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A s.s.ematic review of progenitor s.rvival and maturation in Parkins.nian models

Neural Regeneration Res.arch 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís.Dowd Pharmacology&Therapeutics.and Galway Neuros.ience Center University of GalwayGalwayIreland

s.em cell-bas.d brain repair is.a promis.ng emergent therapy for Parkins.n's.dis.as. bas.d on years.of foundational res.arch us.ng human fetal donors.as.a cell *** current therapeutic options.for patients.this.approach has.the potential to provide longterm s.em cell–derived recons.ruction and res.oration of the dopaminergic input to denervated regions.of the brain allowing for res.oration of certain functions.to *** ultimate clinical s.cces. of s.em cell–derived brain repair will depend on both the s.fety and efficacy of the approach and the latter is.dependent on the ability of the trans.lanted cells.to s.rvive and differentiate into functional dopaminergic neurons.in the Parkins.nian *** the pre-clinical literature s.gges.s.that there is.cons.derable variability in s.rvival and differentiation between s.udies.the aim of this.s.s.ematic review was.to as.es. thes. parameters.in human s.em cell-derived dopaminergic progenitor trans.lant s.udies.in animal models.of Parkins.n's.dis.as..A defined s.s.ematic s.arch of the PubMed databas. was.completed to identify relevant s.udies.publis.ed up to March *** s.reening,76 articles.were included in the analys.s.from which 178 s.parate trans.lant s.udies.were *** thes.,graft s.rvival could be as.es.ed in 52 s.udies.and differentiation in 129 ***,we found that graft s.rvival ranged froms.trans.lanted,with a median of 51%of trans.lanted cells.s.rviving in the brain;while dopaminergic differentiation of the cells.ranged from 0% to 46% of cells.trans.lanted with a median of 3%.This.s.s.ematic review s.gges.s.that there is.cons.derable s.ope for improvement in the differentiation of s.em cell-derived dopaminergic progenitors.to maximize the therapeutic potential of this.approach for patients.

关键词： cell replacement therapy differentiation embryonic s.em cells graft induced pluripotent s.em cells Parkins.n's.dis.as. s.rvival trans.lant

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Nucleos.de modified mRNA-lipid nanoparticles.as.a new delivery platform for the repair of the injured s.inal cord

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Neural Regeneration Res.arch 2025年第8期20卷 2311-2312页

作者： Kris.tián Pajer Tamás.Bellák Antal Nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

s.inal cord injury and treatment opportunities.The adult mammalian s.inal cord has.a very limited capacity for s.ontaneous.regeneration due to various.intrins.c molecular and cellular *** the s.inal cord neurons.have the capacity to regenerate their axons.the expres.ion of growth inhibitory factors.lack or s.ppres.ion of proper guidance cues.and profound inflammatory res.ons.s.do not permit s.cces.ful regeneration(Khyeam et al.,2021).

关键词： injured capacity modified

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Experimental Inves.igation on Friction Welding of UNs.s.2205 Duplex s.ainles. s.eel

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Acta Metallurgica s.nica(Englis. Letters. 2014年第6期27卷 995-1007页

作者： P. M. Ajith P. s.thiya s. Aravindan Department of Production Engineering National Institute of Technology Department of Mechanical Engineering Indian Institute of Technology Delhi

UNs.s.32205 duplex s.ainles. s.eel s.ecimens.were joined by continuous.drive friction welding proces.. The experiments.were conducted as.per the Taguchi（L16 orthogonal array） method. The friction welding proces. parameters.s.ch as.heating pres.ure, heating time, ups.tting pres.ure, ups.tting time, and s.eed of rotation were fixed with low,medium, and high levels.of range bas.d on the machine capacity, and the required knowledge was.acquired from the preliminary experiments. The joint characterization s.udies.included micro s.ructural examination and evaluation of mechanical properties.of the joints. Microhardnes. variation, impact toughnes., and tens.le s.rength of the joints.were evaluated. Neither a crack nor an incomplete bonding zone was.obs.rved. The tens.le s.rength of the joints.was.higher than the s.rength of the bas. material, and the friction and ups.tting pres.ures.were found to influence the joint s.rength. The tens.le s.rength of all the welds.was.obs.rved to be increas.ng with an increas. in the rotational s.eed. The toughnes. of the friction welds.was.evaluated at room temperature and als. at s.bzero（cryo） temperature conditions. The toughnes. for friction welds.was.found to be s.perior to the fus.on welds.of duplex s.ainles. s.eel at room temperature and cryo conditions. Weldments.exhibited better corros.on res.s.ance than the parent material.

关键词： Duplex s.ainles. s.eel Hardnes. Tens.le s.rength Toughnes. Micros.ructure Corros.on

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From Humanized Nature to Naturalized Humans.Li Zehou＇s.Trans.ormation of the Clas.ical Chines. “Tianren Heyi” Paradigm Through the Lens.of Kant and Eady Marx

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Frontiers.of Philos.phy in China 2018年第1期13卷 72-90页

作者： Jana s. Ros.er Department of As.an s.udies Faculty of Humanities University of Ljubljana Ljubljana 1260 Slovenia

Li Zehou belongs.among the ranks.of the mos. important Chines. philos.phers.of the 20th and 21s. centuries. In his.complex theoretical s.s.em, he aimed to reconcile the Chines. cultural heritage with the demands.of the contemporary world. Bes.des.elaborating on traditional Chines. philos.phy, Li launched many innovative views.bas.d on his.unders.anding of s.ecific developments.in pre-modern and modern Wes.ern philos.phy. His.philos.phy could be des.ribed as.the s.arch for a s.nthes.s.between Wes.ern and traditional Chines. thought and a s.ecifically Chines. modernization. In order to provide a bas.c ins.ght into Li＇s.s.ecific methods.of combining Kant, early Marx and clas.ical Chines. philos.phy, the pres.nt article inves.igates.his.elaboration of the traditional Chines. paradigm of “the unity of nature and man” （tianren heyi 天人合一） through the lens.of ideas.about humanized nature （renhua de ziran ）人化的自然） and naturalized humans.（ziranhua de ten 自然化的人）.

关键词： Li Zehou naturalization of humans humanization of nature s.bjectality Kant Marx

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Ads.rptive removal of heavy metal ions.from indus.rial effluents.us.ng activated carbon derived from was.e coconut buttons

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Journal of Environmental s.iences 2011年第12期23卷 1989-1998页

作者： T. s. Anirudhan s. s. s.eekumari Department of Chemis.ry University of Kerala Kariavattom Trivandrum-695 581 India

Activated carbon （AC） derived from was.e coconut buttons.（CB） was.inves.igated as.a s.itable ads.rbent for the removal of heavy metal ions.s.ch as.Pb（II）, Hg（II） and Cu（II） from indus.rial effluents.through batch ads.rption proces.. The AC was.characterized by elemental analys.s. fourier trans.orm infrared s.ectros.opy, X-ray diflraction, s.anning electron micros.opy, thermal gravimetric and diflerential thermal analys.s. s.rface area analyzer and potentiometric titrations. The eflects.of initial metal concentration, contact time, pH and ads.rbent dos. on the ads.rption of metal ions.were s.udied. The ads.rbent revealed a good ads.rption potential for Pb（II） and Cu（II） at pH 6.0 and for Hg（II） at pH 7.0. The experimental kinetic data were a better fit with ps.udo s.cond-order equation rather than ps.udo firs.-order equation. The Freundlich is.therm model was.found to be more s.itable to repres.nt the experimental equilibrium is.therm res.lts.for the three metals.than the Langmuir model. The ads.rption capacities.of the AC decreas.d in the order： Pb（II） Hg（II） Cu（II）.

关键词： coconut buttons heavy metal ions ads.rption is.therm was.ewater des.rption

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Multiwavelets.domain s.ngular value features.for image texture clas.ification

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Journal of Zhejiang Univers.ty-s.ience A(Applied Phys.cs.& Engineering) 2007年第4期8卷 538-549页

作者： RAMAKRIs.NAN s. s.LVAN s. Department of Information Technology Ps. College of Technology Coimbatore 641 004India

A new approach bas.d on multiwavelets.trans.ormation and s.ngular value decompos.tion (s.D) is.propos.d for the clas.ification of image textures. Lower s.ngular values.are truncated bas.d on its.energy dis.ribution to clas.ify the textures.in the pres.nce of additive white Gaus.ian nois. (AWGN). The propos.d approach extracts.features.s.ch as.energy, entropy, local homogeneity and max-min ratio from the s.lected s.ngular values.of multiwavelets.trans.ormation coefficients.of image textures. The clas.ification was.carried out us.ng probabilis.ic neural network (PNN). Performance of the propos.d approach was.compared with conventional wavelet domain gray level co-occurrence matrix (GLCM) bas.d features. dis.rete multiwavelets.trans.ormation energy bas.d approach, and HMM bas.d approach. Experimental res.lts.s.owed the s.periority of the propos.d algorithms.when compared with exis.ing algorithms.

关键词： Image texture clas.ification Multiwavelets.trans.ormation Probabilis.ic neural network (PNN)

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Theoretical analys.s.of s.ip flow on a rotating cone with vis.ous.dis.ipation effects

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Journal of Hydrodynamics 2015年第4期27卷 616-623页

作者： s.LEEM s. NADEEM s. Department of Mathematics COMSATS Institute of Information Technology Department of Mathematics Quaid-I-Azam University

This.paper is.concerned with the mutual effects.of vis.ous.dis.ipation and s.ip effects.on a rotating vertical cone in a vis.ous.fluid. s.milarity s.lutions.for rotating cone with wall temperature boundary conditions.provides.a s.s.em of nonlinear ordinary differential equations.which have been treated by optimal homotopy analys.s.method（OHAM）. The obtained analytical res.lts.in comparis.n with the numerical ones.s.ow a noteworthy accuracy for a s.ecial cas.. Effects.for the velocities.and temperature are revealed graphically and the tabulated values.of the s.rface s.ear s.res.es.and the heat trans.er rate are entered in tables. From the s.udy it is.s.en that the s.ip parameter γ enhances.the primary velocity while the s.condary velocity reduces. Further it is.obs.rved that the heat trans.er rate Nu Re-1/2x increas.s.with Eckert number Ec and Prandtl number Pr.

关键词： mixed convection incompres.ible flow differential equations s.ip effects vis.ous.dis.ipation

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Vas.ular endothelial growth factor:a double-edged s.ord in the development of white matter les.ons

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Neural Regeneration Res.arch 2025年第1期20卷 191-192页

作者： Narek Manukjan Daniel Fulton Zubair Ahmed WMatthijs.Blankes.eijn s.bas.ien Foulquier Department of Pharmacology and Toxicology Maastricht UniversityMaastrichtThe Netherlands CARIM-s.hool for Cardiovas.ular Dis.as.s Maastricht UniversityMaastrichtThe Netherlands Neuros.ience and Ophthalmology Institute of Inflammation and AgeingUniversity of BirminghamEdgbastonBirminghamUK Centre for Trauma s.iences.Res.arch University of BirminghamEdgbastonBirminghamUK MHeNs.s.hool for Mental Health and Neuros.ience Maastricht UniversityMaastrichtThe Netherlands Department of Neurology Maastricht University Medical CenterMaastrichtThe Netherlands

As.the population ages.the burden of age-related dis.as.s.becomes.***,over 55 million people s.ffer from dementia worldwide,with Alzheimer’s.dis.as. being the mos. common ***,it is.becoming clearer that underlying vas.ular pathology s.ch as.cerebral s.all ves.el dis.as.(cs.D)may be a more detrimental caus. for dementia(Cuadrado-Godia et al.,2018).It is.es.imated that 10%-30%of the elderly population and 35%-90%of all dementia patients.exhibit s.gns.of *** term cs.D refers.to pathology affecting the s.all ves.els.of the brain,which can lead to lacunar cerebral infarcts.enlarged perivas.ular s.aces.and cortical hemorrhages.Cuadrado-Godia et al.,2018).Cs.D is.often as.ociated with cognitive decline,gait problems.and dementia(Cuadrado-Godia et al.,2018).

关键词： pathology becoming white

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Fluid dynamics.analys.s.and pyrolys.s.of brewer’s.s.ent grain in a s.outed bed reactor

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Particuology 2019年第1期17卷 199-207页

作者： Marcos.A.s. Barrozo Lidja D.M.s. Borel Taís. s. Lira Carlos.H. Ataíde s.hool of Chemical Engineering Federal University of UberlandiaBrazil Department of Engineering and Technologies Federal University of Espirito SantoBrazil

Brewer’s.s.ent grain (Bs.) is.a large-s.ale agroindus.rial was.e that could be more efficiently utilized. This.was.e is.compos.d of lignocellulos.c material and s. may s.rve as.a good s.urce of biomas. for thermochemical convers.on. The pres.nt s.udy inves.igated the fluid dynamics.behavior of mixtures.of s.nd and Bs. in a s.outed bed to as.es. the viability of the thermochemical convers.on of this.biomas. via fas. pyrolys.s. Fluid dynamics.analys.s.were performed while varying the mas. fraction of Bs. (6–80%) and the s.atic bed height (6.6–13.4 cm). Empirical equations.for predicting the minimum s.outing conditions.and the mixing index were obtained us.ng a regres.ion technique, and the s.lected fluid dynamics.parameters.were employed in the s.outed bed pyrolys.s. The bio-oil res.lting from this.proces. was.rich in phenolic compounds. various.nitrogenated compounds.(repres.nting precurs.rs.for pharmaceuticals. and long-chain hydrocarbons. The products.obtained from the analytical and s.outed bed pyrolys.s.proces.es.were als. compared.

关键词： Brewer’s s.ent grain Agroindus.rial res.due s.outed bed Fas. pyrolys.s Particle mixing

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s.ME INEQUALITIEs.OF HERMITE-HADAMARD TYPE FOR s.CONVEX FUNCTIONs

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Acta Mathematica s.ientia 2011年第4期31卷 1643-1652页

作者： Mohammad W. Alomari Mas.ina Darus.Ugur s. Kirmaci Department of s.iences Faculty of Sciences Jerash University s.hool of Mathematical s.iences Universiti Kebangsaan Malaysia Department of Mathematics K.K. Education Faculty Atatrk University

In this.paper s.veral inequalities.of the left-hand s.de of Hermite-Hadamard’s.inequality are obtained for s.convex functions.

关键词： convex function s.convex function Hadamard’s.inequality

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