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Unusual Presentation of Endometrial Cancer: A Clinicopathological Study of One Case

Open Journal of Ob.tetrics and Gynecology 2015年第1期5卷 23-27页

作者： J. Munné F. Alameda A. b.rgueiro G. Manceb. L. Garrigós T. b.ró b. lloveras J. Gimeno R. Carreras S. Serrano Department of Pathology Hospital del Mar Barcelona Spain Universitat Autonoma de b.rcelona Barcelona Spain Department of Ob.tetrics and Gynecology Hospital del Mar Barcelona Spain Department of Oncology Hospital del Mar Barcelona Spain

Endometrial carcinoma is the most frequent genital tract malignancy. The first symptom (guide-symptom) is usually metrorrhagia;however, in around 10% of cases it is not. In contrast, osseous metastases are infrequent in endometrial cancer. The b.nes of the pelvis and lower extremities are those most frequently involved in disseminated metastatic diseases. In these cases, endometrial cancer is usually high grade (Grade III). Case report: 56-year-old woman who presented right inguinal pain. The X-ray showed a lithic lesion in the right ischium. A histopathological study demonstrated a metastatic lesion, suspected to b. endometrial cancer. The computer tomography scan revealed a uterine mass and a second lithic lesion in the right tib.a. The patient received chemotherapy (carb.platin and paclitaxel), and the b.ne lesions were irradiated. The patient is still alive 18 months after the diagnosis. This case emphasizes the importance of considering an endometrial primary tumor when evaluating b.ne metastasis of unknown primary cancer.

关键词： Osseous Metastasis Endometrial Carcinoma Immunohistochemistry

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Pulmonary coinfection b. Pneumocystis jiroveci and Cryptococcus neoformans

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Asian Pacific Journal of Tropical b.omedicine 2012年第1期2卷 80-82页

作者： b.va Javier lloveras Susana Garro Santiago Troncoso Alcides Lab.ratory of Parasitology Infectious Diseases Hospital Division of Infectious Diseases Francisco Muniz Hospital Department of Infectious Diseases Tropical MedicineSchool of Medicine.Buenos Aires University

We communicate the diagnosis b. microscopy of a pulmonary coinfection produced b. Cryptococcus neoformans and Pneumocystis jiroveci,from a respiratory secretion ob.ained b. b.onchoalveolar lavage of an AIDS *** review of literature identified this coinfection as unusual *** infections associated with HIV infection are increasingly *** may occur at an early stage of *** concurrent opportunistic infections may occur,coexisting Pneumocystis jiroveci pneumonia(PCP)and disseminated cryptococcosis with cryptococcal pneumonia is *** lungs of individuals infected with HIV are often affected b. opportunistic infections and tumours and over two-thirds of patients have at least one respiratory episode during the course of their *** is the leading HIV-associated *** present the case of a man who presented dual Pneumocystis jiroveci and cryptococcal pneumonia in a patient with *** diagnosis of PCP and Cryptococcus requires demonstration of these organisms in pulmonary tissues or *** patients withb.onchoalveolar lavage should b. *** patient was successfully treated with amphotericin b.and trimethoprim *** 1 week the patient showed clinical and radiologic improvement and was discharged 3 weeks later.

关键词： Cryptococcus neoformans Pneumocystis jiroveci Pulmonary coinfection Diagnosis test Opportunistic pathogen Pneumonia Definitive diagnosis

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人乳头瘤病毒检测作为宫颈癌低危妇女的初筛方法:希腊经验

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世界核心医学期刊文摘（妇产科学分册） 2005年第7期1卷 32-33页

作者： Agorastos T. Dinas K. lloveras b. 王克芳 1st Univ. Clin. Ob.tet. and Gynecol. Aristotle University of Thessaloniki Hippokrateion Hospital 93 Plastira Street 55132 Thessaloniki Greece

Ob.ective. To compare the performance of human papillomavirus (HPV) DNA detection against routine Papanicolaou smear for the detection of low- and high- grade cervical intraepithelial neoplasia in a low- risk population. Materials and methods. A cross- sectional study was performed involving 1296 women attending six outpatient clinics in Northern Greece (Thessaloniki, Thermi, Mihaniona, Corfu, Veria, and Serres). Women underwent a gynecological examination, including collection of exfoliated cervical cells for Papanicolaou cytology and HPV DNA detection. Cytology was processed according the conventional routine manner, and HPV DNA was determined using the polymerase chain reaction technique. In positive cases of either method, a complete colposcopic evaluation was performed with directed b.opsies. Tests (HPV DNA, cytology, and colposcopy) performance characteristics were determined using the histopathologic diagnosis as the reference standard. Results. HPV DNA testing showed a significantly b.tter sensitivity than the Papanicolaou smear in detecting cervical intraepithelial neoplasia (75% versus 50% for high- grade lesions and 81.2% versus 50% for lesions of any grade, respectively). Specificity, and positive and negative predictive values did not significantly differ. Even after dividing women in younger or older than 30 years, the sensitivity of the HPV DNA test was greater than cytology (100% and 70% versus 50% for cytology in b.th groups, respectively), with a 6.3% loss in specificity when performed in women younger than 30 years. Conclusion. HPV testing could b. useful in screening women at low risk for cervical cancer, either as an adjunct tool to augment existing cytology programs or as a unique test of its own.

关键词：人乳头瘤病毒初筛方法巴氏细胞学检查常规巴氏涂片瘤样病变阴道镜阳性病例筛查手段巴氏涂片法 DNA

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