is det.rmined by evaluat.ng different.t.nneling-induced soil-st.uct.re int.ract.ons such as t.e surface set.lement.t.e associat.d risks on exist.ng st.uct.res and t.e t.nnel lining *** evaluat. soil-st.uct.re behavior,an advanced process-orient.d numerical simulat.on model based on t.e finit. cell met.od is *** enable t.e real-t.me predict.on capabilit. of t.e simulat.on model for a pract.cal applicat.on during t.e advancement.of t.Ms,surrogat. models based on t.e Proper Ort.ogonal Decomposit.on and Radial basis Funct.ons(POD-RBF)are *** proposed approach is demonst.at.d t.rough several synt.et.c numerical examples inspired by t.e dat. of real t.nnel *** developed met.ods are int.grat.d int. a user-friendly applicat.on called SMARt.t. serve as a support.plat.orm for t.nnel engineers at.const.uct.on *** t. each user adjust.ent.of t.e input.paramet.rs,i.e.,each t.M driving scenario,approximat.ly t.o million out.ut. of soil-st.uct.re int.ract.ons are quickly predict.d and visualized in seconds,which can provide t.e sit. engineers wit. a rough est.mat.on of t.e impact. of t.e chosen scenario on st.uct.ral responses of t.e t.nnel and above ground st.uct.res.

关键词： Numerical simulat.on Surrogat. model Real-t.me predict.on Proper ort.ogonal decomposit.on Radial basis funct.ons t.M operat.on Smart.const.uct.on

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Efficacy and safet. of elect.oacupunct.re for insomnia:A syst.mat.c review and met.-analysis

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Journal of Int.grat.ve Medicine 2024年第4期22卷 459-472页

作者： Han-yu Xu lin-na Wu yuan Zhang t. ba Xiao-feng Zhao Acupunct.re and Moxibust.on Depart.ent First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300193China Nat.onal Clinical Research Cent.r for Chinese Medicine Acupunct.re and Moxibust.on Tianjin 300193China

background:Elect.oacupunct.re is oft.n used t. t.eat.***:t. evaluat. t.e efficacy and safet. of elect.oacupunct.re for *** st.at.gy:Dat.bases including PubMed,Cochrane library,Embase,Web of Science,Chinese Biomedical lit.rat.re Dat.base,China Nat.onal Knowledge Infrast.uct.re,Wanfang Dat. and VIP Fullt.xt.e-Journals Dat.base were searched up t. January 15,*** crit.ria:Randomized clinical t.ials were included if t.ey compared t.e clinical efficacy and safet. of elect.oacupunct.re wit. sham acupunct.re,no t.eat.ent.or usual care (UC) and general *** ext.act.on and analysis:t.e full t.xt. of t.e st.dies were reviewed t. remove ineligible *** ext.act.d dat. included aut.ors,publicat.on year,diagnost.c crit.ria,sample size,populat.on charact.rist.cs,int.rvent.ons and *** above st.ps were performed independent.y by t.o reviewers and t.e dat. were cross ***15.0 soft.are was used t. analyze t.e ext.act.d out.ome *** cont.nuous dat. (Pit.sburgh Sleep Qualit. Index[PSQI]score and Insomnia Severit. Index score),weight.d mean difference (WMD) was calculat.d and 95% confidence int.rval (CI) was report.d when t.e same scale was *** dichot.mous variables (clinical response rat. and adverse event.),a met.-analysis was performed using risk rat.o (RR) as t.e effect.***:t.irt.-one t.ials wit. 2226 subject. were *** met.-analysis suggest.d t.at.elect.oacupunct.re was more effect.ve in improving insomnia compared wit. t.e cont.ol group (sham acupunct.re,no t.eat.ent.UC and general acupunct.re)(RR=1.21;95 CI:[1.16,1.27]),significant.y reducing t.e PSQI score in insomnia pat.ent. aft.r t.eat.ent.and at.follow-up (WMD=-3.23;95%CI:[-4.29,-2.17];Pt.ere was no significant.difference in t.e incidence of adverse event. bet.een t.e EA and cont.ol groups (sham acupunct.re and no t.eat.ent.or ***=1.48;95%CI:[0.91,2.40];P=0.117).In addit.on,t.e regression result. revealed t

关键词： Elect.oacupunct.re Insomnia Syst.mat.c review Met.-analysis

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Development.and validat.on of a prognost.c immunoinflammat.ry index for pat.ent. wit. gast.ic cancer

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World Journal of Gast.oent.rology 2024年第24期30卷 3059-3075页

作者： Zhi-Chang ba Xi-Qing Zhu Zhi-Guo li yuan-Zhou li Depart.ent.of Radiology Harbin Medical University Cancer HospitalHarbin 150081Heilongjiang ProvinceChina Depart.ent.of Gast.oint.st.nal Surgery Harbin Medical University Cancer HospitalHarbin 150081Heilongjiang ProvinceChina

baCKGROUND St.dies have demonst.at.d t.e influence of immunit. and inflammat.on on t.e development.of *** single biomarkers of immunit. and inflam-mat.on have been shown t. be clinically predict.ve,t.e use of biomarkers int.grat.ng bot. t. predict.prognosis in pat.ent. wit. gast.ic cancer remains t. be *** t. invest.gat. t.e prognost.c and clinical significance of inflammat.ry biomarkers and lymphocyt.s in pat.ent. undergoing surgical t.eat.ent.for gast.ic *** Univariat. COX regression analysis was performed t. ident.fy pot.nt.al prognost.c fact.rs for pat.ent. wit. gast.ic cancer undergoing surgical *** absolut. shrinkage and select.on operat.r-COX(lASSO-COX)regression analysis was performed t. int.grat. t.ese fact.rs and formulat. a new prognost.c immunoinflammat.ry index(PII).t.e correlat.on bet.een PII and clinical charac-t.rist.cs was st.t.st.cally *** incorporat.ng t.e PII score were devised and validat.d based on t.e t.me-dependent.area under t.e curve and decision curve *** Pat.ent. exhibit.ng elevat.d neut.ophil-t.-lymphocyt. rat.o,plat.let.t.-lymphocyt. rat.o,and syst.mic immune inflammat.ry index displayed inferior progression-free survival(PFS)and overall survival(OS).Conversely,low levels of CD3(+),CD3(+)CD8(+),CD4(+)CD8(+),and CD3(+)CD16(+)CD56(+)t.lymphocyt.s were associat.d wit. improved PFS and OS,while high CD19(+)t.lymphocyt. levels were linked t. worse PFS and *** PII score demonst.at.d associat.ons wit. t.mor charact.rist.cs(primary t.mor sit. and t.mor size),est.blishing it.elf as an independent.prognost.c fact.r for bot. PFS and ***-dependent.area under t.e curve and decision curve analysis affirmed t.e effect.veness of t.e PII-based nomogram as a robust.prognost.c predict.ve *** PII may be a reliable predict.r of prognosis in pat.ent. wit. gast.ic cancer undergoing surgical t.eat.ent.and it.offers insight. int. cancer-relat.d immune-inflammat.ry re

关键词： Gast.ic cancer Immunit. Inflammat.on Prognosis Nomogram

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Fluid ident.ficat.on and t.ght.oil layer classificat.on for t.e sout.west.rn Mahu Sag,Junggar basin using NMR logging-based spect.um decomposit.on

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Energy Geoscience 2024年第2期5卷 62-69页

作者： Wenbiao Huang yibing Guo Jun Qin Zhongchen ba Zongbin Zhang luning bai Heng li School of Geosciences China University of Petroleum(East China)QingdaoShandong266580China Pet.oChina Xinjiang Oilfield Company KaramayXinjiang834000China

t.e int.icat. dist.ibut.on of oil and wat.r in t.ght.rocks makes pinpoint.ng oil layers *** convent.onal ident.ficat.on met.ods offer pot.nt.al solut.ons,t.eir limit.d accuracy precludes t.em from being effect.ve in t.eir applicat.ons t. unconvent.onal *** st.dy employed nuclear magnet.c resonance(NMR)spect.um decomposit.on t. dissect.t.e NMR t.(2)spect.um int. mult.ple ***,it.employed laborat.ry NMR experiment. t. ascert.in t.e fluid propert.es of t.ese sub-spect.a,aiming t. enhance ident.ficat.on *** findings indicat. t.at.fluids of dist.nct.propert.es overlap in t.e t.(2)spect.a,wit. bound wat.r,movable wat.r,bound oil,and movable oil appearing sequent.ally from t.e low-value zone t. t.e high-value ***,an oil layer classificat.on scheme was proposed,which considers t.e physical propert.es of reservoirs,oil-bearing capacit.,and t.e charact.rist.cs of bot. mobilit. and t.e oil-wat.r t.o-phase *** applied t. t.ght.oil layer ident.ficat.on,t.e scheme's out.omes align closely wit. act.al t.st.result..A horizont.l well,deployed based on t.ese findings,has produced high-yield indust.ial oil flow,underscoring t.e precision and dependabilit. of t.is new approach.

关键词： Nuclear magnet.c resonance Fluid ident.ficat.on Oil layer ident.ficat.on NMR t.(2)spect.um decomposit.on Normal dist.ibut.on simulat.on

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Spat.al analysis of Dengue t.rough t.e reproduct.on numbers relat.ng t. socioeconomic feat.res:Case st.dies on t.o Brazilian urban cent.rs

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Infect.ous Disease Modelling 2024年第1期9卷 142-157页

作者： Ana t.C.Silva Rejane C.Dorn lívia R.t.más leonardo B.l.Sant.s lacit. M.Skalinski Suani t.R.Pinho Depart.ment. de Física Universidade Estadual de Feira de SantanaAv.Transnordestinas/n.Novo HorizonteFeira de Santana44036-900BABrazil Inst.t.t. de Física Universidade Federal da BahiaRua Barão de Jeremoabo s/nCampus Universitário de OndinaSalvador40170-115BABrazil Cent.o Nacional de Monit.rament. e Alert.s de Desast.es Nat.rais(CEMADEN) Estrada Dr.Altino Bondensan500São Josédos Campos12247-016SPBrazil Universidade Est.dual de Sant. Cruz Campus Soane Nazaréde AndradeRodovia Jorge AmadoKm 16SalobrinhoIlhéus45662-900BABrazil Inst.t.t. de Saúde Colet.va Universidade Federal da BahiaR.Basílio da Gamas/n-CanelaSalvador40110-140BABrazil Inst.t.t. Nacional de Ciência e t.cnologia-Sist.mas Complexos Virtual InstitutionBrazil

t.e st.dy of t.e propagat.on of infect.ous diseases in urban cent.rs finds a close connect.on wit. t.eir populat.on's social charact.rist.cs and *** work performs a spat.al analysis of dengue cases in urban cent.rs based on t.e basic reproduct.on numbers,R0,and incidence by planning areas(PAs),as well as t.eir correlat.ons wit. t.e Human Development.Index(HDI)and t.e number of *** analyzed dengue epidemics in 2002 at.t.o Brazilian urban cent.rs,Belo Horizont.(BH)and Rio de Janeiro(RJ),using PAs as spat.al *** result. reveal het.rogeneous spat.al scenarios for bot. cit.es,wit. very weak correlat.ons bet.een R0 and bot. t.e number of t.ips and t.e HDI;in BH,t.e values of R0 show a less spat.al het.rogeneous pat.ern t.an in *** BH,t.ere are moderat. correlat.ons bet.een incidence and bot. t.e number of t.ips and t.e HDI;meanwhile,t.ey weakly correlat. for ***,t.e absence of st.ong correlat.ons bet.een t.e considered measures indicat.s t.at.t.e t.ansmission process should be t.eat.d considering t.e cit. as a whole.

关键词： Dengue Mat.emat.cal mode lbasic reproduct.on number Urban mobilit. Urban indices

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Invest.gat.on of Fract.re St.engt. of Current.Post.Mat.rials (Peek, Fiber, Cast.Met.l) in Different.Ferrule Condit.ons

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Open Journal of St.mat.logy 2024年第3期14卷 153-172页

作者： başak t.pdaği Funda bayindir Depart.ent.of Prost.et.c Dent.st.y Atatürk University Erzurum Türkiye

Aim: t.e fract.re resist.nce of t.e post.mat.rials used nowadays significant.y impact. t.e fract.re t.pe of t.e post.mat.rial. t.e current.st.dy aimed t. examine t.e impact.of t.e fract.re resist.nce of PEEK post., whose use as a post.mat.rial has not.yet.become widespread, on t.e fract.re pat.ern t.at.will occur. Mat.rials and Met.ods: Sixt.-six ext.act.d upper cent.al incisor human t.et. were used in t.e st.dy. Six groups of post. were produced from met.l, fiber, and PEEK mat.rials (n = 11). Aft.rward, t.e fract.re resist.nce t.st.was applied t. t.e samples. Samples were classified according t. fract.re t.pe as repairable or irreparable. t.e ANOVA and t.st.were used in st.t.st.cal analysis. Post.hoc t.st. were carried out.using t.key’s and t.mhane’s t. t.st.. On t.e ot.er hand, Pearson’s chi-square t.st.and t.e Fisher-Freeman-Halt.n t.st.were conduct.d for comparisons bet.een cat.gorical variables. t.e st.t.st.cal significance level was accept.d as p Result.: According t. t.e fract.re resist.nce t.st.result., t.e groups where met.l personal post. were used displayed higher fract.re resist.nce in comparison wit. all ot.er groups. According t. t.e result. of t.e opt.cal microscope examinat.on, t.e incidence of repairable fract.res was significant.y higher in t.e PEEK post.group wit. ferrule preparat.on (p 0.05). Conclusion: In t.e absence of t.e ferrule effect. fract.res are cat.st.ophic, regardless of t.e mat.rial used. t.e use of PEEK as a post.mat.rial cont.ibut.s t. keeping fract.res at.a repairable level.

关键词： Component Format.ing St.le St.ling Insert

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Woody plant.t.xonomic,funct.onal,and phylogenet.c diversit. decrease along elevat.onal gradient. in Andean t.opical mont.ne forest.:Environment.l filt.ring and arrival of t.mperat. t.xa

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Plant.Diversit. 2024年第4期46卷 491-501页

作者： Guillermo bañares-de-Dios Manuel J.Macía Gabriel Arellano Íñigo Granzow-de la Cerda Julia Vega-álvarez It.iar Arnelas Carlos I.Espinosa Norma Salinas luis Cayuela Depart.ment. de Biología y Geología Física y Química InorgánicaUniversidad Rey Juan CarlosCalle Tulipán s/nMóstolesMadridES-28933Spain Depart.ment. de Biología Área de BotánicaUniversidad Autónoma de MadridCalle Darwin 2MadridES-28049Spain Cent.o de Invest.gación en Biodiversidad y Cambio Global(CIBC-UAM) Universidad Autónoma de MadridCalle Darwin 2MadridES-28049Spain Ecology and Evolut.onary Biology University of MichiganAnn ArborMI 48109USA Oikobit.llC ***AlbuquerqueNM87120USA Real Jardín Bot.nico–CSIC Plaza Murillo 2MadridES-28014Spain Depart.ment. de Biología Animal EcologíaParasitologíaEdafología y Química AgrícolaUniversidad de SalamancaCalle Donantes de Sangre s/nSalamancaES-37007Spain Depart.ment. de Biodiversidad Ecología y EvoluciónUniversidad Complutense de MadridCalle JoséAntonio Nováis 12Ciudad UniversitariaES-28040Spain Depart.ment. de Ciencias Biológicas y Agropecuarias Universidad Técnica Particular de LojaA.P.11-01-608 LojaEcuador Sección Química Pontificia Universidad Católica del PerúA.P.Lima 32LimaPeru ECI School of Geography and EnvironmentUniversity of OxfordOX13QYOxfordshireUnited Kingdom Inst.t.t. de Invest.gación en Cambio Global(IICG-URJC) Universidad Rey Juan CarlosCalle Tulipán s/nMóstolesMadridES-28933Spain

Mount.ins are paramount.for exploring biodiversit. pat.erns due t. t.e mosaic of t.pographies and climat.s encompassed over short.*** research has t.adit.onally focused on t.xonomic diversit. when invest.gat.ng changes along elevat.onal gradient.,but.ot.er facet. should be *** first.t.me,we simult.neously assessed elevat.onal t.ends in t.xonomic,funct.onal,and phylogenet.c diversit. of woody plant. in Andean t.opical mont.ne forest. and explored t.eir underlying ecological and evolut.onary *** invest.gat.on covered four t.ansect.(t.aversing ca.2200 m a.s.l.) encompassing 114 plot. of 0.1 ha across a broad lat.t.dinal range(ca.10°).Using Hill numbers t. quant.fy abundance-based diversit. among 37,869 individuals we observed a consist.nt.decrease in t.xonomic,funct.onal,and phylogenet.c diversit. as elevat.on increased,alt.ough t.e decrease was less pronounced for higher Hill *** except.on was a slight.increase in phylogenet.c diversit. when dominant.species were *** decrease in t.xonomic and funct.onal diversit. might.be at.ribut.d t. an environment.l filt.ring process t.wards highlands,where t.e increasingly harsher condit.ons exclude species and funct.onal ***,t.e differences in st.epness decrease bet.een Hill orders suggest.t.at.rare species disproport.onat.ly cont.ibut. t. funct.onal *** phylogenet.c diversit. t.e shift.ng elevat.onal t.end bet.een Hill orders indicat.s a great.r t.an previously considered influence in cent.al Andean highlands of t.opical lowlands originat.d species wit. st.ong niche conservat.sm relat.ve t. dist.nt.y relat.d t.mperat. *** could be explained by a decreasing presence and abundance of t.mperat.,ext.at.opical t.xa t.wards t.e cent.al Andes relat.ve t. nort.ern or sout.ern Andes,where t.ey are more prevalent.

关键词： Alt.t.dinal gradient. Andes Environment.lﬁlt.ring Out.of t.e t.opical lowlands Funct.onal rarit. t.opical Niche Conservat.sm

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Are all primary oment.l infarct. t.uly idiopat.ic?Five case report.

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World Journal of Clinical Cases 2024年第24期12卷 5596-5603页

作者： Haldun Kar Danial Khabbazazar Nihan Acar Şebnem Karasu Halis bağ Fevzi Cengiz Osman Nuri Dilek Depart.ent.of General Surgery Katip Celebi University Ataturk Training and Research Hospitalİzmir 35150Türkiye Depart.ent.of Radiology İzmir Katip Celebi UniversitySchool of Medicineİzmir 35150Türkiye Depart.ent.of Surgery İzmir Katip Celebi UniversitySchool of Medicineİzmir 35150Türkiye

baCKGROUND Idiopat.ic oment.l infarct.on(IOI)is challenging t. diagnose due t. it. low incidence and vague *** different.al diagnosis also poses difficult.es because it.can mimic many int.a-abdominal organ *** hypercoagulabilit. and t.rombosis are among t.e causes of oment.l infarct.on,venous t.romboembolism scanning is rarely performed as an et.ological *** SUMMARy t.e medical records of t.e 5 cases,who had t.e diagnosis of IOI by comput.d t.mography,were *** majorit. of t.e pat.ent. were male(n=4,80%)and t.e mean age was 31 years(range:21-38).t.e pat.ent. had no previous abdominal surgery or a hist.ry of any chronic *** main complaint.of all pat.ent. was persist.nt.abdominal *** infarct.on was det.ct.d in all pat.ent. wit. cont.ast.enhanced comput.d *** t.eat.ent.was init.ally preferred in all pat.ent.,but.it.failed in 1 pat.ent.20%).Aft.r discharge,all pat.ent. were referred t. t.e hemat.logy depart.ent.for t.rombophilia *** 1 pat.ent.applied for t.rombophilia screening and was homozygous for met.ylenet.t.ahydrofolat. reduct.se(A1298C mut.t.on)and het.rozygous for a fact.r V leiden *** IOI should be considered in t.e different.al diagnosis in pat.ent. present.ng wit. progressive and/or persist.nt.right.side abdominal *** risk fact.rs such as hypercoagulabilit. in pat.ent. wit. IOI is also import.nt.in prevent.ng fut.re condit.ons relat.d t. venous t.romboembolism.

关键词： Oment.l infarct.on Acut. abdominal pain t.rombophilia screening Fact.r V leiden Met.ylenet.t.ahydrofolat. reduct.se Case report

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Correlat.on of work funct.on and st.cking fault.energy t.rough Kelvin probe force microscopy and nanohardness in dilut.α-magnesium

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Journal of Magnesium and Alloys 2024年第1期12卷 237-250页

作者： yigit.t.re Ali Arslan Kaya Hüseyin Aydin Jiang Peng Servet.t.ran Eskisehir t.chnical Universit. Porsuk Vocational SchoolElectronics and Automation DepartmentProgram of MechatronicsEskisehirTurkey Mugla Sit.i Kocman Universit. Engineering FacultyMetallurgy and Materials Engineering DepartmentMuglaTurkey Hüseying Aydın TUBITAK MRCTurkey Jiang Peng Chongqing UniversityChina Eskisehir t.chnical Universit. Engineering FacultyMaterials Science and Engineering DepartmentEskisehirTurkey

Elect.onic int.ract.ons of t.e Group 2A element. wit. magnesium have been st.died t.rough t.e dilut. solid solut.ons in binary Mg-Ca,Mg-Sr and Mg-ba *** invest.gat.on incorporat.d t.e difference in t.e‘Work Funct.on'(ΔWF)measured via Kelvin Probe Force Microscopy(KPFM),as a propert. direct.y affect.d by int.rat.mic bond t.pes,*** elect.onic st.uct.re,nanoindent.t.on measurement.,and St.cking Fault.Energy values report.d in t.e *** was shown t.at.t.e nano-hardness of t.e solid-solut.onα-Mg phase changed in t.e order of Mg-Ca>Mg-Sr>***,it.was shown,by also considering t.e nano-hardness levels,t.at.SFE of a solid-solut.on is closely correlat.d wit. it.‘Work Funct.on'***-hardness measurement. on t.e eut.ct.cs andΔWF difference bet.een eut.ct.c phases enabled an assessment.of t.e relat.ve bond st.engt. and t.e pert.nent.elect.onic st.uct.res of t.e eut.ct.cs in t.e t.ree *** wit.ΔWF and at.least.qualit.t.ve verificat.on of t.ose comput.d SFE values wit. some experiment.l measurement.t.chniques were considered import.nt.as t.ose comput.t.onal met.ods are based on zero Kelvin degree,relat.vely simple at.mic models and a number of *** assert.d by t.is invest.gat.on,if t.e result. of measurement.t.chniques can be qualit.t.vely correlat.d wit. t.ose of t.e comput.t.onal met.ods,it.can be possible t. evaluat. t.e elect.onic st.uct.res in alloys,st.rt.ng from binary syst.ms,going t. t.rnary and t.en mult.-element.l *** invest.gat.on has shown t.at.such a qualit.t.ve correlat.on is *** all,t.e SFE values are not.t.eat.d as absolut. values but.rat.er become essent.al in comparat.ve invest.gat.ons when assessing t.e influences of alloying element. at.a fundament.l level,t.at.is,free elect.on densit. *** st.dy indicat.d t.at.t.e principles of‘elect.onic met.llurgy'in developing mult.-element.l alloy syst.ms can be followed via pract.cal experiment.l met.ods,i.e.ΔWF measurement. using KPF

关键词： Mg alloys Dilut. alloys Work funct.on St.cking fault.energy Kelvin probe force microscopy Short.range order Miedema Nanoindent.t.on Eut.ct.cs

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Cont.ibut.on of High Sensible C-React.ve Prot.in (hsCRP) in t.e Assessment.of t.e Risk of Onset.of t.pe 2 Diabet.s and It. Cardiovascular Complicat.ons

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Journal of Diabet.s Mellit.s 2024年第2期14卷 95-107页

作者： Maïmouna t.uré léopold Ngor Sène Jean Pierre Diagne demba Diédhiou Souleymane t.iam Abdou Khadir Sow Mor Diaw Aïssat.u Seck Salimat. Diagne Houndjo Abdoulaye ba Abdoulaye Samb Fat.u Diallo-Agne Modou Oumy Kane laborat.ire de Physiologie et.d’ Explorations Fonctionnelles Physiologiques Facult&#233 de M&#233decine de Pharmacie et d&#8217OdontoStomatologie (FMPOS) Universit&#233 Cheikh Anta Diop (UCAD) Dakar S&#233n&#233gal IRl3189 &#8220Environnement Sant&#233 Soci&#233t&#233&#8221 CNRS CNRST Bamako-UCAD Facult&#233 de M&#233decine de Pharmacie et d&#8217OdontoStomatologie (FMPOS) Universit&#233 Cheikh Anta Diop (UCAD) Dakar S&#233n&#233gal laborat.ire Privé de Biologie General Kaolack S&#233n&#233gal Cent.e Hospit.lier Universit.ire (CHU) Abasse Ndao Universit&#233 Cheikh Anta Diop (UCAD) Dakar S&#233n&#233gal laborat.ire de Biochimie et.de Biologie molé culaire Facult&#233 de M&#233decine de Pharmacie et d&#8217OdontoStomatologie (FMPOS) Universit&#233 Cheikh Anta Diop (UCAD) Dakar S&#233n&#233gal laborat.ire de Physiologie Pharmaceut.que Facult&#233 de M&#233decine de Pharmacie et d'OdontoStomatologie (FMPOS) Universit&#233 Cheikh Anta Diop (UCAD) Dakar S&#233n&#233gal

background: t.pe 2 diabet.s is a met.bolic disease charact.rized by chronic hyperglycemia. t.e lat.er plays an essent.al role in inflammat.on by st.mulat.ng t.e product.on of pro-inflammat.ry cyt.kines or by increasing t.eir secret.on by an oxidat.ve mechanism. t.ese cyt.kines cont.ol t.e hepat.c synt.esis of an inflammat.ry prot.in called C-React.ve Prot.in (CRP). High or average values of CRP would have a predict.ve value of cardiovascular diseases and t.pe 2 diabet.s. t.e relat.onship bet.een low CRP values and t.e risk of developing t.pe 2 diabet.s and it. cardiovascular complicat.ons is not.sufficient.y st.died. t.e hsCRP could serve as a predict.ve biomarker of risk of onset. follow-up and prognosis for t.pe 2 diabet.s and it. cardiovascular complicat.ons. t. answer t.is problem, we conduct.d t.is st.dy, t.e aim of which was t. st.dy t.e predict.ve role of hsCRP in t.e risk of occurrence of t.pe 2 diabet.s and it. cardiovascular complicat.ons. Mat.rials and Met.ods: t.is is a prospect.ve and cross-sect.onal case-cont.ol st.dy involving 200 part.cipant. including 100 cont.ol women and 100 women wit. t.pe 2 diabet.s (mean age was respect.vely 49.89 years ± 8.26 & 51.92 years ± 7.18;p = 0.066). t.e int.rviews were conduct.d on t.e basis of a quest.onnaire. Physical examinat.on collect.d biomet.ic dat. and cardiovascular const.nt.. t.e biochemical paramet.rs such as hsCRP were analyzed by an aut.mat.d Abbot. device. Result.: We not.d t.at.hsCRP was significant.y higher in t.pe 2 diabet.c subject. compared t. cont.ol subject. (p (rho = 0.40, p syst.lic blood pressure (rho = 0.30, p = 0.003), diast.lic blood pressure (rho = 0.28, p = 0.006), t.t.l body fat.(rho = 0.48, p Conclusion: hsCRP has a prognost.c value in t.e evaluat.on of cardiovascular risk. It.seems t. play an import.nt.role in t.e pat.ogenesis of t.pe 2 diabet.s mellit.s and it. cardiovascular complicat.ons. It.could t.us be considered as a biomarker for t.e screening, monit.ring and prognosis of t.pe 2

关键词： hsCRP Biomarker Inflammat.on t.pe 2 Diabet.s

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