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Magnetic Resonance Letters 2021年第2期1卷 153-159页

作者： Kui Yan zhengwu bai Shaohua Huang Institute of Drug Discovery and Technology Ningbo UniversityNingbo315211China School of Chemistry and Environmental Engineering Wuhan Institute of TechnologyWuhan430073China Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of SciencesQingdao266101China

Diffusion-ordered nuclear magnetic resonance spectroscopy(DOSY),dubbed chromato-graphic NMR spectroscopy,can be used to simultaneously distinguish and identify the structures of components in a mixture according to their different diffusion *** order to improve the resolution of DOSY on the diffusion dimension,a lot of matrices have been developed to expand the application of this technique in mixture ***,there is no matrix to detect the mixture of ionic liquids(ILs).Herein,we introduced a new matrix,poly(sodium-p-styrenesulfonate)(PSSNa),which can be used to fully separate the signals of a mixture of different *** mixture of three imidazolium ILs of 1-butyl-3-methylimidazolium bromide,1-allyl-3-vinylimidazolium bromide and 1-arboxymethy-3-methylimidazolium chloride could be fully distinguished by virtue of their different interactions with *** also investigated the influences of PSSNa amount,IL con-centration and solution pH value on the signal resolution of *** work provides a scientific reference for the analysis of the other IL analytes.

关键词： Nuclear magnetic resonance(NMR) DOSY Matrix poly(sodium-p-styrenesulfonate) Ionic liquid

Preparative Optimization of Cellulose Microspheres Applied as Supports for High-Performance Liquid Chromatography

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Journal of Wuhan University of Technology(Materials Science) 2013年第3期28卷 460-466页

作者：陈伟 ZHANG Juan FAN Qingchun bai zhengwu 周兴平 XIE Xiaolin Key Lab for Large-Format Battery Materials and Systems Ministry of Education School of Chemistry and Chemical Engineering Huazhong University of Science and Technology Key Lab of Green Chemical Process Ministry of Education Hubei Key Laboratory of Novel Chemical Reactor and Green Chemical Technology Wuhan Institute of Technology

The aim of this work is optimizing the techniques to prepare pure cellulose microspheres, which are used as packing adsorbents for high-performance liquid chromatography. Thereupon, cellulose was dissolved in a pre-cooled NaOH/urea solution, from which various-size microspheres were prepared. The volume-average diameters were controlled approximately at 30 p,m, 8 ~tm and 4 pm grades when cyclohexane, liquid paraffin and pump oil were used as dispersants, respectively. The present investigations reveal that higher viscosity dispersant is suitable for the preparation of smaller-size microspheres, while larger size microspheres are prepared preferably using lower-viscosity dispersant. The chiral stationary phase derived from 8 μm grade microspheres can separate the enantiomers of efavirenz.

关键词： cellulose NaOH/urea aqueous solution microsphere packing material high-performance liquid chromatograph

A New Biselector Chiral Stationary Phase Derived from Tartaric Acid and Its Enantioseparation Evaluation

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Wuhan University Journal of Natural Sciences 2012年第5期17卷 383-390页

作者： CHEN Wei ZHANG Juan LI Yingzhao bai zhengwu HUANG Shaohua Key Laboratory of Green Chemical Process of Ministry of Education/Hubei Key Laboratory of Novel Chemical Reactor and Green Chemical Technology/Wuhan Institute of Technology Wuhan 430073 Hubei China Key Laboratory of Biodiesel of the Chinese Academy of Sciences Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of Sciences Qingdao 266101 Shandong China

Two chiral selectors were synthesized from tartaric acid. The selectors were simultaneously immobilized on 3-aminopropyl silica gel to obtain a new biselector chiral stationary phase （CSP） in order to determine the influence of selector structure of biselector CSPs on the chiral recognition capability. For comparison, the single-selector CSP was also prepared. The biselector CSP shows an improved overall chiral recognition capability in comparison with the single-selector CSP. During the enantioseparation, temporary diastereoisomers are likely formed by complexation between a chiral analyte and the two selectors on the biselector CSP. The functional groups in the two selectors are complementary in electronic effect and/or in steric hindrance for the chiral recognition.

关键词： biselector chiral stationary phase enantioseparation chiral recognition mechanism high-performance liquid chromatography

Preparation and Chiral Recognition of New Chiral Stationary Phases Derived from Cellulose Microspheres

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Wuhan University Journal of Natural Sciences 2012年第3期17卷 205-210页

作者： JIN Fenfen ZHANG Juan CHEN Wei FAN Qingchun bai zhengwu Key Laboratory of Green Chemical Process of Ministry of Education/Hubei Key Laboratory of Novel Chemical Reactor and Green Chemical Technology/Wuhan Institute of Technology Wuhan 430073HubeiChina

A new way to prepare cellulose-type chiral stationary phases （CSPs） has been established in the present *** microspheres with a volume-average diameter of 11.5 m were prepared by an emulsion-solidification *** new CSPs were obtained by crosslinking the cellulose microspheres with terephthaloyl chloride （TPC）,and then modifying the crosslinked microspheres with 4-methylbenzoyl chloride,3,5-dimethylbenzoyl chloride and 3,5-dichlorobenzoyl chloride,*** microspheres and the CSPs were characterized by FT-IR,element analysis and scanning electronic microscopy （SEM）.The chiral recognition ability of the CSPs was evaluated with high-performance liquid chromatography （HPLC）.The chromatographic results demonstrate that the CSP prepared from 3,5-dichlorobenzoyl chloride possesses better chiral recognition ability compared with two other CSPs.

关键词： cellulose microspheres stationary phase chiral recognition high-performance liquid chromatography

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聚酯型Gd(Ⅲ)配合物的合成与表征

高分子学报 1998年第2期8卷 191-195页

作者：柏正武卓仁禧武汉大学化学系国家教委生物医用高分子材料开放实验室

将二乙三胺五乙酸双酐与五种分子量不同的聚乙二醇共缩聚，制得聚酯型大分子配体，配体与ＧｄＣｌ３·６Ｈ２Ｏ反应，生成相应的配合物，并测试了配合物的弛豫速率．结果表明这些配合物比现用于临床的磁共振成像造影剂Ｇｄ（ＤＴＰＡ）... 详细信息

将二乙三胺五乙酸双酐与五种分子量不同的聚乙二醇共缩聚，制得聚酯型大分子配体，配体与ＧｄＣｌ３·６Ｈ２Ｏ反应，生成相应的配合物，并测试了配合物的弛豫速率．结果表明这些配合物比现用于临床的磁共振成像造影剂Ｇｄ（ＤＴＰＡ）具有更高的弛豫速率．

关键词： MRI 造影剂钆配合物聚酯型磁共振成像合成

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单氢钌配合物催化氢化苯乙烯的位阻效应

化学学报 2009年第6期67卷 519-522页

作者：尹传奇冯权武柏正武武汉工程大学绿色化工过程省部共建教育部重点实验室武汉430074

研究了溶剂分别为THF,H2O/THF,CH3CN/THF以及ROH/THF(R=Me,Et,iso-Pr,tert-Bu)条件下TpRuH(PPh3)-(CH3CN)[Tp=hydrotris(pyrazolyl)borate]催化氢化苯乙烯生成乙基苯的反应,发现向干燥THF体系中添加微量H2O,CH3CN或ROH对催化反应都具有显著的促进作用.催化机理研究表明,小分子添加物首先取代TpRuH(PPh3)(CH3CN)中的PPh3配体形成中间体TpRuH(CH3CN)L(L=H2O,CH3CN或ROH),降低空间位阻,CH3CN配体随后被苯乙烯取代生成中间体TpRuH(H2C=CHPh)L;η2-苯乙烯插入Ru—H键后形成的Ru-烷基中间物与H2反应生成η2-H2配合物TpRu(CH2CH2Ph)(H2)L或TpRu[CH(CH3)Ph](H2)L,进而发生σ-复分解反应生成乙基苯完成催化循环.

关键词：苯乙烯位阻催化氢化单氢钌配合物

石墨烯衍生物作为无金属碳基催化剂在有机催化中的应用

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化学学报 2021年第11期79卷 1360-1371页

作者：黄杰奚江波陈伟柏正武武汉工程大学化学与环境工程学院绿色化工过程教育部重点实验室武汉430205

近年来,随着绿色化学和可持续发展等创新理念的提出,无金属催化剂逐渐成为催化领域的研究热点和前沿.石墨烯作为一种新型纳米碳材料,具有机械强度大、比表面积高、稳定性好、电学性质优异等特点,经过改性或功能化后的衍生物可以作为无... 详细信息

近年来,随着绿色化学和可持续发展等创新理念的提出,无金属催化剂逐渐成为催化领域的研究热点和前沿.石墨烯作为一种新型纳米碳材料,具有机械强度大、比表面积高、稳定性好、电学性质优异等特点,经过改性或功能化后的衍生物可以作为无金属碳基催化剂,在有机反应中展现了良好的应用前景.本文综述了石墨烯衍生物的结构和性质,探究了石墨烯基材料的结构与催化活性之间的关系,总结了此类材料作为无金属催化剂在氧化、还原/氢化、偶联、取代反应以及其他有机反应中的应用和反应机理.

关键词：石墨烯石墨烯衍生材料碳基催化剂有机反应无金属催化催化机理

纤维素型手性固定相制备及手性分离综合实验设计

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实验技术与管理 2017年第5期34卷 44-47页

作者：陈伟柏正武武汉工程大学环境与化工清洁生产实验教学中心湖北武汉430073

以微晶纤维素为原料,合成了纤维素-三(1-萘基氨基甲酸酯),再将其涂覆于氨丙基硅胶表面,制备成手性固定相。利用傅里叶变换红外光谱仪、元素分析仪、扫描电镜等方法对纤维素衍生物及固定相进行了表征。将该固定相填充于空的色谱柱中,制... 详细信息

以微晶纤维素为原料,合成了纤维素-三(1-萘基氨基甲酸酯),再将其涂覆于氨丙基硅胶表面,制备成手性固定相。利用傅里叶变换红外光谱仪、元素分析仪、扫描电镜等方法对纤维素衍生物及固定相进行了表征。将该固定相填充于空的色谱柱中,制备成手性色谱柱,用高效液相色谱检测了所制备色谱柱对几种手性样品的对映体分离性能。本实验涉及有机合成和表征的相关知识,并结合手性药物色谱分析等应用性问题,综合性较强,可作为大学本科综合实验教学内容。

关键词：综合化学实验手性固定相对映体分离高效液相色谱

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超高脱乙酰度壳聚糖制备与表征综合实验设计

实验技术与管理 2018年第8期35卷 42-45,50页

作者：陈伟柏正武武汉工程大学环境与化工清洁生产实验教学中心湖北武汉430073

介绍超高脱乙酰度壳聚糖的制备与表征的综合实验教学设计。该综合实验以虾壳为原料,经脱乙酰和降解等过程,制备超高脱乙酰度壳聚糖。用黏度法测定壳聚糖分子量,用核磁共振波谱法测定脱乙酰度,用傅里叶变换红外光谱法和元素分析法对壳聚... 详细信息

介绍超高脱乙酰度壳聚糖的制备与表征的综合实验教学设计。该综合实验以虾壳为原料,经脱乙酰和降解等过程,制备超高脱乙酰度壳聚糖。用黏度法测定壳聚糖分子量,用核磁共振波谱法测定脱乙酰度,用傅里叶变换红外光谱法和元素分析法对壳聚糖进行了表征。该实验条件简单,壳聚糖分子量可控,涉及高分子材料的制备和结构表征、结果分析等多方面内容,有利于提高学生的综合运用知识和进行科研的能力。

关键词：综合化学实验壳聚糖脱乙酰度

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溶解-沉淀可逆的酶载体的合成及其应用

武汉大学学报（自然科学版） 1998年第4期44卷 409-411页

作者：柏正武卓仁禧武汉大学化学学院教育部生物医用高分子材料开放实验室

由丙烯酸、甲基丙烯酸甲酯和顺丁烯二酸酐共聚，合成了ｐＨ敏感的溶解－沉淀可逆的共聚物，并测试了共聚物溶解－沉淀相分离的临界ｐＨ值．以这种共聚物为载体，进行了木瓜蛋白酶的固定化．

关键词： pH敏感高分子可逆溶解-沉淀固定化酶