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Enhanced Precision Therapy of Multiple Myeloma Through Engineered biomimetic Nanoparticles with Dual Targeting

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Engineering 2024年第5期36卷 178-192页

作者： Ruogu Qi Shanshan Wang Jiayi Yu Tianming Lu Zhiqiang bi Weibo Liu yuanyuan Guo Yong bian Jianliang Shen Xuesong Zhang Wenhao Hu School of Medicine Nanjing University of Chinese MedicineNanjing 210023China Laboratory Animal Center Nanjing University of Chinese MedicineNanjing 210023China Key Laboratory of Carcinogenesis and Translational Research Ministry of Education/BeijingDepartment of Radiation OncologyBeijing Cancer HospitalBeijing 100142China Department of Orthopedics The Fourth Medical CenterThe Chinese People’s Liberation Army General HospitalBeijing 100853China State Key Laboratory of Ophthalmology Optometry and Vision ScienceSchool of Biomedical EngineeringWenzhou Medical UniversityWenzhou 325027China

Multiple myeloma(MM)is the second most prevalent hematological *** MM treatment strategies are hampered by systemic toxicity and suboptimal therapeutic *** study addressed these limitations through the development of a potent MM-targeting chemotherapy strategy,which capitalized on the high binding affinity of alendronate for hydroxyapatite in the bone matrix and the homologous targeting of myeloma cell membranes,termed T-PB@*** results from our investigations highlight the considerable bone affinity of T-PB@M,both in vitro and in ***,this material demonstrated a capability for drug release triggered by low pH ***,T-PB@M induced the generation of reactive oxygen species and triggered cell apoptosis through the poly(ADP-ribose)polymerase 1(PARP1)-Caspase-3-B-cell lymphoma-2(Bcl-2)pathway in MM ***,T-PB@M preferentially targeted bone-involved sites,thereby circumventing systemic toxic side effects and leading to prolonged survival of MM orthotopic ***,this designed target-MM nanocarrier presents a promising and potentially effective platform for the precise treatment of MM.

关键词： Multiple myeloma Bortezomib Drug delivery Dual targeting Controlled release

Enhancing efficiency and stability of organic solar cells through a simplified four-step synthesis of fully non-fused ring electron acceptor

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Journal of Energy Chemistry 2024年第6期93卷 601-608,I0015页

作者： Chenyang Han Huanhuan Gao Yanna Sun yuanyuan Kan Zhaozhao bi Wei Ma Yani Zhang Juan Antonio Zapien Yingguo Yang Ke Gao College of New Energy Xi’an Shiyou UniversityXi’an 710065ShaanxiChina Shandong Provincial Key Laboratory for Science of Material Creation and Energy Conversion Institute of Frontier ChemistrySchool of Chemistry and Chemical EngineeringShandong UniversityQingdao 266237ShandongChina State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an 710049ShaanxiChina Department of Materials Science and Engineering City University of Hong KongKowloonHong Kong 99907China School of Microelectronics Fudan UniversityShanghai 200433China

Design and synthesis of superior cost-effective non-fullerene acceptors(NFAs)are still big challenges for facilitating the commercialization of organic solar cells(OSCs),yet to be ***,two medium bandgap fully non-fused ring electron acceptors(NFREAs,medium bandgap,i,e.,1,3-1,8 eV),namely PTR-2Cl and PTR-4Cl are synthesized with only four steps by using intramolecular noncovalent interaction central core,structured alkyl side chain orientation linking units and flanking with different electron-withdrawing end *** them,PTR-4C1 exhibits increased average electrostatic potential(ESP)difference with polymer donor,enhanced crystallinity and compactπ-πstacking compared with the control molecule *** a result,the PTR-4Cl-based OSC achieved an impressive power conversion efficiency(PCE)of 14.72%,with a much higher open-circuit voltage(V_(OC))of 0.953 V and significantly improved fill factor(FF)of 0.758,demonstrating one of the best acceptor material in the top-performing fully NFREA-based OSCs with both high PCE and V_(OC).Notably,PTR-4Cl-based cells maintain a good T_80lifetime of its initial PCE after over 936 h under a continuous thermal annealing treatment and over1300 h T_(80)lifetime without *** work provides a cost-effective design strategy for NFREAs on obtaining high V_(OC),efficient exciton dissociation,and ordered molecular packing and thus high-efficiency and stable OSCs.

关键词： Organic solar cells Fully non-fused ring acceptors End group engineering Morphology regulation High efficiency

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印度的语言政策与族群关系

思想战线 2021年第2期47卷 12-20页

作者：肖宪毕媛媛云南大学国际关系研究院云南昆明650091 云南大学国际合作与交流处

语言在民族身份认同中具有识别、构建和强化的作用,对民族国家往往具有统一和分裂的双重作用。当代印度独特的语言问题和语言政策对其国内的族群关系产生了深远影响。英属印度时期,英国殖民者力图通过语言霸权达到同化印度的目的,但却... 详细信息

语言在民族身份认同中具有识别、构建和强化的作用,对民族国家往往具有统一和分裂的双重作用。当代印度独特的语言问题和语言政策对其国内的族群关系产生了深远影响。英属印度时期,英国殖民者力图通过语言霸权达到同化印度的目的,但却催生了现代印度民族主义。印度独立后的国家语言规划面临极大的挑战;建国初期推行的印地语国语化政策加剧了国内的民族冲突;原殖民语言——英语地位的恢复起到了平衡内部族群冲突、维护国家统一的作用;“三语模式”的确立体现了国家语言政策对复杂民族关系的再一次妥协。在全球化与本土化两股潮流的冲击下,印度的语言政策和族群关系仍将面临严峻考验。

关键词：印度语言政策国家认同族群关系

解构与回归:20世纪90年代文化守成主义思潮的两种倾向——以《叔叔的故事》和《白鹿原》为例

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商丘师范学院学报 2013年第11期29卷 89-94页

作者：毕媛媛厦门大学中文系福建厦门361005

20世纪90年代以降,中国文坛掀起了一股复杂多元又影响甚广的文化守成主义思潮,该思潮又反过来影响文学创作,体现在向传统回归和对启蒙解构两个维度上。从两部具有代表性的作品《叔叔的故事》和《白鹿原》即可以看出"解构"和"回归"是如... 详细信息

20世纪90年代以降,中国文坛掀起了一股复杂多元又影响甚广的文化守成主义思潮,该思潮又反过来影响文学创作,体现在向传统回归和对启蒙解构两个维度上。从两部具有代表性的作品《叔叔的故事》和《白鹿原》即可以看出"解构"和"回归"是如何成为90年代文化守成主义思潮关键词的。

关键词：文化守成主义解构回归思想转型

INVESTIGATION ON THE CATALYTIC ACTIVITY OF biS-QUATERNARY AMMONIUM PEROXOTUNGSTATES （PEROXOMOLYBDATES） IN THE OXIDATION OF ALCOHOL USING H2O2 AS OXIDANT

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INVESTIGATION ON THE CATALYTIC ACTIVITY OF BIS-QUATERNARY AM...

老年冠心病患者联合采用冠脉造影与动态心电图监测诊断的临床意义

40th IUPAC Congress

作者： Xianying Shi Junfa Wei yuanyuan bi and Jie Hu School of Chemistry and Material Science Shaanxi Normal University Xi’an 710062 China

来源： cnki会议评论

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cnki会议

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中国社区医师 2017年第10期33卷 105-106页

作者：闭媛媛广西壮族自治区江滨医院心电图科 530000

目的:探讨联合采用冠脉造影与动态心电图监测诊断老年冠心病的临床价值。方法:收治老年冠心病患者60例,均采用冠脉造影与动态心电图联合诊断,分析诊断结果。结果:60例患者中,冠脉造影检测50例阳性,10例阴性;心电图诊断42例阳性,18例阴... 详细信息

目的:探讨联合采用冠脉造影与动态心电图监测诊断老年冠心病的临床价值。方法:收治老年冠心病患者60例,均采用冠脉造影与动态心电图联合诊断,分析诊断结果。结果:60例患者中,冠脉造影检测50例阳性,10例阴性;心电图诊断42例阳性,18例阴性。结论:联合采用冠脉造影与动态心电图监测诊断老年冠心病患者的价值要优于单用某种诊断方法。

关键词：老年冠心病冠脉造影动态心电图

Tildrakizumab for moderate-to-severe plaque psoriasis in Chinese patients:A 12-week randomized placebo-controlled phase III trial with long-term extension

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Chinese Medical Journal 2024年第10期137卷 1190-1198页

作者： Chen Yu Songmei Geng bin Yang Yunhua Deng Fuqiu Li Xiaojing Kang Mingye bi Furen Zhang Yi Zhao Weili Pan Zhongwei Tian Jinhua Xu Zhenghua Zhang Nan Yu Xinsuo Duan Shuping Guo Qing Sun Weiquan Li Juan Tao Zhijun Liu yuanyuan Yin Gang Wang Department of Dermatology Xijing HospitalThe Fourth Military Medical UniversityXi’anShaanxi 710032China Department of Dermatology The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi 710004China Department of Dermatology Dermatology Hospital of Southern Medical UniversityGuangzhouGuangdong 510091China Department of Dermatology Tongji HospitalHuazhong University of Science and TechnologyWuhanHubei 430030China Department of Dermatology The Second Hospital of Jilin UniversityChangchunJilin 130041China Department of Dermatology People’s Hospital of Xinjiang Uygur Autonomous RegionUrumqiXinjiang 830001China Department of Dermatology Wuxi People’s Hospital of Wuxi CityWuxiJiangsu 214023China Department of Dermatology Shandong Provincial Hospital for Skin Diseases&Shandong Provincial Institute of Dermatology and VenereologyShandong First Medical University&Shandong Academy of Medical SciencesJinanShandong 250022China Department of Dermatology Beijing Tsinghua Changgung HospitalBeijing 102218China Department of Dermatology Zhejiang Provincial People’s HospitalHangzhouZhejiang 310014China Department of Dermatology The First Affiliated Hospital of Xinxiang Medical CollegeXinxiangHenan 453100China Department of Dermatology Huashan Hospital Affiliated to Fudan UniversityShanghai 200040China Department of Dermatology General Hospital of Ningxia Medical UniversityYinchuanNingxia 750000China Department of Dermatology Affiliated Hospital of Chengde Medical UniversityChengdeHebei 067000China Department of Dermatology The First Hospital of Shanxi Medical UniversityTaiyuanShanxi 030001China Department of Dermatology Qilu Hospital of Shandong UniversityJinanShandong 250012China Department of Dermatology Yuebei People’s HospitalShaoguanGuangdong 512026China Department of Dermatology Union Hospital Tongji Medical Collage Huazhong University of Science and TechnologyWuhanHubei 430022China Department of Dermatology and Venereal Diseases The First Affiliated Hospit

Background:There is a need for effective and safe therapies for psoriasis that provide sustained *** aim of this study was to assess the efficacy and safety of tildrakizumab,an anti-interleukin-23p19 monoclonal antibody,for treating moderate-to-severe plaque psoriasis in Chinese ***:In this multi-center,double-blind,phase III trial,patients with moderate-to-severe plaque psoriasis were enrolled and randomly assigned(1:1)to receive subcutaneous tildrakizumab 100 mg or placebo at weeks 0 and *** initially assigned to placebo were switched to receive tildrakizumab at weeks 12,16,and every 12 weeks *** in the tildrakizumab group continued with tildrakizumab at week 16,and every 12 weeks until week *** primary endpoint was the Psoriasis Area and Severity Index(PASI 75)response rate at week ***:At week 12,tildrakizumab demonstrated significantly higher PASI 75 response rates(66.4%[73/110]vs.12.7%[14/110];difference,51.4%[95%confidence interval(CI),40.72,62.13];P<0.001)and Physician’s Global Assessment(60.9%[67/110]vs.10.0%[11/110];difference,49.1%[95%CI,38.64,59.62];P<0.001)compared to *** 75 response continued to improve over time in both tildrakizumab and placebo-switching to tildrakizumab groups,reaching maximal efficacy after 28 weeks(86.8%[92/106]vs.82.4%[89/108])and maintained up to 52 weeks(91.3%[95/104]vs.87.4%[90/103]).Most treatment-emergent adverse events were mild and not related to ***:Tildrakizumab demonstrated durable efficacy through week 52 and was well tolerated in Chinese patients with moderate-to-severe plaque *** registration:***,NCT05108766.

关键词： Tildrakizumab Interleukin 23 Plaque psoriasis Chinese Randomized controlled trial

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R波递增不良诊断前壁心肌梗死价值研究

临床心电学杂志 2016年第1期25卷 17-19页

作者：闭媛媛林松广西壮族自治区江滨医院 530021 广西医科大学第一附属医院 530021

目的研究心电图R波递增不良在临床对前壁心肌梗死的临床诊断价值。方法研究时间为2008年1月~2014年12月,对象选择为2400例心电图检查中均出现R波递增不良的患者,根据病变的不同将其分为器质性病变组（1400例）和非器质性病变组（1000例... 详细信息

目的研究心电图R波递增不良在临床对前壁心肌梗死的临床诊断价值。方法研究时间为2008年1月~2014年12月,对象选择为2400例心电图检查中均出现R波递增不良的患者,根据病变的不同将其分为器质性病变组（1400例）和非器质性病变组（1000例）,分别在不同的标准下进行前壁心肌梗死的诊断。结果分别参照Wamer、Depace、Zema、Marquette四种常规诊断标准,器质性病变组诊断率平均在30.0%~45.0%,非器质性病变组诊断率平均在3.0%~9.0%,器质性病变组诊断率高于非器质性病变组,组间具有显著统计学差异（p〈0.05）。以超声心动图检查结果为标准,心电图R波递增不良与前壁心肌梗死具有显著相关性（p〈0.01）。结论临床对前壁心肌梗死的诊断标准不一,心电图R波递增不良可对前壁心肌梗死进行诊断,但诊断率不高,在临床使用中具有一定的局限性。

关键词：心电图 R波递增不良前壁心肌梗死

“互联网+”时代餐饮管理人员电子商务素养提升对策

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美食研究 2018年第4期35卷 22-25页

作者：高功步毕缘媛林仁状扬州大学商学院江苏扬州225009 浙江旅游信息中心有限公司浙江杭州310007

自"互联网+"战略提出以来,各行各业加快了"互联网+"融合的步伐。互联网与信息技术的普及,也推动着各行各业电子商务的迅猛发展。面临互联网+电子商务带来的新变化和新机遇,针对当前餐饮管理人员电子商务素养存在的问题,提出了提高互联... 详细信息

自"互联网+"战略提出以来,各行各业加快了"互联网+"融合的步伐。互联网与信息技术的普及,也推动着各行各业电子商务的迅猛发展。面临互联网+电子商务带来的新变化和新机遇,针对当前餐饮管理人员电子商务素养存在的问题,提出了提高互联网驾驭能力,培养混合式技能;提高电子商务技术运用能力,完善生产管理体系;推进线上运营多元化,多渠道扩大宣传效果;提高互联网趋势把握能力,形成信息化建设的长效机制等对策建议。

关键词：互联网+ 餐饮企业企业管理电子商务提升对策