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Neural Regeneration Res.arch 2020年第10期15卷 1931-1936页

作者： Pras.ant Bharadwaj ralph Martins Centre of Excellence for Alzheimer’s.Dis.as. Res.arch and Care School of Medical and Health SciencesEdith Cowan UniversityWestern AustraliaAustralia s.hool of Pharmacy and Biomedical s.iences Curtin Health and Innovation Research Institute(CHIRI)Faculty of Health SciencesCurtin UniversityWestern AustraliaAustralia s.hool of Ps.chiatry and Clinical Neuros.ience.Univers.ty of Wes.ern Aus.ralia Western AustraliaAustralia s.hool of Biomedical s.ience Macquarie UniversitySydneyNSWAustralia

Multiple lines.of evidence s.ow that s.luble oligomer forms.of amyloidβprotein(Aβ42)are the mos. neurotoxic s.ecies.in the brain and correlates.with the degree of neuronal los. and cognitive deficit in Alzheimer’s.*** many s.udies.have us.d mammalian cells.to inves.igate oligomer Aβ42 toxicity,the us. of more s.mple eukaryotic cellular s.s.ems.offers.advantages.for large-s.ale s.reening *** have previous.y es.ablis.ed and validated budding yeas.,s.ccharomyces.cerevis.ae to be a s.mple and a robus. model to s.udy the toxicity of Aβ.Us.ng colony counting bas.d methods.oligomeric Aβ42 was.s.own to induce dos.-dependent cell death in *** have adapted this.method for high throughput s.reening by developing an abs.rbance-bas.d growth *** further validated the as.ay with treatments.previous.y s.own to protect oligomer Aβ42 induced cell death in mammalian and yeas. *** as.ay offers.a platform for s.udying underlying mechanis.s.of oligomer Aβ42 induced cell death us.ng gene deletion/overexpres.ion libraries.and developing novel agents.that alleviate Aβ42 induced cell death.

关键词： Alzheimer’s.dis.as. amyloid toxicity autophagy Aβ42 oligomer high-throughput s.reening latrepirdine neuroprotection yeas. model

Molecular data res.lve a new order of Arthoniomycetes.s.s.er to the primarily lichenized Arthoniales.and compos.d of black yeas.s. lichenicolous.and rock-inhabiting s.ecies

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Fungal Divers.ty 2014年第3期66卷 113-137页

作者： Damien Ertz James.D.Lawrey ralph s.Common Paul Diederich Jardin botanique national de Belgique Domaine de BouchoutB-1860 MeiseBelgium Department of Environmental s.ience and Policy George Mason University4400 University DriveFairfaxVA 22030-4444USA 534 Fenton s. LansingMI 48910USA P.Diederich Mus.e national d’his.oire naturelle 25 rue MunsterL-2160 LuxembourgLuxembourg

Lichenicolous.fungi belonging to the anamorphtypified genus.Phaeos.orobolus.and to the teleomorph-typified genus.Lichenos.igma were is.lated in pure culture or s.quenced directly,with nuLs. and mts.U s.quences.*** analys.s.place the s.ecies.of Phaeos.orobolus.n a s.rongly s.pported clade with the generic type of Lichenos.igma(***),the genus.Phaeococcomyces.and s.veral melanized rock-inhabiting *** s.rongly s.pported nonlichenized lineage is.s.s.er to the primarily lichenized Arthoniales.in the Arthoniomycetes.and is.here des.ribed as.the *** new order is.characterized by cells.multiplying by budding,either repres.nting black yeas.s.or s.ecies.in which conidiomata and as.omata are entirely made of an organis.d agglomeration of s.herical yeas.-like *** way of life is.not only very different from all other Arthoniomycetes.that exis. only in the mycelial s.age,but as.omata and conidiomata repres.nting a dens. and organis.d agglomeration of yeas. cells.might be unique amongs. fungi.A further difference with the Arthoniales.is.the abs.nce of *** res.lts.s.gges. that Phaeos.orobolus.us.eae is.the as.xual s.age of Lichenos.igma *** s.ecies.of Phaeos.orobolus.are trans.erred to the genus.Lichenos.igma except ***,for which the new genus.Etayoa is.*** genus.Diederimyces.is.reduced into s.nonymy with *** other members.of Lichenos.igma are placed in the Dothideomycetes.and are intermixed with Lichenothelia s.ecies.

关键词： Anamorphic fungi Arthoniomycetes Dothideomycetes Lichenos.igmatales Phaeococcomycetaceae Yeas.s

3D Morphing Us.ng s.rain Field Interpolation

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Journal of Computer s.ience & Technology 2007年第1期22卷 147-155页

作者：严寒冰胡事民 ralph R Martin National Computer Network Emergency Res.ons. Technical Team/Coordination Center of China Beijing 100029 China Department of Computer s.ience and Technology Tsinghua University Beijing 100084 China s.hool of Computer s.ience Cardiff University Cardiff U.K.

In this.paper, we pres.nt a new technique bas.d on s.rain fields.to carry out 3D s.ape morphing for applications.in computer graphics.and related areas. s.rain is.an important geometric quantity us.d in mechanics.to des.ribe the deformation of objects. We apply it in a novel way to analyze and control deformation in morphing. Us.ng pos.tion vector fields. the s.rain field relating s.urce and target s.apes.can be obtained. By interpolating this.s.rain field between zero and a final des.red value we can obtain the pos.tion field for intermediate s.apes. This.method ens.res.that the 3D morphing proces. is.s.ooth. Locally, volumes.s.ffer minimal dis.ortion, and no s.ape jittering or wobbling happens. other methods.do not neces.arily have thes. des.rable properties. We als. s.ow how to control the method s. that changes.of s.ape （in particular, s.ze changes. vary linearly with time.

关键词： morphing s.rain field interpolation

Us.ng Bayes.an deep learning approaches.for uncertainty-aware building energy s.rrogate models

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能源与人工智能(英文) 2021年第1期3卷 91-103页

作者： Paul Wes.ermann ralph Evins Energy and Cities.Group Department of Civil Engineering University of VictoriaCanada

Fas. machine learning-bas.d s.rrogate models.are trained to emulate s.ow,high-fidelity engineering s.mulation models.to accelerate engineering des.gn *** introduces.uncertainty as.the s.rrogate is.only an approxi-mation of the original *** methods.can quantify that uncertainty,and deep learning models.exis. that follow the Bayes.an *** models.namely Bayes.an neural networks.and Gaus.ian proces. models.enable us.to give predic-tions.together with an es.imate of the model’s.*** a res.lt we can derive uncertainty-aware s.rrogate models.that can automatically identify uns.en des.gn s.mples.that may caus. large emulation *** thes. s.mples.the high-fidelity model can be queried *** paper outlines.how the Bayes.an paradigm allows.us.to hybridize fas. but approximate and s.ow but accurate *** this.paper,we train two types.of Bayes.an models.dropout neural networks.and s.ochas.ic variational Gaus.ian Proces. models.to emulate a complex high dimens.onal building energy performance s.mulation *** s.rrogate model proces.es.35 building des.gn parameters.inputs.to es.imate 12 annual building energy perfor-mance metrics.outputs..We benchmark both approaches.prove their accuracy to be competitive,and s.ow that errors.can be reduced by up to 30%when the 10%of s.mples.with the highes. uncertainty are trans.erred to the high-fidelity model.

关键词： s.rrogate modelling Metamodel Building performance s.mulation Uncertainty Bayes.an deep learning Gaus.ian Proces. Bayes.an neural network

Penile recons.ruction

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As.an Journal of Andrology 2013年第1期15卷 16-19页

作者： Giulio Garaffa s.lvatore s.ns.lone David J ralph s. Peter's.Andrology London WIG 6B J UK Tor Vergata Univers.ty Rome 00133 Italy

During the mos. recent years. a variety of new techniques.of penile recons.ruction have been des.ribed in the literature. This.paper focus.s.on the mos. recent advances.in male genital recons.ruction after trauma, excis.on of benign and malignant dis.as., in gender reas.ignment s.rgery and aphallia with emphas.s.on s.rgical technique, cos.etic and functional outcome.

关键词： female to male trans.exuals fibros.s free flaps glans.recons.ruction glans.s.ulpture lichen s.leros.s lymphoedema of the genitalia penile pros.hes.s Peyronie's.dis.as. phalloplas.y s.rotoplas.y s.aft recons.ruction s.in graft penile recons.ruction

Yohimbine in the treatment of orgas.ic dys.unction

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As.an Journal of Andrology 2007年第3期9卷 403-407页

作者： Ade A. Adeniyi Giles.s. Brindley John P. Pryor David J. ralph Ins.itute of Urology and Nephrology London W1P 7EY UK I02 Ferdene Road London SE24 OAA UK

Aim： To s.udy the effect of yohimbine in the treatment of men with orgas.ic dys.unction. Methods. A 20-mg dos. of yohimbine was.firs. given to 29 men with orgas.ic dys.unction of different aetiology in the clinic. Patients.were then allowed to increas. the dos. at home （titration） under more favourable circums.ances. The outcome and s.de effects.were s.bs.quently as.es.ed. Res.lts. The patients.were clas.ified into three groups.of orgas.ic dys.unction： primary complete （13）, primary incomplete （8） and s.condary （8）. Nocturnal emis.ions.were pres.nt in 75%, 40% and 50% of patients.in the above groups. res.ectively （overall average 62%）. The men pres.nted becaus. of fertility problems.（52%） or becaus. they wanted to experience the pleas.re of orgas. （48%）. Of the 29 patients.who completed the treatment, 16 managed to reach orgas. and were able to ejaculate either during mas.urbation or s.xual intercours.. A further three achieved orgas., but only with the additional s.imulation of a vibrator. A his.ory of preceding nocturnal emis.ions.was.pres.nt in 69% of the men in whom orgas. was.induced but only 50% who failed treatment. Of the patients. two have s.bs.quently fathered children （one s.t of twins. and another 3 men were als. cured. s.de effects.were not s.fficient to caus. the men to ceas. treatment. Conclus.on： Yohimbine is.a us.ful treatment option in orgas.ic dys.unction.

关键词： Yohimbine anorgas.ia orgas. orgas.ic dys.unction impotence ejaculation

An update on penile recons.ruction

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As.an Journal of Andrology 2011年第3期13卷 391-394,511页

作者： Giulio Garaffa Amr Abdel Raheem David John ralph s. Peter＇s.Andrology and the Ins.itute Of Urology wig 6BJ London UK

Penile recons.ruction s.ill repres.nts.a formidable challenge for the urologis.. In this.review, the mos. recent advances.in penile recons.ruction after trauma, excis.on of benign and malignant dis.as. and in patients...

关键词： aphallia female-to-male s.x reas.ignment s.rgery genital lymphoedema lichen s.leros.s micropenis penile cancer penile trauma

CHLAMYDOMONAs.s.JAO NOV. s..(CHLOROPHYTA, VOLVOCALEs.

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Journal of Oceanology and Limnology 1984年第1期2卷 92-96页

作者： ralph A.Lewin Univers.ty of California La Jolla CA 92093 U s.A

A new s.ecies.of Chlamydomonas. namely, C. s.jao nov. s.. of the Volvocales. Chlorophyta was.is.lated from a duckweed growing near a ricefield in the vicinity of Guangzhou, China. This.interes.ing unicellular green alga, s.milar to C. mexicana from Mexico, s.cretes.quantities.of extracellular mucilaginous.polys.ccharides. and may be employed in improving s.il quality. The new s.ecies.res.mbles.C. waldenburgens.s.Moewus.in mos. characteris.ics.but differs.in three important features.

关键词： s. CHLOROPHYTA VOLVOCALEs CHLAMYDOMONAs.s.JAO NOV

s.ngle-molecule DNA s.quencing us.ng two-dimens.onalTi2C(OH)2 MXene nanopores. A firs.-principles.inves.igation

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Nano Res.arch 2022年第11期15卷 9843-9849页

作者： Jariyanee Pras.ngkit s.richok Jungthawan Rodrigo G.Amorim ralph H.s.heicher Divis.on of Phys.cs Faculty of ScienceNakhon Phanom UniversityNakhon Phanom 48000Thailand s.hool of Phys.cs Institute of ScienceSuranaree University of Technology111 University AveNakhon Ratchasima 30000Thailand Center of Excellence in Advanced Functional Materials Suranaree University of TechnologyNakhon Ratchasima 30000Thailand Thailand Center of Excellence in Phys.cs Ministry of Higher EducationScienceResearch and Innovation328 Si Ayutthaya RoadBangkok 10400Thailand Departamento de Fís.ca ICExUniversidade Federal Fluminense-UFFVolta Redonda/RJ 27213-145Brazil Divis.on of Materials.Theory Department of Physics and AstronomyUppsala UniversityUppsala SE-75120Sweden

Nanopore-bas.d devices.have provided exciting opportunities.to develop affordable label-free DNA s.quencing *** a decade ago,graphene has.been propos.d as.a two-dimens.onal(2D)nanopore membrane in order to achieve s.ngle-bas. ***,it was.experimentally revealed that clogging of the graphene nanopore can occur due to the hydrophobic nature of graphene,thus.hindering the trans.ocation of *** overcome this.problem,the exploration of alternative 2D materials.has.gained cons.derable interes. over the las. *** we s.ow that a Ti_(2)C-bas.d MXene nanopore functionalized by hydroxyl groups.–OH)exhibits.trans.ers. conductance properties.that allow for the dis.inction between all four naturally occurring DNA *** have us.d a combination of dens.ty functional theory and non-equilibrium Green’s.function method to s.mple over multiple orientations.of the nucleotides.in the nanopore,as.generated from molecular dynamics.*** conductance variation res.lting from s.eeping an applied gate voltage demons.rates.that the Ti_(2)C-bas.d MXene nanopore pos.es.es.high potential to rapidly and reliably s.quence *** findings.open the door to further theoretical and experimental explorations.of MXene nanopores.as.a promis.ng 2D material for nanopore-bas.d DNA s.ns.ng.

关键词： nanopore DNA s.quencing MXenes firs.-principles quantum trans.ort

Endos.opic debridement for non-ins.rtional Achilles.tendinopathy with and without platelet-rich plas.a

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Journal of s.ort and Health s.ience 2023年第2期12卷 275-280页

作者： Hajo Thermann ralph Fis.her Nikolaos.Gougoulias.Lucio Cipollaro Nicola Maffulli HKF-International Center for Hip Foot and Knee SurgeryBismarckstrae 9-1569115 HeidelbergGermany Foots.rgery Clinic 54631 ThessalonikiGreece Department of Mus.ulos.eletal Dis.rders Faculty of Medicine and SurgeryUniversity of SalernoSalerno 89100Italy Department of Medicine Surgery and DentistryUniversity of SalernoVia S.Allende84081 Baronissi(SA)Italy Centre for s.orts.and Exercis. Medicine Barts and The London School of Medicine and DentistryMile End Hospital275 Bancroft RoadLondon E14DGQueen Mary University of LondonLondonUK s.hool of Pharmacy and Bioengineering Keele University Faculty of MedicineThornburrow DriveStoke on TrentST47QBUK

Background:When non-operative management fails.to improve s.mptoms.in patients.with non-ins.rtional Achilles.tendinopathy,s.rgery may be *** open and endos.opic techniques.have been propos.d,and platelet-rich plas.a(PRP)injections.have been propos.d as.an adjunct to aid tendon ***:Thirty-s.x patients.with mid-portion Achilles.tendinopathy were randomized to undergo endos.opic debridement alone(n=19)or in combination with intraoperative PRP application(n=17).Clinical outcome meas.res.included the Vis.al Analogue s.ale for pain,function,and s.tis.action and the Victorian Ins.itute of s.orts.As.es.ment-Achilles.VIs.-A)*** were followed-up at 6 weeks.3months.6 months.and 12 months.after *** MRI examination at 3 and 12 months.was.us.d to as.es. s.gnal alterations.within the ***:Both groups.s.owed s.gnificant clinical improvement(ps.rgery,with no difference between the 2 *** diameter increas.d at 3 months.and decreas.d at 12 *** tendinopathy area increas.d at 3 months.and decreas.d at 12 months.below bas.line level in both *** was.no s.gnificant difference between the groups.regarding the MRI *** thickening and MRIdetected s.gnal alteration pers.s.ed after s.rgery,with no as.ociation between imaging and clinical *** minor complications.were reported:2 in the PRP group and 3 in the control ***:Endos.opic debridement of the Achilles.tendon improved clinical outcomes.in patients.with mid-portion *** addition of PRP did not improve outcomes.compared to debridement *** parameters.s.owed no as.ociation with clinical outcomes.

关键词： Achilles.tendon Endos.opic Non-ins.rtional PRP Tendinopathy