A New Biselector Chiral Stationary Phase Derived from Tartaric Acid and Its Enantioseparation Evaluation

作     者：CHEN Wei ZHANG Juan LI Yingzhao BAI Zhengwu HUANG Shaohua 

作者机构：Key Laboratory of Green Chemical Process of Ministry of Education/Hubei Key Laboratory of Novel Chemical Reactor and Green Chemical Technology/Wuhan Institute of Technology Wuhan 430073 Hubei China Key Laboratory of Biodiesel of the Chinese Academy of Sciences Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of Sciences Qingdao 266101 Shandong China 

出 版 物：《Wuhan University Journal of Natural Sciences》 (武汉大学学报（自然科学英文版）)

年 卷 期：2012年第17卷第5期

页      面：383-390页

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070302[理学-分析化学] 0703[理学-化学] 

基　　金：Supported by the National Natural Science Foundation of China (20675061 and 50973086) the Research Project of Department of Education of Hubei Province (Z20081501) 

主　　题：biselector chiral stationary phase enantioseparation chiral recognition mechanism high-performance liquid chromatography 

摘      要：Two chiral selectors were synthesized from tartaric acid. The selectors were simultaneously immobilized on 3-aminopropyl silica gel to obtain a new biselector chiral stationary phase （CSP） in order to determine the influence of selector structure of biselector CSPs on the chiral recognition capability. For comparison, the single-selector CSP was also prepared. The biselector CSP shows an improved overall chiral recognition capability in comparison with the single-selector CSP. During the enantioseparation, temporary diastereoisomers are likely formed by complexation between a chiral analyte and the two selectors on the biselector CSP. The functional groups in the two selectors are complementary in electronic effect and/or in steric hindrance for the chiral recognition.