The complex role of physical exercise and reactive oxygen species on brain

作     者：Zsolt Radak Orsolya Marton Eniko Nagy Erika Koltai Sataro Goto 

作者机构：Institute of Sport ScienceFaculty of Physical Education and Sport ScienceSemmelweis University Department of Exercise PhysiologySchool of Health and Sport ScienceJuntendo University 

出 版 物：《Journal of Sport and Health Science》 (运动与健康科学（英文）)

年 卷 期：2013年第2卷第2期

页      面：87-93页

核心收录：

学科分类：0403[教育学-体育学] 040302[教育学-运动人体科学(可授教育学、理学、医学学位)] 04[教育学] 

基　　金：supported by Hungarian grants(gsl) from ETT 38388 TeT JAP13/02 OTKA(gs2)(K75702) TAMOP-4.2.2/B-10/1-2010-0013 awarded to Z.Radak 

主　　题：Exercise Neurotrophins brain function Oxidative damage Oxidative stress 

摘      要：Reactive oxygen species （ROS） are continuously generated during aerobic metabolism and at moderate level. They play a role in redox signaling, but in significant concentration they cause oxidative damage and neurodegeneration. Because of the enhanced sensitivity of brain to ROS, it is especially important to maintain the normal redox state in different types of neuron cells. In last decade it became clear that regular exercise beneficially affects brain function, and can play an important preventive and therapeutic role in stroke, Alzheimer, and Parkinson diseases. The effects of exercise appear to be very complex and could include neurogenesis via neurotrophic factors, increased capillariszation, decreased oxidative damage, and increased proteolyfic degradation by proteasome and neprilysin. Data from our and other laboratories indicate that exercise-induced modulation of ROS levels plays a role in the protein content and expression of brain-derived neurotrophic factor, tyrosinerelated kinase B （TrkB）, and cAMP response element binding protein, resulting in better function and increased neurogenesis. Therefore, it appears that exercise-induced modulation of the redox state is an important means, by which exercise benefits brain function, increases the resistance against oxidative stress, facilitates recovery from oxidative stress, and attenuates age-associated decline in cognition.