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Germline mutations in hereditary diffuse gastric cancer

Chinese Journal of Cancer Research 2018年第1期30卷 122-130页

作者： Hao Zhang Mengmeng Feng yi Feng Zhaode bu Ziyu Li Shuqin Jia Jiafu Ji Surgery Laboratory the Affiliated Hospital of Inner Mongolia Medical University Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Department of Molecular Diagnostics Peking University Cancer Hospital & Institute Department of Gynecology Weifang Maternal and Child Health Hospital Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Center of Gastrointestinal Surgery Peking University Cancer Hospital &Institute

Gastric cancer is one of the leading causes of cancer-related deaths worldwide. Among which, about 1%–3% of gastric cancer patients were characterized by inherited gastric cancer predisposition syndromes, knowing as hereditary diffuse gastric cancer（HDGC）. Studies reported that CDH1 germline mutations are the main cause of HDGC. With the help of rapid development of genetic testing technologies and data analysis tools, more and more researchers focus on seeking candidate susceptibility genes for hereditary cancer syndromes. In addition, National Comprehensive Cancer Network（NCCN） guidelines recommend that the patients of HDGC carrying CDH1 mutations should undergo prophylactic gastrectomy or routine endoscopic surveillances. Therefore, genetic counseling plays a key role in helping individuals with pathogenic mutations make appropriate risk management plans. Moreover, experienced and professional genetic counselors as well as a systematic multidisciplinary team（MDT） are also required to facilitate the development of genetic counseling and benefit pathogenic mutation carriers who are in need of regular and standardized risk management solutions. In this review, we provided an overview about the germline mutations of several genes identified in HDGC, suggesting that these genes may potentially act as susceptibility genes for this malignant cancer syndrome. Furthermore, we introduced information for prevention, diagnosis and risk management of HDGC. Investigations on key factors that may have effect on risk management decision-making and genetic data collection of more cancer syndrome family pedigrees are required for the development of HDGC therapeutic strategies.

关键词： CDH1 CTNNA1 germline mutation hereditary diffuse gastric cancer genetic counseling

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Maximal Regularity of Second Order Delay Equations in Banach Spaces

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Acta Mathematica Sinica,English Series 2009年第1期25卷 21-28页

作者： Shang Quan bu Department of Mathematical Science Tsinghua University Beijing 100084 P. R. China

Using known Ca-multiplier result, we give necessary and sufficient conditions for the second order delay equations：u″（t）=Au（t）＋Fut＋Gu′＋f（t）,t∈Rto have maximal regularity in HSlder continuous function spaces C^α （R, X）, where X is a Banach space, A is a closed operator in X, F, G ∈L（C（[-r, 0], X）, X） are delay operators for some fixed r 〉 0.

关键词： maximal regularity delay equations Hoelder continuous functions C^α-multiplier

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Well-Posedness of Equations with Fractional Derivative

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Acta Mathematica Sinica,English Series 2010年第7期26卷 1223-1232页

作者： Shang Quan bu Department of Mathematical Science Tsinghua University Beijing 100084 P. R. China

We study the well-posedness of the equations with fractional derivative D^αu（t） = Au（t）＋ f（t）,0≤ t ≤ 2π, where A is a closed operator in a Banach space X, α 〉 0 and D^α is the fractional derivative in the sense of Weyl. Using known results on LP-multipliers, we give necessary and/or sufficient conditions for the LP-well-posedness of this problem. The conditions we give involve the resolvent of A and the Rademacher boundedness. Corresponding results on the well-posedness of this problem in periodic Besov spaces, periodic Triebel-Lizorkin spaces and periodic Hardy spaces are also obtained.

关键词： well-posedness fractional derivative fractional Sobolev spaces Fourier multipliers

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Well-Posedness of Equations with Fractional Derivative via the Method of Sum

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Acta Mathematica Sinica,English Series 2012年第1期28卷 37-44页

作者： Shang Quan bu Department of Mathematical Science University of Tsinghua

We study the well-posedness of the equations with fractional derivative D^αu（t）= Au（t）＋ f（t）（0 ≤ t ≤ 2π）, where A is a closed operator in a Banach space X, 0 〈 α 〈 1 and D^αis the fractional derivative in the sense of Weyl. Although this problem is not always well-posed in L^P（0, 2π; X） or periodic continuous function spaces Cper（[0, 2π]; X）, we show by using the method of sum that it is well-posed in some subspaces of L^P（0, 2π; X） or Cper （[0, 2π]; X）.

关键词： Well-posedness fractional derivative the method of sum real interpolation spaces fractional Sobolev spaces

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Removable urea solves the COF dilemma

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Science China Chemistry 2022年第7期65卷 1221-1222页

作者： Xian-He bu School of Materials Science and Engineering Nankai UniversityTianjin 300350China

Since the first report in 2005 [1], covalent organic frameworks(COFs) have become a major platform for materials design owing to their high crystallinity, low density, large surface area, tailorable pore aperture, and versatile molecular architecture, which has attracted wide attention in gas storage, separation, electronics, and catalysis [2–5].

关键词： versatile catalysis separation

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Sex steroids and cardiovascular disease

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Asian Journal of Andrology 2014年第2期16卷 239-247,I0008,I0009页

作者： bu Beng Yeap School of Medicine and Pharmacology University of Western Australia Perth and Department of Endocrinology and Diabetes Fremantle Hospital Fremantle WA Australia

As men grow older, testosterone （T） levels decline and the significance of this change is debated. The evidence supporting a causal role for lower circulating T, or its metabolites dihydrotestosterone （DHT） and estradiol, in the genesis of atherosclerosis and cardiovascular disease （CVD） in men is limited. Observational studies associate low baseline T levels with carotid atherosclerosis, aortic and peripheral vascular disease, and with the incidence of cardiovascular events and mortality. Studies using mass spectrometry suggest that when total T is assayed optimally, calculation of free T might not necessarily improve risk stratification. There is limited evidence to support an association of estradiol with CVD. Interventional studies of T therapy in men with coronary artery disease have shown beneficial effects on exercise-induced myocardial ischemia. However, placebo-controlled, randomized clinical trials （RCTs） of T therapy in men with the prespecified outcomes of cardiovascular events or deaths are lacking. Meta-analyses of randomized controlled trials of T published up to 2010 found no increase in cardiovascular events, mortality, or prostate cancer with therapy. Recently, in a trial of older men with mobility limitations, men randomized to receive a substantial dose of T reported cardiovascular adverse effects. This phenomenon was not reported from a comparable trial where men received a more conservative dose of T, suggesting a prudent approach should be adopted when considering therapy in frail older men with existing CVD. Adequately powered RCTs of T in middle-aged and older men are needed to clarify whether or not hormonal intervention would reduce the incidence of CVD.

关键词： atherosclerosis cardiovascular disease dihydrotestosterone estradiol mortality testosterone

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Design of the microlens arrays coupling with imagingfiber bundle

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Optoelectronics Letters 2013年第3期9卷 169-172页

作者： YAN Xing-tao YANG Jian-feng XUE Bin MA Xiao-long LI Fu ZHAO yi-yi bu Fan Key Laboratory of Spectral Imaging Technology Xi 'an Institute of Optics and Precision Mechanics ChineseAcademy of Sciences Xi 'an 710119 China Graduate School of Chinese Academy of Sciences Beijing 100039 China

To ameliorate the disadvantages of imaging system coupled with imaging fiber bundle, a method by adding square aperture microlens arrays at both entrance and exit ends of the imaging fiber bundle is proposed to increase the system's coupling efficiency. The expressions for solving the parameters of both ends' microlens units are deducted particularly. The microlens arrays used for an infrared imaging fiber bundle with the single fiber diameter of 100 μm and core diameter of 70 μm are designed by this method. The simulation results show that compared with the system without microlens arrays, the fill factor of the imaging fiber bundle coupled microlens arrays system is increased from 44.4% to more than 90%, and the coupling efficiency is doubled too. So the design method is correct, and the introduction of microlens arrays into imaging fiber bundle coupled system is feasible and superior.

关键词：微透镜阵列耦合效率设计方法成像系统纤维束纤维直径红外成像仿真结果

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More than just aligning the teeth:Clear aligners with multifunctional prowess

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Nano Research 2024年第8期17卷 7665-7674页

作者： Yang Chen Lei-Ming Cao Nian-Nian Zhong Zi-Zhan Li Lin-Lin bu Fang-yi Huo Hong He State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei Key Laboratory of StomatologySchool and Hospital of StomatologyWuhan UniversityWuhan 430079China Department of Oral and Maxillofacial-Head Neck Oncology School and Hospital of StomatologyWuhan UniversityWuhan 430079China Department of Zhuankou Clinical Branches School and Hospital of StomatologyWuhan UniversityWuhan 430000China Department of Orthodontics School and Hospital of StomatologyWuhan UniversityWuhan 430079China

With the increasing demand for beauty and health,clear aligners(CAs)have been widely applied among patients with ***,patients treated with CAs also face some potential complications,such as demineralization,dental caries,and periodontal *** addition,some patients have additional needs to improve their quality of life,such as bleaching *** order to prevent or solve these problems,the modification of CAs is a promising method because their extensive long-term contact with tooth surfaces makes them ideal devices for implementing adjuvant medical *** this review,we discuss various advanced CAs with medical functions based on the clinical needs of *** far as we know,the additional functions of CAs mainly include antibacterial,remineralization,whitening,and accelerating tooth *** functions are achieved by two major pathways,the combination of CAs with drugs/biomaterials and increasing the capacity or affinity of *** addition,we discuss the current limitations of in vitro experiments which are designed to explore the effectiveness and properties of novel CAs,and the challenges of bringing a multifunctional appliance from proposal to clinical *** the end of this review,we provide insights into the broader prospects for the improvement of CAs.

关键词： advanced clear aligners medical device modification drug delivery system personalized medicine

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Injective coloring of planar graphs with girth 5

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Frontiers of Mathematics in China 2022年第3期17卷 473-484页

作者： Yuehua bu Piaopiao YE School of Mathematical Sciences Zhejiang Normal UniversityJinhua 321004China Xingzhi College Zhejiang Normal UniversityJinhua 321004China

A coloring of a graph G is injective if its restriction to the neighbour of any vertex is *** injective chromatic number x_(i)(G)of a graph G is the least k such that there is an injective *** this paper,we prove that... 详细信息

关键词： Planar graph girth injective coloring face

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Depletion of MRPL35 inhibits gastric carcinoma cell proliferation by regulating downstream signaling proteins

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World Journal of Gastroenterology 2021年第16期27卷 1785-1804页

作者： Ling Yuan Jia-Xin Li yi Yang Yan Chen Ting-Ting Ma Shuang Liang Yang bu Lei Yu yi Nan Pharmacy College of Ningxia Medical University Yinchuan 750004Ningxia Hui Autonomous RegionChina Key Laboratory of Hui Ethnic Medicine Modernization of Ministry of Education Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Traditional Chinese Medicine College Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Department of Oncology and Endocrinology Yinchuan Hospital of Traditional Chinese Medicine Affiliated to Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Department of Hepatobiliary Surgery General Hospital of Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Department of Infectious Diseases The Fourth Hospital of Harbin Medical UniversityHarbin 150001Heilongjiang ProvinceChina

BACKGROUND Gastric carcinoma(GC)is a digestive system disease with high morbidity and ***,early clinical detection is difficult,and the therapeutic effect for advanced disease is not ***,finding new tumor markers and therapeutic targets conducive to the treatment of GC is ***35 is a member of the large subunit family of mitochondrial ribosomal ***35 shows the characteristic of oncogene in colorectal cancer and esophageal cancer,which promotes the exploration of the correlation between MRPL35 and *** proposed that the expression of MRPL35 might be critical in *** To study the effect of MRPL35 knockdown on GC cell *** The expression of MRPL35 in GC was evaluated based on data from the publictumor database UALCAN(***).The effect of theexpression of MRPL35 on the prognosis was evaluated with KMplot(***).The expression of MRPL35 was assessed on the tissuemicroarray by immunohistochemistry and the level of MRPL35 mRNA in 25 pairsof clinical GC tissues and matched adjacent tissues was detected by quantitativereverse transcription-polymerase chain *** cell count assay,colonyformation assay,and flow cytometry were used to assess the role of MRPL35 inGC cell proliferation and apoptosis in ***,tumor formationexperiment in BALB/c nude mice was utilized to determine the effect of MRPL35on GC cell *** knockdown of MRPL35,related proteins wereidentified by isobaric tags for relative and absolute quantification analysis,andthe expression of related proteins was detected by Western *** expression of MRPL35 was up-regulated in GC(P=1.77×10^(-4)).The Kaplan-Meier plots of the overall survival indicated that high expression of MRPL35 wasassociated with a poor survival in *** with adjacent tissues,theexpression of MRPL35 in GC tissues was increased,which was related to age(P=0.03),lymph node metastasis(P=0.007),and patholog

关键词： Gastric carcinoma MRPL35 Apoptosis Proliferation Tissue microarray Isobaric tags for relative and absolute quantification

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