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Long-chain acyl-CoA synthetase regulates systemic lipid homeostasis via glycosylation-dependent lipoprotein production

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Life Metabolism 2024年第2期3卷 38-54页

作者： Jie Li Yue Dong Tianxing zhou He Tian Xiahe Huang Yong Q.Zhang Yingchun Wang Sin Man Lam Guanghou shui State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100101China Lipidall Technologies Company Limited ChangzhouJiangsu 213000China

Interorgan lipid transport is crucial for organism development and the maintenance of physiological ***,we demonstrate that Drosophila long-chain acyl-CoA synthetase(dAcsl),which catalyzes the conversion of fatty acids into acyl-coenzyme As(acyl-CoAs),plays a critical role in regulating systemic lipid *** deficiency in the fat body led to the ectopic accumulation of neutral lipids in the gut,along with significantly reduced lipoprotein contents in both the fat body and *** aberrant phenotypes were rescued by fat body-specific overexpression of apolipophorin.A multi-omics investigation comprising lipidomics,metabolomics,and proteomics in conjunction with genetic screening revealed that glycosylation processes were suppressed in dAcsl knockdown *** of CG9035,human ortholog of which is implicated in the congenital disorder of glycosylation,ame-liorated gut lipid accumulation in *** lipoprotein glycosylation led to accelerated proteasome-related degradation and induced ER stress in dAcsl knockdown flies,impairing lipoprotein release into the circulation which compromised interorgan lipid transport between the fat body and the *** of ubiquitin-proteasome-dependent degradation alleviated the phenotype of gut ectopic fat accumulation in dAcsl knockdown ***,we verified that ACSL4,the human homolog of dAcsl,also regulated lipoprotein levels in HepG2 cells,indicating that the role of dAcsl in modulating lipoprotein secretion and systemic lipid homeostasis is possibly conserved in humans.

关键词： lipid homeostasis apolipoprotein glycosylation lipidomics metabolomics proteomics

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Dynamic Control of Multiple Optical Patterns of Cholesteric Liquid Crystal Microdroplets by Light-Driven Molecular Motors

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CCS Chemistry 2024年第2期6卷 427-438页

作者： Jiaqin Li Shuting Xie Jiahui Meng Yuying Liu Qi Zhan Yang Zhang Lingling shui Guofu zhou Ben L.Feringa Jiawen Chen SCNU-UG International Joint Laboratory of Molecular Science and Displays National Center for International Research on Green OptoelectronicsSouth China Normal UniversityGuangzhou 510006 Joint Laboratory of Optofluidic Technology and Systems Guangdong Provincial Key Laboratory of Nanophotonic Functional Materials and DevicesSchool of Information and Optoelectronic Science and EngineeringSouth China Normal UniversityGuangzhou 510006 Stratingh Institute for Chemistry University of Groningen9747AG Groningen

The key to high-level encryption and anti-counterfeiting techniques is the storage of multiple levels of distinct information that can be individually and precisely addressed by certain *** continues to be a formidable challenge as the concealed images or codes must be read with fast response and high resolution without cross-talk to the first layer of ***,we report a non-fluorescencebased strategy to establish responsive encryption labels taking advantage of solely tuning multiple optical patterns of cholesteric liquid crystal(CLC)microdroplets doped with light-driven molecular *** photo-triggered unidirectional rotation of the motor induced not only changes in the helical twist power value but the opposite helical orientation of the superstructure in CLCs as well,resulting in changes in both the structural color and the selective reflection of circularly polar *** designed labels,which featured highly selective addressability of dual-level distinct information,good reversibility,and viewing angle-independence,were applied to build devices for daily practical use,demonstrating great potential in anti-counterfeiting technology and provide a versatile platform for enhanced data protection and encryption of authentic information.

关键词： molecular motor chirality amplification cholesteric liquid crystal anti-counterfeiting label data encryption

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Measurement of the high energyγ-rays from heavy ion reactions usingČerenkov detector

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Nuclear Science and Techniques 2024年第2期35卷 123-130页

作者： Da-Wei Si Yan zhou Sheng Xiao Zhi Qin Dong Guo Yu-Hao Qin Yi-Jie Wang Bo-Yuan Zhang bai-Ting Tian Zhi-Gang Xiao Department of Physics Tsinghua UniversityBeijing 100084China

The energetic bremsstrahlung photons up to 100 MeV produced in heavy ion collisions can be used as a sensitive probe for short-range correlation in atomic nuclei. The energy of the γ-rays can be measured by collecting the Čerenkov light in the medium induced by the fast electrons generated in the Compton scattering or electromagnetic shower of the incident γray. Two types of detectors based on pure water and lead glass as sensitive materials were designed for this purpose. The γresponse and optical photon propagation in the detectors were simulated based on electromagnetic and optical processes in Geant4. The inherent energy resolutions of 0.022(4) + 0.51(2)∕E^(1/2)_(γ) for water and 0.0026(3) + 0.446(3)∕E^(1/2)_(γ) for lead glass were obtained. The geometry sizes of the lead glass and water were optimized to 30 cm × 30 cm × 30 cm and 60 cm × 60 cm ×120 cm, respectively, to detect high-energy γ-rays at 160 MeV. The Hough transform method was applied to reconstruct the direction of the incident γ-rays, providing the ability to experimentally distinguish the high-energy γ-rays produced in the reactions on the target from random background cosmic-ray muons.

关键词： Bremsstrahlungγ-rays Čerenkov Geant4 Energy resolution Direction reconstruction Hough transform

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Asymmetric Autotandem Palladium Catalysis forα,β-Unsaturated Lactones:Merging Olefin and Ester Hydrogenation

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CCS Chemistry 2024年第8期6卷 1987-1999页

作者： Lei Sun Han Wang Die bai Chang-Bin Yu Bo Wu Rong-Zhen Liao Yong-Gui zhou State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023Liaoning School of Chemistry and Chemical Engineering Huazhong University of Science and TechnologyWuhan 430074Hubei

Autotandem catalysis(ATC)is fascinating since a single catalyst can promote tandem reactions involving two or more mechanisms in a single reactor and is a highly desirable approach to realize multifarious transformations in organic synthetic ***,a palladium-catalyzed asymmetric autotandem hydrogenation ofα,β-unsaturated lactones is disclosed,providing chiral saturated *** this reaction,the C=C bond inα,β-unsaturated lactones was first hydrogenated to give the dihydrocoumarins with high enantioselectivity,followed by hydrogenation of the ester group with the same catalytic ***,after decreasing the reaction temperature,hydrogenation of the single C=C bond proceeded smoothly,delivering the dihydrocoumarin products with high yield and *** experiments and density functional theory calculations were carried out to elucidate the cause of this unusual asymmetric autotandem ***,the homogeneous palladium catalyst was successfully applied in the hydrogenation of esters under neutral conditions.

关键词： autotandem catalysis asymmetric hydrogenation chiral dihydrocoumarins hydrogenation of esters α β-unsaturated esters

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OsFK1 encodes C-14 sterol reductase,which is involved in sterol biosynthesis and affects premature aging of leaves in rice

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The Crop Journal 2024年第4期12卷 1010-1021页

作者： Ping Li Xia Zhang Wuzhong Yin Yang shui Jie Zhang Nana Xu Dasong bai Qingxiong Huang Yuanyuan Li Pan Qi Xing Li Qianlong Li Shihong Yang Guotao Yang Hong Chen Peng Qin Yungao Hu Youlin Peng Rice Research Institute School of Life Science and EngineeringSouthwest University of Science and TechnologyMianyang 621010SichuanChina Hainan Yazhou Bay Seed Laboratory Sanya 572025HainanChina Rice Research Institute State Key Laboratory of Crop Gene Exploration and Utilization in Southwest ChinaSichuan Agricultural UniversityChengdu 610061SichuanChina Yazhouwan National Laboratory Sanya 572704HainanChina

The enzyme C-14 sterol reductase is involved in biosynthesis of brassinosteroids(BR)and sterols,as well as plant ***1,a member of the sterol biosynthesis pathway located in the endoplasmic reticulum(ER),encodes C-14 sterol ***,there is little research on the function of C-14 sterol reductase in *** with the wild type,an osfk1 mutant showed dwarf phenotype and premature aging in the second leaf during the trefoil stage,and abnormal development of leaf veins during the tillering *** osfk1 mutant showed signs of aberrant PCD,as evidenced by TUNEL *** suggested that high ROS buildup caused DNA damage and ROS-mediated cell death in the *** osfk1 mutant also showed decreased chlorophyll content and aberrant chloroplast *** of the osfk1 mutant allele revealed a non-synonymous G to A mutation in the final intron,leading to early ***,we identified the OsFK1 allele,cloned it by Mutmap sequencing,and verified it by ***-MS/MS assays demonstrated that the osfk1 mutation caused lower phytosterol *** findings showed that the OsFK1 allele encoding C-14 sterol reductase is involved in phytosterol biosynthesis and mediates normal development of rice plants.

关键词： Leaf development ROS Phytosterol biosynthesis Rice

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Recent advances in flexible self-oscillating actuators

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eScience 2024年第5期4卷 91-109页

作者： Jingjing Li Wenjin Guo Weiqiang Zhao Yutian Zhu Jie bai Zhigang Xia Xiang zhou Zunfeng Liu School of Textile Science and Engineering State Key Laboratory of New Textile Materials and Advanced Processing TechnologiesWuhan Textile UniversityWuhan 430200China State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Functional Polymer MaterialsTianjin Key Laboratory of Functional Polymer MaterialsSmart Sensing Interdisciplinary Science CenterCollege of ChemistryNankai UniversityTianjin 300350China College of Material Chemistry and Chemical EngineeringKey Laboratory of Organosilicon Chemistry and Material TechnologyMinistry of EducationKey Laboratory of Organosilicon Material TechnologyHangzhou Normal UniversityHangzhou 311121China College of Chemistry and Chemical Engineering Inner Mongolia Univ TechnolChem Engn CollHohhot 010051China Department of Science China Pharmaceutical UniversityNanjing 211198China

Soft actuators are constituted by a type of intelligent materials,and they can generate reversible mechanical motions under external *** usually achieve continuous actuation by manual turning on or off the power supply,which significantly increases the operation *** contrast,self-oscillating actuators can achieve autonomous motions under constant stimuli,and have recently attained great advancements,as well as promoted the development of autonomous soft *** this review,the latest achievements of soft oscillators are ***,the self-oscillating mechanisms mainly including oscillating chemical reactions and self-shadowing-induced mechanical negative feedback loops are *** oscillators constructed with various materials and configurations,driven by different stimuli and applied in different fields are then presented in ***,the difficulties and hopes of oscillators are ***,self-oscillating actuators are in the stage of vigorous development,and we believe that in the future,they will be used in various fields and make many scenarios more intelligent and autonomous.

关键词： Oscillating actuator Artificial muscles Polymer composite Biomimetic Smart materials

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Periodontitis exacerbates pulmonary hypertension by promoting IFNγ^(+)T cell infiltration in mice

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International Journal of Oral Science 2024年第2期16卷 359-369页

作者： Xiaoqian Meng Linjuan Du Shuo Xu Lujun zhou Boyan Chen Yulin Li Chumao Chen Huilin Ye Jun Zhang Guocai Tian Xuebing bai Ting Dong Wenzhen Lin Mengjun Sun Kecong zhou Yan Liu Wuchang Zhang Shengzhong Duan Department of Endodontics Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineShanghaiChina Laboratory of Oral Microbiota and Systemic Diseases Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghaiChina Hongqiao International Institute of Medicine Shanghai Tongren Hospital/Faculty of Basic MedicineKey Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of EducationShanghai Jiao Tong University School of MedicineShanghaiChina Department of Orthodontics Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineShanghaiChina Department of Periodontology Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineShanghaiChina Stomatology Hospital School of StomatologyZhejiang University School of MedicineHangzhouChina

Uncovering the risk factors of pulmonary hypertension and its mechanisms is crucial for the prevention and treatment of the *** the current study,we showed that experimental periodontitis,which was established by ligation of molars followed by orally smearing subgingival plaques from patients with periodontitis,exacerbated hypoxia-induced pulmonary hypertension in ***,periodontitis dysregulated the pulmonary microbiota by promoting ectopic colonization and enrichment of oral bacteria in the lungs,contributing to pulmonary infiltration of interferon gamma positive(IFNγ^(+))T cells and aggravating the progression of pulmonary *** addition,we identified Prevotella zoogleoformans as the critical periodontitis-associated bacterium driving the exacerbation of pulmonary hypertension by periodontitis,and the exacerbation was potently ameliorated by both cervical lymph node excision and IFNγneutralizing *** study suggests a proof of concept that the combined prevention and treatment of periodontitis and pulmonary hypertension are necessary.

关键词： hypertension prevention interferon

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Treatment of primary nasal tuberculosis with anti-tumor necrosis factor immunotherapy:A case report

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World Journal of Clinical Cases 2024年第17期12卷 3271-3276页

作者： Yong-Cai Liu Min-Li zhou Ke-Jia Cheng shui-Hong zhou Xue Wen Department of Otolaryngology The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangZhou 310003Zhejiang ProvinceChina Department of Otolaryngology The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Department of Pathology The First Affiliated HospitalMedical CollegeZhejiang UniversityHangzhou 310000Zhejiang ProvinceChina

BACKGROUND Primary nasal tuberculosis(TB)is a rare form of extrapulmonary TB,particularly in patients receiving anti-tumor necrosis factor(TNF)*** a result,its diagnosis remains *** SUMMARY A 58-year-old male patient presented to the ear,nose,and throat department with right-sided nasal obstruction and bloody discharge for 1 *** was diagnosed with psoriatic arthritis and received anti-TNF immunotherapy for 3 years prior to *** findings revealed chronic granulomatous inammation and a few acid-fast bacilli,suggestive of primary nasal *** was referred to our TB management department for treatment with oral anti-TB *** 9 months,the nasal lesions had *** recurrence was noted during *** The diagnosis of primary nasal TB should be considered in patients receiving TNF antagonists who exhibit thickening and crusting of the nasal septum mucosa or inferior turbinate,particularly when pathological findings suggest granulomatous inflammation.

关键词： Primary nasal tuberculosis Anti-tumor necrosis factor immunotherapy Granulomatous inflammation Psoriatic arthritis acid-fast bacilli Case report

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Differential Transcriptional Responses in Corneal and Lung Epithelial Cells to Seasonal Influenza With Potential Function of LGALS9

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Infectious Microbes & Diseases 2024年第3期6卷 141-151页

作者： Yang Han Ting Zhang Dan bai Changcheng Wu Beiwei Ye Jianfang zhou Yingze Zhao George F.Gao Jun Liu National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouChina State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouChina NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention(China CDC)BeijingChina Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry Guangxi Medical UniversityNanningChina National Key Laboratory of Intelligent Tracking and Forecasting for InfectiousDiseases(NITFID) National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijingChina

Seasonal flu,primarily caused by influenza A H1N1 and H3N2 subtype viruses or influenza B viruses,is the most prevalent respiratory tract infection globally and leads to substantial morbidity andmortality *** the influenza virus being initially recognized as a respiratory pathogenwithwell-characterized transmission through respiratory droplets,its impact on the ocular epithelium and associated gene expression remains relatively *** this study,we investigated the transcriptional profiles of immortalized human corneal epithelial cells(HCE-S)and A549 human lung epithelial cells infected with H1N1 and H3N2 influenza *** comparison with A549 cells,a reduced number of differentially expressed geneswas observed in HCE-S upon influenza virus ***,there was a significant upregulation of the genes IFI44L and OAS1,along with lower release of the CCL5/RANTES ***,our findings revealed uniquely upregulated LGALS9(encoding galectin-9)in HCE-S following infection with the 2009 pandemic H1N1 ***,targeted knockdown of LGALS9 in these cells resulted in a measurable decrease in viral infection,highlighting its role in the cellular responses to influenza virus and suggesting a novel avenue for antiviral ***,our findings provide insight into the distinct mechanisms of influenza virus interactions with different epithelial cells and underscore the importance of studying the ocular surface in understanding influenza pathogenesis.

关键词： immortalized human corneal epithelial cell line human pulmonary epithelial cell line influenza A virus transcriptome sequencing LGALS9

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Network pharmacology study and in vitro experimental validation of Xiaojianzhong decoction against gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 3932-3954页

作者： Guo-Qing Chen Yi Nan Na Ning Shi-Cong Huang Yu-Ting bai Zi-Ying zhou Gu Qian Wei-Qiang Li Ling Yuan College of Pharmacy Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Key Laboratory of Ningxia Minority Medicine Modernization Ministry of EducationNingxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Department of Pharmacy Ningxia Chinese Medicine Research CenterYinchuan 750021Ningxia Hui Autonomous RegionChina Department of Pharmacy General Hospital of Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Department of Chinese Medical Gastroenterology The Affiliated TCM Hospital of Ningxia Medical UniversityWuzhong 751100Ningxia Hui Autonomous RegionChina

BACKGROUND Cancer is one of the most serious threats to human health *** treatments such as surgery and chemotherapy are associated with some *** recent years,traditional Chinese medicine treatment has been increasingly advocated by patients and attracted attention from clinicians,and has become an indispensable part of the comprehensive treatment for gastric *** To investigate the mechanism of Xiaojianzhong decoction(XJZ)in the treatment of gastric cancer(GC)by utilizing network pharmacology and experimental validation,so as to provide a theoretical basis for later experimental *** We analyzed the mechanism and targets of XJZ in the treatment of GC through network pharmacology and ***,we verified the impact of XJZ treatment on the proliferative ability of GC cells through CCK-8,apoptosis,cell cycle,and clone formation ***,we performed Western blot analysis and real-time quantitative PCR to assess the protein and mRNA expression of the core *** XJZ mainly regulates IL6,PTGS2,CCL2,MMP9,MMP2,HMOX1,and other target genes and pathways in cancer to treat *** inhibition of cell viability,the increase of apoptosis,the blockage of the cell cycle at the G0/G1 phase,and the inhibition of the ability of cell clone formation were observed in AGS and HGC-27 cells after XJZ *** addition,XJZ induced a decrease in the mRNA expression of IL6,PTGS2,MMP9,MMP2,and CCL2,and an increase in the mRNA expression of *** significantly inhibited the expression of IL6,PTGS2,MMP9,MMP2,and CCL2 proteins and promoted the expression of the heme oxygenase-1 *** XJZ exerts therapeutic effects against GC through multiple components,multiple targets,and multiple *** findings provide a new idea and scientific basis for further research on the molecular mechanisms underlying the therapeutic effects of XJZ in the treatment of GC.

关键词： Xiaojianzhong decoction Gastric cancer Network pharmacology Molecular mechanism In vitro experiment

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