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Protein Arginine Methyltransferase 1 Ablation in Motor Neurons Causes Mitochondrial Dysfunction leading to Age-related Motor Neuron Degeneration with Muscle loss

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Research 2024年第1期2023卷 637-649页

作者： Hyun-Kyung So Hyebeen Kim Jinwoo lee Chang-lim You Chae-Eun Yun Hyeon-Ju Jeong Eun-Ju Jin Yunju Jo Dongryeol Ryu Gyu-un bae Jong-Sun Kang Department of Molecular Cell biology Sungkyunkwan University School of MedicineSuwonKorea Single Cell Network Research Center Sungkyunkwan University School of MedicineSuwonKorea Research Institute of Aging-Related Diseases AniMusCureInc.SuwonKorea Drug Information Research Institute Muscle Physiome Research CenterCollege of PharmacySookmyung Women’s UniversitySeoulKorea

Neuromuscular dysfunction is tightly associated with muscle wasting that occurs with age or due to degenerative ***,the molecular mechanisms underlying neuromuscular dysfunction are currently *** studies have proposed important roles of Protein arginine methyltransferase 1(Prmt1)in muscle stem cell function and muscle *** the current study,we set out to determine the role of Prmt1 in neuromuscular function by generating mice with motor neuron-specific ablation of Prmt1(mnKO)using *** exhibited age-related motor neuron degeneration and neuromuscular dysfunction leading to premature muscle loss and ***1 deficiency also impaired motor function recovery and muscle reinnervation after sciatic nerve *** transcriptome analysis of aged mnKO lumbar spinal cords revealed alterations in genes related to inflammation,cell death,oxidative stress,and ***,mnKO lumbar spinal cords of sciatic nerve injury model or aged mice exhibited elevated cellular stress response in motor ***,Prmt1 inhibition in motor neurons elicited mitochondrial *** findings demonstrate that Prmt1 ablation in motor neurons causes agerelated motor neuron degeneration attributing to muscle ***,Prmt1 is a potential target for the prevention or intervention of sarcopenia and neuromuscular dysfunction related to aging.

关键词： degeneration impaired prevention

考虑间隙水体阻尼修正的过驳双船系统动力响应研究

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船舶力学 2024年第6期28卷 856-865页

作者：刘利琴刘依伦王岭郭颖孟春蕾天津大学水利工程仿真与安全国家重点实验室天津300072 天津航海仪器研究所天津300131

利用阻尼修正的势流理论对过驳双船系统进行研究。建立了过驳双船系统CFD数值计算模型,通过在双船间隙自由水面施加粘性阻尼盖的方法对势流理论进行修正。对双船过驳系统在考虑与不考虑修正两种情况下的时域结果进行对比分析,结果表明:... 详细信息

利用阻尼修正的势流理论对过驳双船系统进行研究。建立了过驳双船系统CFD数值计算模型,通过在双船间隙自由水面施加粘性阻尼盖的方法对势流理论进行修正。对双船过驳系统在考虑与不考虑修正两种情况下的时域结果进行对比分析,结果表明:双船各自由度的运动响应以及各系缆护舷的受力,在不计及粘性修正时的计算结果皆高于修正后的结果,因而考虑流体粘性的修正是非常必要的。

关键词：过驳系统粘性修正时域分析势流理论

“三个务必”融入高校思政课教学的价值与实践

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苏州科技大学学报（社会科学版） 2024年第1期41卷 25-31,107页

作者：孙崇明温波苏州科技大学马克思主义学院江苏苏州215009

党的二十大报告首次提出“三个务必”,这既是对新时代新征程中全体党员的引领与塑造,也是重要的思政课教学资源。“三个务必”融入高校思政课教学是落实思政课立德树人根本任务的育人使命,是挖掘“三个务必”思想教育资源的教学之需,是... 详细信息

党的二十大报告首次提出“三个务必”,这既是对新时代新征程中全体党员的引领与塑造,也是重要的思政课教学资源。“三个务必”融入高校思政课教学是落实思政课立德树人根本任务的育人使命,是挖掘“三个务必”思想教育资源的教学之需,是引导青年学生抵御和反对“躺平”无为的时代诉求。要创造性地将“三个务必”融入高校思政课教学,就要明确立德树人的教学目标;促进“三个务必”理论成果向教学内容转化;丰富运用课堂叙事、探索启发、社会体验等教学方法;以“四个熔铸”教学格局整体提升高校思政课贯彻落实“三个务必”的能力和水平。

关键词： “三个务必” 高校思政课

Two-dimensional Dirac plasmon-polaritons in graphene,3D topological insulator and hybrid systems

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light(Science & Applications) 2022年第11期11卷 2602-2616页

作者： Chihun In un Jeong Kim Hyunyong Choi Department of Physics Freie Universitat BerlinBerlin 14195Germany Department of Physical Chemistry Fritz-Haber-lInstitute of the Max-Planck-SocietyBerlin 14195Germany Department of Physics and Astronomy Seoul National UniversitySeoul 08826Republic of Korea Institute of Applied Physics Seoul National UniversitySeoul 08826Republic of Korea Advanced Sensor laboratory Samsung Advanced Institute of TechnologySuwonGyeonggido 16419Republic of Korea

Collective oscillations of massless particles in two-dimensional(2D)Dirac materials offer an innovative route toward implementing atomically thin devices based on low-energy quasiparticle *** confinement of nearfield distribution on the 2D surface is essential to demonstrate extraordinary optoelectronic functions,providing means to shape the spectral response at the mid-infrared(IR)*** the dynamic polarization from the linear response theory has successfully accounted for a range of experimental observations,a unified perspective was stll elusive,connecting the state-of-the-art developments based on the 2D Dirac ***,we review recent works on graphene and three-dimensional(3D)topological insulator(TI)plasmon-polariton,where the mid-IR and terahertz(THz)radiation experiences prominent confinement into a deep-subwavelength scale in a novel optoelectronic *** presenting general light-matter interactions between 2D Dirac plasmon and subwavelength quasiparticle excitations,we introduce various experimental techniques to couple the plasmonpolaritons with electromagnetic *** and optical controls over the plasmonic excitations reveal the hybridized plasmon modes in graphene and 3D Tl,demonstrating an intense near-field interaction of 2D Dirac plasmon within the highly-compressed *** findings can further be applied to invent optoelectronic biomolecular sensors,atomically thin photodetectors,and laser-driven light sources.

关键词： structure Dirac topological

Artificial synaptic and self-rectifying properties of crystalline(Na_(1-x)K_(x))NbO_(3)thin films grown on Sr_(2)Nb_(3)O_(10)nanosheet seed layers

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Journal of Materials Science & Technology 2022年第28期123卷 136-143页

作者： In-Su Kim Jong-un Woo Hyun-Gyu Hwang bumjoo Kim Sahn Nahm Department of Materials Science and Engineering Korea UniversitySeoul 02841Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul 02841Republic of Korea

Crystalline(Na_(1-x)K_(x))NbO_(3)(NKN)thin films were deposited on Sr_(2)Nb_(3)O_(10)/TiN/Si(S-TS)substrates at 370°***_(2)Nb_(3)O_(10)(SNO)nanosheets served as a template for the formation of crystalline NKN films at low *** the NKN film was deposited on one SNO monolayer,the NKN memristor exhibited normal bipolar switching characteristics,which could be attributed to the formation and destruction of oxygen vacancy ***,the NKN memristor with one SNO monolayer exhibited artificial synaptic ***,the NKN memristor deposited on two SNO monolayers exhibited self-rectifying bipolar switching properties,with the two SNO monolayers acting as tunneling barriers in the *** conduction mechanism of the NKN memristor with two SNO monolayers in the highresistance state is attributed to Schottky emission,direct tunneling,and Fowler–Nordheim(FN)*** current conduction in this memristor in the low-resistance state was governed by direct tunneling and FN ***,the NKN memristor with two SNO monolayers exhibited large ON/OFF and rectification ratios and artificial synaptic ***,an NKN memristor with two SNO monolayers can be used for fabricating artificial synaptic devices with a cross-point array structure.

关键词： bipolar switching properties Self-rectifying bipolar switching properties Artificial synaptic properties Crystalline NKN thin film Sr_(2)Nb_(3)O_(10)nanosheet seed layer

Radiative capture of proton by ^(9)be(p,γ)^(10)b at low energy

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Communications in Theoretical Physics 2022年第2期74卷 78-82页

作者： Abdul Kabir Jameel-un Nabi Sumair Sagheer laiba Rashid Department of Space Science Institute of Space TechnologyIslamabadPakistan university of Wah Quaid AvenueWah Cantt 47040PunjabPakistan Faculty of Engineering Sciences GIK Institute of Engineering Sciences and TechnologyTopi 23640SwabiKhyber PakhtunkhwaPakistan

Radiative capture p+^(9)be→^(10)b+γ at energies bearing astrophysical importance is a key process for the spectroscopic study of ^(10)*** this work,we consider the radiative capture cross-section for the ^(9)be(p,γ)^(10)b within the framework of the potential model and the R-matrix method for the multi-entrance channel *** certain cases,when the potential fails,therefore,the R-matrix approach is better to use for the description of partial components of the cross-section that have sharp or broad *** all possible electric and magnetic dipole transitions,partial components of the astrophysical S-factor are *** computed value of the total S-factor at zero energy is consistent with the reported results.

关键词： potential model R-matrix approach E1 transitions M1 transitions cross-section astrophysical S-factor

National guidelines for the diagnosis and treatment of hilar cholangiocarcinoma

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World Journal of Gastroenterology 2024年第9期30卷 1018-1042页

作者： Faisal Saud Dar Zaigham Abbas Irfan Ahmed Muhammad Atique Usman Iqbal Aujla Muhammad Azeemuddin Zeba Aziz Abu bakar Hafeez bhatti Tariq Ali bangash Amna Subhan butt Osama Tariq butt Abdul Wahab Dogar Javed Iqbal Farooqi Faisal Hanif Jahanzaib Haider Siraj Haider Syed Mujahid Hassan Adnan Abdul Jabbar Aman Nawaz Khan Muhammad Shoaib Khan Muhammad Yasir Khan Amer latif Nasir Hassan luck Ahmad Karim Malik Kamran Rashid Sohail Rashid Mohammad Salih Abdullah Saeed Amjad Salamat Ghias-un-Nabi Tayyab Aasim Yusuf Haseeb Haider Zia Ammara Naveed Department of Hepatopancreatic biliary Surgery&liver Transplant Pakistan Kidney and Liver Institute&Research CentreLahore 54000Pakistan Department of Hepatogastroenterology and liver Transplantation Dr.Ziauddin University HospitalKarachi 75600SindhPakistan university of Aberdeen Aberdeen B243FXUnited Kingdom Department of Pathology Pakistan Kidney and Liver Institute&Research CentreLahore 54000Pakistan Department of Gastroenterology&Hepatology Pakistan Kidney and Liver Institute&Research CentreLahore 54000Pakistan Department of Radiology Aga Khan UniversityKarachi 74800Pakistan Department of Oncology Hameed Latif HospitalLahore 54000Pakistan Division of Hepatopancreatic biliary Surgery&liver Transplantation Shifa International HospitalIslamabad 44000Pakistan Department of Hepatopancreatic biliary Surgery&liver Transplant Shaikh Zayed Hospital and Post Graduate Medical InstituteLahore 54000Pakistan Department of Medicine Aga Khan University HospitalKarachi 74800Pakistan Department of liver Transplant Pir Abdul Qadir Shah Jeelani Institute of Medical SciencesGambat 66020Pakistan Department of Medicine&Gastroenterology Lifecare Hospital and Research CentrePeshawar 25000Khyber PakhtunkhwaPakistan Department of Hepatopancreatobiliary&liver Transplant Bahria International HospitalLahore 54000Pakistan Department of Surgery Hepatopancreatobiliary&Liver TransplantDow University of Health SciencesKarachi 74800Pakistan Department of Gastroenterology Hepatology&NutritionPir Abdul Qadir Shah Jeelani Institute of Medical SciencesGambat 66020Pakistan Department of Oncology Dr.Ziauddin HospitalKarachi 74800Pakistan Department of Radiology Rehman Medical InstitutePeshawar 25000Pakistan Army liver Transplant unit Pak Emirates Military HospitalRawalpindi 46000Pakistan Department of Gastroenterology Sindh Institute of Urology and TransplantationKarachi 75500Pakistan Rashid Nursing Home and Cancer Clinic Rashid Nursing Home and Cancer ClinicRawalpindi 46000Pakistan Department of Gastroentero

A consensus meeting of national experts from all major national hepatobiliary centres in the country was held on May 26,2023,at the Pakistan Kidney and liver Institute&Research Centre(PKlI&RC)after initial consultations with the *** Pakistan Society for the Study of liver Diseases(PSSlD)and PKlI&RC jointly organised this *** effort was based on a comprehensive literature review to establish national practice guidelines for hilar cholangiocarcinoma(hCCA).The consensus was that hCCA is a complex disease and requires a multidisciplinary team approach to best manage these *** coordinated effort can minimise delays and give patients a chance for curative treatment and effective *** diagnostic and staging workup includes high-quality computed tomography,magnetic resonance imaging,and magnetic resonance *** cytology or biopsy utilizing endoscopic retrograde cholangiopancreatography is a mainstay for ***,histopathologic confirmation is not always required before *** ultrasound with fine needle aspiration of regional lymph nodes and positron emission tomography scan are valuable adjuncts for *** only curative treatment is the surgical resection of the biliary tree based on the bismuth-Corlette *** patients with unresectable hCCA can be considered for liver *** chemotherapy should be offered to patients with a high risk of *** use of preoperative biliary drainage and the need for portal vein embolisation should be based on local multidisciplinary *** with acute cholangitis can be drained with endoscopic or percutaneous biliary *** chemotherapy with cisplatin and gemcitabine has shown improved survival in patients with irresectable and recurrent hCCA.

关键词： Hilar cholangiocarcinoma bismuth-Corlette classification Memorial Sloan Kettering Cancer Centre Staging Preoperative biliary drainage Portal vein embolisation Surgical resection Hepatectomy

Effects of Sn addition on the microstructure and mechanical properties of extruded Mg-bi binary alloy

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Journal of Magnesium and Alloys 2022年第3期10卷 920-931页

作者： Sang-Cheol Jin Jong un lee Jongbin Go Hui Yu Sung Hyuk Park School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566South Korea Department of Materials Science and Engineering Kyoto UniversityYoshida-honmachiSakyo-kuKyoto606-8501Japan School of Materials Science and Engineering Hebei University of TechnologyTianjin 300130China

We investigated the effects of Sn addition on the microstructural characteristics and mechanical properties of an extruded Mg-bi binary alloy by comparing Mg-5 bi(b5)and Mg-5 bi-4 Sn(bT54).both the extruded alloys exhibit a partially recrystallized grain structure with a strong extrusion fiber texture and numerous Mg3bi2 ***,the addition of Sn significantly decreases the average grain size of the extruded alloy from 123.9 to 75.2μ*** Sn solute atoms inhibit the activity of dislocation slip,which reduces the internal strain energy accumulated in the dynamically recrystallized(DRXed)grains during ***,this reduced strain energy leads to the decrease in the DRXed grain size owing to weakened grain growth during natural *** extruded bT54 alloy exhibits higher tensile strength and ductility than the extruded b5 *** improvement in the strength by the Sn addition is attributed to the combined effects of grain refinement,Sn solute atoms,and increased dislocation *** formation of{10-11}and{10-11}-{10-12}twins during tension is suppressed by the grain refinement,thereby improving the tensile elongation considerably.

关键词： Mg±bi alloy Extrusion Dynamic recrystallization Microstructure Mechanical properties.

Accelerated precipitation behavior of cast Mg-Al-Zn alloy by grain refinement

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Journal of Materials Science & Technology 2018年第2期34卷 265-276页

作者： Sang-Hoon Kim Jong un lee Ye Jin Kim Jun Ho bae bong Sun You Sung Hyuk Park School of Materials Science and Engineering Kyungpook National University Implementation Research Division Korea Institute of Materials Science

This study demonstrates that the precipitation behavior of 13-Mg17Al12 phase during aging and the resultant variation in hardness and mechanical properties of cast Mg-Al-Zn alloy are strongly dependent on initial grain size. Grain size reduction accelerates discontinuous precipitation at the early stage of aging treatment by increasing the area fraction of grain boundaries that can act as nucleation sites for discontinuous precipitates （DP）, but it does not influence DP growth rate. Grain refinement also prematurely terminates continuous precipitation because the formation of a large number of DP reduces the amount of AI dissolved in the matrix, which is required for the formation of continuous precipitates （CP）. This promotion of DP formation and early termination of CP formation significantly decrease the peak-aging time to one-third. The enhanced precipitation behavior also leads to an additional hardness improvement in the aged alloy, along with an increase in hardness owing to grain boundary strengthening by grain refinement. The amount of increase in hardness changes with aging time, which is determined by the variation of three variables with aging time： DP fraction difference between refined and nonrefined alloys, hardness difference between DP and matrix, and matrix hardness difference between the two alloys. Grain refinement improves both tensile strength and ductility of the homogenized alloy owing to grain boundary strengthening and suppression of twinning activation, respectively. However, the loss of ductility after peak-aging treatment is greater in the refined alloy because of the larger amount of DP acting as a crack source in this alloy.

关键词： Magnesium Grain refinement Aging Precipitation Tensile properties