Revealing the scientific connotation of compatibility of Chinese medicine medica based on self-assembly technology

作     者：DONG Yingying GUO Qin GAO Yuan WANG Huanhuan BAI Dong 

作者机构：Institute of Basic Theory of Chinese MedicineChina Academy of Chinese Medical SciencesBeijing 100700China Basic Medical SchoolShaanxi University of Chinese MedicineXianyang 712046China 

出 版 物：《Journal of Traditional Chinese Medicine》 (中医杂志（英文版）)

年 卷 期：2024年第44卷第6期

页      面：1288-1295页

核心收录：

学科分类：08[工学] 0812[工学-计算机科学与技术（可授工学、理学学位）] 

基　　金：the Science and Technology Innovation Project of the China Academy of Chinese Medical Sciences:Establishment of Research Methods for Protein Supramolecular Components in Chinese Medicine decoction C12021A00108 Independent Selection Project of Institute of Basic Theory of Chinese Medicine,China Academy of Chinese Medical Sciences:Exploration and Case Study of the Research Model of"Theory and Experiment"on the Compatibility of Traditional Chinese Medicine,YZ-202109 

主　　题：Chinese materia medica compatibility medicine Chinese Traditional self-assembly phenomenon reduce adverse reactions and increase desired effects component interactions review 

摘      要：Chinese materia medica(CMM) compatibility is one core content in the theory of Traditional Chinese Medicine(TCM), and elaborating the scientific connotation of CMM compatibility is of great significance to promote the modernization of TCM. Self-assembly is the combination of active ingredients into aggregates through noncovalent bonds, such as hydrogen bonding, electrostatic interactions, ionic interactions, and hydrophobic interactions. The complex properties and special structures of CMM components create the basis for selfassembly. The self-assembled materials formed after CMM compatibility is an important part of the material basis for the efficacy of TCM, which can help explain the scientific connotations of CMM compatibility. This review summarizes the self-assembly phenomenon from the perspective of drug pair combinations in recent decades and explains the scientific connotation of CMM compatibility about the material basis, pharmacodynamic changes, and mechanism of action, providing new ideas and methods for the study of TCM.