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Folate receptor-targeted near-infrared photodynamic therapy for folate receptor-overexpressing tumors

World Journal of Clinical Oncology 2022年第11期13卷 880-895页

作者： Winn Aung Atsushi b Tsuji Kenjiro hanaoka Tatsuya higashi Department of Molecular Imaging and Theranostics Institute for Quantum Medical ScienceNational Institutes for Quantum and Radiological Science and TechnologyChiba 263-8555Japan Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences Keio UniversityTokyo 105-8512Japan

bACKGROUND Photodynamic therapy(PDT)is a minimally invasive form of cancer therapy,and the development of a novel photosensitizer(PS)with optimal properties is important for enhancing PDT *** receptor(FR)membrane protein is frequently overexpressed in 40%of human cancer and a good candidate for tumor-specific *** active targeting of PS to FR can be achieved by conjugation with the folate moiety.A folate-linked,near-infrared(NIR)-sensitive probe,folate-Si-rhodamine-1(FolateSiR-1),was previously developed and is expected to be applicable to *** To investigate the therapeutic efficacy of NIR-PDT induced by FolateSiR-1,a FRtargeted PS,in preclinical cancer *** FolateSiR-1 was developed by conjugating a folate moiety to the Si-rhodamine derivative through a negatively charged tripeptide *** expression in the designated cell lines was examined by western blotting(Wb).The selective binding of FolateSiR-1 to FR was confirmed in FR overexpressing Kb cells(FR+)and tumors by fluorescence microscopy and in vivo fluorescence *** FR expressing OVCAR-3 and A4 cell lines were used as negative controls(FR-).The NIR light(635±3 nm)-induced phototoxic effect of FolateSiR-1 was evaluated by cell viability imaging *** time-dependent distribution of FolateSiR-1 and its specific accumulation in Kb tumors was determined using in vivo longitudinal fluorescence *** PDT effect of FolateSiR-1 was evaluated in Kb tumor bearing mice divided into four experimental groups:(1)FolateSiR-1(100μmol/L)alone;(2)FolateSiR-1(100μmol/L)followed by NIR irradiation(50 J/cm2);(3)NIR irradiation(50 J/cm2)alone;and(4)no *** volume measurement and immunohistochemical(IhC)and histological examinations of the tumors were performed to analyze the effect of *** high FR expression was observed in the Kb cells by Wb,but not in the OVCAR-3 and A4 *** FR-specific binding of FolateSiR-1 was observed by in vitro an

关键词： Photodynamic therapy Near-infrared Photosensitizer Folate receptor Fluorescence Cancer

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高强度输送机胶带的前景和研制经验

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国外金属矿山 1995年第7期20卷 59-60页

作者： h.b.阿姆皮洛戈娃 Д.C.巴塔绍娃 h.Α.伊格纳托娃李显靖俄罗斯国立莫斯科矿业大学莫斯科"考丘克"工业联合公司

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利用声强测量方法确定声功率

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噪声与振动控制 1985年第3期 23-25页

作者： S.盖德 ,h.沃尔夫 ,K.b.金恩 ,于治会

前言声强测量的目的在于: 1.在啤酒厂背景噪声很高的出液机房中测量贴标鉴机全速工作时的噪声值。 2.检验贴标鉴机操作位置处的声压级是否低于该机生产厂的规定指标(85db(A))。

关键词：声强测量声学量测量声功率级贴标签机

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欧盟流域管理规划试点项目

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水利水电快报 2012年第1期33卷 19-26,44页

作者： h.b.麦德森 O.T.约根森 L.S.安德森唐湘茜孙远丹麦环境部欧登塞环境中心 EU China River basin Management Programme

丹麦的欧登塞河流域是欧洲14个流域之一,也是实施欧盟《水框架指令》流域管理规划的试点。作为共同实施战略的一部分,通过测试一系列技术指导文件,以确保形成统一的流域管理规划模式。项目成果包括3个部分,即流域特性报告、典型河流流... 详细信息

丹麦的欧登塞河流域是欧洲14个流域之一,也是实施欧盟《水框架指令》流域管理规划的试点。作为共同实施战略的一部分,通过测试一系列技术指导文件,以确保形成统一的流域管理规划模式。项目成果包括3个部分,即流域特性报告、典型河流流域管理计划和用于公众咨询的简易报告。通过欧登塞河流域试点项目的实施,欧盟各成员国的水管理机构及欧盟委员会获得了流域管理的知识和经验,同时可为中国未来的流域管理规划提供有益的借鉴。

关键词：水资源管理管理规划《水框架指令》流域管理欧盟

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Avian evolution and speciation in the Southeast Asian tropics

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Current Zoology 2015年第5期61卷 898-900页

作者： A. Townsend PETERSON Robert G. MOYLE Fumin LEI Luke C. CAMPILLO Peter A. hOSNER Luke b. KLICKA haw C. LIM Arpad S. NYARI Yanhua QU Sushma REDDY Frederick h. ShELDON FashengZOU biodiversity Institute University of Kansas Lawrence KS 66045 USA Key Laboratory of Zoological Systematics and Evolution Chinese Academy of Sciences Beijing 100101 China Department of biology University of Florida Gainesville FL 32611 USA Department of Vertebrate Zoology Smithsonian Institution Washington DC20560 USA Department of Integrative biology Oklahoma State University Stillwater OK 74078 USA biology Department Loyola University Chicago Chicago IL 60660 USA Museum of Natural Science and Department of biological Sciences Louisiana State University Baton Rouge LA 70803 USA Guangdong Entomological Institute Guangzhou 510260 China

An emerging paradigm in analysis of geographic differentiation and speciation is integration of phylogeographic analyses and paleo-distributional projections to gain insight into these complex historical processes （P... 详细信息

关键词：物种形成南亚热带进化鸟类分布预测地理分析形态分析地理分化

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Scleroderma and hIV Infection: A Case Report with Literature Review

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Open Journal of Internal Medicine 2018年第4期8卷 255-260页

作者： I. A. Dembélé N. R. Nyanke D. Traore A. K. Souckho D. Sy M. Cissoko A. Sanogo b. b. Sangaré O. A. Cisse K. Dao K. T. Tighankpa M. Malle M. Togo A. Keita A. Traore M. Saliou Y. Fofana D. Sangaré N. Tolo N. Doumbia A. Doumbia b. b. berthé b. D. Camara S. A. Coulibaly N. Sawadogo M. Dembélé A. K. Traore h. A. Traore Internal Medicine Department Point G Teaching Hospital Bamako Mali Department of Internal Medicine Kaya Regional Hospital Kaya Burkina Faso

Introduction: Acquired immunodeficiency syndrome (AIDS) linked to hIV infection is accompanied by auto-immune phenomena. Autoimmune diseases can develop in people living with hIV, most in a context of good immunological control (vasculitis, anti-phospholipid syndrome). Since the advent of antiretroviral therapy, an increasing number of autoimmune connective tissue diseases such as systemic lupus erythematosus, dermatomyositis, and syndromes of Sj?gren and scleroderma have been reported. Purpose: To describe this association’s not very common scleroderma and hIV infection. Observation: We report the case of a 56-year-old lady admitted into the service for functional impotence that would have been evolving for a week. Prior to her hospitalization, she presented edemas of the lower limbs associated with anesthesia of the lower limbs for 5 months. The painting is accompanied by a productive cough and an intermittent fever. At the physical examination a weight loss (bMI = 13.74 Kg/m2), fever (38.7°C): Oral candidiasis, lower lip ulceration, perlicking, undernutrition folds, sclerodactyly and homogeneous hepatomegaly was noted. The diagnosis of immunosuppression to hIV Stage 3 with Tb co-morbidity and positive hepatitis b Serology was retained while diffuse Scleroderma was selected from the ACR/EULAR criteria of 2012 with a score of 10 (sclerodactyly = 4 point;Raynaud’s phenomenon = 3 point and Ac Anti Scl 70 positive = 3 point). Conclusion: These associations of chronic pathology must be described to improve the future treatment of our patients.

关键词： Scleroderma hIV Internal Medicine

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Evaluation of genetic potential of the polyvoltine silkworm (bombyx mori L.) germplasm and identification of parents for breeding programme

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Journal of Zhejiang University-Science b(biomedicine & biotechnology) 2006年第3期7卷 215-220页

作者： RAO C.G.P. SEShAGIRI S.V. RAMESh C. IbRAhIM bAShA K. NAGARAJU h. ChANDRAShEKARAIAh Andhra Pradesh State Sericulture Research and Development Institute (APSSRDI) Kirikera Hindupur-515 211 India

In the present study, polyvoltine germplasm stock ofAndhra Pradesh State Sericulture Research and Development, Institute （APSSRDI） was evaluated for its performance based on quantitative and qualitative traits. Twenty-one oval and 10 peanut cocoon shaped lines were reared in different seasons of the year. Since the polyvoltines are non-diapausing, six generations were reared and evaluated for various economically important traits based on evaluation index and sub-ordinate function statistical methods. Ten top ranked lines obtained by using both the methods were identified as potential parental strains. Among oval lines, APMI4, APMI 1, APMIS, APMW9, and APMI9, and among peanut lines APMD5, APMDI, APMD3, APMD9 and APMD8 were selected as base material. The identified high yielding lines will be used in various breeding programmes as initial parents for the synthesis of superior polyvoltine breeds/hybrids.

关键词： Polyvoltine Silkworm Germplasm Performance Evaluation

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膨胀石墨基镍/炭复合物(英文)

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新型炭材料 2011年第5期26卷 335-340页

作者： I.M.Afanasov O.I.Lebedev b.A.Kolozhvary A.V.Smirnov G.Van Tendeloo Chemistry Department Moscow State University119991 MoscowRussia Laboratoire CRISMAT UMR 6508 CNRS/ENSICAEN6 bd du Maréchal Juin F-14050 CAEN Cedex 4France EMAT University of AntwerpGroenenborgerlaan 171B-2020AntwerpBelgium

NiO粒子修饰的压缩膨胀石墨(EGNiO)浸以煤焦油沥青,经550℃裂解,继而800℃水蒸气活化,制得Ni/C复合物块体。应用TEM考察了复合物中含Ni纳米粒的微结构排列方式。以N2吸附测定分析了复合物的比表面积和孔隙度。以2,2,3—三甲基戊烷脱氢... 详细信息

NiO粒子修饰的压缩膨胀石墨(EGNiO)浸以煤焦油沥青,经550℃裂解,继而800℃水蒸气活化,制得Ni/C复合物块体。应用TEM考察了复合物中含Ni纳米粒的微结构排列方式。以N2吸附测定分析了复合物的比表面积和孔隙度。以2,2,3—三甲基戊烷脱氢裂解模型反应评估了复合物的催化活性并与EGNiO常规h2处理获得的参照物的活性做了比较。

关键词：膨胀石墨镍/炭复合物微结构催化活性

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Anti-oxidative effects of functional food,Lignosus rhinocerus sclerotia(TM02®cultivar)using a type 2 diabetes mellitus rodent model

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Food bioscience 2022年第5期49卷 825-832页

作者： Chee-Sum A.Yap Muhammad F.M.Razif Szu-Ting Ng Chon-Seng Tan Amira h.Abd Jamil Shin-Yee Fung Medicinal Mushroom Research Group(MMRG) Department of Molecular MedicineFaculty of MedicineUniversiti Malaya50603Kuala LumpurMalaysia LiGNO Research Initiative Department LiGNO Biotech Sdn.Bhd.43300 Balakong JayaSelangorMalaysia Center for Natural Products Research and Drug Discovery(CENAR) Universiti Malaya50603Kuala LumpurMalaysia University of Malaya Centre for Proteomics Research(UMCPR) Universiti Malaya50603Kuala LumpurMalaysia Department of Pharmaceutical Life Sciences Faculty of PharmacyUniversiti Malaya50603Kuala LumpurMalaysia

Lignosus rhinocerus is a highly valued medicinal mushroom traditionally consumed by the indigenous communities of Southeast Asia as treatment for numerous ailments,some of which are linked to its antioxidative *** the antioxidative capacity of *** has been established in vitro,lack of translational studies are available on the effect of *** in the pathogenesis of diseases driven by high oxidative *** study aims to investigate the in vivo antioxidative effects of cultivated Lignosus rhinocerus(TM02®)sclerotia in a multifaceted in vivo model of oxidative stress,induced by chronic hyperglycemia associated with diabetes.A type 2 diabetes mellitus(T2DM)rodent model was generated using a high-fat diet in combination with low dose streptozotocin after which TM02®cultivar,at a dose of 200 mg/kg,was administered orally for 14 *** rats treated with TM02®cultivar had decreased plasma AGEs concentration,complemented with improved mitochondrial respiratory function associated with elevated cardiac and skeletal muscle ATP concentrations in both diabetic and non diabetic ***,TM02®cultivar-treated rats have improved glycemic control,with the potential ability to induce insulin *** findings revealed that TM02®exhibits antioxidative effects to potentially alleviate diabetes-related complications associated with AGEs accumulation,with significant effects in enhancing mitochondrial function and energy production.

关键词： Lignosus rhinocerus TM0_(2)®cultivar Anti-oxidative ATP Advanced glycation end products

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A Periglacial Palaeoenvionment in the Upper Carboniferous-Lower Permian Tobra Formation of the Salt Range,Pakistan

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Acta Geologica Sinica(English Edition) 2017年第3期91卷 1063-1078页

作者： Irfan U.JAN Shahid IQbAL Sarah J.DA VIES Jan A.ZALASIEWICZ Michael h.STEPhENSON Michael WAGREICh Muhammad hANEEF Muhammad hANIF Sajjad AhMAD National Centre of Excellence in Geology University of Peshawar Department of Earth Sciences Quaid-i-Azam University Islamabad Department of Geodynamics and Sedimentology University of Vienna Department of Geology University of Leicester british Geological Survey Department of Earth Sciences Comsats Institute of Technology Abbottabad Department of Geology University of Peshawar

The Upper Carboniferous-Lower Permian （Upper Pennsylvanian-Asselian） Tobra Formation is exposed in the Salt and Trans Indus ranges of Pakistan. The formation exhibits an alluvial plain （alluvial fan-piedmont alluvial plain） facies association in the Salt Range and Khisor Range. In addition, a stream flow facies association is restricted to the eastern Salt Range. The alluvial plain facies association is comprised of clast-supported massive conglomerate （Gmc）, diamictite （Dm） facies, and massive sandstone （Sm） iithofacies whereas the stream flow-dominated alluvial plain facies association includes fine-grained sandstone and sUtstone （Fss）, fining upwards pebbly sandstone （Sf）, and massive mudstone （Fro） lithofacies. The lack of glacial signatures （particularly glacial grooves and striations） in the deposits in the Tobra Formation, which are, in contrast, present in their time-equivalent and palaeogeographically nearby strata of the Arabian peninsula, e.g. the Al Khlata Formation of Oman and Unayzah b member of the Sandi Arabia, suggests a pro-to periglacial, i.e. glaciofluvial depositional setting for the Tobra Formation. The sedimentology of the Tobra Formation attests that the Salt Range, Pakistan, occupied a palaeogeographic position just beyond the maximum glacial extent during Upper Pennsylvanian-Asselian time.

关键词： Pennsylvanian-Asselian Tobra Formation Salt Range Khisor Range glaciofluvial Pakistan

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