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Folate Metabolism Interferes with Plant Immunity through 1C Methionine Synthase-Directed Genome-wide DNA Methylation Enhancement

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Molecular Plant 2019年第9期12卷 1227-1242页

作者： beatriz Gonzalez Pablo Vera Instituto de Biologia Molecular y Celular de Plantas Universidad Politecnica de Valencia-C.S.I.CCiudad Politecnica de la InnovacionEdificio 8EIngeniero Fausto Elios/n.46022 ValenciaSpain

Plants rely on primary metabolism for flexible adaptation to environmental ***,through a combination of chemical genetics and forward genetic studies in Arabidopsis plants,we identified that the essential folate metabolic pathway exerts a salicylic acid-independent negative control on plant *** of the folate pathway promotes enhanced resistance to Pseudom onas syringae DC3000 via activation of a primed immune state in plants,whereas its implementation results in enhanced *** proteomics analysis using immune-defective mutants identified a methionine synthase(METS1),in charge of the synthesis of Met through the folate-dependent 1C metabolism,acting as a nexus between the folate pathway and plant *** of METS1 represses plant immunity and is accompanied by genome-wide global increase in DNA methylation,revealing that imposing a methylation pressure at the genomic level compromises plant *** together,these results indicate that the folate pathway represents a new layer of complexity in the regulation of plant defense responses.

关键词： folate pathway plant immunity methionine DNA methylation

Evaluating human behaviour during a disaster evacuation process:A literature review

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Journal of Traffic and Transportation Engineering(English Edition) 2023年第4期10卷 485-507页

作者： Elnaz Bakhshian beatriz Martinez-Pastor School of Civil Engineering University College DublinIreland

The frequency of natural and man-made disasters has increased over the past few decades,which has doubled the significance of evacuation planning because it directly affects people’s lives and *** evacuees behave during a disaster and the methodologies to assess their behaviour are vital factors in managing any emergency *** example,during the evacuation of a transportation network,users’amount of information and how they react are imperative to achieve a resilient response to a *** though there are numerous approaches for assessing evacuee behaviour,further research is needed to determine how and when each methodology should be *** paper intends to evaluate and classify the methodologies that have been presented up to date to create a more consistent approach to interpreting human behaviour during an evacuation *** majority of studies focus on how people behave during an evacuation of a building,with less attention paid to how they behave during a transport *** the proposed methodologies in this paper,the virtual reality approach,in individual behaviour,and agent-based models,in crowd behaviour,have more advantages than other ***,a comparison between the proposed approaches is made in the discussion *** output of this study provides the classifications and suggestions for researchers to pick an appropriate approach based on the types of problems,and some direction for future studies are *** reach the research goal,177 papers have been reviewed between 1954 and 2022.

关键词： Evacuation planning Human behaviour Transportation network Route choice behaviour Simulation Pedestrians

Construction of a Quadratic Model for Predicted and Measured Global Solar Radiation in Chile

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Chinese Physics Letters 2007年第1期24卷 291-293页

作者： Ercan YILMAZ beatriz CANCINO Edmundo LOPEZ Department of Physics Mustafa Kemal University 31040 Antakya Turkey Department of Food Engineering Pontificia Universidad Catdlica de Valparaiso Chile Department of Electrical Engineering Pontificia Universidad Cat61ica de Valparaiso Chile

Global solar radiation data for sites in Chile are analysed and presented in a form suitable for their use in engineering. A new model for monthly average data is developed to predict monthly average global radiation with acceptable accuracy by using actinographic data due to scarcing of pyranometer data. Use of the new quadratic model is proposed because of its relatively wider spectrum of values for Angstrom coefficients ao, al, and a2.

关键词： Quadratic Model Global Solar Radiation Chile engineering

Key innovations in ruminant evolution: a paleontological perspective

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Integrative Zoology 2014年第4期9卷 412-433页

作者： Daniel DeMIGUEL beatriz AZANZA Jorge MORALES Catalan Institute of Paleontology Miquel Crusafont Autonomus University of BarcelonaBarcelonaSpain Department of Earth Sciences University of ZaragozaUniversity Research Institute in Environmental SciencesZaragozaSpain Department of Paleobiology National Museum of Natural SciencesMadridSpain

Key innovations are newly acquired structures that permit the performance of a new function and open new adaptive zones,and are,therefore,of paramount significance for understanding the history of the Ruminantia,particularly its diversification through the *** we review and discuss what is known about these evolutionary novelties,with special emphasis on the appearance and evolution of cranial appendages and high-crowned(or hypsodont)*** appendages probably favored the diversification of pecorans by being structures strongly related to sexual selection,whereas the acquisition of hypsodont teeth could have expanded potential dietary breadth and allowed species to extend diets into the grazing range without eliminating browsing as a potential *** analyzed in conjunction with patterns of faunal diversity and in the context of climatic changes,it seems that the overall view that ruminant cranial appendages and hypsodonty may have started responding to increased patterns of seasonality and the opening-up of ecosystems is roughly ***stead,they occurred through several distinct pulses and varied widely among *** review is,to our knowledge,the first to highlight that the evolution of these innovations has been far from constant and uniform through ***,we identify that both a first attempt to increase hypsodonty starting in the early Miocene and a first evolution of antlers and pronghorns were interrupted as a consequence of wide climatic fluctuations in the early-middle Miocene transition.

关键词： Artiodactyla climate change cranial appendages diversity hypsodonty

Testing carbonate chemostratigraphy across differentiated ancient shallow-platform environments(Early Kimmeridgian,S Iberia)

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Geoscience Frontiers 2019年第6期10卷 2203-2218页

作者： Rute Coimbra beatriz Marques Federico Oloriz GeoBioTec Departamento de GeocienciasUniversidade de AveiroPortugal MARE Departamento de Ciencias da TerraUniversidade de CoimbraPortugal Faculdade de Ciencias e Tecnologia Universidade Nova de LisboaPortugal Departamento de Estratigrafia y Palaeontologia Universidad de GranadaSpain

Shallow-platform settings with marked differences in paleoplatform bottom physiography influence the degree of connection with oceanic waters and overall circulation patterns,even when sharing the same palaeoclimatic *** Kimmeridgian shallow-marine settings have been explored to test the sensitivity and reliability of carbonate chemostratigraphy to detect such *** integrated overview of the obtained elemental trends depicted four major facies,shared along specific stratigraphic intervals of both depositional *** obliterated original geochemical signals only throughout the siliciclastics-rich interval,corresponding to the most landward *** the remaining facies,elemental features could be attributed to the differential action of forcing mechanisms operating along the south-Iberian paleomargin during Kimmeridgian *** highest degree of continental influence can be recognized by a strong relationship between Fe and Mn for the most proximal setting,which fades out along the mixed carbonate-fine siliciclastic rhythmic deposition in more open settings.A characteristic geochemical signature of progressively more positiveδ^(13)C values and significantly higher Sr content is identified for the interval dominated by biogenic sponge *** a local response is related to local forcing by upwelling in the surroundings of a coral *** geochemical signature of a hydrothermal origin can be clearly differentiated from the influence of mere terrigenous ***,the decoupling of Fe and Mn along marginal settings is the clue to detecting major events of palaeogeographic *** temporal variations in Mg content along both studied sections are attributed to tectonic activity influencing nearshore/coastal water *** integrating chemostratigraphic information and complementary evidence,the palaeoenvironmental mechanisms promoting differentiated sedimentary records along ancient subtropical,shallow

关键词： Palaeoenvironment Carbonate chemostratigraphy Shallow-water carbonates Diagenesis Kimmeridgian

Stem cell-based approaches: Possible route to hearing restoration?

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World Journal of Stem Cells 2020年第6期12卷 422-437页

作者： María beatriz Durán-Alonso Institute of Biology and Molecular Genetics University of ValladolidValladolid 47003Spain

Disabling hearing loss is the most common sensorineural disability *** affects around 466 million people and its incidence is expected to rise to around 900 million people by 2050,according to World Health Organization *** cases of hearing impairment are due to the degeneration of hair cells(HCs)in the cochlea,mechano-receptors that transduce incoming sound information into electrical signals that are sent to the *** to these cells is mainly caused by exposure to aminoglycoside antibiotics and to some anti-cancer drugs such as cisplatin,loud sounds,age,infections and genetic *** deficits may also result from damage to the spiral ganglion neurons that innervate cochlear *** from what is observed in avian and nonmammalian species,there is no regeneration of missing sensory cell types in the adult mammalian cochlea,what makes hearing loss an irreversible *** review summarizes the research that has been conducted with the aim of developing cell-based strategies that lead to sensory cell replacement in the adult cochlea and,ultimately,to hearing *** main lines of research are discussed,one directed toward the transplantation of exogenous replacement cells into the damaged tissue,and another that aims at reactivating the regenerative potential of putative progenitor cells in the adult inner *** from some of the studies that have been conducted are presented and the advantages and drawbacks of the various approaches discussed.

关键词： Hearing loss Cochlear hair cells Spiral ganglion neurons Cell regeneration Adult stem cells Cell transplantation

P-functionalized carbon nanotubes promote highly stable electrocatalysts based on Fe-phthalocyanines for oxygen reduction: Experimental and computational studies

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Journal of Energy Chemistry 2022年第9期31卷 276-290,I0008页

作者： beatriz Martinez-Sanchez Diego Cazorla-Amors Emilia Morallon Departamento de Quimica Fisica and Instituto Universitario de Materiales de Alicante(IUMA)University of Alicante Ap.99.03080 AlicanteSpain Departamento de Quimica Inorganica and Instituto Universitario de Materiales de Alicante(IUMA) University of AlicanteAp.9903080 AlicanteSpain

Iron(Ⅱ) phthalocyanines(FePc) supported on functionalized nanostructured carbon materials have been studied as electrocatalysts for the oxygen reduction reaction(ORR) in an alkaline medium. Herein, two types of carbon nanotubes(CNTs) have been explored as support, Single-Walled Carbon Nanotubes and Herringbone Carbon Nanotubes(SWCNTs and h CNTs, respectively), both electrochemically modified with ortho-aminophenylphosphonic acid(2APPA), which provides phosphate axial coordinating ligands for the immobilization of FePc molecules. All the catalysts were prepared via a facile incipient wetness impregnation method. Comprehensive experimental analysis together with density functional theory(DFT) calculations has demonstrated both the importance of the five-coordinated Fe macrocycles that favor the interaction between the FePc and the carbon support, as well as the effect of the CNT structure in the ORR. FePc axial coordination provides a better dispersion, leading to higher stability and a favorable electron redistribution that also tunes the ORR performance by lowering the stability of the reaction intermediates. Interestingly, such improvement occurs with a very low content of metal(~1 wt% Fe),which is especially remarkable when h CNT support is employed. This work provides a novel strategy for the development of Fe-containing complexes as precious metal-free catalysts towards the ORR.

关键词： Carbon nanotubes Iron phthalocyanine Oxygen reduction Electrocatalysis Axial ligand

Inflammatory bowel diseases: A disease (s) of modern times? Is incidence still increasing?

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World Journal of Gastroenterology 2008年第36期14卷 5491-5498页

作者： Cristina Saro Gismera beatriz Sicilia Aladrén Service of Digestive Diseases Hospital de Cabuees Gijón Spain Service of Digestive Diseases Alcaiz Hospital Spain

Inflammatory bowel diseases (IBD) are a heterogeneous group of diseases, not always easy to diagnose, even more difficult to classify, and diagnostic criteria are not always uniform. Well done population-based studies are not abundant, and so comparisons among different geographical areas or populations are not always very reliable. In this article, we have reviewed epidemiological studies available on the world’s population while making a critical review of published data.

关键词： Inflammatory bowel diseases Epidemiological Incidence Diagnostic criteria

Conserved Curvature of RNA Polymerase Ⅰ Core Promoter Beyond rRNA Genes: The Case of the Tritryps

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Genomics, Proteomics & Bioinformatics 2015年第6期13卷 355-363页

作者： Pablo Smircich María Ana Duhagon beatriz Garat Molecular Interactions Laboratory School of Sciences University of the Republic Genetics Departament School of Medicine University of the Republic

In trypanosomatids, the RNA polymerase I （RNAPI）-dependent promoters controlling the ribosomal RNA （rRNA） genes have been well identified. Although the RNAPI transcription machinery recognizes the DNA conformation instead of the DNA sequence of promoters, no con- formational study has been reported for these promoters. Here we present the in silico analysis of the intrinsic DNA curvature of the rRNA gene core promoters in Trypanosoma brucei, Trypanosoma cruzi, and Leiskmania major. We found that, in spite of the absence of sequence conservation, these promoters hold conformational properties similar to other eukaryotic rRNA promoters. Our results also indicated that the intrinsic DNA curvature pattern is conserved within the Leishmania genus and also among strains of T. cruzi and T. brucei. Furthermore, we analyzed the impact of point mutations on the intrinsic curvature and their impact on the promoter activity. Furthermore, we found that the core promoters of protein-coding genes transcribed by RNAPI in T. brucei show the same conserved conformational characteristics. Overall, our results indicate that DNA intrinsic curvature of the rRNA gene core promoters is conserved in these ancient eukaryotes and such con- served curvature might be a requirement of RNAPI machinery for transcription of not only rRNA genes but also protein-coding genes.

关键词： Intrinsic curvature RNA polymerase I Core promoter Trypanosoma Leishmania