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Journal of Pharmaceutical Analysis 2024年第3期14卷 427-430页

作者： Ju Yeon Lee Muhammad Shoaib Jin-Woong Choi Rishabh C.Choudhary Tai Yin Nara Yoon Kei Hayashida Seunguk J.baek Santiago J.Miyara Lance b.becker Junhwan Kim Research Center of bioconvergence Analysis Korea Basic Science InstituteCheongjuSouth Korea bio-Analytical Science University of Science and TechnologyCheongjuSouth Korea Laboratory for Critical Care Physiology Feinstein Institutes for Medical ResearchManhassetNY11030USA Donald and barbara Zucker School of Medicine at Hofstra/Northwell School of Medicine HempsteadNY11549USA Mathematics and Computer Science Adelphi UniversityGarden CityNY11530USA Department of Emergency Medicine North Shore University HospitalManhassetNY11030USA

Cardiac arrest(CA)is a life-threatening condition with complex pathophysiology and limited treatment *** gain deeper insights into the pathological state of vital organs,we employed a proteomics analysis in rodents to assess proteome alterations in the brain,heart,kidney,and liver using a rat model of *** brain displayed severe protein alterations in essential cellular pathways,including three major energy-generating pathways after CA,which worsened after resuscitation,resulting in the most significant overall protein changes among the ***,the liver,experiencing the most substantial protein alterations post-CA,demonstrated significant recovery,presenting the least protein changes post-resuscitation.

关键词： alterations organs damage

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烧合成气的燃气轮机在设计和运行中的经验

燃气轮机技术 1997年第2期10卷 41-47页

作者： N.Vortmeyer M.Huth b.Schetter b.becker J.Karg W.tmsperger 陈晓平德国西门子公司发电集团西门子(中国)有限公司发电部

本文对采用西门子燃气轮机的政州IGCC电厂作了简短概述。着重讨论了buggenumIGCC电厂在示范运行阶段的运行经验。从1994年4月以来，一台燃烧和燃料系统经过改进的V94．2燃机已累计运行了几千小时，并且为西门子合成气燃烧系统提供了首... 详细信息

本文对采用西门子燃气轮机的政州IGCC电厂作了简短概述。着重讨论了buggenumIGCC电厂在示范运行阶段的运行经验。从1994年4月以来，一台燃烧和燃料系统经过改进的V94．2燃机已累计运行了几千小时，并且为西门子合成气燃烧系统提供了首次现场经验．完全整体化的电厂（10％气化空气抽自压气机出口）和各种不同的运行要求需要燃气轮机具有很高的灵活性。对燃用常规（备用）燃料、中热值和低热值煤气的所有正常和紧急负荷工况都进行了成功的试验．

关键词：燃气轮机 IGCC 燃料合成气燃烧系统

Impact of the 2010 resuscitation guidelines training on layperson chest compressions

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World Journal of Emergency Medicine 2015年第4期6卷 270-276页

作者： Audrey L.blewer David G.buckler Jiaqi Li Marion Leary Lance b.becker Judy A.Shea Peter W.Groeneveld Mary E.Putt benjamin S.Abella Department of Emergency Medicine and Center for Resuscitation Science University of Pennsylvania School of Nursing University of Pennsylvania Department of Medicine University of Pennsylvania Department of biostatistics and Epidemiology University of Pennsylvania

bACKGROUND: Survival from cardiac arrest is sensitive to the quality of delivered CPR. In 2010, updated international resuscitation guidelines emphasized deeper chest compressions and faster rates, yet it is unknown whether training laypersons using updated guidelines resulted in changed CPR performance. We hypothesized that laypersons taught CPR using the 2010 guidelines performed deeper and faster compressions than those taught using the 2005 ***: This work represents a secondary analysis of a study conducted at eight hospitals where family members of hospitalized cardiac patients were trained in CPR. An initial cohort was trained using the 2005 guidelines, and a subsequent cohort was trained using the 2010 guideline materials. Post training, CPR skills were quantified using a recording ***: between May 2009 to August 2013, 338 subjects completed the assessment. Among the subjects, 176 received 2005 training and 162 underwent 2010 training. The mean compression rate in the 2005 cohort was 87(95%CI 83–90) per minute, and in the 2010 cohort was 86(95%CI 83–90) per minute(P=ns), while the mean compression depth was 34(95%CI 32–35) mm in the 2005 cohort and 46(95%CI 44–47) mm in the 2010 cohort(Pbut there was no change in compression rate. Nevertheless, the majority of CPR performed by trainees in both cohorts was below the guideline recommendation, highlighting an important gap between training goals and trainee performance.

关键词： Cardiopulmonary resuscitation Cardiac arrest Sudden death Education Guidelines

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分泌过多性青光眼

中华眼科杂志 1957年第6期8卷 573-573页

作者： b.becker G.R.Keskey RE.Christensen 李紹珍

作者們檢查了1500次眼压描記圖,为1300名重复檢查的患者作記录。發现其中65人(128只眼)显然具有眼內压增高,而其房水流出条件正常,房角是开放的,且一向未作过眼部手术。文內詳明所謂房水分泌过多是指其房水流出量是在每分鐘4立方毫米以上。

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Formation of primary intermetallic phases in the interaction of Fe-containing melts of recycled Al-Si alloys with Al_(2)O_(3)and Al_(2)O_(3)-C filter materials:Aμ-CT study

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Journal of Materials Science & Technology 2024年第17期184卷 88-100页

作者： H.becker b.Fankhänel A.Charitos S.baier-Stegmaier A.Leineweber W.Pantleon Institute of Materials Science TU Bergakademie FreibergGustav-Zeuner-Straße 509599 FreibergGermany Institute of Nonferrous Metallurgy and Purest Materials TU Bergakademie FreibergLeipziger Straße 3409599 FreibergGermany Department of Physics Technical Univeristy of DenmarkFysikvej 3102800 Kgs.LyngbyDenmark Department of Civil and Mechanical Engineering Technical Univeristy of DenmarkProduktionstorvet 4252800 Kgs.LyngbyDenmark

Fe is the most detrimental impurity element in recycled Al-Si alloys due to the formation of brittle,primary,Fe-containing,intermetallic particles during *** removal from the Al-Si melts *** filtration can reduce the Fe *** active filter materials can facilitate the formation of these particles for their removal and contribute to the production of high-quality,recycled Al-Si *** interaction of the alloy with the filter material can lead to modification of the thermodynamics of the alloy or of the kinetics of the particle ***-resolved,three-dimensional microstructural inves-tigations have been carried out to study the formation of primary intermetallic particles in Al7.1Si1.5Fe and Al7.1Si0.75Fe0.75Mn alloy melts in contact with Al_(2)O_(3)and Al_(2)O_(3)-C filter substrate material during a melt conditioning treatment at 620°*** microstructures,in particular the primary intermetallic particlesαc andαh,have been characterized by computed tomography(CT)and supplementary scanning electron microscopy(SEM).As expected by thermodynamics,the total volume fraction of primary par-ticles remains unchanged by the interaction with the substrate ***,kinetic advantages for Fe-removal efficiency can be achieved by an accelerated and preferred selective particle formation in contact with the Al_(2)O_(3)-C ***,particle formation is discussed in view of its different stages:nucleation,growth,and ripening.

关键词： Aluminum alloys Intermetallic phases Solidification X-ray computed tomography Scanning electron microscopy

Quantum-orbit theory of low-energy above-threshold ionization on and off axis

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Chinese Optics Letters 2015年第7期13卷 18-22页

作者： W.becker D.b.Miloevi Max-born-Institut Faculty of Science University of Sarajevo Academy of Sciences and Arts of bosnia and Herzegovina

Intense-laser-induced above-threshold ionization of a bound electron into continuum states with low energy is investigated in the context of the strong-field approximation that allows for one act of rescattering of the re- visiting electron. The quantum orbits for forward and backward scattering are evaluated and generalized to arbitrary scattering angles. The velocity map of the liberated electron exhibits the well-known low-energy structure as well as other features off the polarization axis.

关键词： Quantum-orbit theory of low-energy above-threshold ionization on and off axis

MicroRNAs in NF-κb signaling

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Journal of Molecular Cell biology 2011年第3期3卷 159-166页

作者： Xiaodong Ma Lindsey E.becker buscaglia Juanita R.barker Yong Li Department of biochemistry and Molecular biology School of MedicineUniversity of Louisville319 Abraham Flexner WayLouisvilleKY 40202USA

Nuclear factor κb(NF-κb)is a transcriptional factor that regulates a battery of genes that are critical to innate and adaptive immunity,cell proliferation,inflammation,and tumor ***(miRNAs)are short RNA molecules of 20-25 nucleotides in length that negatively regulate gene expression in animals and plants primarily by targeting 3′untranslated regions of *** this work,we review the convergence of miRNAs and NF-κb signaling and dysregulation of miRNAs and NF-κb activation in human diseases,particularly in *** function of miR-146,miR-155,miR-181b,miR-21,and miR-301a in NF-κb activation and their impact on tumorigenesis are *** that over 1000 human miRNAs have been identified,rendering miRNAs one of the most abundant classes of regulatory molecules,deciphering their biological function and pathological contribution in NF-κb dysregulation is essential to appreciate the complexity of immune systems and to develop therapeutics against cancer.

关键词： microRNA NF-κb cancer

Improving the haploidization toolbox:Maternal factors take the stage

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Molecular Plant 2023年第4期16卷 651-653页

作者： Maria Flores-Tornero Helena Sapeta Jorg D.becker Instituto de Tecnologia Quimica e biologica Universidade Nova de LisboaAv.daRepublica2780-157OeirasPortugal

Plant breeders have a great interest in obtaining plants that are genetically homogeneous as quickly as possible,with high efficiency and at low *** approaches,including selfing or backcrossing,cannot provide *** technologies,however,offer a solution and are therefore the subject of intensive research,in particular during the last decade.

关键词： breed homogeneous quickly

Extracellular matrices, artificial neural scaffolds and the promise of neural regeneration

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Neural Regeneration Research 2014年第17期9卷 1573-1577页

作者： Christian b.Ricks Samuel S.Shin Christopher becker Ramesh Grandhi Department of Neurological Surgery University of Pittsburgh Medical CenterPittsburghPAUSA University of Pittsburgh School of Medicine PittsburghPAUSA

Over last 20 years, extracellular matrices have been shown to be useful in promoting tissue regeneration. Recently, they have been used and have had success in achieving neurogenesis. Recent developments in extracellular matrix design have allowed their successful in vivo incorporation to engender an environment favorable for neural regeneration in animal models. Promising treatments under investigation include manipulation of the intrinsic extracellular matrix and incorporation of engineered naometer-sized scaffolds through which inhibition of molecules serving as barriers to neuroregeneration and delivery of neurotrophic factors and/or cells for successful tissue regeneration can be achieved. Further understanding of the changes incurred within the extracellular matrix following central nervous system injury will undoubtedly help design a clinically efficacious extracellular matrix scaffold that can mitigate or reverse neural degeneration in the clinical setting.

关键词： extraceUular matrix neurogenesis scaffolds neural stem cells

Predictive value of Ki67 and p53 in locally advanced rectal cancer:Correlation with thymidylate synthase and histopathological tumor regression after neoadjuvant 5-FU-based chemoradiotherapy

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World Journal of Gastroenterology 2008年第7期14卷 1060-1066页

作者： Christiane Jakob Torsten Liersch Wolfdietrich Meyer Heinz becker Gustavo b baretton Daniela E Aust Institute for Pathology University of TechnologyFetscherstr. 74D-01307 DresdenGermany Department of General Visceral and Transplantation SurgeryUniversity Medical Center of GttingenRobert-Koch-Str. 40D-37075 GttingenGermany

AIM: To investigate the predictive value of Ki67 and p53 and their correlation with thymidylate synthase (TS) gene expression in a rectal cancer patient cohort treated according to a standardized recommended neoadjuvant treatment ***: Formalin fixed, paraffin embedded pre-therapeutical tumor biopsies (n = 22) and post-therapeutical resection specimens (n = 40) from patients with rectal adenocarcinoma (clinical UICC stage Ⅱ/Ⅲ) receiving standardized neoadjuvant 5-fluorouracil (5-FU) based chemoradiotherapy were studied for Ki67 and p53 expression by immunohistochemistry and correlated with TS mRNA expression by quantitative TaqMan real-time PCR after laser microdissection. The results were compared with histopathological tumor regression according to a standardized semiquantitative score grading ***: Responders (patients with high tumor regression) showed a significantly lower Ki67 expression than non-responders in the pre-therapeutical tumor biopsies (81.2% vs 16.7%; P biopsies (corr. coef. = 0.46; P between p53 and TS mRNA expression or tumor ***: Ki67 has, like TS, predictive value in rectal cancer patients after neoadjuvant 5-FU based chemoradiotherapy. The close correlation between Ki67 and TS indicates that TS is involved in active cell cycle processes.

关键词： p53 Ki67 Neoadjuvant treatment Rectal cancer Thymidylate synthase