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Heat distribution model under hydrogen-rich low-carbon conditions in blast furnace

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Journal of Iron and Steel Research International 2024年第3期31卷 584-594页

作者： Gang Wang Jun Xu Kun He Zhong-ping Zou Hao bai School of Metallurgy and Ecological Engineering University of Science and Technology BeijingBeijing 100083China CISDI Low-Carbon Blast Furnace Research Office MCC Low-Carbon Technology Research InstituteChongqing 401122China

Low carbon development of blast furnaces is one of the key technological directions in the current development of *** to the differences in the physical and chemical properties of hydrogen and carbon,hydrogen-rich media entering a blast furnace will change the heat distribution,thus affecting the stability of ***,a heat distribution model was proposed to study the temperature distribution in a blast furnace,simultaneously considering gas-solid heat exchange,slag and iron melting,and chemical *** model was used to analyze the temperature distribution of a 2300 m^(3) blast furnace and was verified via comparison with actual production ***,the effects of the injection rate of hydrogen-rich media,H2 concentration,and oxygen enrichment rate of the blast on the temperature distribution were *** indicated that the increase in the injection rate of the hydrogen-rich media decreased the amount of direct reduction and led to an increase in the furnace ***,an increase in the oxygen enrichment rate led to a decrease in the furnace temperature,but could reduce the solid fuel ratio,while the change in H2 concentration had less effect on the temperature *** combination of hydrogen-rich media injection and the increase in the oxygen enrichment rate would help to adjust the temperature distribution to the same level as the conventional blast furnace conditions.

关键词： Heat distribution Blast furnace Low-carbon condition Hydrogen enrichment Calculation model

Sequence of fat partitioning and its relationship with whole body insulin resistance

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Chinese Medical Journal 2010年第24期123卷 3605-3611页

作者： bai xiu-ping LI Hong-liang YANG Wen-ying XIAO Jian-zhong WANG Bing LOU Da-jun DU Rui-qin Department of Endocrinology China-Japan Friendship Hospital Beijing 100029 China Department of Endocrinology Second Hospital of Shanxi Medical University Taiyuan Shanxi 030001 China

Background Currently it is unclear whether lipid accumulation occurs in a particular sequence and its relationship with whole body insulin resistance （IR）. This study aimed to answer this *** Male Sprague-Dawley （SD） rats were fed on a normal or a high-fat diet for 20 weeks. Serum triglycerides （TG）, serum free fatty acids （FFA）, fasting plasma glucose （FPG）, and liver and skeletal muscle TG were measured. The glucose infusion rate （GIR） and mRNA levels of acetyl-CoA carboxylase （ACC） and carnitine palmitoyltransferase-1 （CPT-1） in the liver and skeletal muscle were determined at different *** Compared with rats fed on the normal diet, serum FFA was not significantly increased in rats fed on the high-fat diet until 20 weeks. In contrast, liver TG was significantly increased by the high-fat diet by four weeks （20-fold; P ＜0.01）,and remained elevated until the end of the study. However, skeletal muscle TG was not significantly increased by the high-fat diet until 20 weeks （10.6-fold; P＜0.01）, and neither was the FPG. The GIR was significantly reduced （1.6-fold; P ＜0.01） by the high-fat diet after 8 weeks. The mRNA levels of ACC gradually increased over time and CPT-1 decreased over time, in both the liver and skeletal muscle in rats fed the high-fat *** Lipid accumulation in the liver occurs earlier than lipid accumulation in the skeletal muscle. Fatty liver may be one of the early markers of whole body IR. Changes in the gene expression levels of ACC and CPT-1 may have important roles in the process of IR development.

关键词： body fat distribution insulin resistance dietary fats Sprague-Dawley rat

Impact of letters to the editor and publications in 2023

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Zoological Research 2024年第1期45卷 136-137页

作者： xiu-ping Zhang Xue-Long Jiang Yong-Gang Yao Editorial Office of ZR&ZRDC Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China

A letter to the editor constitutes a short communication addressing a range of topics pertinent to the readership of a journal(Dkhar,2018).This format offers several benefits,such as timeliness,accessibility,innovation,and conciseness,thereby serving as an effective means to disseminate cuttingedge scientific *** the past five years,there has been a considerable increase in the number of letters published,representing the highest growth rate(approximately 20%)observed in the last three decades(Figure 1A).In the field of academic publishing,letters to the editor are typically more concise than typical research papers.

关键词： journal editor Figure

Molecular evaluation of Conogethes punctiferalis(Guenée,1854):Species status and intraspecific divergence

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Zoological Systematics 2024年第3期49卷 267-275页

作者： Jin An Yalin Yao ping Gao Minghua xiu Chengmin Shi College of Plant Protection Hebei Agricultural UniversityBaoding 071000China State Key Laboratory of North China Crop Improvement and Regulation Baoding 071000China College of Plant Protection Shenyang Agricultural UniversityShenyang 110866China

Species are not only the fundamental units of taxonomy but also the basic units of pest *** of Conogethes are important agricultural and forestry ***,species boundaries within Conogethes often appear *** the present study,we reevaluated the species status of Conogethes by applying three species delimitation approaches based on the mitochondrial DNA sequences,with particular emphasis on the yellow peach moth ***(Guenée,1854).We first optimized species delimitation and inter-species genetic divergence threshold using a DNA barcoding *** results revealed that several nominal species of Conogethes species harbored deeply diverged mitochondrial lineages which were recognized as independent species by the species delimitation *** p-distance between the delimited putative species ranged from 0.0159 to 0.1321 with a mean of *** we refined the species status of *** using the smallest interspecific distance threshold based on a geographically comprehensive population-scale *** procedure narrowed the species concept of *** to a genetically coherent *** investigation of its intraspecific divergence in the geographic context revealed that the refined *** was still widely distributed with the same or highly similar mitochondrial haplotypes occurring across South and East Asia.

关键词： Species delimitation DNA barcoding genetic distances mitochondrial DNA

非酒精性脂肪肝合并2型糖尿病的降糖药物选择

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生命科学 2019年第8期31卷 856-864页

作者：张蕾白秀平山西医科大学第二临床医学院太原030001 山西医科大学第二医院太原030001

非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)是常见的慢性肝病病因,在一般人群中的患病率约为20%~30%,但在2型糖尿病(type 2 diabetes mellitus,T2DM)患者中则达到55%。降糖药物可能在延缓疾病进展中起关键作用。二... 详细信息

非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)是常见的慢性肝病病因,在一般人群中的患病率约为20%~30%,但在2型糖尿病(type 2 diabetes mellitus,T2DM)患者中则达到55%。降糖药物可能在延缓疾病进展中起关键作用。二甲双胍在T2DM的治疗中是最常用的药物,对肝纤维化未见明显改善,但可用于NAFLD危险因素的治疗,如体重、转氨酶、胆固醇、糖化血红蛋白水平,且降低患者罹患肝癌的风险。噻唑烷二酮类药物在肝脏气球样变、小叶炎症和纤维化方面均有改善。胰高血糖素样肽-1受体激动剂中最常用的药物是利拉鲁肽,能显著降低转氨酶水平、改善肝细胞气球样变和脂肪变性。关于二肽基肽酶-4和钠-葡萄糖共转运蛋白-2抑制剂作用的资料较少。胰岛素的使用与实体肿瘤,尤其是肝细胞癌的发生可能相关。所有的降糖药物都可以安全地应用于代偿期肝硬化患者,而胰岛素则是肝硬化失代偿期的首选药物。本文就降糖药物治疗NAFLD的有效性和安全性进行综述。

关键词：非酒精性脂肪性肝病 2型糖尿病降糖药物

Update understanding on diagnosis and histopathological examination of atrophic gastritis:A review

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4080-4091页

作者： xiu-Zhen Ma Ni Zhou xiu Luo Si-Qi Guo ping Mai The First School of Clinical Medicine Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Gastroenterology Gansu Provincial People's HospitalLanzhou 730000Gansu ProvinceChina Department of Gastroenterology Xi'an International Medical CenterXi’an 710000Shaanxi ProvinceChina The First School of Clinical Medicine Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina

Chronic atrophic gastritis(CAG)is a complex syndrome in which long-term chronic inflammatory stimulation causes gland atrophy in the gastric mucosa,reducing the stomach's ability to secrete gastric juice and pepsin,and interfering with its normal physiological *** pathogenic factors contribute to CAG incidence,the most common being Helicobacter pylori infection and the immune reactions resulting from gastric ***,CAG has a broad spectrum of clinical manifestations,including gastroenterology and extraintestinal symptoms and signs,such as hematology,neurology,and ***,the initial CAG evaluation should involve the examination of clinical and serological indicators,as well as diagnosis confirmation via gastroscopy and histopathology if *** on the severity and scope of atrophy affecting the gastric mucosa,a histologic staging system(Operative Link for Gastritis Assessment or Operative Link on Gastritis intestinal metaplasia)could also be ***,chronic gastritis has a higher risk of progressing to gastric cancer(GC).In this regard,early diagnosis,treatment,and regular testing could reduce the risk of GC in CAG ***,the optimal interval for endoscopic monitoring in CAG patients remains uncertain,and it should ideally be tailored based on individual risk evaluations and shared decision-making *** there have been many reports on CAG,the precise etiology and histopathological features of the disease,as well as the diagnosis of CAG patients,are yet to be fully ***,this review offers a detailed account of CAG,including its key clinical aspects,aiming to enhance the overall understanding of the disease.

关键词： Atrophic gastritis Helicobacter pylori infection Autoimmune gastritis Diagnosis Operative link for gastritis assessment staging Gastric cancer risk

Erythrodermic mycosis fungoides: A case report

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World Journal of Clinical Cases 2024年第1期12卷 130-135页

作者： Wu-Bing Xu Ya-ping Zhang Su-ping Zhou Hao-Yang bai Department of Radiology Shaoxing People’s HospitalKey Laboratory of Functional Molecular Imaging of Tumor and Interventional Diagnosis and Treatment of Shaoxing CityShaoxing 312000Zhejiang ProvinceChina

BACKGROUND Mycosis fungoides is the most common primary cutaneous T-cell lymphoma,whereas generalized erythroderma is *** this report,we describe a case of mycosis fungoides with generalized erythroderma using complete clinical data and[18F]fluoroDglucose positron emission tomography/computed tomography(18F-FDG PET/CT)*** SUMMARY Systemic skin redness with desquamation for three years confirmed mycosis fungoides within one *** patient underwent left axillary lymphadenectomy biopsy;pathological biopsy suggested abnormal T-cell lesions consistent with mycosis fungoides involving lymph *** patient received methotrexate,5 mg twice weekly,as part of their chemotherapy *** January half after discharge,no obvious cause of high fever,left axillary lymph nodes with red heat pain,and rupture entered our hospital for *** The 18F-FDG PET/CT is essential for early diagnosis and timely treatment.

关键词： Mycosis fungoides Positron emission tomography/computed tomography Imaging Diagnosis Differential diagnosis Treatment Case report

Total glucosides of paeony alleviates cGAS-STING-mediated diseases by blocking the STING-IRF3 interaction

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Chinese Journal of Natural Medicines 2024年第5期22卷 402-415页

作者： xiu Ye WANG Sihao ZHANG ping LI Chengwei WU Zhixin WEN Jincai XU Yingjie LV Guiji ZHAO Xiaomei DONG Xu CHEN Yichong LI Junjie WANG Yan ZOU Liang XIAO Xiaohe bai Zhaofang School of Pharmacy Fujian University of Traditional Chinese MedicineFuzhou 350122China Department of Hepatology The Fifth Medical Center of PLA General HospitalBeijing 100039China China Military Institute of Chinese Materia Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China Department of Pharmacy Medical Supplies Center of PLA General HospitalBeijing 100039China School of Food and Biological Engineering Chengdu UniversityChengdu 610106China National Key Laboratory of Kidney Diseases Chinese PLA General HospitalBeijing 100039China

In the realm of autoimmune and inflammatory diseases,the cyclic GMP-AMP synthase(cGAS)stimulator of interferon genes(STING)signaling pathway has been thoroughly investigated and *** this,the clinical approval of drugs targeting the cGAS-STING pathway has been *** Total glucosides of paeony(TGP)is highly anti-inflammatory and is commonly used in the treatment of rheumatoid arthritis(RA),emerged as a subject of our *** found that the TGP markedly reduced the activation of the cGAS-STING signaling pathway,triggered by various cGAS-STING agonists,in mouse bone marrow-derived macrophages(BMDMs)and Tohoku Hospital Pediatrics-1(THP-1)*** inhibition was noted alongside the suppression of interferon regulatory factor 3(IRF3)phosphorylation and the expression of interferon-beta(IFN-β),C-X-C motif chemokine ligand 10(CXCL10),and inflammatory mediators such as tumor necrosis factor-alpha(TNF-α)and interleukin-6(IL-6).The mechanism of action appeared to involve the TGP’s attenuation of the STING-IRF3 interaction,without affecting STING oligomerization,thereby inhibiting the activation of downstream signaling *** vivo,the TGP hindered the initiation of the cGAS-STING pathway by the STING agonist dimethylxanthenone-4-acetic acid(DMXAA)and exhibited promising therapeutic effects in a model of acute liver injury induced by lipopolysaccharide(LPS)and D-galactosamine(D-GalN).Our findings underscore the potential of the TGP as an effective inhibitor of the cGAS-STING pathway,offering a new treatment avenue for inflammatory and autoimmune diseases mediated by this pathway.

关键词： Total glucosides of gaeony cGAS-STING pathway Inflammation LPS/D-GalN STING inhibitor

Elemene Antitumor Drugs Development Based on "Molecular Compatibility Theory" and Clinical Application: A Retrospective and Prospective Outlook

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Chinese Journal of Integrative Medicine 2024年第1期30卷 62-74页

作者： JIANG Xiao-ying SHI Li-ping ZHU Jun-long bai Ren-ren XIE Tian School of Pharmacy Hangzhou Normal UniversityHangzhou(311121)China Key Laboratory of Elemene Class Anti-cancer Chinese Medicines Engineering Laboratory of Development and Application of Traditional Chinese MedicinesCollaborative Innovation Center of Traditional Chinese Medicines of Zhejiang ProvinceHangzhou Normal UniversityHangzhou(311121)China Good Clinical Practice Center Affliliated Hospital of Nanjing University of Chinese MedicineNanjing(210000)China

Elemene, derived from Curcuma wenyujin, one of the "8 famous genuine medicinal materials of Zhejiang province," exhibits remarkable antitumor activity. It has gained wide recognition in clinical practice for effectiveness on tumors. Dr. XIE Tian introduced the innovative concept of "molecular compatibility theory" by combining Chinese medicine principles, specifically the "monarch, minister, assistant, and envoy" theory, with modern biomedical technology. This groundbreaking approach, along with a systematic analysis of Chinese medicine and modern biomedical knowledge, led to the development of elemene nanoliposome formulations. These novel formulations offer numerous advantages, including low toxicity, well-defined composition, synergistic effects on multiple targets, and excellent biocompatibility. Following the principles of the "molecular compatibility theory", further exploration of cancer treatment strategies and methods based on elemene was undertaken. This comprehensive review consolidates the current understanding of elemene's potential antitumor mechanisms, recent clinical investigations, advancements in drug delivery systems, and structural modifications. The ultimate goal of this review is to establish a solid theoretical foundation for researchers, empowering them to develop more effective antitumor drugs based on the principles of "molecular compatibility theory".

关键词： molecular compatibility theory Chinese integrative medicine elemene antitumor activity drug delivery structural modification