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Implications of oxidative damage to proteins and DNA in aging and its intervention by caloric restriction and exercise

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Journal of Sport and Health Science 2013年第2期2卷 75-80页

作者： Sataro Goto Zsolt radak Institute of Health and Sports Science & Medicine Juntendo University Graduate School Research Institute of Sport Science Semmelweis University

In this short review we describe implications of age-related changes of protein and DNA oxidation as a public mechanism of biological aging. Oxidatively modified protein and DNA have been demonstrated to increase with advancing age in rodents. Half-life of proteins is extended and DNA repair activity declines in old animals. Dietary restriction initiated late in life can shorten the half-life of proteins to levels of young animals, thus contributing to reduce level of altered proteins in old animals by the regimen. Regular exercise reduced oxidatively modified proteins in the brain with improved cognitive functions. It attenuated oxidative stress in the liver, i.e., ameliorating activation of nuclear factor κb, increasing reduced glutathione, and decreasing oxidized guanine base in nuclear and mitochondrial DNA. These findings suggest that regular exercise has systemic effects in reducing oxidative stress. Thus, life-styles such as diet and exercise may extend health span, by up-regulating overall anti-oxidant capacities that include proteins involved in protein turnover and DNA repair, resulting in reduction of damaged proteins and DNA that potentially promote physiological and pathological aging.

关键词： Aging Dietary restriction DNA Exercise Oxidative stress Protein

纳秒、皮秒和飞秒激光脉冲对材料表面的改性(英文)

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光学精密工程 2011年第2期19卷 221-227页

作者： TRTICAM S GAKOVIC b M radak b.b.bATANI D TARASENKO V F PETROVIC S STASIC J MILOVANOVIC D KRMPOT A JELENKOVIC b VINCA Institute of Nuclear Sciences University of Belgrade P.O. BOX 522 11001 Belgrade Serbia Universita degli Studi di Milano bicocca Piazza della Scienza 3 20126 Milano Italy High Current Electronics Institute Sb of RAS 634055 Tomsk Russia Institute of Physics P.O. BOX 57 11001 Belgrade Serbia

对基体材料镉镍铁合金600和多层TiAlN/TiN涂层的激光表面改性在基础研究和实际应用中有着很好的前景。本文观察了由超短脉冲(fs和ns)和短脉冲(ns)激光器引起的镉镍铁合金600和TiAlN/TiN镀层的表面变化。结果显示,3种激光都能使靶面发生... 详细信息

对基体材料镉镍铁合金600和多层TiAlN/TiN涂层的激光表面改性在基础研究和实际应用中有着很好的前景。本文观察了由超短脉冲(fs和ns)和短脉冲(ns)激光器引起的镉镍铁合金600和TiAlN/TiN镀层的表面变化。结果显示,3种激光都能使靶面发生形态改变,超短脉冲的破坏轮廓更为清晰。与ps激光脉冲相比,fs激光脉冲能产生更严重的破坏。与产生半球体形状的ps激光束相反,fs激光脉冲产生的破坏斑是圆锥形的。另外,ns脉冲辐照时热效应占支配地位,且所有的辐照都伴随着等离子体。

关键词：纳秒脉冲皮秒脉冲飞秒脉冲 Inconel 600镀层 TiAlN/TiN镀层激光改性

The complex role of physical exercise and reactive oxygen species on brain

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Journal of Sport and Health Science 2013年第2期2卷 87-93页

作者： Zsolt radak Orsolya Marton Eniko Nagy Erika Koltai Sataro Goto Institute of Sport Science Faculty of Physical Education and Sport ScienceSemmelweis University Department of Exercise Physiology School of Health and Sport ScienceJuntendo University

Reactive oxygen species （ROS） are continuously generated during aerobic metabolism and at moderate level. They play a role in redox signaling, but in significant concentration they cause oxidative damage and neurodegeneration. because of the enhanced sensitivity of brain to ROS, it is especially important to maintain the normal redox state in different types of neuron cells. In last decade it became clear that regular exercise beneficially affects brain function, and can play an important preventive and therapeutic role in stroke, Alzheimer, and Parkinson diseases. The effects of exercise appear to be very complex and could include neurogenesis via neurotrophic factors, increased capillariszation, decreased oxidative damage, and increased proteolyfic degradation by proteasome and neprilysin. Data from our and other laboratories indicate that exercise-induced modulation of ROS levels plays a role in the protein content and expression of brain-derived neurotrophic factor, tyrosinerelated kinase b （Trkb）, and cAMP response element binding protein, resulting in better function and increased neurogenesis. Therefore, it appears that exercise-induced modulation of the redox state is an important means, by which exercise benefits brain function, increases the resistance against oxidative stress, facilitates recovery from oxidative stress, and attenuates age-associated decline in cognition.

关键词： Exercise Neurotrophins brain function Oxidative damage Oxidative stress

Is the routine screening for significant atherosclerotic renal artery stenosis during coronary angiography/intervention indispensable?

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Journal of Zhejiang University-Science b.b.omedicine & biotechnology) 2013年第1期14卷 83-84页

作者： Srdjan b.b.C Dusko NEZIC Djordje radak Institute for Cardiovascular Disease "Dedinje" BelgradeSerbia School of Medicine University of BelgradeBelgradeSerbia

We read the article "Screening for significantatherosclerotic renal artery stenosis with a regressionmodel in patients undergoing transradial coronaryangiography/intervention" by Pu et al. (2012), pub-lished in Journa... 详细信息

关键词：内科学血管疾病治疗临床

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一种简单的相对激光功率计

现代测量与实验室管理 1991年第4期8卷 57-58页

作者： bojan b.radak 李熙

1.前言由于用于一般目的的激光功率计通常是已校准的仪器,其在工作中具有较大的测量选择范围,因此,通常相当昂贵。对于应用于在线监视或在设备中某一位置上测量激光功率的仪器,对激光功率计所要求的覆盖值的范围并不大,这时一些通常的... 详细信息

1.前言由于用于一般目的的激光功率计通常是已校准的仪器,其在工作中具有较大的测量选择范围,因此,通常相当昂贵。对于应用于在线监视或在设备中某一位置上测量激光功率的仪器,对激光功率计所要求的覆盖值的范围并不大,这时一些通常的特性很少用得到。此外,

关键词：激光功率计探测器散热片时间常数测量在线监视仪器激光器激光光束温差

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运动与毒物兴奋效应

中国老年学杂志 2011年第11期31卷 2134-2136页

作者：赵丽熊开宇王正珍 Zsolt radak 北京体育大学运动生理学教研室北京100084 不详

毒物兴奋效应（Hormesis）是当今毒理学界争论的热点问题,又称为＂低剂量有毒物质的刺激作用＂.目前认为毒物兴奋效应是指化学物在低于不可见的有害作用水平（NOXEL）以下的剂量具有兴奋或刺激的作用,与高剂量的作用相反,一般有益于受... 详细信息

毒物兴奋效应（Hormesis）是当今毒理学界争论的热点问题,又称为＂低剂量有毒物质的刺激作用＂.目前认为毒物兴奋效应是指化学物在低于不可见的有害作用水平（NOXEL）以下的剂量具有兴奋或刺激的作用,与高剂量的作用相反,一般有益于受试的生物体.其曲线特征指机体在应答诸如化学试剂、毒素或放射性等损伤时所表现出的一种钟形曲线的反应.

关键词：运动毒物兴奋效应

blood flow restriction during the resting periods of high-intensity resistance training does not alter performance but decreases MIR-1 and MIR-133A levels in human skeletal muscle

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Sports Medicine and Health Science 2021年第1期3卷 40-45页

作者： Ferenc Torma Peter bakonyi Zsolt Regdon Zoltan Gombos Matyas Jokai Gergely b.b.zki Marcell Fridvalszki Laszl Virg Hisashi Naito SyedRehan Iftikhar bukhari Zsolt radak Research Center of Molecular Exercise Science University of Physical EducationBudapestHungary Department of Medical Chemistry Faculty of MedicineUniversity of DebrecenHungary Department of Exercise Physiology Graduate School of Health and Sports Science&MedicineJuntendo UniversityJapan Doctoral School of Clinical Medicine Semmelweis UniversityBudapestHungary Faculty of Sport Sciences Waseda UniversityJapan

blood flow restriction(bFR)during exercise bouts has been used to induce hypertrophy of skeletal muscle,even with low ***,the effects of bFR during the rest periods between sets are not *** have tested the hypothesis that bFR during rest periods between sets of high-intensity resistance training would enhance ***-two young adult male university students were recruited for the current study,with n=11 assigned to bFR and n=11 to a control *** results revealed that four weeks training at 70%of 1 RM,five sets and 10 repetitions,three times a week with and without bFR,resulted in similar progress in maximal strength and in the number of maximal *** miR-1 and miR-133a decreased significantly in the vastus lateralis muscle of bFR group compared to the group without bFR,while no significant differences in the levels of miR133b,miR206,miR486,and miR499 were found between *** conclusion,it seems that bFR restrictions during rest periods of high-intensity resistance training,do not provide benefit for enhanced performance after a four-week training ***,bFR-induced downregulation of miR-1 and miR-133a might cause different adaptive responses of skeletal muscle to high intensity resistance training.

关键词： blood flow restriction Occlusion Skeletal muscle High intensity resistance training microRNA

PRGR基因突变错义导致外显子跳跃性RNA剪接异常

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世界核心医学期刊文摘（眼科学分册） 2005年第3期1卷 41-42页

作者： Demirci F.Y.K. radak A.L. Rigatti b.W. 张少娟 Department of Ophthalmology School of Medicine Pittsburg h PA United State Dr

Purpose A patient with retinitis pigmentosa demonstrated a novel RPGR mutation (213G > A, last base of exon 2) predicted to cause a missense change (G52R) in the final protein. This study w as performed to determine whether thismutation altered the effectiveness of the adjacent splice site. Design Observational case report. Methods Total RNA was ex tracted from leukocytes of the proband and his carrier mother. Reverse transcrip tion polymerase chain reaction (RT PCR) was performed by using the primers flan king exon 2 of RPGR transcript, followed by gel purification and direct sequenci ng. Results Sequencing revealed skipping of exon 2 in the mutated transcript, le ading to in frame deletion of 42 amino acids affecting the critical RCC1 like domain. Conclusions The last base of exons is conserved as “G”in 80%of splici ng consensus sequences, yet when changed, can completely disrupt constitutive sp licing as in this patient. Our data confirm that the evaluation of the effects o f some DNA sequence alterations at the RNA level might have important implicatio ns for appropriate genotypephenotype correlations.

关键词：跳跃性 RNA剪接基因突变 PRGR基因错义视网膜炎直接测序基因表型色素性 DNA

运动疲劳对男性前弓步动作时下肢的生物力学影响

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运动疲劳对男性前弓步动作时下肢的生物力学影响