检索结果-南通市图书馆

Are EPb41 and alpha-synuclein diagnostic biomarkers of sport-related concussion?Findings from the NCAA and Department of Defense CARE Consortium

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2023年第3期12卷 379-387页

作者： Rany Vorn Christina Devoto Timothy b.meier Chen Lai Sijung Yun Steven P.broglio Sara Mithani Thomas W.McAllister Christopher C.Giza Hyung-Suk Kim Daniel Huber Jaroslaw Harezlak Kenneth L.Cameron Gerald McGinty Jonathan Jackson Kevin M.Guskiewicz Jason P.Mihalik Alison brooks Stefan Duma Steven Rowson Lindsay D.Nelson Paul Pasquina Michael A.McCrea Jessica M.Gill the CARE Consortium Investigators Johns Hopkins School of Nursing and Medicine BaltimoreMD 21205USA National Institutes of Health BethesdaMD 20892USA Department of Neurosurgery Medical College of WisconsinMilwaukeeWI 53226USA Predictiv Care Inc.Mountain ViewCA 94086USA Michigan Concussion Center University of MichiganAnn ArborMI 48109USA Department of Psychiatry Indiana University School of MedicineIndianapolisIN 46202USA Departments of Pediatrics and Neurosurgery University of California at Los Angeles(UCLA)Los AngelesCA 90024USA Department of Epidemiology and biostatistics School of Public Health–bloomington Indiana UniversityBloomingtonIN 47405USA John A.Feagin Sports Medicine Fellowship Keller Army Community HospitalWest PointNY 10996USA United States Air Force Academy Colorado SpringsCO 80840USA Mathew Gfeller Center Department of Exercise and Sport ScienceUniversity of North Carolina at Chapel HillChapel HillNC 27514USA Department of Orthopedics Division of Sports MedicineSchool of Medicine and Public HealthUniversity of WisconsinMadisonWI 53705USA Department of biomedical Engineering and Mechanics Virginia TechBlacksburgVA 24061USA Center for Neuroscience&Regenerative Medicine Uniformed Services UniversityBethesdaMD 20814USA 不详 Current affiliation:School of Nursing University of Texas Health Science Center San AntonioSan AntonioTX 78229USA

background:Current protein biomarkers are only moderately predictive at identifying individuals with mild traumatic brain injury or ***,more accurate diagnostic markers are needed for sport-related ***:This was a multicenter,prospective,case-control study of athletes who provided blood samples and were diagnosed with a concussion or were a matched non-concussed control within the National Collegiate Athletic Association-Department of Defense Concussion Assessment,Research,and Education Consortium conducted between 2015 and *** blood was collected within 48 h of injury to identify protein abnormalities at the acute and subacute *** with concussion were divided into 6 h post-injury(0-6 h post-injury)and after 6 h postinjury(7-48 h post-injury)*** applied a highly multiplexed proteomic technique that used a DNA aptamers assay to target 1305proteins in plasma samples from athletes with and without sport-related ***:A total of 140 athletes with concussion(79.3%males;aged 18.71±1.10 years,mean±SD)and 21 non-concussed athletes(76.2%males;19.14±1.10 years)were included in this *** identified 338 plasma proteins that significantly differed in abundance(319 upregulated and 19 downregulated)in concussed athletes compared to non-concussed *** top 20 most differentially abundant proteins discriminated concussed athletes from non-concussed athletes with an area under the curve(AUC)of 0.954(95%confidence interval:0.922-0.986).Specifically,after 6 h of injury,the individual AUC of plasma erythrocyte membrane protein band 4.1(EPb41)and alpha-synuclein(SNCA)were 0.956 and 0.875,*** combination of EPb41 and SNCA provided the best AUC(1.000),which suggests this combination of candidate plasma biomarkers is the best for diagnosing concussion in athletes after 6 h of ***:Our data suggest that proteomic profiling may provide novel diagnostic protein markers and that a combina

关键词： biomarkers College athletes Concussion Mild traumatic brain injury Sport injury

Pillararene-based fluorescent sensors for the tracking of organic compounds

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2019年第10期30卷 1758-1766页

作者： Derong Cao Herbert meier School of Chemistry and Chemical Engineering South China University of TechnologyGuangzhou 510641China Institute of Organic Chemistry University of MainzD-55099 MainzGermany

Fluorescent chemosensors based on pillararene complexes represent a new, promising branch in sensor technology. because of CH-π interactions, aliphatic chains are well suited for the columnar cavities of pillararenes and bulky or sheet-like(sub)structures can be arranged on the portals. Thus, pillararenes form versatile receptors and an alteration of the fluorescence behavior upon complexation ensures the function of these chemosensors as the reporter. Although this field of research exists only since a few years, remarkable chemosensors were developed for substances as diverse as medical drugs,biochemicals, herbicides and explosives.

关键词： Pillararene Fluorescent chemosensor Complex Host-guest Fluorescent cavity

完全闭塞血管用激光导丝行血管成型术的临床试验

在线全文

学校读者我要写书评

暂无评论

岭南心血管病杂志 2001年第2期7卷 151-151页

作者： P.W.Serruys J.N.Hamburger J.J.Koolen J.Fajadet M.Haude H.Klues R.Seabra-Gomes T.Corcos C.Hamm L.Pizzuli b.meier D.Mathey E.Flleck Y.Taeymans R.Melkert Y.Teunissen R.Simon 陈爱华 Department of interventional Cardiology.Heart Centre of the University Hospital Rotterdam

目的该随机试验用于评估激光导丝在治疗慢性冠状动脉闭塞方面的安全性和疗效.方法和结果 18个欧洲中心的303例患有慢性冠状动脉闭塞的病人,被随机分为激光导丝治疗组(n=144)或常规导丝治疗组(机械导丝,n=159).研究初级终点,即在X线曝光... 详细信息

目的该随机试验用于评估激光导丝在治疗慢性冠状动脉闭塞方面的安全性和疗效.方法和结果 18个欧洲中心的303例患有慢性冠状动脉闭塞的病人,被随机分为激光导丝治疗组(n=144)或常规导丝治疗组(机械导丝,n=159).研究初级终点,即在X线曝光时间30min内,通过指定的导丝到达闭塞远端的真腔为治疗成功.激光导丝与机械导丝的成功率比较:52.8%(n=76)vs 47.2%(n=75),P=0.33.继初始导丝试通后的严重不良事件分别为0(激光导丝)和0.6%(机械导丝).179例病人血管成型术(在导丝成功穿通后进行)成功(成功率91%,激光导丝n=79,机械导丝n=100).149例病人(79%)随后置入支架.6个月时的血管造影随访,两者的再狭窄率(激光导丝比机械导丝:45.5%vs38.3%,P=0.72)或再闭塞率(25.8%vs16.1%,P=0.15)方面的差异未达到统计学意义.在1个月、6个月和12个月随访时,心绞痛和无事件生存率为69%、35%和24%(激光导丝)比74%、40%和31%(机械导丝).

关键词：慢性完全冠状动脉闭塞随机试验激光血管成型术治疗

Green Light for PPP on German Motorways?

在线全文

学校读者我要写书评

暂无评论

Frontiers of Law in China-Selected Publications from Chinese Universities 2019年第3期14卷 311-334页

作者： Hartmut bauer Michael meier Augsburg University AugsburgGermany Faculty of Law Potsdam UniversityPotsdam 14482Germany LL.b. Bucerius Law SchoolHamburgGermany

While public-private partnerships(PPPs)have surged worldwide since the 1990s,they have been met with growing skepticism during the last years.A recent revision of Germany's constitutional rules on motorway construction and observations on the use of PPPs published by both the German and the European Courts of Auditors illustrate this new *** two examples fit into a general trend towards a revival of the public sector,which can be summarized under the cross-level umbrella term"publicization."It would,however,be remiss to replace the uncritical euphoria that once surrounded privatization with a similarly undifferentiated euphoria regarding ***,it is crucial to identify the most appropriate solution for the fulfilment of each public task from the"toolbox"of publicization on the one hand and privatization on the other hand in order to ensure the most effective completion of public functions.

关键词： publicization remunicipalization recommunalization nationalization renationalization public-private partnerships PPPs privatization motorways infrastructure construction toll economic efficiency court of auditors debt ceiling economic impact analysis

Innovating Pedagogical Practices through Professional Development in Computer Science Education

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Computer Science Research 2023年第3期5卷 46-56页

作者： Xiaoxue Du Ellen b.meier MIT Media Lab MITCambridgeMA 02139USA Teachers College Columbia UniversityNew York CityNY 10027USA

Recent advancements in technology have opened up new avenues for educators to facilitate teaching and leverage more learning access in the digital *** the demand for computational skills continues to grow in preparation for future careers,both teachers and students face the challenge of developing problem-solving,critical thinking,communication,and collaboration skills within an emerging digital *** adoption,big data,cloud computing and artificial intelligence pose ongoing challenges for both teachers and students in adapting to the changing workforce development *** tackle these challenges,the paper highlights the importance of exploring the implications of learning sciences in classroom teaching,developing a holistic vision for professional development in education,and understanding the complexities of teacher *** effectively implement these components,it is crucial to adopt design approaches that prioritize student ownership in education and embrace the principles of inclusive education to reconceptualize the teaching practices in education and technology.

关键词： Education Computational thinking Teacher education Professional development Design Equity

Comparison of Cardiovascular Parameters and Internal Training Load of Different 1-h Training Sessions in Non-elite CrossFit^(®)Athletes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Science in Sport and Exercise 2023年第2期5卷 130-141页

作者： Nicole meier Danien Sietmann Annette Schmidt Institut Für Sportwissenschaft Fakultät Für HumanwissenschaftenUniversität Der Bundeswehr MünchenWerner‑Heisenberg‑Weg 3985577 NeubibergGermany

Purpose The fact that CrossFit^(®)is the best-known and rapidly growing concept for high-intensity interval training(HIIT)and high-intensity functional training(HIFT)results in a continuous increase of athletes performing CrossFit^(®).In the more than 15,000 CrossFit^(®)Affiliates worldwide,the training concept is usually offered in 1-h training sessions containing the CrossFit^(®)-related workout of the day(WOD),as well as a general warm-up,movement demonstrations,and skill ***,we report how physiological parameters measured by heart rate(HR)values vary during four different 1-h CrossFit^(®)training sessions of non-elite athletes(n=27)in a local affiliated training center and what influencing factors may *** The duration of the 1-h training sessions were divided into a warm-up part(WU-part),a skill development part combined with strength exercises(A-part),followed by the WOD part(b-part).Results Analysis of HR values shows high training intensity(≥91%HR_(max))not throughout the duration of each training session,only during *** mean HR values in b-part differ significantly compared to the remaining training parts(Pbetween beginner and experienced CrossFit^(®)*** Our results may suggest that practicing CrossFit^(®)in 1-h training sessions combined anaerobic and aerobic exercise intensities,with the training concept allows beginners and experienced athletes to be trained with the same cardio-vascular responses and training intensities.

关键词： CrossFit^(®)performance Training load Exercise intensity Cardiovascular response High-intensity functional training

SiC纤维（Nicalon）增强玻璃陶瓷的蠕变行为

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

华东理工大学学报（自然科学版） 1996年第4期22卷 445-450页

作者：刘健 meier,b 华东理工大学技术化学物理研究所德国Karlsruhe大学材料研究二所

考察了文题材料的蠕变行为，发现其以取决于所施加的应力与温度而出现的蠕变第一、第二、第三阶段为特征。蠕变过程中出现的主要结构变化为纤维重排、富碳界面层的氧化以及基质中晶体的生长。虽然复合材料的受力极限取决于残余玻璃相，... 详细信息

考察了文题材料的蠕变行为，发现其以取决于所施加的应力与温度而出现的蠕变第一、第二、第三阶段为特征。蠕变过程中出现的主要结构变化为纤维重排、富碳界面层的氧化以及基质中晶体的生长。虽然复合材料的受力极限取决于残余玻璃相，但纤维的引入使得材料的热机械性能得以大幅度地提高。

关键词：蠕变玻璃陶瓷机械性能碳化硅纤维增强

Diketopyrrolopyrrole based D-π-A-π-D type small organic molecules as hole transporting materials for perovskite solar cells

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2018年第4期27卷 1175-1182页

作者： Haoliang Cheng Xiaojuan Zhao Yan Shen Mingkui Wang Lingyun Wang Herbert meier Derong Cao School of Chemistry and Chemical Engineering State Key Laboratory of Luminescent Materials and DevicesSouth China University of TechnologyGuangzhou 510641Guangdong China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 4300F4HubeiChina Institute of Organic Chemistry University of MainzMainz 55099Germany

Three novel diketopyrrolopyrrole （DPP） based small organic molecules were synthesized as hole transporting materials for perovskite solar cells. The effects of different donors and zr bridges on the performance of perovskite solar cells （PSCs） were discussed. The efficiency of TPADPP-1, TPADPP-2. PTZDPP-2 was 5.10%, 9.85% and 8.16% respectively. Compared to TPADPP-2, the voltage of PTZDPP-2 was higher. because the electron-donatingability of phenothiazine based donor was larger than that of triphenylamine based donor, the HOMO level of PTZDPP-2 was lower than that of TPADPP-2. The results indicated that the diketopyrrolopyrrole based D-π-A-π-D type small organic molecule might be a promising hole trans- porting material in the perovskite solar cells.

关键词： Perovskite solar cells Diketopyrrolopyrrole Hole transporting materials Donors π bridges

Crystal Structure and Host-Guest binding Ability of Three Types of Pillar[5]arenes

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2015年第3期33卷 346-350页

作者： Luzhi Liu Wengui Duan Yuhui Kou Lingyun Wang Herbert meier Derong Cao School of Chemistry and Chemical Engineering South China University of TechnologyGuangzhouGuangdong 510640China School of Chemistry and Chemical Engineering Guangxi UniversityNanningGuangxi 530004China Institute of Organic Chemistry University of MainzMainz 55099Germany

A systematic research of the structural characterization and the host-guest binding abilities between three types of pillar[5]arenes 3-5(3 for Structure Type I,4 for Structure Type II and 5 for Structure Type III)is carried out by 1H NMR measurements and X-ray *** results show that the configurations or symmetry of their cavities not only have large difference in these three types of pillar[5]arenes,but also have more or less variations even in the same structure type or the same host locked different guests such as crystals of 3a-3b,*** the other hand,the complexation behavior of pillar[5]arenes with 1,4-dibromobutane(Dbb)is affected by the different symmetri-cal structure or substituents on the rings.

关键词： pillararenes crystal structure configuration complexation behavior