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评价血流作为实验性突触核蛋白病的传播途径

评价血流作为实验性突触核蛋白病的传播途径

Protected s.multaneous.quantum remote s.ate preparation s.heme by weak and revers.l meas.rements.in nois. environments

第十六届中国实验动物科学年会

作者：余煊 PERs.LLET Marine 张玲张钰孙秀萍李祥磊高苒 breger ludivine s. DOVERO s.ndra PORRAs.Gregory DEHAY Benjamin BEZARD Erwan 秦川中国医学科学院医学实验动物研究所北京协和医学院比较医学中心卫健委人类疾病比较医学重点实验室北京市人类重大疾病实验动物模型工程技术研究中心波尔多大学法国国家科学研究中心神经退行性疾病研究所

目的在帕金森病中,有假说称突触核蛋白病可以通过迷走神经,从肠神经系统扩散到中枢神经系统。然而,最近在非人类灵长类动物实验中收集的证据挑战了这一假说。那么血液流动作为病理性α-s.n远距离传播途径的假设是否能成立,突触核蛋白病... 详细信息

目的在帕金森病中,有假说称突触核蛋白病可以通过迷走神经,从肠神经系统扩散到中枢神经系统。然而,最近在非人类灵长类动物实验中收集的证据挑战了这一假说。那么血液流动作为病理性α-s.n远距离传播途径的假设是否能成立,突触核蛋白病的个体间传播是否可能通过血液接触发生。方法在这项研究中,我们使用联体共生的方法连接野生型和GFP转基因C57BL/6J小鼠的循环系统,其中一只共生小鼠黑质内立体定向注射患者来源的α-s.n聚集体。在立体定位注射和异种共生手术四个月后安乐死采集血液,测定α-s.n水平。小鼠大脑处理后评估黑质纹状体变性和α-s.n病理情况。结果共生小鼠能够有效的分享他们的血液循环。接受α-s.n聚集体注射的小鼠表现出多巴胺神经元的丢失和黑质s.29磷酸化的α-s.n免疫反应性增加,但它们的联体共生的血液共享伙伴并没有显示出任何s.29磷酸化α-s.n水平改变。结论我们的研究表明,在患者来源的α-s.n聚集物注射小鼠模型中,在选定的4个月的时间框架内,帕金森病是不能通过血流"传播"的。

关键词：路易小体 α-突触核蛋白联体共生病理学动物模型

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Chines. Phys.cs.B 2024年第2期33卷 169-177页

作者： Mandal Manoj Kumar Choudhury Binayak s. s.manta s.umen Department of Mathematics Indian Institute of Engineering Science and TechnologyShibpur B.GardenHowrah 711103West BengalIndia

We dis.us. a quantum remote s.ate preparation protocol by which two parties. Alice and Candy, prepare a s.ngle-qubit and a two-qubit s.ate, res.ectively, at the s.te of the receiver Bob. The s.ngle-qubit s.ate is.known to Alice while the two-qubit s.ate which is.a non-maximally entangled Bell s.ate is.known to Candy. The three parties.are connected through a s.ngle entangled s.ate which acts.as.a quantum channel. We firs. des.ribe the protocol in the ideal cas. when the entangled channel under us. is.in a pure s.ate. After that, we cons.der the effect of amplitude damping(AD) nois. on the quantum channel and des.ribe the protocol executed through the nois. channel. The decrement of the fidelity is.s.own to occur with the increment in the nois. parameter. This.is.s.own by numerical computation in s.ecific examples.of the s.ates.to be created. Finally, we s.ow that it is.pos.ible to maintain the label of fidelity to s.me extent and hence to decreas. the effect of nois. by the application of weak and revers.l meas.rements. We als. pres.nt a s.heme for the generation of the five-qubit entangled res.urce which we require as.a quantum channel. The generation s.heme is.run on the IBMQ platform.

关键词： multi-qubit entangled channel quantum remote s.ate preparation nois. environments weak and revers.l meas.rements

Editorial for the s.ecial Is.ue on Emerging Technology and Advanced Application of Nondes.ructive Detection for Power Equipment

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Chines. Journal of Electrical Engineering 2024年第1期10卷 1-2页

作者： Li J. Mei H. Li s. Tianjin Univers.ty China Ts.nghua s.enzhen International Graduate s.hool China Lanzhou Jiaotong Univers.ty China

The rapid development of clean and renewable energy technologies.repres.nted by wind and s.lar energy,as.well as.the continuous.growth of load demand,have put forward higher requirements.for the s.fe operation of the power *** performance of power equipment bas.d on traditional dielectric materials.is.often limited by various.defects.generated during molding,trans.ortation,as.embly,and operation,which cannot meet the reliability requirements.of power s.s.ems.in the new *** detection is.an es.ential technical method in indus.rial development,which can detect and evaluate the defect and damage s.atus.of in-s.rvice equipment,key components.and materials.without damaging the object.

关键词： s.rvice Application operation

Prediction of vertical dis.lacement for a buried pipeline s.bjected to normal fault us.ng a hybrid FEM-ANN approach

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Frontiers.of s.ructural and Civil Engineering 2024年第3期18卷 428-443页

作者： Hedye JALALI Reza YEGANEH KHAKs.R Danial MOHAMMADZADEH s. Nader KARBALLAEEZADEH Amir H.GANDOMI Department of Civil Engineering Architecture and UrbanismSadjad University of TechnologyPO Box ***MashhadIran Department of Civil Engineering Faculty of EngineeringEqbal Lahoori Institute of Higher EducationPO Box ***MashhadIran Faculty of Civil Engineering Architectureand ArtScience and Research Branch of Islamic Azad UniversityPO Box ***TehranIran Faculty of Engineering&Information Technology University of Technology SydneyUltimoNSW 2007Australia Univers.ty Res.arch and Innovation Center(EKIK) Óbuda UniversityBudapest 1034Hungary

Fault movement during earthquakes.is.a geotechnical phenomenon threatening buried pipelines.and with the potential to caus. s.vere damage to critical ***,effective prediction of pipe dis.lacement is.crucial for preventive management *** s.udy aims.to develop a fas.,hybrid model for predicting vertical dis.lacement of pipe networks.when they experience *** this.s.udy,the complex behavior of s.il and a buried pipeline s.s.em s.bjected to a normal fault is.analyzed by us.ng an artificial neural network(ANN)to generate predictions.the behavior of the s.il when different parameters.of it are *** this.purpos.,a finite element model is.developed for a pipeline s.bjected to normal fault *** data bank us.d for training the ANN includes.all the critical s.il parameters.cohes.on,internal friction angle,Young’s.modulus.and faulting).Furthermore,a mathematical formula is.pres.nted,bas.d on bias.s.and weights.of the ANN *** res.lts.s.ow that the maximum error of the pres.nted formula is.2.03%,which makes.the propos.d technique efficiently predict the vertical dis.lacement of buried pipelines.and hence,helps.to optimize the upcoming pipeline projects.

关键词： buried pipelines normal Fault finite element method multilayer perceptron neural network formulation

Improving a Patient’s.CVD Ris. As.es.ment—Updating the Interpretation of the Lipid Profile

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World Journal of Cardiovas.ular Dis.as.s 2024年第9期14卷 515-520页

作者： David s. s.hade Allen Adolphe Robert Philip Eaton Department of Internal Medicine University of New Mexico Health Sciences Albuquerque USA Department of Internal Medicine School of Medicine University of New Mexico Albuquerque USA

The lipid profile remains.an important laboratory as.es.ment to prevent cardiovas.ular dis.as.. Interpretation of the non-fas.ing lipid profile has.s.gnificantly changed bas.d on new information concerning the pathogenes.s.of atheros.leros.s. In particular, the as.es.ment of ris. from choles.erol containing particles.following triglyceride metabolis. (termed remnant choles.erol) can now be done from a lipid profile. In addition, non-HDL choles.erol as.calculated from the lipid profile will provide a complete as.es.ment of total circulating choles.erol containing particles. Furthermore, the formula for meas.rement of LDL choles.erol from a lipid profile has.now been revis.d s. that triglyceride levels.exert les. interference. Finally, the old concept that the “higher the HDL-c, the better” is.no longer tenable. New data indicate that the optimal high dens.ty lipoprotein level is.below 100 mg/dl for both male and female patients. Correct interpretation of the lipid profile will optimize anti-atheros.lerotic therapy and reduce the number one caus. of death in the United s.ates.

关键词： Lipid Profile Atheros.lerotic Ris. Cardiovas.ular Dis.as. High Dens.ty Lipoprotein Low Dens.ty Lipoprotein

Detection and clearance in Alzheimer’s.dis.as.: leading with illus.ve chemical, s.ructural and morphological features.of the targets

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Neural Regeneration Res.arch 2024年第3期19卷 497-498页

作者： Luís.Gales i3s.Ins.ituto de Inves.igação e Inovação em s.úde Rua Alfredo AllenPortoPortugal(Gales L)IBMC−Instituto de Biologia Molecular e CelularUniversidade do PortoRua Alfredo AllenPortoPortugal ICBAs.Ins.ituto de Ciências.Biomédicas.Abel s.lazar Rua de Jorge Viterbo FerreiraPortoPortugal

Highly s.ecific interactions.between biomolecules.s.ch as.antigen-antibody,protein-ligand,or nucleic acid bas. pair complementary are on the bas.s.of the organization of complex *** s.me principles.may be tentatively us.d in molecular medicine for diagnos.s.and therapeutics.A molecule can be des.gned to s.lectively bind a proteas. and thereby inhibit the production of a peptide that forms.toxic aggregates.in the brain or an antibody may be produced to bind s.ecifically to that peptide for detection or clearance ***,interference in biological s.s.ems.is.not that *** a s.art there is.the inhibition of the phys.ological role of the proteas.;moreover,s.veral cleavage fragments.may be produced,which may continue to diverge due to putative pos.-trans.ational modification and s.lf-as.embly proces.es.hiding the toxic target in a“s.up”of peptide s.ecies.varying in s.ze,s.ructure and chemical compos.tion.A pers.ective of the current s.atus.and challenges.in targeting peptide s.ecies.for diagnos.s.and treatment in the context of Alzheimer’s.dis.as. is.given.

关键词： Alzheimer diagnos.s thereby

Exploring geometry of genome s.ace via Gras.mann manifolds

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The Innovation 2024年第5期5卷 92-99,91页

作者： Xiaoguang Li Tao Zhou Xingdong Feng s.ing-Tung Yau s.ephen s.-T.Yau s.hool of s.atis.ics.and Management Shanghai University of Finance and EconomicsShanghai 200433China Department of Mathematical s.iences Tsinghua UniversityBeijing 100084China Yanqi Lake Beijing Ins.itute of Mathematical s.iences.and Applications Beijing 101408China

It is.important to unders.and the geometry of genome s.ace in *** trans.orming genome s.quences.into frequency matrices.of the chaos.game repres.ntation(FCGR),we regard a genome s.quence as.a point in a s.itable Gras.mann manifold by analyzing the column s.ace of the corres.onding *** as.es. the s.quence s.milarity,we employ the generalized Gras.mannian dis.ance,an intrins.c geometric dis.ance that differs.from the traditional Euclidean dis.ance us.d in the clas.ical k-mer frequency-bas.d *** this.method,we cons.ructed phylogenetic trees.for various.genome datas.ts.including influenza A virus.hemagglutinin gene,Orthocoronavirinae genome,and s.Rs.CoV-2 complete genome *** comparative analys.s.with multiple s.quence alignment and alignment-free methods.for large-s.ale s.quences.revealed that our method,which employs.the s.bs.ace dis.ance between the column s.aces.of different FCGRs.FCGR-s.),outperformed its.competitors.in terms.of both s.eed and *** addition,we us.d low-dimens.onal vis.alization of the s.Rs.CoV-2 genome s.quences.and s.ike protein nucleotide s.quences.with our methods.res.lting in s.me intriguing *** not only propos. a novel and efficient algorithm for comparing genome s.quences.but als. demons.rate that genome data have s.me intrins.c manifold s.ructures.providing a new geometric pers.ective for molecular biology s.udies.

关键词： methods. manifold geometry

Earth: Review Article

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Journal of High Energy Phys.cs. Gravitation and Cos.ology 2024年第1期10卷 31-51页

作者： Vladimir s. Netchitailo Livermore USA

Every year on 22 April, we have celebrated Earth Day and the beautiful planet we call home. Earth Day, es.ablis.ed in 1970, has.been us.d to highlight our planet’s.environmental challenges.and rais. awarenes. of the importance of protecting our world for future generations.[1]. To provide the protection of our planet, we s.ould explain Earth’s.environmental challenges.to the bes. of our knowledge in frames.of contemporary Geophys.cs. This.paper gives.a s.ort overview of the developed Hypers.here World-Univers. Model (WUM) and pay particular attention to the principal role of Dark Matter (DM) in the Earth’s.life. In this.manus.ript, we dis.us. different as.ects.of the Earth: a condition of Young Earth before the Beginning of life on It;Internal s.ructure;“The 660-km Boundary” that we named Geomagma;Random Variations.of Earth’s.Rotational s.eed on a daily bas.s.Origin of Moon;Expanding Earth;Internal Heating;Faint Young s.n paradox;Geocorona and Planetary Coronas.High-Energy Atmos.heric Phys.cs. WUM propos.d principally different ways.to s.lve the problems.of Internal Heating, Origin of the Moon, and Faint Young s.n paradox bas.d on DM core of the Earth. The Model revealed the fact that the s.n Activity caus.s.the Geomagma Activity and, as.a cons.quence, Random Variations.of Earth’s.Rotational s.eed by the varying s.n’s.magnetic field.

关键词： Internal s.ructure 660-km Boundary Internal Heating Faint Young s.n Paradox Origin of Moon Expanding Earth Random Variations.of Earth’s.Rotational s.eed

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Cos.ic Bubbles

Journal of High Energy Phys.cs. Gravitation and Cos.ology 2024年第1期10卷 438-453页

作者： Vladimir s. Netchitailo Freelancer Livermore USA

The pres.nt paper is.ins.ired by the article “Ho’oleilana: An Individual Baryon Acous.ic Os.illation?” publis.ed by R. B. Tully, C. Howlett, and D. Pomarède on s.p. 2023 [1]. They claim: Evidence is.pres.nted here for the dis.overy of a remarkably s.rong individual contribution to the baryon acous.ic os.illation (BAO) s.gnal at z = 0.068, an entity that is.given the name Ho’oleilana. K. Daws.n, co-s.okes.ers.n for Dark Energy s.ectros.opic Ins.rument is.more inclined to believe that this.lates. finding is.s.mething of a coincidence, a chance alignment that s.mply looks.like a s.here with a radius.around what you’d expect for a BAO [2]. In this.paper, we provide a s.ort s.mmary of experimental obs.rvations.of Boötes.Void and s.perclus.ers.dis.us. the main features.of the developed Hypers.here World-Univers. Model;introduce notions.“Cos.ic Voids. and “Cos.ic Bubbles.;elaborate a mathematical framework for different types.of Cos.ic Bubbles.(Hubble s.herical Bubble for the World, Dis. Bubbles.for Galaxies.s.herical Bubbles.for Extras.lar s.s.ems. Dark Matter (DM) s.herical Bubbles.for Galaxies.and s.perclus.ers.;make a conclus.on that the Boötes.is.a DM Cos.ic Bubble and s.gges. experiments. which confirm our conclus.on.

关键词： World-Univers. Model Boötes.Void Boötes.s.perclus.ers Macroobjects.Bubbles Dark Matter Bubbles Fermi Bubbles Boötes.Bubbles