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Human umbilical cord mesenchymal stem cells derivedexosomes on VEGF-A in hypoxic-induced mice retinal astrocytes and mice model of retinopathy of prematurity

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1238-1247页

作者： Xiao-Tian Zhang bo-Wen Zhao Yuan-Long Zhang song Chen Tianjin Eye Hospital Tianjin 300020China Tianjin Key Lab of Ophthalmology and Visual Science Tianjin 300020China

AIM:To observe the effect of human umbilical cord mesenchymal stem cells(hUCMSCs)secretions on the relevant factors in mouse retinal astrocytes,and to investigate the effect of hUCMSCs on the expression of vascular endothelial growth factor-A(VEGF-A)and to observe the therapeutic effect on the mouse model of retinopathy of prematurity(ROP).METHODS:Cultured hUCMSCs and extracted exosomes from them and then retinal astrocytes were divided into control group and hypoxia *** assay,flow cytometry,reverse transcription-polymerase chain reaction(RT-PCR)and Western blot were used to detect related *** mechanisms by which hUCMSCs exosomes affect VEGF-A expression in hypoxia-induced mouse retinal astrocytes were *** last,the efficacy of exosomes of UCMSCs in a mouse ROP model was ***6 was used to comprehensively process data ***:The secretion was successfully extracted from the culture supernatant of hUCMSCs by gradient *** oxygen species(ROS)and hypoxia inducible factor-1α(HIF-1α)of mice retinal astrocytes under different hypoxia time and the expression level of VEGF-A protein and VEGF-A mRNA increased,and the ROP cell model was established after 6h of *** secretions of medium and high concentrations of hUCMSCs can reduce ROS and HIF-1α,the expression levels of VEGF-A protein and VEGF-A mRNA are statistically significant and concentration *** with the ROP cell model group,the expression of phosphatidylinositol 3-kinase(PI3K)/protein kinase b(AKT)/mammalian target of rapamycin(mTOR)signal pathway related factors in the hUCMSCs exocrine group is significantly *** intravitreal injection of the secretions of medium and high concentrations of hUCMSCs can reduce VEGF-A and HIF-1αin ROP model *** staining shows that the number of retinal neovascularization in ROP mice decreases with the increase of the dose of hUCMSCs ***:In a hypoxia induced

关键词： human umbilical cord mesenchymal stem cells retinal astrocytes retinopathy of prematurity vascular endothelial growth factor hypoxia inducible factor

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Influence of network structure on spreading dynamics via tie range

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Chinese Physics b 2024年第8期33卷 606-613页

作者：李敏宋玉蓉宋波李汝琦蒋国平张晖 College of Automation and College of Artificial Intelligence Nanjing University of Posts and TelecommunicationsNanjing 210023China School of Modern Posts Nanjing University of Posts and TelecommunicationsNanjing 210023China School of Computer Science Nanjing University of Posts and TelecommunicationsNanjing 210023China Full Truck Alliance Co.Ltd. Nanjing 210012China

There are various phenomena of malicious information spreading in the real society, which cause many negative impacts on the society. In order to better control the spreading, it is crucial to reveal the influence of network structure on network spreading. Motifs, as fundamental structures within a network, play a significant role in spreading. Therefore, it is of interest to investigate the influence of the structural characteristics of basic network motifs on spreading *** the edges of the basic network motifs in an undirected network correspond to different tie ranges, two edge removal strategies are proposed, short ties priority removal strategy and long ties priority removal strategy. The tie range represents the second shortest path length between two connected nodes. The study focuses on analyzing how the proposed strategies impact network spreading and network structure, as well as examining the influence of network structure on network spreading. Our findings indicate that the long ties priority removal strategy is most effective in controlling network spreading, especially in terms of spread range and spread velocity. In terms of network structure, the clustering coefficient and the diameter of network also have an effect on the network spreading, and the triangular structure as an important motif structure effectively inhibits the spreading.

关键词： network spreading network motifs tie range edge removal strategy

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Single-atom photo-catalysts:Synthesis,characterization,and applications

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Nano Materials Science 2024年第3期6卷 284-304页

作者： Siqi Li Ziwang Kan He Wang Jiaxiao bai Yunyi Liu song Liu Yingjie Wu College of Chemistry Chemical Engineering and Resource UtilizationNortheast Forestry UniversityHarbin150040China School of Medicine and Health Harbin Institute of TechnologyHarbin150001China

Single-atom catalysts(SACs)are gaining popularity in catalytic reactions due to their nearly 100%atomic utilization and defined active sites,which provide great convenience for studying the catalytic mechanism of ***,SACs still present challenges such as complex formation processes,low loading and easy agglomeration of ***,we systematically discuss the synthesis methods for SACs,including coprecipitation,impregnation,atomic layer deposition,pyrolysis and Anti-Ostwald ripening *** techniques for characterizing single-atom catalysts(SACs)are described in *** utilization of individual atoms in various photocatalytic reactions and their mechanisms of action in different reactions are *** purpose of this review is to introduce single-atom synthesis methods,characterization techniques,specific catalytic action and their applications in the direction of photocatalysis,and to provide a reference for the industrialization of photocatalytic single-atoms,which is currently impossible,in the hope of promoting further development of photocatalytic single-atoms.

关键词： Photocatalysis Single atom Catalytic mechanism

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Suppressing a mitochondrial calcium uniporter activates the calcium signaling pathway and promotes cell elongation in cotton

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The Crop Journal 2024年第2期12卷 411-421页

作者： Yujia Duan Xiaoguang Shang Ruiping Tian Weixi Li Xiaohui song Dayong Zhang Wangzhen Guo State Key Laboratory of Crop Genetics&Germplasm Enhancement and Utilization Nanjing Agricultural UniversityNanjing 210095JiangsuChina Engineering Research Center of Ministry of Education for Cotton Germplasm Enhancement and Application Nanjing Agricultural UniversityNanjing 210095JiangsuChina

Mitochondrial calcium uniporter(MCU)is a conserved calcium ion(Ca^(2+))transporter in the mitochondrial inner membrane of eukaryotic *** MCU proteins regulate Ca^(2+)flow and modulate plant cell development remain largely ***,we identified the gene GhMCU4 encoding a MCU protein that negatively regulates plant development and fiber elongation in cotton(Gossypium hirsutum).GhMCU4expressed constitutively in various tissues with the higher transcripts in elongating fiber *** of GhMCU4 in cotton significantly elevated the plant height and root *** calcium signaling pathway was significantly activated and calcium sensor genes,including Ca^(2+)dependent modulator of interactor of constitutively active ROP(GhCMI1),calmodulin like protein(GhCML46),calciumdependent protein kinases(GhCPKs),calcineurin b-like protein(GhCbLs),and CbL-interacting protein kinases(GhCIPKs),were dramatically upregulated in GhMCU4-silenced *** processes were preferentially enriched,and genes related to regulation of transcription were upregulated in GhMCU4-silenced *** contents of Ca^(2+)and H_(2)O_(2)were significantly increased in roots and leaves of GhMCU4-silenced *** length and Ca^(2+)and H_(2)O_(2)contents in fibers were significantly increased in GhMCU4-silenced *** study indicated that GhMCU4 plays a negative role in regulating cell elongation in cotton,thus expanding understanding in the role of MCU proteins in plant growth and development.

关键词： Calcium signaling Hydrogen peroxide Metabolic processed Gossypium hirsutum

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P7C3-A20 treats traumatic brain injury in rats by inhibiting excessive autophagy and apoptosis

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Neural Regeneration Research 2024年第5期19卷 1078-1083页

作者： Zhiqing Yang Zhenchao Wang Xiaoqi Deng Lingxin Zhu Zhaomeng song Changyu Cao Xinran Li School of Life Science and Engineering Foshan UniversityFoshanGuangdong ProvinceChina Foshan University Veterinary Teaching Hospital FoshanGuangdong ProvinceChina

Traumatic brain injury is a severe health problem leading to autophagy and apoptosis in the brain.3,6-Dibromo-beta-fluoro-N-(3-methoxyphenyl)-9H-carbazole-9-propanamine(P7C3-A20)can be neuroprotective in various diseases,including ischemic stroke and neurodegenerative ***,whether P7C3-A20 has a therapeutic effect on traumatic brain injury and its possible molecular mechanisms are ***,in the present study,we investigated the therapeutic effects of P7C3-A20 on traumatic brain injury and explored the putative underlying molecular *** established a traumatic brain injury rat model using a modified weight drop method.P7C3-A20 or vehicle was injected intraperitoneally after traumatic brain *** neurological deficits were found in rats after traumatic brain injury,with deterioration in balance,walking function,and learning ***,hematoxylin and eosin staining showed significant neuronal cell damage,while terminal deoxynucleotidyl transferase mediated dUTP nick end labeling staining indicated a high rate of *** presence of autolysosomes was observed using transmission electron microscope.P7C3-A20 treatment reversed these pathological *** blotting showed that P7C3-A20 treatment reduced microtubule-associated protein 1 light chain 3-Ⅱ(LC3-Ⅱ)autophagy protein,apoptosis-related proteins(namely,bcl-2/adenovirus E1b 19-kDa-interacting protein 3[bNIP3],and bcl-2 associated x protein[bax]),and elevated ubiquitin-binding protein p62(p62)autophagy protein ***,P7C3-A20 can treat traumatic brain injury in rats by inhibiting excessive autophagy and apoptosis.

关键词： apoptosis autophagy cortex hippocampus motor function P7C3-A20 traumatic brain injury

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Heterostructured Co_(3)Se_(4)/CoSe_(2)@C nanoparticles attached on three-dimensional reduced graphene oxide as a promising anode towards Li-ion batteries

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Frontiers of Materials Science 2024年第2期18卷 101-115页

作者： Mingjun Pang Zhaoyang song Miaomiao Mao Shang Jiang Ruxia Zhang Runwei Wang Jianguo Zhao Engineering Research Center of Coal-based Ecological Carbon Sequestration Technology of the Ministry of Education Shanxi Datong UniversityDatong 037009China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of ChemistryJilin UniversityChangchun 130012China

In situ carbon-coated Co_(3)Se_(4)/CoSe_(2)(Co_(x)Se_(y))nanoparticles(NPs)attached on three-dimensional(3D)reduced graphene oxide(rGO)sheets were skillfully developed in this work,which involved the environment-friendly hydrothermal method,freeze drying,and selenide *** the structure,the glucose-derived carbon layer exhibited significantly homogeneous dispersion under an argon *** structure not only has enhanced stability,but also can effectively mitigate the volume swell of Co_(x)Se_(y) *** resulted Co_(3)Sea/CoSe_(2)@C/rGO(CSe@C/rGO)exhibited a specific surface area(SSA)of 240.9 m^(2)·g^(-1),offering more electrochemically active sites for the storage of energy related to lithium *** rGO matrix held exceptional flexibility and functional structural rigidity,facilitating the swift ion intercalation and ensuring the high conductivity and recyclability of the *** applied to anodes designed for lithium-ion batteries(Libs),this material demonstrated distinguished rate and ultra-high reversible capacity(872.98 mA·h·g^(-1) at 0.5 A·g^(-1)).Meanwhile,its capacity retention reached 119.5%after 500 cycles at 2 A·g^(-1),with a coulombic efficiency of 100%.This work potentially paves the way for generating fast and powerful metal selenide anodes and initiating Libs with good performance.

关键词： CSe@C/rGO lithium-ion battery reduced graphene oxide electrochemicalperformance heterostructure

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Wavelength injection locking actively q-switched random fiber laser based on random phase-shifted fiber bragg grating and electro-optic modulator

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Optoelectronics Letters 2024年第3期20卷 135-141页

作者： PAN Honggang ZHANG bo song Dianyou CHEN Zhipan CHEN Chunqi LI Rupeng School of Integrated Circuit Science and Engineering Tianjin University of TechnologyTianjin 300384China

In this paper, an actively q-switched wavelength injection locking random fiber laser(RFL) based on random phase-shifted fiber bragg grating(RPS-FbG) is proposed, and the performance of the laser is verified by experiments. Within the reflection bandwidth range of RPS-FbG, spanning from 1 549.2 nm to 1 549.9 nm, different laser modes with stable central wavelength and peak power can be selectively chosen by varying the injected light wavelength. The power fluctuation within 1 h is less than 0.1 d bm, and the central wavelength drift is less than 0.02 nm. When the pump power increases from 90 mW to 300 mW, the pulse width decreases from 3.2 μs to 1.5 μs, and the pulse repetition frequency is 20 kHz. The RFL can reach a stable locking state at the lowest pump power of 100 mW and the lowest injection power of 3 d bm. When the wavelength is locked, the output pulse is a single pulse. On the contrary, the unlocked output pulse is multi-pulse. The laser has the characteristics of high wavelength tunability in the reflection range of RPS-FbG and it can be an ideal light source in the fields of laser imaging and pulse coding.

关键词： fiber switched modulator

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A review of geophysical studies on the Mongolian Plateau

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Earthquake Science 2024年第3期37卷 224-240页

作者： Lei Zhang Zhouchuan Huang Xiaodong song qingju Wu SinoProbe Laboratory School of Earth and Space SciencesPeking UniversityBeijing 100871China Hebei Hongshan National Observatory on Thick Sediments and Seismic Hazards Peking UniversityBeijing 100871China School of Earth Sciences and Engineering Nanjing UniversityNanjing 210023China Institute of Geophysics China Earthquake AdministrationBeijing 100081China

The Mongolian Plateau in Central Asia is an intracontinental tectonic system far from active plate *** its distance from these boundaries,the plateau is characterized by intense crustal deformation accompanied by voluminous Cenozoic volcanism and active modern ***,the intraplate deformation mechanism has long been debated owing to the scarcity of observations and contradictions between different *** recent years,growing geophysical studies have been conducted on the Mongolian Plateau,providing constraints on its lithospheric structure and ***,we review the geophysical research on the Mongolian Plateau over the last decade,including seismological,geodetic,gravity,magnetotelluric,and geodynamic *** review aims to(a)describe crustal and mantle structures based on multiscale seismic images;(b)describe deformation patterns based on seismic anisotropy,focal mechanisms,and global positioning system(GPS)observations;and(c)discuss the mechanisms behind intraplate deformation,volcanism,and seismic activity across the Mongolian *** images show that the crustal structure of the plateau has significant east-west *** blocks in the western Mongolian Plateau have thick crusts,including the Altai Mountains,Hovsgol Rift,and Hangay *** lithospheric deformation across the Mongolian Plateau has strong lateral variation,with NE-SW shortening in the Altai Mountains and W-E or NW-SE shear deformation in the Hangay Dome region and the eastern *** varied deformation may result from the superposition of multiple mechanisms,including far-field stress in the Altai Mountains,mantle upwelling,and mantle flow in the Hangay Dome ***,it is difficult to identify the geodynamics of the formation of the entire Mongolian Plateau because the deformation is too complicated,and the present models are not sufficient and are always ***,this review encompasses recent advances in seismic observa

关键词： Mongolian Plateau Central Asia seismic tomography crust-mantle structure intraplate deformation

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Optogenetics in oral and craniofacial research

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Journal of Zhejiang University-Science b(biomedicine & biotechnology) 2024年第8期25卷 656-671页

作者： qinmeng ZHANG Luyao song Mengdie FU Jin HE Guoli YANG Zhiwei JIANG Stomatology Hospital School of StomatologyZhejiang University School of MedicineZhejiang Provincial Clinical Research Center for Oral DiseasesKey Laboratory of Oral Biomedical Research of Zhejiang ProvinceCancer Center of Zhejiang UniversityHangzhou 310000China Zhejiang University School of Medicine Hangzhou 310058China

Optogenetics combines optics and genetic engineering to control specific gene expression and biological functions and has the advantages of precise spatiotemporal control,noninvasiveness,and high *** modified photosensory sensors are engineered into proteins to modulate conformational changes with light ***,optogenetic techniques can provide new insights into oral biological processes at different levels,ranging from the subcellular and cellular levels to neural circuits and behavioral ***,we introduce the origins of optogenetics and highlight the recent progress of optogenetic approaches in oral and craniofacial research,focusing on the ability to apply optogenetics to the study of basic scientific neural mechanisms and to establish different oral behavioral test models in vivo(orofacial movement,licking,eating,and drinking),such as channelrhodopsin(ChR),archaerhodopsin(Arch),and halorhodopsin from Natronomonas pharaonis(NpHR).We also review the synergic and antagonistic effects of optogenetics in preclinical studies of trigeminal neuralgia and maxillofacial *** addition,optogenetic tools have been used to control the neurogenic differentiation of dental pulp stem cells in translational *** the scope of optogenetic tools is increasing,there are limited large animal experiments and clinical studies in dental *** future directions include exploring therapeutic strategies for addressing loss of taste in patients with coronavirus disease 2019(COVID-19),studying oral bacterial biofilms,enhancing craniomaxillofacial and periodontal tissue regeneration,and elucidating the possible pathogenesis of dry sockets,xerostomia,and burning mouth syndrome.

关键词： Lasers Cell differentiation bacterial virulence Nervous system Neurophysiology behavioral science

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Depositional model of the Member Deng-2 marginal microbial mound-bank complex of the Dengying Formation in the southwestern Sichuan basin, SW China: Implications for the Ediacaran microbial mound construction and hydrocarbon exploration

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Petroleum Science 2024年第2期21卷 806-822页

作者： Jin-Min song Xin Jin Zhong Luo Shu-Gen Liu Shao-bo Liu Xing-Zhi Ma Zhi-Wu Li Xue-song Lu Ling-Li Zhao Ke-Ran Li Jia-Xin Ren Li-Zhou Tian Hao-Shuang Deng State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Chengdu University of TechnologyChengdu610059SichuanChina PetroChina Research Institute of Petroleum Exploration and Development Beijing100083China Xihua University Chengdu610039SichuanChina

Recent advances in hydrocarbon exploration have been made in the Member Deng-2 marginal microbial mound-bank complex reservoirs of the Dengying Formation in the western Sichuan basin, SW China,where the depositional process is regarded confusing. The microfacies, construction types, and depositional model of the Member Deng-2 marginal microbial mound-bank complex have been investigated using unmanned aerial vehicle photography, outcrop section investigation, thin section identification,and seismic reflections in the southwestern Sichuan basin. The microbialite lithologic textures in this region include thrombolite, dendrolite, stromatolite, fenestral stromatolite, spongiostromata stone,oncolite, aggregated grainstone, and botryoidal grapestone. based on the comprehensive analysis of“depositional fabrics-lithology-microfacies”, an association between a fore mound, mound framework,and back mound subfacies has been proposed based on water depth, current direction, energy level and lithologic assemblages. The microfacies of the mound base, mound core, mound flank, mound cap, and mound flat could be recognized among the mound framework subfacies. Two construction types of marginal microbial mound-bank complex have been determined based on deposition location, mound scale, migration direction, and sedimentary facies association. Type Jinkouhe microbial mound constructions(TJMMCs) develop along the windward margin owing to their proximity to the seaward subfacies fore mound, with a northeastwardly migrated microbial mound on top of the mud mound,exhibiting the characteristics of large-sized mounds and small-sized banks in the surrounding area. Type E'bian microbial mound constructions(TEMMCs) primarily occur on the leeward margin, resulting from the presence of onshore back mound subfacies, with the smaller southwestward migrated microbial mounds existing on a thicker microbial flat. The platform margin microbial mound depositional model can be correlated with certain late

关键词： Sichuan basin The Member Deng-2 Marginal microbial mound-bank complex Depositional model Exploration implications

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