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Sensitivity Analysis of Pollutants and Pattern Factor in a Gas Turbine Model Combustor due to Changes in Stabilizing Jets Characteristics

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Journal of Thermal Science 2022年第5期31卷 1622-1641页

作者： bazdidi-tehrani farzad TEYMOORI Alireza GHIYASI Mehdi School of Mechanical Engineering Iran University of Science and TechnologyTehran16846-13114Iran

In the present paper,a sensitivity analysis of pollutants and pattern factor in a model combustor due to changes in the geometrical characteristics of stabilizing jets has been carried *** exhaust pollutants including NO_(x),CO and soot have been chosen due to their harmful effect on the *** pattern factor has been also considered owing to its impact on turbine *** geometrical characteristics comprise diameter,angle and position of stabilizing ***-Lagrangian approach has been employed to model liquid fuel injection and distribution,breakup and evaporation of *** the analysis of reactive-spray flow characteristics,RANS approach,realizable k-εturbulence model,discrete ordinates radiative heat transfer model and steady flamelet combustion model together with the chemical reaction mechanism of diesel fuel(C_(10)H_(22))have been ***_(x) modeling has been performed via *** analysis is such that by making variations in the problem inputs(diameter,angle and position of jets)in an organized manner,the effects on the outputs(NO_(x),CO,soot and pattern factor)are *** number and order of simulations are predicted by design of experiments and full factorial *** have been analyzed using analysis of *** has been observed that if interactions among the characteristics of jets are considered,it is possible to analyze the exhaust pollutants more *** fact,by using the interactions,it is likely to find a point where all output parameters are *** show that by considering interactions of stabilizing jet characteristics,the maximum values of NO_(x),CO,soot and pattern factor change from 13.927 ppm,11.198%mole fraction,2.877 ppm and 0.043 to 26.233 ppm,14.693%mole fraction,142.357 ppm and 0.060,***,the minimum values change from 5.819 ppm,7.568%mole fraction,0.013 ppm and 0.029 to 6.098 ppm,5.987%mole fraction,0.002 ppm and 0.027,respectively.

关键词： model jet-stabilized combustor liquid fuel injection sensitivity analysis design of experiments pollutants pattern factor

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Hippo-YAP/TAZ signaling in breast cancer:Reciprocal regulation of microRNAs and implications in precision medicine

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Genes & Diseases 2024年第2期11卷 760-771页

作者： farzad Sadri Seyede fatemeh Hosseini Zohreh Rezaei Mohammad Fereidouni Student Research Committee Birjand University of Medical SciencesBirjand ***Iran Tabas School of Nursing Birjand University of Medical SciencesBirjand ***Iran Department of Biology University of Sistan and BaluchestanZahedan ***Iran Cellular and Molecular Research Center Birjand University of Medical SciencesBirjand ***Iran

Breast cancer is a molecularly heterogeneous disease and the most common female *** recent years,therapy approaches have evolved to accommodate molecular diversity,with a focus on more biologically based therapies to minimize negative *** regulate cell fate in human breast cells,the Hippo signaling pathway has been associated with the alpha subtype of estrogen *** pathway regulates tissue size,regeneration,and healing,as well as the survival of tissue-specific stem cells,proliferation,and apoptosis in a variety of organs,allowing for cell *** signaling is mediated by the kinases MST1,MST2,LATS1,and LATS2,as well as the adaptor proteins SAV1 and *** kinases phosphorylate the downstream effectors of the Hippo pathway,yes-associated protein(YAP),and transcriptional coactivator with PDZ-binding motif(TAZ),suppressing the expression of their downstream target *** Hippo signaling pathway kinase cascade plays a significant role in all *** the principles of this kinase cascade would prevent the occurrence of breast *** recent years,small noncoding RNAs,or microRNAs,have been implicated in the development of several malignancies,including breast *** interconnections between miRNAs and Hippo signaling pathway core proteins in the breast,on the other hand,remain poorly *** this review,we focused on highlighting the Hippo signaling system,its key parts,its importance in breast cancer,and its regulation by miRNAs and other related pathways.

关键词： Breast cancer Hippo signaling Large tumor suppressor kinase 1 microRNAs PDZ-binding motif Yes-associated protein

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Cellulose-MXene composites: New platforms with outstanding multifunctional characteristics

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Journal of Bioresources and Bioproducts 2024年第3期9卷 243-245页

作者： farzad Seidi Wensi Jiang Zhaochuan Yu Chao Deng Jiangsu Co-Innovation Center for Efficient Processing and Utilization of Forest Resources and International Innovation Center for Forest Chemicals and Materials Nanjing Forestry UniversityNanjing 210037China Macromolecular Chemistry and Bavarian Polymer Institute University of BayreuthBayreuth 95440Germany

The progress of society has caused a quick rise in the requirement for materials with superior *** composite materials demonstrate exceptional performance due to the synergistic effects resulting from the combination of unique properties exhibited by their constituent *** advantageous characteristic enables these materials to leverage the collective strengths of each component,leading to their outstanding *** leveraging the strengths of each individual component,the shortcomings can be overcome and the strong points can be shared effectively.

关键词： composites MXene composite

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Niosome-encapsulated auraptene reduced the mRNA expression of VEGF-A and PDGFs genes in human retinaderived RPE cell line

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1028-1035页

作者： Akram Vahidi Teymoor Khosravi farzad Dastaviz Mehdi Sheikh Arabi Ayyoob Khosravi Morteza Oladnabi Student Research Committee Golestan University of Medical SciencesGorgan ***Iran Department of Medical Nanotechnology Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Stem Cell Research Center Golestan University of Medical SciencesGorgan ***Iran Department of Molecular Medicine Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Gorgan Congenital Malformations Research Center Golestan University of Medical SciencesGorgan ***Iran

AIM:To evaluate the effect of auraptene(AUR)treatment in forms of free and encapsulated in niosome nanoparticles by investigating the mRNA expression level of vascular endothelium growth factor(VEGF)-A and platelet-derived growth factors(PDGFs)in human retinal pigment epithelium(RPE)cell ***:Niosome nanocarriers were produced using two surfactants Span 60 and Tween *** cell line was treated with both free AUR and *** dosage of treatments was calculated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)*** of VEGF-A and PDGF-A,PDGF-B,PDGF-C,PDGF-D genes was measured after total RNA extraction and cDNA synthesis,using real-time polymerase chain reaction(RT-PCR).RESULTS:The highest entrapment efficiency(EE)was achieved by Span 60:cholesterol(1:1)with 64.3%.The half maximal inhibitory concentration(IC50)of free and niosome-encapsulated AUR were 38.5 and 27.78µg/mL,*** study revealed that niosomal AUR had more gradual delivery to the ***-PCR results showed reduced expression levels of VEGF-A,PDGF-A,PDGF-B,PDGF-C,and PDGF-D after treatment with both free and niosomal ***:Niosomal formulation of Span 60:cholesterol(1:1)is an effective drug delivery approach to transfer AUR to RPE ***-A,PDGF-A,PDGF-B,PDGF-C,and PDGF-D are four angiogenic factors,inhibiting which by niosomal AUR may be effective in age-related macular degeneration.

关键词： auraptene niosome age-related macular degeneration angiogenesis nanocarrier

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Impact of umbelliprenin-containing niosome nanoparticles on VEGF-A and CTGF genes expression in retinal pigment epithelium cells

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 7-15页

作者： farzad Dastaviz Akram Vahidi Teymoor Khosravi Ayyoob Khosravi Mehdi Sheikh Arabi Abouzar Bagheri Mohsen Rashidi Morteza Oladnabi Stem Cell Research Center Golestan University of Medical SciencesGorgan ***Iran Department of Medical Genetics School of Advanced Technologies in MedicineGolestan University of Medical SciencesGorgan ***Iran Student Research Committee Golestan University of Medical SciencesGorgan ***Iran Department of Molecular Medicine Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Department of Medical Nanotechnology Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Department of Clinical Biochemistry and Genetics Faculty of MedicineMazandaran University of Medical SciencesSari ***Iran Department Pharmacology Faculty of MedicineMazandaran University of Medical SciencesSari ***Iran Gorgan Congenital Malformations Research Center Golestan University of Medical SciencesGorgan ***Iran

AIM:To investigate the impact of niosome nanoparticles carrying umbelliprenin(UMB),an anti-angiogenic and anti-inflammatory plant compound,on the expression of vascular endothelial growth factor(VEGF-A)and connective tissue growth factor(CTGF)genes in a human retinal pigment epithelium(RPE)-like retina-derived cell ***:UMB-containing niosomes were created,optimized,and ***-like cells were treated with free UMB and UMB-containing *** IC_(50)values of the treatments were determined using an MTT *** expression of VEGF-A and CTGF was evaluated using real-time polymerase chain reaction after RNA extraction and cDNA ***’characteristics,including drug entrapment efficiency,size,dispersion index,and zeta potential were *** UMB had an IC_(50)of 96.2μg/mL,while UMB-containing niosomes had an IC_(50)of 25μg/***:Treatment with UMB-containing niosomes and free UMB resulted in a significant reduction in VEGF-A expression compared to control cells(P=0.001).Additionally,UMB-containing niosomes demonstrated a significant reduction in CTGF expression compared to control cells(P=0.05).However,there was no significant reduction in the expression of both genes in cells treated with free ***:Both free UMB and niosome-encapsulated UMB inhibits VEGF-A and CTGF genes ***,the latter demonstrates significantly greater efficacy,potentially due to the lower UMB dosage and gradual *** findings have implications for anti-angiogenesis therapeutic approaches targeting age-related macular degeneration.

关键词： umbelliprenin niosome age-related macular degeneration vascular endothelial growth factor-A connective tissue growth factor

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Late infection after peri-orbital autologous micro-fat graft:a case presentation and literature review

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 603-606页

作者： farzad Pakdel Hassan Asadigandomani Melika Arab Bafrani Zohreh Nozarian Zohre Abedinifar Niloofar Pirmarzdashti Behzad Jafari Zaynab Siami Department of Oculofacial Plastic Surgery Farabi HospitalSchool of MedicineTehran University of Medical SciencesTehran ***Iran Craniomaxillofacial Research Center Tehran University of Medical SciencesTehran ***Iran Department of Ophthalmology School of MedicineTehran University of Medical SciencesTehran ***Iran Department of Pathology Farabi HospitalSchool of MedicineTehran University of Medical SciencesTehran ***Iran Department of Microbiology Farabi HospitalSchool of MedicineTehran University of Medical SciencesTehran ***Iran Pediatric Cell and Gene Therapy Research Center Children’s Medical CenterSchool of MedicineTehran University of Medical SciencesTehran ***Iran

Citation:Pakdel F,Asadigandomani H,Arab Bafrani M,Nozarian Z,Abedinifar Z,Pirmarzdashti N,Jafari B,Siami *** infection after peri-orbital autologous micro-fat graft:a case presentation and literature *** J Ophthalmol ... 详细信息

关键词： graft orbital after

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Development of hybrid optimization algorithm for structures furnished with seismic damper devices using the particle swarm optimization method and gravitational search algorithm

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Earthquake Engineering and Engineering Vibration 2022年第2期21卷 455-474页

作者： Najad Ayyash farzad Hejazi Civil Engineering University Putra MalaysiaSeri Kembangan 43300Malaysia

Previous studies about optimizing earthquake structural energy dissipation systems indicated that most existing techniques employ merely one or a few parameters as design variables in the optimization process,and thereby are only applicable only to simple,single,or multiple degree-of-freedom *** current approaches to optimization procedures take a specific damper with its properties and observe the effect of applying time history data to the building;however,there are many different dampers and isolators that can be ***,there is a lack of studies regarding the optimum location for various viscous and wall *** main aim of this study is hybridization of the particle swarm optimization(PSO) and gravitational search algorithm(GSA) to optimize the performance of earthquake energy dissipation systems(i.e.,damper devices) simultaneously with optimizing the characteristics of the *** types of structural dampers device are considered in this study:(ⅰ) variable stiffness bracing(VSB) system,(ⅱ) rubber wall damper(RWD),(ⅲ) nonlinear conical spring bracing(NCSB) device,(iv) and multi-action stiffener(MAS) *** many parameters may affect the design of seismic resistant structures,this study proposes a hybrid of PSO and GSA to develop a hybrid,multi-objective optimization method to resolve the aforementioned *** characteristics of the above-mentioned damper devices as well as the section size for structural beams and columns are considered as variables for development of the PSO-GSA optimization algorithm to minimize structural seismic response in terms of nodal displacement(in three directions) as well as plastic hinge formation in structural members simultaneously with the weight of the *** that,the optimization algorithm is implemented to identify the best position of the damper device in the structural frame to have the maximum effect and minimize the seismic structure *** examine the performance

关键词： hybrid optimization algorithm structures earthquake seismic damper devices particle swarm optimization method gravitational search algorithm

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Evaluating Simultaneous Impact of Slag and Tire Rubber Powder on Mechanical Characteristics and Durability of Concrete

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Journal of Renewable Materials 2022年第8期10卷 2155-2177页

作者： Mostafa Amiri farzad Hatami Emadaldin Mohammadi Golafshani Department of Civil Engineering Science and Research BranchIslamic Azad UniversityTehranIran Structural and Earthquake Research Center(SERC) Amirkabir University of Technology(Tehran Polytechnic)TehranIran Department of Civil Engineering Monash UniversityMelbourneAustralia

In this experimental study,the impact of Portland cement replacement by ground granulated blast furnace slag(GGBFS)and micronized rubber powder(MRP)on the compressive,flexural,tensile strengths,and rapid chloride migration test(RCMT)of concrete were *** this study,samples with different binder content and water to binder ratios,including the MRP with the substitution levels of 0%,2.5%and 5%,and the GGBFS with the substitution ratios of 0%,20%and 40%by weight of Portland cement were *** to the results,in the samples containing slag and rubber powder in the early ages,on average,a 12.2%decrease in the mechanical characteristics of concrete was observed,nonetheless with raising the age of the samples,the impact of slag on reducing the porosity of concrete lowered the negative impact of rubber *** durability characteristics,the RCMT results of the samples were enhanced by using rubber powder because of its insulation ***,adding slag into the MRP-included mixtures results in a 23%reduction in the migration rate of the chloride ion *** last,four mathematical statements were derived for the mechanical and durability of concrete containing the MRP and GGBFS utilizing the genetic programming method.

关键词： Micronized rubber powder ground granulated blast furnace slag waste materials mechanical properties durability

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Latent Heat Prediction of Nano Enhanced Phase Change Material by ANN Method

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Energy Engineering 2022年第3期119卷 847-861页

作者： farzad Jaliliantabar Rizalman Mamat Sudhakar Kumarasamy College of Engineering Department of Mechanical EngineeringUniversiti Malaysia PahangKuantan26300Malaysia Automotive Engineering Centre Universiti Malaysia PahangPekan26600Malaysia School of Mechanical Engineering Ningxia UniversityNingxia750000China Faculty of Mechanical and Automotive Engineering Technology Universiti Malaysia PahangPekan26600Malaysia Energy Center Maulana Azad National Institute of TechnologyBhopal462003India

Thermal characteristics of phase change material(PCM)are important in design and utilization of thermal energy storage or other *** have great latent heat but suffer from low thermal ***,in recent years,nano particles have been added to PCM to improve their thermophysical properties such as thermal *** of this nano particles on thermophysical properties of PCM has been a question and many experimental and numerical studies have been done to investigate *** intelligence-based approach can be a good candidate to predict thermophysical properties of nano enhance PCM(NEPCM).Then,in this study an artificial neural network(ANN)has been developed to predict the latent heat of the NEPCM.A comprehensive literature search was conducted to acquire thermal characteristics data from various NEPCM to train and test this artificial neural network *** different types of Nano particle and paraffin based PCMs were used in ANN *** most important properties which are used as the input for the developed ANN model are NP size,density of NP,latent heat of PCM,density of PCM,concentration and latent heat of NEPCM in the range of 1-60 nm,100-8960 kg/m^(3),89.69-311 kJ/kg,760 to 1520 kg/m^(3),0.02-20 wt%and 60.72-338.6 kJ/kg,*** output variable was latent heat of *** result indicates that the ANN model can be applied to predict the latent heat of nano enhanced PCM *** correlation coefficient of the created model was *** result shows ability of ANN to predict the latent heat of NEPCM.

关键词： NEPCM ANN latent heat prediction

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Dynamic evaluation of jack-up platform structure under wave, wind, earthquake and tsunami loads

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Journal of Ocean Engineering and Science 2022年第1期7卷 41-57页

作者： Zaid Mohammed Ghazi Imad Shakir Abbood farzad Hejazi Department of Civil Engineering Universiti Putra MalaysiaMalaysia Engineering Affairs Department Sunni Endowment DiwanBaghdadIraq

Nowadays,the demand for using jack-up platforms to carry out a large percentage of deep-water oil and gas exploration is steadily *** response of jack-up platforms to the severe dynamic loads that may be encountered during the structure life is not examined ***,this study attempts to investigate the response of jack-up platforms performance under the effect of dynamic loads due to wave,wind,earthquake and tsunami forces using the finite element method for two models with the lowest and highest hull *** jack-up platform is located in the Gulf of *** ac-celerations are applied to the model in high and moderate seismic *** addition,tsunami waves are applied to the platform in three different directions at 0°,45°and 90°.This study utilised Airy’s linear wave approach to assess the surface elevations and wave *** reference wind velocity is 10 knots at 10 m over the mean water *** indicate that the dynamic response of the structure is affected by the height of the platform and by the increase of the platform hull *** combination of the El-Centro earthquake,dead and live loads provides the major impact on the platform at the lowest(70 m)and highest(85 m)hull *** comparison of all result proves that the jack-up platform hull under high earthquake intensity and tsunami waves with 45°has experienced maximum ***,raising the deck will increase the response of the dynamic load and displacements but will negatively affect the platform.

关键词： Offshore structures Earthquake Dynamic excitation Jack-up platform Tsunami Seismic zone

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