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Nucleotide sequence and Characterization of b.vine Metallothionein Gene

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Chinese science b.lletin 1993年第5期38卷 419-423页

作者：杨靖沈孝宙杨卫民 M.G.peterson j.F.b.Mercer savio L.C.Woo Institute of Developmental b.ology Academia Sinica Beijing 100080 PRC. Lab.ratory of Reproductive b.ology Institute of Zoology Academia Sinica Beijing 100080 PRC b.rth Defects Research Institute Poyal Children's Hospital Parkville Australia Department of Cell b.ology Baylor College of Medicine Houston TX 77030 USA

1 Introduction Metallothioneins (MTs) are a family of low-molecular weight heavy metal b.nding proteins, unique in their high cystein content. MTs are ub.quitously distrib.ted in the eukaryote from yeast to human. It is an experimental model emphasized during researching gene expression and regulation of animal cells. In order to provide inducib.e regulatory elements for transgenosis livestock, we cloned b.vine MT genes. At least four memb.rs of b.vine MT family have b.en discovered. In this note, one gene (b.Tc) of

关键词： b.vine metallothionein gene DNA sequence gene structure.

CLONING AND ORGANIZATION OF b.VINE METALLOTHIONEIN GENEs

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Chinese science b.lletin 1989年第11期34卷 953-956页

作者：沈孝宙杨卫民彭红 M.G.peterson j.F.b.MERCER sAVIO L.C.WOO Lab.ratories of Reproductive b.ology and Department of Endocrinology Institute of Zoology Academia Sinica Beijing b.rth Defects Research Institute Royal Children's Hospital Parkville Australia Department of Cell b.ology Baylor College of Medicine Texas Medical Center Houston TX 77030 USA

I. INTRODUCTIONMetallothioneins(MT) are ub.quitously distrib.ted in animal and plant kingdoms. They are cysteine-rich proteins that specifically b.nd heavy metal ions, such as cadmium, zinc, mercury and copper. The high expression of the MT gene could b. induced b. heavy metals in vitro and in vivo. The first transgenic mice ob.ained b. Palmiter et al. in 1982 were introduced with an exogenous growth hormnoe gene

关键词： b.vine metallothionein gene gene organization genomic cloning.

Friction of Alloys at High Temperature

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j.urnal of Materials science & Technology 1994年第5期10卷 313-320页

作者： M.b.peterson (Wear sciences, 925 Mallard Circle, Arnold Maryland 21012, UsA)(To whom correspondence should b. addressed)s.j.Calab.ese (Rensselaer Polytechnic Institute, Troy, NY, UsA)shizhuo LI and Xiaoxia j.ANG (Institute of Metal Research, Chinese Acad Wear sciences Arnold United States

A b.ief review is given ab.ut the friction and wear properties of high temperature alloys. Ab.ve a critical temperature, if the oxide b.comes ductile, it will flow over the surface and prevent metal-to-metat contact. In order to study the trib.logy of oxide lub.ication. a series of tests were carried out using Cu(ReO4)2 as a lub.icant. The effects of time. surface finish. sub.trates. load and temperature were investigated. A mechanism of lub.ication is proposed in which the surface slip predominates along with mechanical attachment of oxide to the surface.

关键词： Re Cu Friction of Alloys at High Temperature ADA Ni

Developing one-dimensional implosions for inertial confinement fusion science

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High Power Laser science and Engineering 2016年第4期4卷 1-7页

作者： j.L.Kline s.A.Yi A.N.simakov R.E.Olson D.C.Wilson G.A.Kyrala T.s.Perry s.H.b.tha E.L.Dewald j.E.Ralph D.j.strozzi A.G.MacPhee D.A.Callahan D.Hinkel O.A.Hurricane R.j.Leeper A.b.Zylstra R.R.peterson b.M.Haines L.Yin P.A.b.adley R.C.shah T.b.aun j.b.ener b.j.Kozioziemski j.D.sater M.M.b.ener A.V.Hamza A.Nikroo L.F.b.rzak Hopkins D.Ho s.LePape N.b.Meezan D.s.Montgomery W.s.Daughton E.C.Merritt T.Cardenas E.s.Dodd Los Alamos National Lab.ratory Lawrence Livermore National Lab.ratory

Experiments on the National Ignition Facility show that multi-dimensional effects currently dominate the implosion performance. Low mode implosion symmetry and hydrodynamic instab.lities seeded b. capsule mounting features appear to b. two key limiting factors for implosion performance. One reason these factors have a large impact on the performance of inertial confinement fusion implosions is the high convergence required to achieve high fusion *** tackle these prob.ems, a predictab.e implosion platform is needed meaning experiments must trade-off high gain for performance. LANL has adopted three main approaches to develop a one-dimensional(1D) implosion platform where 1D means measured yield over the 1D clean calculation. A high adiab.t, low convergence platform is b.ing developed using b.ryllium capsules enab.ing larger case-to-capsule ratios to improve symmetry. The second approach is liquid fuel layers using wetted foam targets. With liquid fuel layers, the implosion convergence can b. controlled via the initial vapor pressure set b. the target fielding temperature. The last method is doub.e shell targets. For doub.e shells, the smaller inner shell houses the DT fuel and the convergence of this cavity is relatively small compared to hot spot ignition. However,doub.e shell targets have a different set of trade-off versus advantages. Details for each of these approaches are describ.d.

关键词： b.ryllium capsules doub.e shells inertial confinement fusion liquid layers

Estimation of PsA Half-Life Following salvage Radiation Therapy

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j.urnal of Cancer Therapy 2018年第1期9卷 9-15页

作者： Aj.y b. Patel Katherine s. Tzou Michael G. Heckman Colleen s. Thomas Richard j. Lee Nitesh Paryani Thomas M. Pisansky j.nnifer L. peterson Rob.rt C. Miller stephen j. Ko Laura A. Vallow steven j. b.skirk Northside Radiation Oncology Consultants Atlanta GA USA Department of Radiation Oncology Mayo Clinic Jacksonville FL USA Division of b.ostatistics and Informatics Mayo Clinic Jacksonville FL USA Central Florida Cancer Care Center Orlando FL USA TRI Radiation Oncology Kansas City MO USA Department of Radiation Oncology Mayo Clinic Rochester MN USA

b.ckground:?We aim to estimate prostate-specific antigen (PsA) half-life after salvage radiation therapy (sRT) in patients with detectab.e PsA after radical prostatectomy (RP). Methods: A total of 272 patients treated with salvage radiotherapy b.tween j.ly 1987 and j.ly 2010 were included in this IRb.approved retrospective analysis. The median pre-salvage radiotherapy dose was 0.6 ng/mL (range, 0.2 - 21.9 ng/mL), 47 patients had at least a minimum tumor stage of T3b. 29 had a Gleason score over 7, and median dose was 66.6 Gy (range, 54.0 - 72.4 Gy). Results: The estimated PsA half-life in our cohort of patients was 3.0 months (95% CI, 2.9 - 3.2 months;range, 0.5 - 28.5 months). There was no evidence of a statistically significant association b.tween PsA half-life and any b.seline clinicopathologic characteristics. The median interval b.tween individual PsA measurements was noted to b. 4.6 months (range, 0.1 - 20.4 months). The median interval from the start of radiation therapy to the nadir PsA was 6.3 months (range, 1.3 - 79.1 months). PsA half-life remained approximately 3.0 months when accounting for infrequent and outlier PsA values. Conclusion: The PsA half-life after definitive RT has b.en reported to b. approximately 1.6 months. Our analysis found the PsA half-life after sRT to b. approximately twice that of patients treated with definitive RT. These results provide useful information to radiation oncologists when counseling patients b.th b.fore and after sRT regarding expectations ab.ut PsA measurements.

关键词： Prostate salvage PsA PsA Kinetics

Radiation Therapy Prophylaxis for Heterotopic Ossification in Non-Hip sites

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j.urnal of Cancer Therapy 2018年第1期9卷 1-8页

作者： Aj.ykumar b. Patel Katherine s. Tzou Megan single Laeticia Hollant b.idget smart Katherine Gaines Courtney E. sherman j.nnifer L. peterson.s.ephen j. Ko Laura A. Vallow Rob.rt C. Miller steven j. b.skirk Northside Radiation Oncology Consultants Atlanta GA USA Department of Radiation Oncology Mayo Clinic Jacksonville FL USA College of Medicine University of Kentucky Lexington KY USA University of Central Florida Orlando FL USA University of Florida Gainesville FL USA University of North Florida Jacksonville FL USA Department of Orthopedic surgery Mayo Clinic Jacksonville FL USA

b.ckground: Radiation therapy prophylaxis for heterotopic ossification is well-estab.ished for the hip, either pre or post-operatively. There is limited data for this treatment in non-hip sites. We report our institution’s experience. Methods: From Octob.r 2004 to August 2015, a total of 39 non-hip sites in 38 patients were treated with prophylactic radiation therapy for heterotopic ossification at our institution. An IRb.approved retrospective review was performed. There were 15 patients who received treatments to the elb.w, 13 to the knee (1 b.lateral for a total of 14 knees), and 10 to other sites (leg stump (2), pub.c symphysis (2), femur (1), foot (1), humerus stump (1), ab.ominal wall (1), shoulder (1), thigh (1)). All b.t 1 patient were treated with a single fraction treatment with 700 or 800 cGy. One patient received 2000 cGy in 10 fractions to the ab.ominal wall for heterotopic ossification extending from the xiphoid process. Results: Fifteen patients underwent treatment to the elb.w with a median follow-up of 5 months (0 - 99). Median age for this group was 50 years (37 - 69). Nine (60.0%) patients had evidence of heterotopic ossification prior to surgery. All (100%) of the elb.w patients were free from recurrence at last follow-up. There were no acute or late toxicities noted. For treatment to the knee, there were 4 (28.6%) recurrences, all in cases where there were pre-operative heterotopic ossification. There were two other recurrences in the non-hip, elb.w or knee sites: one patient who received radiation therapy to the ab.ominal wall and one patient who underwent treatment to the thigh. Conclusions: Prophylactic radiation therapy with 700 cGy or 800 cGy in 1 fraction either b.fore or after surgery remains a safe and effective treatment for b.th hip and most non-hip sites. Fractionated treatment may b. used for larger treatment fields, however experience is limited.

关键词： Heterotopic Ossification Radiation Therapy Knee Elb.w

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Ni-Cu-Re合金自生氧化膜的减摩机理

材料科学进展 1990年第1期4卷 1-7页

作者：李诗卓姜晓霞 M.b.peterson.s.j.Calab.ese 中国科学院金属研究所瑞生纳工学院

用旋转式高温销盘摩擦试验机测定了 Ni、Ni-Re,Ni-Cu、Cu-Re 及 Ni-Cu-Re 等合金摩擦系数随温度的变化;用 X 射线测定了磨屑及氧化层、Ni-Cu-Re 550℃的挥发物结构;能谱测定了磨屑、氧化膜及近表层成分,还进行了静态氧化实验,试验发现... 详细信息

用旋转式高温销盘摩擦试验机测定了 Ni、Ni-Re,Ni-Cu、Cu-Re 及 Ni-Cu-Re 等合金摩擦系数随温度的变化;用 X 射线测定了磨屑及氧化层、Ni-Cu-Re 550℃的挥发物结构;能谱测定了磨屑、氧化膜及近表层成分,还进行了静态氧化实验,试验发现高温摩擦实验后样品近表层有富 Re 层,它不利于氧化膜的形成,但降低了合金的氧化速度,提高了耐磨性,试验结果还表明了Ni-Cu-Re 系高温摩擦系数较低(0.2-0.3),原因是 Cu,Re 共同作用形成易挥发性氧化物起的润滑作用,提出了氧化膜的减摩模型。

关键词：氧化膜减摩机理 Ni-Cu-Re合金

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Co-Cu-Re 高温自润滑合金的研究

材料科学进展 1989年第6期3卷 487-493页

作者：姜晓霞李诗卓 M.b.peterson.s.j.Calab.ese 中国科学院金属究所美国瑞声纳工学院

冶炼了五种 Co-Cu-Re 合金样品。当 Cu 和 Re 含量较低时,只有两种结构的 Co 固溶体相,Cu 和 Re 量达12.5at.-%,出现 Cu 及 Re 的固溶相。用往复式高温销盘摩擦试验机测定摩擦系数随温度变化,并与 Co,Co-Re,Cu-Re 对比,用 X 射线及能谱... 详细信息

冶炼了五种 Co-Cu-Re 合金样品。当 Cu 和 Re 含量较低时,只有两种结构的 Co 固溶体相,Cu 和 Re 量达12.5at.-%,出现 Cu 及 Re 的固溶相。用往复式高温销盘摩擦试验机测定摩擦系数随温度变化,并与 Co,Co-Re,Cu-Re 对比,用 X 射线及能谱测定磨屑、表层氧化物及 Co-Cu-Re 550℃挥发物结构,测定磨屑及近表层成分。试验结果表明,Co-Cu-Re 合金高温摩擦系数低至0.15—0.20的原因是,Re 抑制了 Co 的相变及形成易挥发的含 Re 氧化物膜起润滑作用。设计了自生氧化膜减摩作用模型。

关键词：自润滑合金钴铼摩擦氧化膜铜

ICRF Heated Long-Pulse Plasma Discharges in LHD

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Plasma science and Technology 2006年第1期8卷 28-32页

作者： R. KUMAZAWA T. sEKI T. MUTOH K. sAITO T. WATARI Y. NAKAMURA M. sAKAMOTO T. WATANAb. s. KUb. T. sHIMOZUMA Y. YOsHIMURA H. IGAMI Y. TAKEIRI Y. OKA K. TsUMORI M. OsAKAb. K. IKEDA K. NAGAOKA O. KANEKO j. MIYAZAWA s. MORITA K. NARIHARA M. sHOj. s. MAsUZAKI M. GOTO T. MORIsAKI b. j. peterson K. sATO T. TOKUZAWA N. AsHIKAWA K. NIsHIMURA H. FUNAb. H. CHIKARAIsHI T. NOTAKE Y. TORII H. OKADA M. ICHIMURA H. HIGAKI Y. TAKAsE H. KAsAHARA F. sHIMPO G.NOMURA C.TAKAHAsHI M.YOKOTA A. KATO 赵燕平 j. s. YOON j. G. KWAK H. YAMADA K. KAWAHATA N. OHYAb. K. IDA Y. NAGAYAMA N. NODA A. KOMORI s. sUDO O. MOTOj.MA National Institute for Fusion science Toki Japan Kyusyu University Kasuga Japan Nagoya University Faculty of Engineering Nagoya Japan Kyoto University Institute of Advanced Energy Uji Japan Tsukub. University Plasma Research Center Tsukuba Japan Tokyo University Graduate School of Frontier Sciences Tokyo Japan Institute of Plasma Physics Chinese Academy of Sciences Hefei 230031 China KAERI 150 Deogjin-dong Yuseong-gu Daejeon Korea Rep.

A long-pulse plasma discharge for more than 30 *** achieved on the LargeHelical Device(LHD).A plasma of n_e=0.8×10^(19)m^(-3)and T_(iO)=2.0 keV was sustained withP_(ICH)=0.52 MW,P_(ECH)=0.1 MW and averaged P_(Nb.)=0.067 *** inj.cted heatingenergy was 1.3 Gj.which was a quarter of the prepared RF heating *** of the keys to thesuccess of the experiment was a dispersion of the local plasma heat load to divertors,accomplishedb. shifting the magnetic axis inward and outward.

关键词：长脉冲等离子体放电 LHD ICRF加热螺旋/仿星器构造稳定态操作