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坏死性凋亡分子机制及与牙周炎的相关性

中国组织工程研究 2025年第12期29卷 2569-2574页

作者：孙欢欢赵菲陶然刘冰河北医科大学口腔医学院·口腔医院河北省口腔医学重点实验室河北省口腔疾病临床医学研究中心河北省石家庄市050017

背景:近年来,随着细胞死亡研究的不断深入,坏死性凋亡逐渐成为学术界研究的热点和难点,其多种信号通路及蛋白在牙周炎的发生发展中起到不可忽视的作用,人们试图通过阻止细胞坏死性凋亡的发生,从而延缓牙周组织炎症的进程。目的:就坏死... 详细信息

背景:近年来,随着细胞死亡研究的不断深入,坏死性凋亡逐渐成为学术界研究的热点和难点,其多种信号通路及蛋白在牙周炎的发生发展中起到不可忽视的作用,人们试图通过阻止细胞坏死性凋亡的发生,从而延缓牙周组织炎症的进程。目的:就坏死性凋亡的分子机制及其与牙周炎的相关性进行综述,期望为牙周炎的预防、诊断、治疗及预后提供新思路、新方向。方法:第一作者于2023年10月应用计算机检索PubMed、中国知网等数据库建库到2024年4月发表的相关文献,以“坏死性凋亡,细胞程序性死亡,牙周炎,牙周,免疫,炎症,受体相互作用蛋白激酶1,受体相互作用蛋白激酶3,混合系列蛋白激酶样结构域”为中文检索词;“necroptosis,programmed cell death,periodontitis,periodontal,immunity,inflammation,RIP1,RIP3,MLKL”为英文检索词,阅读每篇文献的文题、摘要、引言进行初步筛选,最终纳入56篇文献进行总结分析。结果与结论:①牙周炎的主要发病机制为牙周致病菌刺激机体,导致牙周微环境发生改变,打破原有免疫平衡并释放各种炎症因子,引发炎症反应造成牙周组织破坏,坏死性凋亡可以调控牙周组织免疫炎症反应,从而影响牙周炎的发生发展进程;②坏死性凋亡的发生与多种蛋白、信号通路及信号分子有关,已有动物实验证实了磷酸化混合系列蛋白激酶样结构域(pMLKL)的表达量与炎症程度有关,且在患有牙周炎小鼠的牙周组织中,RIP3和pMLKL高表达,通过阻断RIP3/MLKL通路,有利于减少牙周组织炎症、控制牙周炎的进展;③探究pMLKL是否可作为牙周炎的诊断指标,在牙周炎的预防、诊断及治疗上有很大价值。

关键词：坏死性凋亡牙周炎炎症免疫细胞程序性死亡损伤相关分子模式 MLKL RIP3

Dynamic clustering of distributed source coding in wireless sensor networks

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The Journal of China Universities of Posts and Telecommunications 2009年第1期16卷 22-26页

作者： liu bing Information Security Department Beijing Electronic Science and Technology Institute Beijing 100070 China

There are correlations of data in adjacent sensor nodes in wireless sensor networks （WSNs）. Distributed source coamg （DSC） is an idea to improve the energy efficiency in WSNs by compressing the sensor data with correlations to others, When utilizing the DSC, the network architecture that, deciding which nodes to transmit the side information and which nodes to compress according to the correlations, influences the compression efficiency significantly. Comparing with former schemes that have no adaptations, a dynamic clustering scheme is presented in this article, with which the network is partitioned to clusters adaptive to the topology and the degree of correlations. The simulation indicates that the proposed scheme has higher efficiency than static clustering schemes.

关键词： WSNs DSC clustering

On the surface brightness radial profile of the extendedγ-ray sources

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Science China(Physics,Mechanics & Astronomy) 2022年第1期65卷 84-91页

作者： Rui-Zhi Yang bing liu Department of Astronomy School of Physical SciencesUniversity of Science and Technology of ChinaHefei 230026China CAS Key Labrotory for Research in Galaxies and Cosmology University of Science and Technology of ChinaHefei 230026China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China Key Laboratory of Modern Astronomy and Astrophysics(Nanjing University) Ministry of EducationNanjing 210093China

The morphology of the extendedγ-ray source is governed by the propagation process of parent relativistic *** this paper,we investigate the surface brightness radial profile of extendedγ-ray sources illuminated by cosmic ray protons and electrons,considering the radiation mechanisms,projection effects,and the response of *** find that the parent particle species and the propagation process can cause considerable differences in the observed radial ***,the surface brightness profile can be used as a unique tool to identify the radiation mechanism and the propagation process of the parent *** addition,we also discuss the possible implications regarding the latest discoveries from very/ultra-high energyγ-ray instruments like LHAASO and HAWC.

关键词： cosmic rays γ-ray sources diffuse emission

Existence and uniqueness of periodic solutions for forced Liénard-type equations

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Applied Mathematics(A Journal of Chinese Universities) 2008年第3期23卷 295-302页

作者： liu bing-wen College of Math. and Inform. Eng. Jiaxing Univ. Jiaxing 314001 China

By using topological degree theory and some analysis skill, some sufficient conditions for the existence and uniqueness of periodic solutions for a class of forced Lienard-type equations are obtained.

关键词： periodic solution Lienard equation topological degree

Algorithm design and the development of a discrete element method for simulating particulate flow and heat transfer

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Clean Energy 2021年第2期5卷 141-166页

作者： bing liu National Institute of Clean-and-Low-Carbon Energy CHN Energy InvestmentBeijing 102211P.R.China

An algorithm using the discrete element method(DEM)for simulating the particulate behaviour of flow and heat transfer is developed and described,the reasonable hypothesis and the ingenious design of which have been presented in *** organizational structure of the developed algorithm contains an efficient method for determining particle collisions,the status analysis for each particle and the particulate-kinematics analysis during the time *** reasonability and correctness of the developed DEM algorithm are validated by laboratory experiments:the discharge process of glass beads from a silo;and heating of metal alloy particles in a ***,a group of validated mechanics parameter values for coal and sand have been tested and verified in the article,preparing for the simulation of the pyrolysis process in a downer or screw reactor in subsequent research projects.

关键词： DEM algorithm particulate flow solid mechanics heat-transfer model

Structural optimization of baffle internals for fast particle pyrolysis in a downer reactor using the discrete element method

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Clean Energy 2021年第2期5卷 167-179页

作者： bing liu National Institute of Clean-and-Low-Carbon Energy CHN Energy InvestmentBeijing 102211P.R.China

The structural optimization of baffle internals for fast pyrolysis of coal with particulate mixing and heat transfer in a downer reactor using the discrete element method(DEM)has been investigated in this *** pyrolysis terminal temperature at the exit of the downer reactor is not only decided by the volume-feeding-rate ratio of the coal to the sand,but also is affected by the inner structural design of the baffle internals in the downer *** presented in the previous publication of the author,the inhibition from the baffle internals in a downer reactor can improve the particulate-mixing degree and heat carrier,and increase the mean residence time of the coal and heat-carrier particles in the downer *** structure of the baffle internals in the downer reactor mentioned in this research can be optimized by the independently developed 3D soft-sphere model of the DEM programme of a 40-mm baffle length,a 30°baffle-slope angle and at least four baffles designed in the downer reactor,which is beneficial for the process design of coal pyrolysis with a heat carrier in the downer reactor.

关键词： structural optimization baffle internals downer reactor DEM coal pyrolysis

Biological Properties of Chitosan Films with Different Degree of Deacetylation

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Journal of Materials Science & Technology 2008年第5期24卷 700-708页

作者： Jing CHANG Wanshun liu Baoqin HAN bing liu Department of Marine Life Science Ocean University of China Qingdao 266003 China

Chitin and chitosan films were prepared by solution casting method. Chitosan specimens used in this study were deacetylated by 50.4%, 69.2%, 85.5% and 96.3%. Their water content, protein adhesion ability, cytocompatibility, cell adhesion ability, in vitro and vivo degradability and biocompatibility were evaluated. Results indicated that with the degree of deacetylation （DD） between 50% and 70%, the chitosan showed higher water content. The higher the DD, the stronger protein adhesion ability the chitosan had. All the films have good cytocompatibility and the films with higher DD have better cell adhesion ability. Chitin films degraded more rapidly than others, which disappeared in 2 to 4 weeks after they were implanted in subcutaneous tissue and musculature. Their inflammatory reaction became weaker as the films degraded. As the DD got higher, the films degraded slower. The films of DD 85.5% and DD 90.3% even didn＇t disappeared in 12 weeks after they were implanted. Their inflammatory reaction was mild at the beginning of degradation, and became severe in 4 to 8 weeks, then weaken at last. This basic result can be very helpful for tissue engineering.

关键词： Chitosan Degree of deacetylation Biodegradability Cytocompatibility Celladhesion ability Biocompatibility

Regulation of solvation structure and the cooperation environment of potassium bonds for wider-temperature adaptive potassium storage

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Rare Metals 2024年第4期43卷 1610-1621页

作者： bing-bing liu Yi-Hui liu You-Bin Zhang Zhen-Guo Qi Guo-Hui Qin State Key Laboratory Base for Eco-Chemical Engineering College of Chemical EngineeringQingdao University of Science and TechnologyQingdao266042China Shandong Synergetic Innovation Center of Ecological and Chemical Engineering Qingdao266042China

Antimony selenide(Sb_(2)Se_(3))is one of the perspective candidates for potassium-ion batteries due to its advanced virtues stem including featured high capacity,fertile reserves and the relative narrow band *** the unique advantages,it is still plagued by the unstable interface compatibility and poor wider-temperature *** optimization of microstructure and the construction of inorganic-organic hybrids with a low desolvation barrier and rapid kinetics behaviors are efficient to address these *** Sb_(2)Se_(3)nanorods enclosed by the S-doped carbon layer(SC),further crosslinked by the poly(N-isopropylacrylamide)(PM)film(PM@Sb_(2)Se_(3)@SC),were artificially fabricated,and it displays the enrichment ion aggregated model as well as contacted ion pair state,the well-tailored cooperation environment of potassium bonds,assuring a homogeneous potassium deposition and an excellent widertemperature *** complicated experimental studies and theoretical calculations authenticate the synergistic effects of geometric conformation and compositional design for the tremendously enhanced potassium ***,the full device over PM@Sb_(2)Se_(3)@SC anode and the potassium Prussian blue cathode manifests impressively durable cycling life and wider-temperature adaptability,verifying the glorious contribution from the finely manipulation in solvation structure and potassium bonds to enhancing the potassium storage behaviors.

关键词： Anode Sb_(2)Se_(3) rods Interface compatibility Inorganic-organic electrode Potassium ion battery

A review of TRISO-coated particle nuclear fuel performance models

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Rare Metals 2006年第Z1期25卷 337-342页

作者： liu bing LIANG Tongxiang TANG Chunhe Institute of Nuclear and New Energy Technology Tsinghua University Beijing 100084 China Institute of Nuclear and New Energy Technology Tsinghua University Beijing 100084 China Institute of Nuclear and New Energy Technology Tsinghua University Beijing 100084 China

The success of high temperature gas cooled reactor depends upon the safety and quality of the coated particle fuel. The understanding and evaluation of this fuel requires the development of an integrated mechanistic fuel performance model that fully describes the mechanical and physicochemical behavior of the fuel particle under irradiation. In this paper, a review of the analytical capability of some of the existing computer codes for coated particle fuel was performed. These existing models and codes include FZJ model, JAERI model, Stress3 model, ATLAS model, PARFUME model and TIMCOAT model. The theoretic model, methodology, calculation parameters and benchmark of these codes were classified. Based on the failure mechanism of coated particle, the advantage and limits of the models were compared and discussed. The calculated results of the coated particles for China HTR-10 by using some existing code are shown. Finally, problems and challenges in fuel performance modeling were listed.

关键词： high temperature gas cooled reactor coated fuel particle model