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Journal of Innovative Optical Health Sciences 2015年第1期8卷 106-112页

作者： brian c.wilson Michael S.Patterson Buhong Li Mark T.Jarvi Department of Medical Biophysics University of Toronto/University Health Network Toronto Ontario M5G 1L7Canada Juravinski cancer centre and McMaster University Hamilton Ontario L8V 5C2Canada MOE Key Laboratory of OptoElectronic Science and Technology for Medicine Fujian Provincial Key Laboratory for Photonics Technology Fujian Normal University FuzhouFujian 350007P.R.China

Excited-state singlet axygen(^(1)O_(2)),generated during photodynamic therapy(PDT),is believed to be the primary cytotoxic agent with a number of clinically approved *** relative concentration in cells or tissues can be measured directly through its near-infrared(NIR)luminescence emission,which has correlated well with in vitro cell and in triro normal skin treatment ***,its correlation with the response of tumor tiss1e in vito is examined,using the photosensitizer meso-tetralydroxyphenylchlorin(mTHPc)in an animal model comprising luciferase-and green fluorescent protein(GFP)-transduced gliosarcoma grown in a dorsal window *** change in the bioluminescence signal,imaged pre-treatment and at 2,5 and 9 d post treatment,was used as a quantitative measure of the tumor response,which was classified in individual tumors as"non","moderate"and"strong"in order to reduce the variance in the *** the bioluminescence-based response vs the^(1)O_(2)counts demonstrated clear correlation,indicating tha^(1)O_(2)luminescence provides a valid do-simetric technique for PDT in tumor tissue.

关键词： Photodynamice therapy singlet axygen lumninescence dosinetry bioluminescence

IN VIVO NEAR-INFRAREDFLUOREScENcEIMAGING OF HUMANcOLONADENOcARcINOMABY SPEcIFIc IMMUNOTARGETINGOFA TUMOR-ASSOcIATEDMUcIN

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Journal of Innovative Optical Health Sciences 2009年第4期2卷 407-422页

作者： RALPH S.DAcOSTA YING TANG TUULA KALLIOMAKI RAYMOND M.REILLY ROBERT WEERSINK ALISHA R.ELFORD NORMAN E.MARcON brian c.wilson Division of Biophysics and Bioimaging Ontario Cancer Institute 610 University of TorontoTorontoOntarioM5G 2M9Canada Department of Medical Biophysics University of Toronto Princess Margaret Hospital/Ontario Cancer Institute University Health NetworkTorontoOntarioCanada NIH/NcI Radiation Oncology Branch BethesdaMDUSA Division of clinical Investigation and Human Physiology Toronto General Hospital Research Institute and University of Toronto Leslie Dan Faculty of Pharmacy TorontoOntarioCanada Laboratory for Applied Biophotonics University Health Network TorontoOntarioCanada campbell Family Institute for Breast cancer Research University Health Network/Ontario cancer Institute Department of Medical Biophysics and Immunology Toronto OntarioCanada St.Michael’s Hospital center for Therapeutic Endoscopy and Endoscopic Oncology Toronto OntarioCanada

Background and Aims: Accurate endoscopic detection of premalignant lesions and earlycancers in the colon is essential for cure, since prognosis is closely related to lesion size andstage. Although it has great clinical potential, autofluorescence endoscopy has limited tumorto-normal tissue image contrast for detecting small preneoplastic lesions. We have developed amolecularly specific, near-infrared fluorescent monoclonal antibody (cc49) bioconjugate whichtargets tumor-associated glycoprotein 72 (TAG72), as a contrast agent to improve fluorescencebased endoscopy of colon cancer. Methods: The fluorescent anti-TAG72 conjugate was evaluated in vitro and in vivo in athymic nude mice bearing human colon adenocarcinoma (LS174T)subcutaneous tumors. Autofluorescence, a fluorescent but irrelevant antibody and the free fluorescent dye served as controls. Fluorescent agents were injected intravenously, and in vivowhole body fluorescence imaging was performed at various time points to determine pharmacokinetics, followed by ex vivo tissue analysis by confocal fluorescence microscopy and histology Results: Fluorescence microscopy and histology confirmed specific LS174T cell membrane targeting of labeled cc49 in vitro and ex vivo. In vivo fluorescence imaging demonstrated significant tumor-to-normal tissue contrast enhancement with labeled-cc49 at three hours postinjection, with maximum contrast after 48 h. Accumulation of tumor fluorescence demonstratedthat modification of cc49 antibodies did not alter their specific tumor-localizing properties, andwas antibody-dependent since controls did not produce detectable tumor fluorescence. conclusions: These results show proof-of-principle that our near-infrared fluorescent-antibody probetargeting a tumor-associated mucin detects colonic tumors at the molecular level in real time,and offer a basis for future improvement of image contrast during clinical fluorescence endoscopy.

关键词： Autofluorescence imaging endoscopy colon adenocarcinoma TAG72 cc49 mucin monoclonal antibody conjugate confocal fluorescence microscopy.

Editorial-Introduction to the Special Issue on Photodynamic Therapy

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Journal of Innovative Optical Health Sciences 2015年第1期8卷 1-3页

作者： Buhong Li brian c.wilson School of Photonics and Electronic Engineering Fujian Normal University China Department of Medical Biophysics University of Toronto and University Health Network Canada

Photodynamic therapy(PDT)is a minimally invasive treatment for malignant and nonmalignant diseases that uses light-activated photosensitizers to destroy or modify cells or *** has been approved by health agencies in several countries for cancers of different sites and stages,and for treatment of age related macular degeneration,various benign skin conditions and localized bacterial infections.

关键词： degeneration Photodynamic diseases

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电子与电脑 1997年第8期 88-88页

作者： brian c.wilson ,李润芬

如果您在本文中没有找到问题的答案,可以寻找在线帮助！最佳的起点是HTML入门指南(***/General/Internet/WWW/***)。这个网点是NcSA为网页制作者制作的初级教程它包括HTML概述和一些Web创作经验。欲了解精深内容,可以访问Microsoft网点... 详细信息

如果您在本文中没有找到问题的答案,可以寻找在线帮助！最佳的起点是HTML入门指南(***/General/Internet/WWW/***)。这个网点是NcSA为网页制作者制作的初级教程它包括HTML概述和一些Web创作经验。欲了解精深内容,可以访问Microsoft网点制作者之角***/workshop/,这里的帮助信息不仅有HTML方面的,还包含编程与管理方面的。而如果想了解应避免哪些操作,可访问***/bad-style/,这里列出了一些不合理使用HTML的常见陋习,它的主页还有Yahool页面设计和版面资源的索引,绝对值得一看。HTML入门指南(***/General/Internet/WWW/***)。这个网点是NcSA为网页制作的初级教程它包括HTML概述和一些Web创作经验。

关键词：帮助信息 www

Highly efficient fiber to Si waveguide free-form coupler for foundry-scale silicon photonics

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Photonics Research 2024年第5期12卷 1055-1066页

作者： LUIGI RANNO JIA Xu brian SIA cOSMIN POPEScU DREW WENINGER SAMUEL SERNA SHAOLIANG YU LIONEL c.KIMERLING ANURADHA AGARWAL TIAN GU JUEJUN HU Department of Materials Science&Engineering Massachusetts Institute of TechnologyCambridgeMassachusetts 02139USA centre for Micro-&Nano-Electronics(cMNE) Nanyang Technological UniversitySingapore 639798Singapore Department of Physics Photonics and Optical EngineeringBridgewater State UniversityBridgewaterMassachusetts 02324USA Zhejiang Laboratory Hangzhou 311100China Materials Research Laboratory Massachusetts Institute of TechnologyCambridgeMassachusetts 02139USA

As silicon photonics transitions from research to commercial deployment,packaging solutions that efficiently couple light into highly compact and functional sub-micrometer silicon waveguides are imperative but remain *** 220 nm silicon-on-insulator(SOI)platform,poised to enable large-scale integration,is the most widely adopted by foundries,resulting in established fabrication processes and extensive photonic component *** development of a highly efficient,scalable,and broadband coupling scheme for this platform is therefore of paramount *** two-photon polymerization(TPP)and a deterministic free-form micro-optics design methodology based on the Fermat’s principle,this work demonstrates an ultraefficient and broadband 3-D coupler interface between standard SMF-28 single-mode fibers and silicon waveguides on the 220 nm SOI *** coupler achieves a low coupling loss of 0.8 dB for the fundamental TE mode,along with 1 dB bandwidth exceeding 180 *** broadband operation enables diverse bandwidthdriven applications ranging from communications to ***,the 3-D free-form coupler also enables large tolerance to fiber misalignments and manufacturing variability,thereby relaxing packaging requirements toward cost reduction capitalizing on standard electronic packaging process flows.

关键词： fiber waveguide enable

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Response of Rice Growth and Nutrient Absorption in a SalineAlkali Paddy to Different Nitrogen Fertilizer Applications

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Rice science 2024年第3期31卷 245-250,I0011-I0017页

作者： WANG Xinyi ZHU Hui YAN Baixing brian SHUTES ZENG Yuan Key Laboratory of Wetland Ecology and Environment Northeast Institute of Geography and AgroecologyChinese Academy of SciencesChangchun 130102China college of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Black Soils conservation and Utilization Changchun 130102China Department of Natural Sciences Middlesex UniversityHendonLondonNW44BTUK Xingkaihu Branch Office of Heilongjiang Agriculture co. LTDJixi 158325China

Nitrogen(N),phosphorus(P)and carbon(c)are essential nutrients for rice growth and development,but the response of nutrient absorption by rice plants to different types of nitrogen fertilizer(N-fertilizer)under saline-alkali conditions is *** study conducted a 147-day field-scale experiment to evaluate rice biomass and nutrient absorption capacity with five N-fertilizer *** results showed that the biomass.

关键词： Nutrient Alkali alkali

Finding the magnetopause location using soft X-ray observations and a statistical inverse method

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Earth and Planetary Physics 2024年第1期8卷 184-203页

作者： Gonzalo cucho-Padin Hyunju connor Jaewoong Jung brian Walsh David G.Sibeck Space Weather Laboratory NASA Goddard Space Flight CenterGreenbeltMDUSA Department of Physics The Catholic University of AmericaWashingtonDCUSA Geospace Physics Laboratory NASA Goddard Space Flight CenterGreenbeltMDUSA Astronomy Department University of Maryland College ParkCollege ParkMDUSA center for Space Physics Department of Mechanical EngineeringBoston UniversityBostonMAUSA

Variability in the location and shape of the dayside magnetopause is attributed to magnetic reconnection,a fundamental process that enables the transfer of mass,energy,and momentum from the solar wind into the *** spatial and temporal properties of the magnetopause,under varying solar and magnetospheric conditions,remain largely unknown because empirical studies using in-situ observations are challenging to *** wide field-of-view(FOV)imaging is the only means to simultaneously observe the spatial distribution of the plasma properties over the vast dayside magnetospheric region and,subsequently,quantify the energy transport from the interplanetary medium into the terrestrial *** upcoming missions,ESA/cAS SMILE and NASA’s LEXI will provide wide-field imagery of the dayside magnetosheath in soft X-rays,an emission generated by charge exchange interactions between high charge-state heavy ions of solar wind origin and exospheric neutral ***-cadence two-dimensional observations of the magnetosheath will allow the estimation of dynamic properties of its inner boundary,the magnetopause,and enable studies of its response to changes in the solar wind dynamic pressure and interplanetary magnetic field *** work introduces a statistically-based estimation approach based on inverse theory to estimate the spatial distribution of magnetosheath soft X-ray emissivities and,with this,identify the location of the magnetopause over the Sun−Earth *** do so,we simulate the magnetosheath structure using the MHD-based OpenGGcM model and generate synthetic soft X-ray images using LEXI’s orbit and attitude *** results show that 3-D estimations using the described statistically-based technique are robust against Poisson-distributed shot noise inherent to soft X-ray ***,our proposed methodology shows that the accuracy of both three-dimensional(3-D)estimation and the magnetopause standoff distance calculation hi

关键词： magnetopause soft X-ray tomography

cD200Rhigghh neutrophils with dysfunctional autophagy establish systemic immunosuppression by increasing regulatory T cells

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cellular & Molecular Immunology 2024年第4期21卷 349-361页

作者： Ye Seon Kim Yu Sun Jeong Geon Ho Bae Ji Hyeon Kang Mingyu Lee brian A.Zabel Yoe-Sik Bae Department of Biological Sciences Sungkyunkwan UniversitySuwon16419Republic of Korea Department of Health Science and Technology SAIHSTSungkyunkwan UniversitySeoul06351Republic of Korea Palo Alto Veterans Institute for Research Veterans Affairs HospitalPalo AltoCA94304USA

Distinct neutrophil populations arise during certain pathological *** generation of dysfunctional neutrophils during sepsis and their contribution to septicemia-related systemic immune suppression remain *** this study,using an experimental sepsis model that features immunosuppression,we identified a novel population of pathogenic cD200R^(high) neutrophils that are generated during the initial stages of sepsis and contribute to systemic immune suppression by enhancing regulatory T(T_(reg))*** to their cD200R^(low)counterparts,sepsis-generated cD200Rhigh neutrophils exhibit impaired autophagy and dysfunction,with reduced chemotactic migration,superoxide anion production,and TNF-α*** soluble cD200 blocks autophagy and neutrophil maturation in the bone marrow during experimental sepsis,and recombinant cD200 treatment in vitro can induce neutrophil dysfunction similar to that observed in cD200R^(high) *** administration of anα-cD200R antibody effectively reversed neutrophil dysfunction by enhancing autophagy and protecting against a secondary infection challenge,leading to increased *** analysis revealed that cD200R^(high) neutrophils expressed high levels of Igf1,which elicits the generation of Treg cells,while the administration of anα-cD200R antibody inhibited Treg cell generation in a secondary infection *** together,our findings revealed a novel cD200R^(high) neutrophil population that mediates the pathogenesis of sepsis-induced systemic immunosuppression by generating Treg cells.

关键词： Sepsis Neutrophils cD200R Autophagy IGF-1 Regulatory T cells

cardiovascular health awareness,risk perception,behavioural intention and INTERHEART risk stratification among middle-aged adults in Malaysia

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Asian Pacific Journal of Tropical Medicine 2024年第2期17卷 61-70页

作者： Siew-Keah Lee Ang-Lim chua clement Heng Yew Fong Ban Hao brian cong Wen Ling Ng Jing Feng Kong Yik-Ling chew Kai Bin Liew Yang Shao M.Kandiah Faculty of Medicine and Health Sciences Universiti Tunku Abdul RahmanMalaysia Faculty of Medicine Universiti Teknologi MARAMalaysia Faculty of Pharmaceutical Sciences UCSI UniversityMalaysia Faculty of Pharmacy University of CyberjayaMalaysia The First Affiliated Hospital of Hainan Medical University China

Objective:To investigate the interrelationship between cardiovascular health awareness,risk perception,behavioural intention,and INTERHEART risk stratification in a middle-aged adult population in ***:A cross-sectional survey with convenience sampling was conducted during November 2022 and January *** completed validated questionnaires assessing cardiovascular health awareness,risk perception of cardiovascular diseases,behavioural intention towards adopting healthy habits,and INTERHEART risk stratification score(IHRS)based on established risk factors.A total of 602 respondents were included in the final *** were analysed with independent t-test/one-way ANOVA or Mann-Whitney/Kruskal-Wallis to test the differences,Pearson correlation or linear regression test to analyze the association of independent and dependent ***:There was a significant positive correlation between medical knowledge related to cardiovascular disease(cVD)and knowledge related to cVD risk prevention,risk perception,behavioural intention and IHRS(Pcorrelation).Notably,individuals with higher IHRS tended to have lower knowledge related to cVD and cVD risk prevention,risk perception,and behavioural ***,laborers,active/former smokers,individuals with lower household income and educational levels,those involved in occupations not related to the healthcare sector,and those who did not receive the cVD health brochure or are unaware of health self-assessment tools are likely to have lower levels of knowledge,risk perception,and poorer behavioural intention regarding cardiovascular health(Pcational level,smoking status,awareness about cVD poster,self-assessment tools were repeatedly significantly associated with knowledge related to cVD and cVD risk prevention,risk perception,behavioral intention and/or IHRS(Pconclusions:These findings underscore the importance of promoting car

关键词： cardiovascular risk Knowledge Risk perception Behavioural intention INTERHEART Middle-aged Lifestyle Physical activity Psychosocial stress

Pathogenic and therapeutic role of exosomes in neurodegenerative disorders

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Neural Regeneration Research 2024年第1期19卷 75-79页

作者： christa c.Huber Hongmin Wang Division of Basic Biomedical Sciences Sanford School of MedicineUniversity of South DakotaVermillionSDUSA

Neurodegenerative disorders affect millions of people worldwide,and the prevalence of these disorders is only projected to rise as the number of people over 65 will drastically increase in the coming *** therapies exist to aid in symptomatic relief,effective treatments that can stop or reve rse the progress of each neurodegenerative disease are ***,research on the role of extracellular vesicles as disease markers and therapeutics has been intensively ***,30-150 nm in diameter,are one type of extracellular vesicles facilitating cell-to-cell *** are thought to play a role in disease propagation in a variety of neurodegenerative diseases,such as Alzheimer's disease,Parkinson s disease,and amyotrophic lateral ***,the exosomes derived from the patients are an invaluable source of disease *** the other hand,exosomes,especially those derived from stem cells,could serve as a therapeutic for these disorders,as seen by a rapid increase in clinical trials investigating the therapeutic efficacy of exosomes in different neurological *** review summarizes the pathological burden and therapeutic approach of exosomes in neurodegenerative *** also highlight how heat shock increases the yield of exosomes while still maintaining their therapeutic ***,this review concludes with outstanding questions that remain to be addressed in exosomal research.

关键词： aging Alzheimer's disease biomarker drug exosome extracellular vesicle neurodegenerative disease Parkinson's disease therapy