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Biomedical and Environmental Sciences 2013年第8期26卷 693-696页

作者： LUO Feng Ji SHI Nian Min LI Li ZHANG Zheng AI Xing YANG Li Qing bai yun hua WANG Zhao yun LU Qiang Chaoyang District Center for Disease Control and Prevention

In the present study, the safety of Hoemophilus influenza type b conjugate vaccines inoculated in the upper arm deltoid and vastus lateralis muscle was evaluated. 680 infants aged 2-5 months and 6-12 months were selected to be the research subjects in whom the Hib conjugate vaccines were inoculated by injection in the upper arm deltoid and vastus lateralis muscle, respectively. The safety analysis indicated that there were no statistic differences in the incidence rates of adverse reactions when the Hib conjugate vaccines were inoculated at different sites. So we concluded that the safety of inoculation injection of Hib conjugate vaccines in vastus lateralis muscle was the same as that inoculated in the upper arm deltoid.

关键词： In Safety Observation Study on Haemophilus Influenza Type B Conjugate Vaccines Injected at Different Sites in Chinese Infants

Rabies Virus Neutralizing Activity,Safety,and Immunogenicity of Recombinant Human Rabies Antibody Compared with Human Rabies Immunoglobulin in Healthy Adults

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Biomedical and Environmental Sciences 2022年第9期35卷 782-791页

作者： ZHANG Jun Nan MENG Ya Juan bai yun hua LI Yu Feng YANG Li Qing SHI Nian Min HAN Hui Xia GAO Jian ZHU Li Juan LI Shu Ping ZHANG Jing ZHAO Qin hua WANG Xiu Qin WEI Jing Shuang REN Le Min CAO Chen hua CHEN Chen ZHAO Wei LI Li Center for Disease Control and Prevention of Chaoyang District Beijing 100021China NCPC New Drug Research and Development Co. Ltd.State Key Laboratory of Antibody Research&DevelopmentShijiazhuang 050015HebeiChina Beijing Institute of Biological Products Beijing 100021China Xiaohongmen Community Healthcare Center Beijing 100023China

Objective Preliminary assessment of rabies virus neutralizing activity,safety and immunogenicity of a recombinant human rabies antibody(NM57)compared with human rabies immunoglobulin(HRIG)in Chinese healthy *** Subjects were randomly(1:1:1)allocated to Groups A(20 IU/kg NM57),B(40 IU/kg NM57),or C(20 IU/kg HRIG).One injection was given on the day of *** samples were collected on days-7 to 0(pre-injection),3,7,14,28,and *** events(AEs)and serious AEs(SAEs)were recorded over a period of 42 days after *** All 60 subjects developed detectable rabies virus neutralizing antibodies(RVNAs)(>0.05 IU/mL)on days 3,7,14,28,and *** RVNA levels peaked on day 3 in all three groups,with a geometric mean concentration(GMC)of 0.2139 IU/mL in Group A,0.3660 IU/mL in Group B,and0.1994 IU/mL in Group *** each follow-up point,the GMC in Group B was significantly higher than that in Groups A and *** areas under the antibody concentration curve over 0-14 days and 0-42 days in Group B were significantly larger than those in Groups A and *** AEs were *** for one grade 2 myalgia in Group C,the other 14 were all grade *** SAEs were *** The rabies virus neutralizing activity of 40 IU/kg NM57 was superior to that of 20 IU/kg NM57 and 20 IU/kg HRIG,and the rabies virus neutralizing activity of 20 IU/kg NM57 and 20 IU/kg HRIG were *** was comparable between NM57 and HRIG.

关键词： Recombinant human rabies antibody NM57 Human rabies immunoglobulin Rabies virus neutralizing activity Safety Immunogenicity

Tumor Necrosis Factor-alpha Induced Protein 3 Interacting Protein I Gene Polymorphisms and Pustular Psoriasis in Chinese Han Population

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Chinese Medical Journal 2016年第13期129卷 1519-1524页

作者： Jian-Wen Han Yong Wang Chulu Alateng Hong-Bin Li yun-hua bai Xin-Xiang Lyu Rina Wu Department of Dermatology The Affiliated Hospital of Inner Mongolia Medical University Hohhot Inner Mongolia 010050 China Department of Rheumatology The Affiliated Hospital of Inner Mongolia Medical University Hohhot Inner Mongolia 010050 China Department of Dermatology Hulunbeier People's Hospital Hulunbeier Inner Mongolia 021000 China

Background： Psoriasis is a common immune-mediated inflammatory dermatosis. Generalized pustular psoriasis （GPP） is the severe and rare type of psoriasis. The association between tumor necrosis factor-alpha induced protein 3 interacting protein 1 （TNIP1） gene and psoriasis was confirmed in people with multiple ethnicities. This study was to investigate the association between TNIP1 gene polymorphisms and pustular psoriasis in Chinese Hart population. Methods： Seventy-three patients with GPP, 67 patients with palmoplantar pustulosis （PPP）, and 476 healthy controls were collected from Chinese Hart population. Six single nucleotide polymorphisms （SNPs） of the TNIP1 gene, namely rs3805435, rs3792798, rs3792797, rs869976, rs 17728338, and rs999011 were genotyped by using polymerase chain reaction-ligase detection reaction. Statistical analyses were performed using the PLINK 1.07 package. Allele frequencies and genotyping frequencies for six SNPs were compared by using Chi-square test, odd ratio （OR）（including 95% confidence interval） were calculated. The haplotype analysis was conducted by Haploview software. Results： The frequencies of alleles of five SNPs were significantly different between the GPP group and the control group （P ≤ 7.22 × 10^-3）, especially in the GPP patients without psoriasis vulgaris （PsV）. In the haplotype analysis, the most significantly different haplotype was H4： ACGAAC, with 13.1% frequency in the GPP group but only 3.4% in the control group （OR = 4.16, P = 4.459 × 10^-7）. However, no significant difference in the allele frequencies was found between the PPP group and control group for each of the six SNPs （P 〉 0.05）. Conclusions： Polymorphisms in TNIP1 are associated with GPP in Chinese Han population. However, no association with PPP was found. These findings suggest that TNIPI might be a susceptibility gene for GPE

关键词： Association Pustular Psoriasis Single Nucleotide Polymorphism Tumor Necrosis Factor-alpha Induced Protein 3Interacting Protein 1

Deciphering the role of mtH_(2)O_(2) in hepatic ischemia-reperfusion injury mechanisms with low-background super-resolution fluorogenic probe

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Science China Chemistry 2025年第1期68卷 297-307页

作者： Bin Fang Limin Wang Haoqin Li Jiaxin Zhang Yang Ding PanPan Li Bo Peng hua bai Lin Li Frontiers Science Center for Flexible Electronics Xi’an Institute of Flexible Electronics(IFE)and Xi’an Institute of Biomedical Materials&EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Institute of Flexible Electronics(IFE Future Technologies)Xiamen UniversityXiamen 361005China

Hepatic ischemia-reperfusion injury(HIRI)is characterized by mitochondrial dysfunction and oxidative *** mitochondrial hydrogen peroxide(mtH_(2)O_(2))levels in real-time through super-resolution imaging is crucial for elucidating its distribution in live cells and its mechanism of action during ***,low-background fluorogenic probes have been overlooked in the context of super-resolution *** this study,we developed a low-background fluorogenic probe(MitoWG)with the potential for super-resolution morphology-correlated mitochondrial identification to track the fluctuates of mtH_(2)O_(2)in *** of the desirable fluorescence properties of the probe by mtH_(2)O_(2)was confirmed using structural illumination microscopy(SIM),enabling high-quality mitochondrial imaging with exceptional specificity and *** in mtH_(2)O_(2)levels were successfully observed in both cellular and rat models of ***,we associated the decline in mitochondrial redox homeostasis with accelerated mtH_(2)O_(2)production during HIRI,which triggered mitophagy deficiency and led to cell *** conclusion,Mito-WG possesses excellent photophysical and low-background properties for SIM imaging,making it a promising tool for mtH_(2)O_(2)tracking in HIRI research and clinical diagnosis.

关键词： hepatic ischemia-reperfusion injury low-background mtH_(2)O_(2)-activatable super-resolution imaging fluorogenic probe

New exploration on pathogenesis and early diagnosis of gestational diabetes

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World Journal of Clinical Cases 2025年第1期13卷 1-5页

作者： hua bai Department of Neurology The Third Affiliated Hospital of Guizhou Medical UniversityDuyun 558099Guizhou ProvinceChina

Gestational diabetes mellitus(GDM)refers to varying degrees of abnormal glucose metabolism that occur during pregnancy and excludes patients pre-viously diagnosed with *** is a unique among the four subtypes of diabetes classified by the international World Health Organization *** GDM patients constitute a small proportion of the total number of diabetes cases,the incidence of GDM has risen significantly over the past decade,posing substantial risk to pregnant women and ***,it warrants considerable *** pathogenesis of GDM is generally considered to resemble that of type II diabetes,though it may have distinct *** blood biochemical proteins in the context of GDM can help elucidate its pathogenesis,thereby facilitating more effective prevention and management *** article reviews this critical clinical issue to enhance the medical community's sufficient understanding of GDM.

关键词： Gestational diabetes mellitus Pathogenesis Proteomics RBP4 ANGPTL8

Searching for new drugs to treat Alzheimer’s disease dementia through multiple pathways

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World Journal of Clinical Cases 2025年第1期13卷 22-28页

作者： hua bai Xiao-Feng Feng Department of Neurology The Third Affiliated Hospital of Guizhou Medical UniversityDuyun 558099Guizhou ProvinceChina Department of Neurology Wulong Branch of the People's Hospital Affiliated to Chongqing UniversityWulong 408500ChongqingChina Department of Neurology Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina

Dementia is a group of diseases,including Alzheimer's disease(AD),vascular dementia,Lewy body dementia,frontotemporal dementia,Parkinson's disease dementia,metabolic dementia and toxic *** treatment of dementia mainly includes symptomatic treatment by controlling the primary disease and accompanying symptoms,nutritional support therapy for repairing nerve cells,psychological auxiliary treatment,and treatment that improves cognitive function through *** them,drug therapy to improve cognitive function is *** review focuses on introducing and commenting on some recent progress in exploring drugs to improve cognitive function,especially the new progress in drug treatment for *** mainly discuss the opportunities and challenges in finding and developing new therapeutic drugs from the aspects of acetylcholinesterase,N-methyl-D-aspartate glutamate receptor,amyloid protein,tau protein and chronic immune inflammation.

关键词： Alzheimer's disease Dementia Cholinesterase inhibitor Beta amyloid Tau protein

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习近平关于青年教育论述的价值意蕴

井冈山大学学报（社会科学版） 2021年第1期42卷 13-18页

作者：白云华武汉大学马克思主义学院湖北武汉430072

高度重视、接续推动青年教育工作是中国共产党与青年互动发展关系的集中体现。党的十八大以来,习近平总书记从理论与实践两个维度系统论述了为谁培养青年、培养什么样的青年、如何培养青年的核心问题,为新时代青年教育工作指明了前进方... 详细信息

高度重视、接续推动青年教育工作是中国共产党与青年互动发展关系的集中体现。党的十八大以来,习近平总书记从理论与实践两个维度系统论述了为谁培养青年、培养什么样的青年、如何培养青年的核心问题,为新时代青年教育工作指明了前进方向,确立了发展要求。深入分析和研究阐释习近平关于青年教育的系列重要论述,对于巩固和扩大中国共产党的青年群众基础、教育和引导青年健康成长成才、抓好和做好青年教育工作具有深刻的理论价值和实践意义。

关键词：青年教育思想武器行动指南原则遵循

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论社会主义核心价值观的优秀传统文化表达

井冈山大学学报（社会科学版） 2018年第4期39卷 71-76页

作者：白云华武汉大学马克思主义学院湖北武汉430072

社会主义核心价值观与中华优秀传统文化关系研究是当前的重点课题。中华优秀传统文化是涵养社会主义核心价值观的重要思想源泉,其中最核心的部分已成为社会主义核心价值观的文化基因。社会主义核心价值观是对中华优秀传统文化"治国"思... 详细信息

社会主义核心价值观与中华优秀传统文化关系研究是当前的重点课题。中华优秀传统文化是涵养社会主义核心价值观的重要思想源泉,其中最核心的部分已成为社会主义核心价值观的文化基因。社会主义核心价值观是对中华优秀传统文化"治国"思想精华、"齐家"价值理念以及"修身"道德精髓的当代表达。积极培育和践行社会主义核心价值观能够保证优秀传统文化的民族特色、彰显优秀传统文化的时代价值、增强优秀传统文化的生机活力。

关键词：社会主义核心价值观优秀传统文化文化基因当代表达

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绿色营销与可持续发展

吉林省经济管理干部学院学报 2008年第2期22卷 50-52页

作者：白云华吉林省经济管理干部学院吉林长春130021

可持续发展观是面向21世纪的新的发展观,它要求人们彻底改变对自然环境的传统态度和观念,调整自己的经济行为,实现社会、经济、环境的可持续协调发展。在这种广泛而深刻的调整和转变中,企业的生产经济活动自然应首当其冲。企业既是社会... 详细信息

可持续发展观是面向21世纪的新的发展观,它要求人们彻底改变对自然环境的传统态度和观念,调整自己的经济行为,实现社会、经济、环境的可持续协调发展。在这种广泛而深刻的调整和转变中,企业的生产经济活动自然应首当其冲。企业既是社会财富的直接创造者,也是自然资源的主要利用者和环境污染的主要制造者,因此,企业应该正视生态环境问题,树立绿色营销观念,制定面向可持续发展的绿色营销战略。

关键词：可持续发展绿色营销

基于新常态背景下的高职院校创新创业教育改革发展策略探讨

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教育教学论坛 2019年第30期 240-241页

作者：白云华吉林省经济管理干部学院

鉴于现阶段我国高职院校创新创业教育地位及重要性大大提高,为了能够推动高职教育新常态发展,应注意推动高职院校创新创业教育改革发展。基于此,分析和探讨如何在新常态背景下促进高职院校创新创业教育改革发展。

关键词：新常态高职院校创新创业教育改革发展