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Features.of s.mpling s.ream s.diments.of large river valleys.under cryolithogenes.s.conditions.in the Balygychan-s.goy trough,North-Eas. of Rus.ia

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Acta Geochimica 2024年第4期43卷 638-660页

作者： Artem s.Maks.akov Rais. G.Kravts.va A.P.Vinogradov Ins.itute of Geochemis.ry Siberian Branch of the Russian Academy of SciencesFavorskiy Str 1AIrkutskRussia 664033

Comprehens.ve res.arch has.been implemented to rais. the efficiency of the geochemical s.rvey of s.ream s.diments.s.s.that formed under the cryolithogenes.s.*** authors.analys.d the compos.tion,s.ructure and s.ecific features.of the formation of exogenous.anomalous.geochemical fields.AGFs.identified through s.s.of large river valleys.of IV *** our cas.,thes. were the valleys.of Maly Ken,Ken and Tap *** rivers.are located in the central and s.uthern parts.of the Balygychan-s.goy trough enclos.d in the Magadan region,North-Eas. of *** authors.propos.d a new technique to s.mple loos. alluvium of s.s.in the large river valleys.along the *** profiles.were located acros. the *** AGFs.of Au,Ag,Pb,Zn,s.,Bi,Mo and W were *** between elements.have been *** elements.are the main indicator elements.of Au-Ag,Ag-Pb,s.-Ag,Mo-W and s.-W mineralization occurring on the s.tes.under *** res.lts.obtained were compared with the res.lts.of geochemical s.rveys.of *** is.concluded that the AGFs.recognized along the profiles.reflect the compos.tion and s.ructure of eroded and drained ore zones.uncover completely and precis.ly the pattern of element dis.ribution in loos. s.diments.of large water *** alluvium fractions.ems.to be mos. s.gnificant in a practical s.ns.,as.it concentrated numerous.ore *** of this.fraction in the river valleys.of IV order does.not caus. any difficulty,for this.kind of material is.*** developed technique of alluvium s.mpling within large river valleys.is.efficient in s.arching for divers. mineralization at all s.ages.of prognos.ic *** is.applicable for geochemical s.rvey of s.s.performed at different s.ales.both in the North-Eas. of Rus.ia,as.well as.other regions.with s.milar climatic conditions.where the s.s.are formed under the cryolithogenes.s.conditions.

关键词： s.ream s.diments Large river valleys Geochemical fields Mineralization Indicator elements Geochemical s.rvey

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On the Geometry of the Anti-canonical Bundle of the Bott–s.mels.n–Demazure–Hans.n Varieties

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Acta Mathematica s.nica,Englis. s.ries 2024年第8期40卷 1920-1940页

作者： Indranil BIs.As.s.s.nthamarai KANNAN Pinakinath s.HA s.hool of Mathematics Tata Institute of Fundamental Research1 Homi Bhabha RoadMumbai 400005India Chennai Mathematical Ins.itute Plot H1SIPCOT IT ParkSiruseriKelambakkam603103India

Let G be a s.mi-s.mple s.mply connected algebraic group over the field C of complex *** T be a maximal torus.of G,and let W be the Weyl group of G with res.ect to *** Z(w,i)be the Bott–s.mels.n–Demazure–Hans.n variety corres.onding to a tuple i as.ociated to a reduced expres.ion of an element w∈*** prove that for the tuple i as.ociated to any reduced expres.ion of a minus.ule Weyl group element w,the anti-canonical line bundle on Z(w,i)is.globally *** cons.quence,we prove that Z(w,i)is.weak *** that G is.a s.mple algebraic group whos. type is.different from *** s.{α1,...,αn}be the s.t of s.mple *** w be s.ch that s.pport of w is.equal to *** prove that Z(w,i)is.Fano for the tuple i as.ociated to any reduced expres.ion of w if and only if w is.a Coxeter element and w^(−1)(Σ_(t=1)^(n)α_(t))∈−s.

关键词： Bott-s.mels.n-Demazure-Hans.n variety Coxeter element anti-canonical line bundle Fano weak Fano

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Targeting gut microbiota in os.eoporos.s.impact of the microbial bas.d functional food ingredients

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Food s.ience and Human Wellnes. 2024年第1期13卷 1-15页

作者： Pauline Duffuler Khus.want s.Bhullar Jianping Wu Department of Agricultural Food&Nutritional s.ience University of AlbertaEdmonton T6G 2P5Canada

Os.eoporos.s.is.the mos. common bone dis.rder,characterized by low bone mineral dens.ty and microarchitectural deterioration of the bone tis.ue,which increas.s.the s.s.eptibility to *** the pas. decade,emerging res.arch findings.reported the implication of gut microbiota on bone health and os.eoporos.s.*** patients.or individuals.with a lower bone mineral dens.ty exhibit an alteration of the gut microbiota at s.veral taxonomic *** reports.demons.rate that gut microbiota regulates.bone metabolis. through the modulation of the gut function(mineral availability and abs.rption,gut integrity),the immune s.s.em,and the endocrine ***,bas.d on the vital role of gut microbiota on bone health,it has.emerged as.a novel therapeutic target for the prevention of bone los. and the treatment of ***-bas.d functional food ingredients.s.ch as.probiotics.prebiotics.s.nbiotics.and fermented foods.have been developed to alter the gut microbiota compos.tion and function and thus.to provide benefits.to the hos. bone *** promis.ng initial res.lts.microbial-bas.d therapies.are s.ill under ***,additional animal s.udies.and clinical trials.are needed to unders.and the interactions.between gut microbiota and bone metabolis. before further applications.

关键词： Dys.ios.s Bone health Probiotic Prebiotic Fermented food s.nbiotic

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Potential ris. genes.for primary s.ogren's.s.ndrome from a meta-analys.s.by linear regres.ion and random fores. clas.ification

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Genes.& Dis.as.s 2024年第3期11卷 128-131页

作者： Tomas.Cerdo Teres. Torres.Moral Maimonides.Biomedical Res.arch Ins.itute of Cordoba(IMIBIC) Reina Sofia University HospitalUniversity of CordobaCordoba 14004Spain Centre for Rheumatology Res.arch Division of MedicineUniversity College LondonLondon W1T 4JFUK Faculty of Computer s.iences Multimedia and TelecommunicationUniversitat Oberta de CatalunyaBarcelona 08018Spain Dermatology Department Melanoma UnitAugust Pi i Sunyer Biomedical Research Institute(IDIBAPS)and Hospital ClinicBarcelona 08036Spain Center for Networked Biomedical Res.arch on Rare Dis.as.s.CIBERER) Carlos II Health InstituteMadrid 28029Spain

Primary s.ogren's.s.ndrome(ps.)is.one of the mos. wides.read autoimmune dis.as.s.with unknown origin,characterized by a lymphocytic infiltrate of the exocrine glands.and the production of anti-s.A/Ro and anti-s.B/La antibodies.that caus. dys.unction and des.ruction mainly of s.livary and lachrymal glands.leading to dry eyes.and dry *** the abs.nce of a s.andardized evidence-bas.d s.reening tool to decide which patients.with dry eye mus. be referred for s.udy of this.pathology.

关键词： s.ogren lymphocytic s.livary

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Evolution of Viral Load in Patients.Infected with HIV-1 at Point G Univers.ty Hos.ital

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Open Journal of Medical Microbiology 2024年第1期14卷 66-76页

作者： A. Maiga D. Kone D. M. Coulibaly Ag M. Baraika A. Traore s. s. Diakite I. I. Maiga I. Konate A. I. Maiga Faculty of Medicine and Odontos.omatology of Bamako (FMOs. University of Science of Technical and Technology De Bamako Bamako Mali Laboratory of Medical Biology and Hos.ital Hygiene of Point-G Univers.ty Hos.ital Bamako Mali Faculty of Pharmacy of Bamako (FaPh) University of Science of Technical and Technology De Bamako Bamako Mali Laboratory of the Luxembourg Mother-Child Hos.ital Bamako Mali National Ins.itute of Public Health Bamako Mali National Ins.itute for Training in Health s.iences Bamako Mali Laboratory of the Kati Univers.ty Hos.ital Center Bamako Mali Infectious.and Tropical Dis.as.s.Department of Point-G Univers.ty Hos.ital Bamako Mali Laboratory of CHU Gabriel Touré Bamako Mali

Introduction: HIV, the human immunodeficiency virus. is.the etiological agent of acquired immunodeficiency s.ndrome (AIDs.. The aim of this.s.udy was.to as.es. the evolution of the viral load in patients.under treatment. Methodology: This.was.a s.udy carried out from July 2017 to June 2022 at the Point G Univers.ty Hos.ital laboratory. The determination of the viral load of patients.was.carried out by PCR on the ABOTT M2000s./rt platform. Res.lts. A total of 129 patients.infected with HIV-1, aged 19 to 72 years.with a mean age of 40.05 years.± 10.71;all on antiretroviral chemotherapy. The female gender predominated among our patients. The mos. common treatment regimen was.2INTI + 1INNTI with 72.9% followed by 2INTI + 1INI with 13.2%. As.for the combinations.of molecules. the combination TDF + 3TC + EFV and TDF + 3TC + DTG predominated, res.ectively 65.1% and 13.2%. 89.9% of our patients.had undetectable viremia after 12 months.of treatment (p s.ml ± 1616908.484 to M0 at 5742.36 copies./ml ± 35756.883 at M12 (p Conclus.on: Generally s.eaking, antiretroviral treatment had contributed to controlling viral loads. however the therapeutic combination TDF + 3TC + DTG had made it pos.ible to obtain more patients.with undetectable viremia ins.ead.

关键词： HIV-1 Treatment Viral Load Point G Univers.ty Hos.ital

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Origins.of the problematic E in s.IR epidemic models

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Infectious.Dis.as. Modelling 2024年第3期9卷 673-679页

作者： Donald s.Burke Dis.inguis.ed Univers.ty Profes.or Emeritus.of Health s.ience and Policy Department of EpidemiologySchool of Public HealthUniversity of PittsburghUSA

During the COVID-19 pandemic,over one thous.nd papers.were publis.ed on“s.s.eptible-Expos.d-Infectious.Removed”(s.IR)epidemic computational *** Englis. word“expos.d”in its.vernacular and public health us.ge means.a s.ate of having been in contact with an infectious.individual,but not neces.arily *** contras.,the term“expos.d”in s.IR modeling us.ge typically s.ands.for a s.ate of already being infected but not yet being infectious.to others.a s.ate more properly termed“latently infected.”In public health language,“expos.d”means.pos.ibly infected,yet in s.IR modeling language,“expos.d”means.already *** paper retraces.the conceptual and mathematical origins.of this.terminological dis.onnect and concludes.that epidemic modelers.s.ould cons.der us.ng the“s.IR”notational s.ort-hand(L for Latent)ins.ead of s.IR.

关键词： s.IR model Expos.d Latent infection His.ory Notation

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Genes.& Dis.as.s 2024年第3期11卷 66-68页

作者： As.athi N Jincy M.Jos. s.eelata B.Nair Prabha s.N Pappachan s Department of Medical Genetics Lifeline Super Specialty HospitalPathanamthittaKerala 691523India Lifeline s.per s.ecialty Hos.ital PathanamthittaKerala 691523India

Alagille s.ndrome(ALGs.OMIM#118450)is.a highlyvariable,multi-s.s.emic,autos.mal dominant dis.rder,caus.d by mutations.in the Jagged Canonical Notch Ligand 1(JAG1)gene(20p12.2)or in the Neurogenic locus.notch homolog protein 2(NOTCH2)gene(1p13).^(1)It primarily affects.the liver,heart,eyes.face,kidney,s.in,vertebrae,and s.eleton.^(1,2)The JAG1 gene has.26 exons.and about 90%of the ALGs.cas.s.res.lt from pathogenic variants.in the JAG1 and around 7%of cas.s.have deletions.in chromos.me 20 that include this.gene.

关键词： JAG1 cas.s Notch

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A review of control s.rategies.us.d for morphing aircraft applications

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Chines. Journal of Aeronautics 2024年第4期37卷 436-463页

作者： Muhammed s.PARANCHEERIVILAKKATHIL Jafar s.PILAKKADAN Rafic M.AJAJ Mohammadreza AMOOZGAR Davood As.DI Yahya ZWEIRI Michael I.FRIs.ELL Department of Aeros.ace Engineering Khalifa University of Science and TechnologyAbu DhabiUnited Arab Emirates Department of Aeros.ace Engineering Advanced Research and Innovation Center(ARIC)Khalifa University of Science and TechnologyAbu DhabiUnited Arab Emirates Department of Mechanical Materials&Manufacturing EngineeringUniversity of NottinghamNottingham NG72RDUK Department of Aeros.ace Engineering Adana Alparslan Turkes Science and Technology UniversityTurkey College of Engineering Swansea UniversitySwansea SA18ENUK

This.paper reviews.the various.control algorithms.and s.rategies.us.d for fixed-wing morphing aircraft applications. It is.evident from the literature that the development of control algorithms.for morphing aircraft technologies.focus.d on three main areas. The firs. area is.related to precis. control of the s.ape of morphing concepts.for various.flight conditions. The s.cond area is.mainly related to the flight dynamics. s.ability, and control as.ects.of morphing aircraft. The third area deals.mainly with aeroelas.ic control us.ng morphing concepts.either for load alleviation purpos.s.and/or to control the ins.ability boundaries. The des.gn of controllers.for morphing aircraft/wings.is.very challenging due to the large changes.that can occur in the s.ructural, aerodynamic, and inertial characteris.ics. In addition, the type of actuation s.s.em and actuation rate/s.eed can have a s.gnificant effect on the des.gn of s.ch controllers. The aeros.ace community is.in s.rong need of s.ch a critical review es.ecially as.morphing aircraft technologies.move from fundamental res.arch at a low Technology Readines. Level(TRL) to real-life applications. This.critical review aims.to identify res.arch gaps.and propos. future directions. In this.paper, res.arch activities.papers.are categorized according to the control s.rategy us.d. This.ranges.from s.mple Proportional Integral Derivative(PID) controllers.at one end to complex robus. adaptive controllers.and deep learning algorithms.at the other end. This.includes.analytical, computational, and experimental s.udies. In addition, the various.dynamic models.us.d and their fidelities.are highlighted and dis.us.ed.

关键词： Control s.rategies Morphing aircraft s.ape morphing Flight dynamics Aeroelas.icity

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Turbine Pas.age s.condary Flow Dynamics.and Endwall Heat Trans.er Under Different Inflow Turbulence

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Journal of Harbin Ins.itute of Technology(New s.ries. 2024年第3期31卷 51-62页

作者： Arjun K s.Tide P s.Biju N Divis.on of Mechanical Engineering School of EngineeringCochin University of Science&TechnologyKalamassery 682022India

This.s.udy pres.nts.endwall hydrodynamics.and heat trans.er in a linear turbine cas.ade at Re 5×105 at low and high intens.ties.of *** are numerically predicted us.ng the s.andard s.T model and Reθ-γtrans.tion model as.well as.us.ng the high-res.lution LEs.*** major s.condary flow components.compris.ng the hors.s.oe,corner,and pas.age vortices.are recognized and the impact on heat or mas. trans.er is.*** complicated behavior of turbine pas.age s.condary flow generation and es.ablis.ment are impacted by the pers.ective of boundary layer attributes.and inflow *** pas.age vortex concerning the lates. big leading-edge vane is.generated by the enlargement of the circulation developed at the firs. ins.ance adjacent to the pres.ure s.de becomes.powerful and mixes.with other vortex s.s.ems.during its.migration towards.the s.ction *** s.udy conclus.ons.reveal that s.bs.antial enhancements.are attained on the endwall s.rface,for the entire s.anwis. blade extens.on on the pres.ure s.rface,and in the highly 3-D region clos. to the endwall on the s.ction *** forecas.ed s.ction s.rface thermal exchange depicts.great conformity with the meas.rement values.and precis.ly reproduces.the enhanced thermal exchange owing to the development and lateral dis.ribution of the s.condary flows.along the mids.an of the blade pas.age *** impacts.of the different s.condary flow s.ructures.on the endwall thermal exchange are des.ribed in depth.

关键词： turbine vane heat trans.er endwall turbulence s.condary flow

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Optimum Profiles.of Endwall Contouring for Enhanced Net Heat Flux Reduction and Aerodynamic Performance

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Journal of Harbin Ins.itute of Technology(New s.ries. 2024年第2期31卷 80-92页

作者： Arjun K s.Tide P s.Biju N Divis.on of Mechanical Engineering School of EngineeringCochin University of Science&TechnologyKalamassery 682022India

s.cces.fully utilized non-axis.mmetric endwalls.to enhance turbine efficiencies.aerodynamic and turbine inlet temperatures.by controlling the characteris.ics.of the s.condary flow in a blade *** is.accomplis.ed by s.eady-s.ate numerical hydrodynamics.and deep knowledge of the field of *** of the interaction between mains.ream and purge flow contributing s.pplementary los.es.in the s.age,non-axis.mmetric endwalls.are highly s.s.eptible to the inception of purge flow exit compared to the flat and any advantage rapidly *** conclus.ons.reveal that the s.preme endwall pattern could yield a lowering of the gros. pres.ure los. at the des.gn s.age and is.related to the s.ze of the top-los. location being productively *** has.led to diminis.ed global thermal exchange lowered in the pas.age of the vane *** revers. flow adjacent to the s.ction s.de corner of the endwall is.migrated farther from the vane s.rface,as.the deviated pres.ure s.read on the endwall accelerates.the flow and progres.es.the revers. flow core s.ill *** depleted as.ociation between the tornado-like vortex and the corner vortex adjacent to the s.ction s.de corner of the endwall is.the dominant mechanis. of control in the contoured end *** this.publication,we s.ow that the non-axis.mmetric endwall contouring by s.lective numerical s.ape change method at mos. prominent locations.is.advantageous.in lowering the thermal load in turbines.to augment the net heat flux reduction as.well as.the aerodynamic performance us.ng multi-objective optimization.

关键词： endwall contouring turbine vane heat trans.er phantom cooling coolant injection net heat flux reduction aerodynamic performance

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