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Plasma metabolic biomarkers for syndrome of phlegm and blood stasis in hyperlipidemia and atherosclerosis

Journal of Traditional Chinese Medicine 2012年第4期32卷 578-583页

作者： dong bai Jiannan Song Institute of Basic Medical Theory of Chinese Medicine China Academy of Chinese Medical Sciences

OBJECTIVE： To explore the plasma metabolite pro- files in patients with the syndrome of phlegm and blood stasis in hyperlipidemia and atherosclerosis （As）, and to search for the metabolic biomarkers of the syndrome. METHODS： The plasma metabolite profiles of 31 patients with the syndrome of phlegm and blood stasis in hyperlipidemia and As, 6 patients with syn- dromes without phlegm and blood stasis, and 10 healthy subjects were analyzed by gas chromatog- raphy-mass spectrometry （GC-MS）. Partial least squares-discriminant analyses （PLS-DA） were used to carry out the pattern-recognition analyses of the data. The plasma metabolic biomarkers of patients were obtained by variable importance plot value （VlP value） and Student＇s t-test. The structures ofbiomarkers were defined by the National Institute of Standards and Technology （NIST） database. RESULTS： PLS-DA score plots of plasma metabo- Iomes did not show overlap between the phlegm-blood stasis syndrome group and syn- dromes without phlegm and blood stasis group, whereas significant differences in the concentra- tions in the plasma of 5 metabolites were found （P〈 0.05）. They were identified as urine, isoleucine, gluc- uronic acid, palmitic acid and glycerol by searching in NIST database. The concentrations of four metab- olites in the plasma of patients with syndrome of phlegm and blood stasis were higher than those with syndromes without phlegm and blood stasis, whereas the glycerol concentration was lower. CONCLUSION： Compared with patients with syn- dromes without phlegm and blood stasis, five me- tabolites showed abnormal levels in patients with the syndrome of phlegm and blood stasis. These metabolites could be diagnostic and prognostic biomarkers.

关键词： Hyperlipidemias Atherosclerosis Metab-olism Biological markers Phlegm and blood stasis

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Applying physics informed neural network for flow data assimilation

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Journal of Hydrodynamics 2020年第6期32卷 1050-1058页

作者： Xiao-dong bai Yong Wang Wei Zhang Ministry of Education Key Laboratory of Coastal Disaster and Defence Hohai UniversityNanjing210098China Max Planck Institute for Dynamics and Self-Organization GöttingenGermany Science and Technology on Water Jet Propulsion Laboratory Marine and Research Institute of ChinaShanghai200011China

Data assimilation(DA)refers to methodologies which combine data and underlying governing equations to provide an estimation of a complex *** informed neural network(PINN)provides an innovative machine learning technique for solving and discovering the physics in *** encoding general nonlinear partial differential equations,which govern different physical systems such as fluid flows,to the deep neural network,PINN can be used as a tool for *** to its nature that neither numerical differential operation nor temporal and spatial discretization is needed,PINN is straightforward for implementation and getting more and more attention in the *** this paper,we apply the PINN to several flow problems and explore its potential in fluid *** the mesoscopic Boltzmann equation and the macroscopic Navier-Stokes are considered as physics *** first introduce a discrete Boltzmann equation informed neural network and evaluate it with a one-dimensional propagating wave and two-dimensional lid-driven cavity *** laminar cavity flow is also considered as an example in an incompressible Navier-Stokes equation informed neural *** parameterized Navier-Stokes,two turbulent flows,one within a C-shape duct and one passing a bump,are studied and accompanying pressure field is *** examples end with a flow passing through a porous *** in this paper show that PINN provides a new way for intelligent flow inference and identification,ranging from mesoscopic scale to macroscopic scale,and from laminar flow to turbulent flow.

关键词： Data assimilation(DA) deep learning physics informed neural network hydrodynamics

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A Quantitative Version of the Bishop–Phelps Theorem for Operators in Hilbert Spaces

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Acta Mathematica Sinica,English Series 2012年第10期28卷 2107-2114页

作者： Li Xin CHENG Yun bai dong School of Mathematical Sciences Xiamen University

In this paper, with the help of spectral integral, we show a quantitative version of the Bishop-Phelps theorem for operators in complex Hilbert spaces. Precisely, let H be a complex Hilbert space and 0 〈 s 〈 1/2. Then for every bounded linear operator T ： H → H and x0 ∈ H with ｜｜T｜｜ = 1 = ｜｜xo｜｜ such that ｜｜Txo｜｜〉 1-6, there exist xε ∈ H and a bounded linear operator S ： H → H with ｜｜S｜｜ = 1 = ｜｜xε｜｜ such that ｜｜Sxε｜｜=1, ｜｜x-ε0｜｜≤√2ε＋4√2ε, ｜｜S-T｜｜≤√2ε.

关键词： Norm attaining operator Hilbert space Bishop-Phelps theorem

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Woods-Saxon-Gaussian potential and alpha-cluster structures of alpha + closed shell nuclei

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Chinese Physics C 2018年第12期42卷 100-105页

作者： dong bai Zhongzhou Ren School of Physics Nanjing UniversityNanjing 210093China School of Physics Science and Engineering Tongji UniversityShanghai 200092China

The Woods-Saxon-Gaussian （WSG） potential is proposed as a new phenomenological potential to sys- tematically describe the level scheme, electromagnetic transitions, and alpha-decay half-lives of tile alpha-cluster structures in various alpha ＋ closed shell nuclei. It modifies the original Woods Saxon （WS） potential with a shifted Gaussian factor centered at the nuclear surface. The free parameters in the WSG potential are determined by reproducing the correct level scheme of ^212Po=^208Pb＋α. It is found that the resulting WSG potential matches the NI3Y double-folding potential at tile surface region and makes corrections to the inner part of the cluster-core l）otential. It was also determined that the WSG potential, with nearly identical parameters to that of ^212Po （except for a rescale（l radius）, could also be used to describe alpha-cluster structures in ^20Ne=^16O＋α and ^44Ti = ^40Ca＋α. In all lhrec cases, the calculated values of the level schemes, electromagnetic transitions, and alpha-decay half-lives agree with the experimental data. which indicates that the WSG potential could indeed capture many important features of the alpha-cluster structures in alpha ＋ closed shell nuclei. This study is a useful complement to the existing cluster-core potentials ill literature. The Gaussian form factor centered at the nuclear surface might also help to improve our understailding of the alpha-cluster formation, which occurs in the same general region.

关键词： alpha cluster alpha decay cluster-core pot ential

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Effect of Wave Headings on the Dynamic Response of the Continuous Mating Operation of Floatover Installation

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China Ocean Engineering 2021年第1期35卷 72-83页

作者： bai Xiao-dong LUO Han-bing XIE Peng State Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin UniversityTianjin 300072China Department of Naval Architecture and Ocean Engineering Tianjin UniversityTianjin 300072China

The topside floatover installation is always a great challenge and is sensitive to environmental *** this study,experimental analysis on the mating operation of the floatover installation in different wave headings is *** continuous mating operation using the rapid transfer technique was experimentally simulated with the assistance of the jacking system and the ballast *** the continuous transfer modeling,the topsides loads were transferred onto the jacket by several consecutive steps,including the first rapid jack-down for the 30%loads,continuous 30%−70%load transfer and the second repaid jack-down for the remaining 30%*** of the barge and the topsides as well as loads on the Deck Support Unite(DSU)and the Leg Mating Unite(LMU)in different wave headings were *** results illustrated the complex motion behavior and load characteristics of the continuous transfer *** indicate that the rapid jack-down operations will lead to impact loads and larger lateral DSU *** bow quartering seas are much more dangerous as it gives rise to the larger motions and *** with the traditional steady-state modeling indicate that the continuous transfer modeling has greater advantages over the steady-state modeling on predicting the loads.

关键词： floatover installation rapid transfer technique model test different wave directions

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Rounded Data Analysis Based on Multi-Layer Ranked Set Sampling

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Acta Mathematica Sinica,English Series 2011年第12期27卷 2507-2518页

作者： Wei Ming LI Zhi dong bai KLMIB and School of Mathematics and Systems Science Beijing University of Aeronautics and Astronautics Beijing 100191 P. R. China Key Laboratory for Applied Statistics of MOE and School of Mathematics and Statistics Northeast Normal University Changchun 130024 P. R. China

Observations of sampling are often subject to rounding, but are modeled as though they were unrounded. This paper examines the impact of rounding errors on parameter estimation with multi-layer ranked set sampling. It shows that the rounding errors seriously distort the behavior of covariance matrix estimate, and lead to inconsistent estimation. Taking this into account, we present a new approach to implement the estimation for this model, and further establish the strong consistency and asymptotic normality of the proposed estimators. Simulation experiments show that our estimates based on rounded multi-layer ranked set sampling are always more efficient than those based on rounded simple random sampling.

关键词： Rounding error multi-layer ranked set sampling work likelihood method

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Uniform Homeomorphisms of Unit Spheres and Property H of Lebesgue–Bochner Function Spaces

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Acta Mathematica Sinica,English Series 2017年第5期33卷 681-690页

作者： Qing Jin CHENG Yun bai dong School of Mathematical Sciences Xiamen University School of Mathematics and Computer Wuhan Textile University

Assume that the unit spheres of Banach spaces X and Y are uniformly *** we prove that all unit spheres of the Lebesgue–Bochner function spaces Lp(μ, X) and Lq(μ, Y)are mutually uniformly homeomorphic where 1 ≤ p, q < ∞. As its application, we show that if a Banach space X has Property H introduced by Kasparov and Yu, then the space Lp(μ, X), 1 ≤ p < ∞,also has Property H.

关键词： Banach space uniform classification Property H Novikov conjecture

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α Decays in Superstrong Static Electric Fields

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Communications in Theoretical Physics 2018年第11期69卷 559-564页

作者： dong bai Zhong-Zhou Ren School of Physics Nanjing University School of Physics Science and Engineering Tongji University

Superstrong static electric fields could deform Coulomb barriers between α clusters and daughter nuclei,and bring up the possibility of speeding up α decays. We adopt a simplified model for the spherical α emitter^(212)Po and study its responses to superstrong static electric fields. We find that superstrong electric fields with field strengths|E|～0.1 MV/fm could turn the angular distribution of α emissions from isotropic to strongly anisotropic, and speed upα decays by more than one order of magnitude. We also study the influences of superstrong electric fields along the Po isotope chains, and discuss the implications of our studies on α decays in superstrong monochromatic laser fields. The study here might be helpful for future theoretical studies of α decay in realistic superstrong laser fields.

关键词： α decay cluster model static electric field

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On the Uniqueness of Ghost-Free Special Gravity

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Communications in Theoretical Physics 2017年第9期67卷 329-334页

作者： dong bai Yu-Hang Xing Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences Beijing 100190 China School of Physical Sciences University of Chinese Academy of Sciences No. 19A Yuquan Road Beijing 100049 China

Special gravity refers to interacting theories of massless gravitons in Minkowski space-time which are invariant under the abelian gauge invariance hab → hab ＋ δ（axb） only. In this article we determine the most general form of special gravity free of Ostrogradski ghosts, meaning its equation of motion is of at most second order. Together with the recent works, this result could be helpful in formulating proofs of General Relativity as the unique physical theory of self-interacting massless gravitons. We also study how to construct gauge invariant couplings to matter fields.

关键词： abelian gauge invariance massless graviton matter couplings

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Revealing the scientific connotation of compatibility of Chinese medicine medica based on self-assembly technology

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Journal of Traditional Chinese Medicine 2024年第6期44卷 1288-1295页

作者： dong Yingying GUO Qin GAO Yuan WANG Huanhuan bai dong Institute of Basic Theory of Chinese Medicine China Academy of Chinese Medical SciencesBeijing 100700China Basic Medical School Shaanxi University of Chinese MedicineXianyang 712046China

Chinese materia medica(CMM) compatibility is one core content in the theory of Traditional Chinese Medicine(TCM), and elaborating the scientific connotation of CMM compatibility is of great significance to promote the modernization of TCM. Self-assembly is the combination of active ingredients into aggregates through noncovalent bonds, such as hydrogen bonding, electrostatic interactions, ionic interactions, and hydrophobic interactions. The complex properties and special structures of CMM components create the basis for selfassembly. The self-assembled materials formed after CMM compatibility is an important part of the material basis for the efficacy of TCM, which can help explain the scientific connotations of CMM compatibility. This review summarizes the self-assembly phenomenon from the perspective of drug pair combinations in recent decades and explains the scientific connotation of CMM compatibility about the material basis, pharmacodynamic changes, and mechanism of action, providing new ideas and methods for the study of TCM.

关键词： Chinese materia medica compatibility medicine Chinese Traditional self-assembly phenomenon reduce adverse reactions and increase desired effects component interactions review

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