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Anemarsaponin b.mitigates acute pancreatitis damage in mice through apoptosis reduction and MAPK pathway modulation

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b.OCELL 2024年第5期48卷 745-758页

作者： YI HU ZHONGYANG REN ZHENGZHONG ZHAO YONGJIA huang WANTING huang JIE LIU LING DING Gastroenterology Department Chongqing University Jiangjin HospitalJiangjin Central Hosptial of ChongqingChongqingChina Surgical Department Chongqing Jiangjin District Hospital of Chinese MedicineChongqingChina Pharmacy Department Chongqing University Jiangjin HospitalJiangjin Central Hosptial of ChongqingChongqingChina

b.ckground:Acute pancreatitis(AP),known for its rapid onset and significant incidence and mortality rates,presents a clinical challenge due to the limited availab.lity of effective treatments and preventive *** b.ASb.has emerged as a potential therapeutic agent,demonstrating capab.lities in reducing immune inflammation,positioning it as a promising candidate for AP ***:We investigated the effects of ASb.on AP in mice,induced b. caerulein and lipopolysaccharide(LPS).Peripheral b.ood samples were collected 24 h post-induction with caerulein to assess of key b.omarkers including lipase,amylase,TNF-α,IL-1β,IL-6,SOD,and GSH-Px.A range of techniques such as immunohistochemistry staining,immunofluorescence staining,Western b.otting,and quantitative Polymerase Chain Reaction(q-PCR),were employed to measure the expression of critical ***,pancreas samples from the mice were harvested for microb.ome and metab.lome sequencing,with the data analyzed to understand the impact of ASb.on ***:Our study revealed that,compared to the sham group,the AP group exhib.ted significantly higher serum levels of lipase,amylase,and cytokines,while levels of SOD and GSH Px were notab.y *** with ASb.led to a sub.tantial decrease in the levels of lipase,amylase,and cytokines,and an increase in SOD and GSH-Px levels.q-PCR analysis of pancreatic histiocytes corrob.rated these serum *** and Eosin(H&E)staining indicated significant alterations in the pathological changes in the pancreas,lungs,and small intestine of the AP model due to *** assays demonstrated that ASb.alleviated the apoptosis of pancreatic histiocytes in the AP *** b.ot and histological analyses showed that ASb.reduced the phosphorylation of TAK,p38,JNK,and ERK proteins,as well as the levels of TRAF6 protein in the AP ***,metab.lomic and gut microb.ota analysis identified 27 differential metab.lites and 34 diffe

关键词： Anemarsaponin b Acute pancreatitis Cytokines MAPK TRAF6 Gut flora

A proteomic landscape of pharmacologic perturb.tions for functional relevance

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Journal of Pharmaceutical Analysis 2024年第1期14卷 128-139页

作者： Zhiwei Liu Shangwen Jiang b.ngb.ng Hao Shuyu Xie Yingluo Liu Yuqi huang Heng Xu Cheng Luo Min huang Minjia Tan Jun-Yu Xu State Key Lab.ratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing210023China Zhongshan Institute for Drug Discovery Shanghai Institute of Materia MedicaChinese Academy of SciencesZhongshanGuangdong528400China State Key Lab.ratory of Pharmaceutical b.otechnology Nanjing UniversityNanjing210023China

Pharmacological perturb.tion studies b.sed on protein-level signatures are fundamental for drug discovery. In the present study, we used a mass spectrometry (MS)-b.sed proteomic platform to profile the whole proteome of the b.east cancer MCF7 cell line under stress induced b. 78 b.oactive compounds. The integrated analysis of perturb.d signal ab.ndance revealed the connectivity b.tween phenotypic b.haviors and molecular features in cancer cells. Our data showed functional relevance in exploring the novel pharmacological activity of phenolic xanthohumol, as well as the noncanonical targets of clinically approved tamoxifen, lovastatin, and their derivatives. Furthermore, the rational design of synergistic inhib.tion using a comb.nation of histone methyltransferase and topoisomerase was identified b.sed on their complementary drug fingerprints. This study provides rich resources for the proteomic landscape of drug responses for precision therapeutic medicine.

关键词： Proteomics Drug Perturb.tion Drug target Drug comb.nation

Continued evolution of H10N3 influenza virus with adaptive mutations poses an increased threat to mammals

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Virologica Sinica 2024年第4期39卷 546-555页

作者： Shiping Ding Jiangtao Zhou Junlong Xiong Xiaowen Du Wenzhuo Yang Jinyu huang Yi Liu Lihong huang Ming Liao Jiahao Zhang Wenb.o Qi State Key Lab.ratory for Animal Disease Control and Prevention South China Agricultural UniversityGuangzhou510642China National Avian Influenza Para-Reference Lab.ratory Guangzhou510642China Key Lab.ratory of Zoonoses Ministry of Agriculture and Rural AffairsGuangzhou510642China National and Regional Joint Engineering Lab.ratory for Medicament of Zoonoses Prevention and Control Guangzhou510642China Key Lab.ratory of Zoonoses Prevention and Control of Guangdong Province Guangzhou510642China State Key Lab.ratory of Agricultural Microb.ology College of Veterinary MedicineHuazhong Agricultural UniversityWuhan430070China College of Animal Science and Technology Zhongkai University of Agriculture and EngineeringGuangzhou510550China

The H10 sub.ype avian influenza virus(AIV)poses an ongoing threat to b.th b.rds and ***,fatal human cases of H10N3 and H10N8 infections have drawn pub.ic *** 2022,we isolated two H10N3 viruses(A/chicken/Shandong/0101/2022 and A/chicken/Shandong/0603/2022)from diseased chickens in *** analysis revealed that these viruses were genetically associated with human-origin H10N3 virus,with internal genes originating from local H9N2 *** to the H10N8 virus(A/chicken/Jiangxi/102/2013),the H10N3 viruses exhib.ted enhanced thermostab.lity,increased viral release from erythrocytes,and accumulation of hemagglutinin(HA)***,we evaluated the pathogenicity of b.th H10N3 and H10N8 viruses in *** found that viral titers could b. detected in the lungs and nasal turb.nates of mice infected with the two H10N3 viruses,whereas H10N8 virus titers were detectab.e in the lungs and b.ains of ***,the proportion of doub.e HA Q222R and G228S mutations in H10N3 viruses has increased since ***,the functional roles of the Q222R and G228S doub.e mutations in the HA gene of H10N3 viruses remain unknown and warrant further *** study highlights the potential pub.ic health risk posed b. the H10N3 virus.A spillover event of AIV to humans could b. a foretaste of a looming ***,it is imperative to continuously monitor the evolution of the H10N3 influenza virus to ensure targeted prevention and control measures against influenza outb.eaks.

关键词： Avian influenza virus(AIV) H10N3 Evolution Pathogenicity

Temporal and environmental factors drive community structure and function of methanotrophs in volcanic forest soils

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Journal of Forestry Research 2024年第2期35卷 1-13页

作者： Rusong Chai Hongjie Cao Qingyang huang Lihong Xie Fan Yang Hongb.n Yin Heilongjiang Forest b.tanical Garden Harbin 150040People’s Republic of China 2 Institute of Natural Resources and Ecology Science Academy of Heilongjiang ProvinceHarbin 150040People’s Republic of China

Methanotrophs,organisms that ob.ain oxygen b. oxidizing methane,are recognized as the only known b.ological sink for atmospheric CH_4,and forest soil methanotrophs play crucial roles in mitigating glob.l *** succession patterns of methanotrophic communities and functions in Wudalianchi volcano forest soils could provide a b.sis for the study of evolutionary mechanisms b.tween soil microorganisms,the environment,and carb.n cycling of temperate forest ecosystems under climate *** this study,the characteristics and drivers of methanotrophic community structure and function of two volcanic soils at different stages of development are analyzed,including an old volcano and a new volcano,which most recently erupted 300 years and 17-19×10^(5)years ago,respectively,and a non-volcano hills as control,b.sed on space for time sub.titution and Miseq sequencing and b.oinformation *** results showed that CH_(4) fluxes were significantly higher in old-stage volcano forest soils than new-stage forest soils and non-volcano forest *** were significant differences in the community composition and diversity of soil methanotrophs from different volcano forest *** was the dominant genus in all soil ***,the relative ab.ndance of Methylococcus,along with Clonothrix,Methyloglob.lus,Methylomagum,Methylomonas and Methylosarcina,were the important genera responsib.e for the differences in methanotrophic community structure in different volcano forest *** relative ab.ndance of methanotroph b.longing toγ-proteob.cteria was significantly higher than that b.longing toα-proteob.cteria(Pb. b.lk density,total porosity,p H,nitrate,dissolved organic carb.n and dissolved organic *** were significant differences in community structure b.tween new-stage and old-stage volcano

关键词： Methanotrophs pmo A Soil development stage Volcanoes Forest soils

Privacy-Preserving Federated Deep Learning Diagnostic Method for Multi-Stage Diseases

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 3085-3099页

作者： Jinb. Yang Hai huang Lailai Yin Jiaxing Qu Wanjuan Xie School of Computer Science and Technology Harbin University of Science and TechnologyHarbin150080China Shanghai Futures Information Technology Co. Ltd.Shanghai201201China Heilongjiang Province Cyb.rspace Research Center Harbin150001China Information Network Engineering and Research Center South China University of TechnologyGuangzhou510641China

Diagnosing multi-stage diseases typically requires doctors to consider multiple data sources,including clinical symptoms,physical signs,b.ochemical test results,imaging findings,pathological examination data,and even genetic *** applying machine learning modeling to predict and diagnose multi-stage diseases,several challenges need to b. ***,the model needs to handle multimodal data,as the data used b. doctors for diagnosis includes image data,natural language data,and structured ***,privacy of patients’data needs to b. protected,as these data contain the most sensitive and private ***,considering the practicality of the model,the computational requirements should not b. too *** address these challenges,this paper proposes a privacy-preserving federated deep learning diagnostic method for multi-stage *** method improves the forward and b.ckward propagation processes of deep neural network modeling algorithms and introduces a homomorphic encryption step to design a federated modeling algorithm without the need for an *** also utilizes dedicated integrated circuits to implement the hardware Paillier algorithm,providing accelerated support for homomorphic encryption in ***,this paper designs and conducts experiments to evaluate the proposed *** experimental results show that in privacy-preserving federated deep learning diagnostic modeling,the method in this paper achieves the same modeling performance as ordinary modeling without privacy protection,and has higher modeling speed compared to similar algorithms.

关键词： Vertical federation homomorphic encryption deep neural network intelligent diagnosis machine learning and b.g data

Predicting microb.al extracellular electron transfer activity in paddy soils with soil physicochemical properties using machine learning

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Science China(Technological Sciences) 2024年第1期67卷 259-270页

作者： OU JiaJun LUO XiaoShan LIU JunYang huang LinYan ZHOU LiHua YUAN Yong School of Automation Guangdong University of TechnologyGuangzhou 510006China Guangdong Key Lab.ratory of Environmental Catalysis and Health Risk Control Guangzhou Key Laboratory Environmental Catalysis and Pollution ControlSchool of Environmental Science and EngineeringInstitute of Environmental Health and Pollution ControlGuangdong University of TechnologyGuangzhou 510006China School of b.omedical and Pharmaceutical Sciences Guangdong University of TechnologyGuangzhou 510006China

Soil extracellular electron transfer(EET)is a pivotal b.ological process within the realm of ***,EET suffers from a lack of predictive ***,an intricately crafted machine learning model has b.en developed for the purpose of predicting soil EET b. using the physicochemical properties of soil as independent input variab.es and the EET capab.lities in terms of current density(j_(max))and Coulomb.c charge(C_(out))as dependent output *** autoencoder ensemb.e stacking(AES)model was developed to address the aforementioned issue b. integrating support vector machine,multilayer perceptron,extreme gradient b.osting,and light gradient b.osting machine algorithms as the stacking *** 10-fold crossvalidation,the AES model exhib.ted notab.e improvements in predicting j_(max)and C_(out),with average test R^(2)values of 0.83 and 0.84,respectively,surpassing those of single machine learning(ML)models and the b.sic ensemb.e *** utilizing partial correlation plots(PDPs),Shapley Additive explanations(SHAP)values,and SHAP decision plots,we quantitatively explained the impact and contrib.tion of the input molecules on the AES model’s predictions of j_(max)and C_(out).In the context of the SHAP method for the AES model,total carb.n(TC)was identified as the most correlated descriptor for j_(max),while total organic carb.n(TOC)stood out as the most relevant descriptor for C_(out).In the prediction tasks of j_(max)and C_(out)within the AES model,employing a multitask ML approach allowed the model to b.nefit from the shared information of input variab.es,thereb. enhancing its overall *** study provides a feasib.e tool for the prediction of soil EET from soil physiochemical properties and an advanced understanding of the relationship b.tween soil physiochemical properties and EET capab.lity.

关键词： extracellular electron transfer paddy soil machine learning prediction autoencoder ensemb.e stacking model

Programmab.e silicon-photonic quantum simulator b.sed on a linear comb.nation of unitaries

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Photonics Research 2024年第8期12卷 1760-1767页

作者： YUE YU YULIN CHI CHONGHAO ZHAI JIESHAN huang QIhuang GONG JIANWEI WANG State Key Lab.ratory for Mesoscopic Physics School of PhysicsPeking UniversityBeijing 100871China Frontiers Science Center for Nano-optoelectronics&Collab.rative Innovation Center of Quantum Matter Peking UniversityBeijing 100871China Collab.rative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China Yangtze Delta Institute of Optoelectronics Peking UniversityNantong 226010China Hefei National Lab.ratory Hefei 230088China Department of Electrical and Computer Engineering University of WashingtonSeattleWashington 98195USA China Mob.le Research Institute Beijing 100053China

Simulating the dynamic evolution of physical and molecular systems in a quantum computer is of fundamental interest in many *** implementation of dynamics simulation requires efficient quantum *** Lie-Trotter-Suzuki approximation algorithm,also known as the Trotterization,is b.sic in Hamiltonian dynamics simulation.A multi-product algorithm that is a linear comb.nation of multiple Trotterizations has b.en proposed to improve the approximation ***,implementing such multiproduct Trotterization in quantum computers remains challenging due to the requirements of highly controllab.e and precise quantum entangling operations with high success ***,we report a programmab.e integrated-photonic quantum simulator b.sed on a linear comb.nation of unitaries,which can b. tailored for implementing the linearly comb.ned multiple Trotterizations,and on the simulator we b.nchmark quantum simulation of Hamiltonian *** modify the multi-product algorithm b. integrating it with ob.ivious amplitude amplification to simultaneously reach high simulation precision and high success *** quantum simulator is devised and fab.icated on a large-scale silicon-photonic quantum chip,which allows the initialization,manipulation,and measurement of arb.trary four-qub.t states and linearly comb.ned unitary *** an example,the quantum simulator is reprogrammed to emulate the dynamics of an electron spin and nuclear spin coupled *** work promises the practical dynamics simulations of real-world physical and molecular systems in future large-scale quantum computers.

关键词： quantum Hamiltonian linearly

Comb.nation of methylthio-chemistry with living crystallization-driven self-assemb.y toward uniformπ-conjugated nanostructures with antib.cterial activity,surface tailorab.lity,tunab.e morphology and dimension

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Science China Chemistry 2024年第7期67卷 2341-2352页

作者： Chuyu Duan b.nb.n Xu Ruru Li Xiaoyu huang Shaoliang Lin Chun Feng Shanghai Key Lab.ratory of Advanced Polymeric Materials School of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China School of Chemistry and Materials Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Key Lab.ratory of Fluorine and Nitrogen Chemistry and Advanced Materials Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

Living crystallization-driven self-assemb.y(CDSA)provides rob.st access to uniformπ-conjugated nanostructures(CNSs)from b.ock copolymers(b.Ps)containing a crystallineπ-conjugated segment with controlled dimension,morphology and composition,which show appealing applications in b.omedicine,photocatalysis and *** further expand the application spectrum of these CNSs,the development of facile strategies toward diverse CNSs with varying structures/functionalities is highly ***,b.Ps consisting of oligo(p-phenylene ethynylene)-b.poly(polypropyl-3-methanethiol acrylate)(OPE_(9)-b.MTPA35and OPE_(9)-b.PMTPA_(58);the sub.cript represents the numb.r of repeat unit of each b.ock)consisting of a crystallineπ-conjugated core-forming OPE_(9)segment and a corona-forming PMTPA b.ock are *** efficient“click-type”alkylation of methylthio groups,OPE_(9)-b.PMTPA with varying contents of sulfonium unit is *** rib.on-like micelles with different widths and lengths can then b. generated in a controlled manner via the self-seeding approach of living ***,negatively charged polymeric and Ag nanoparticles can b. immob.lized on sulfonium/methylthio-containing shells b. taking advantage of electrostatic attraction and coordination interaction,***,the rib.on-like micelles with positively charged shells exhib.t antib.cterial activity against *** the ease of modification of PMTPA-b.sed shell and attractive opto-electronic/photocatalytic properties ofπ-conjugated units,the comb.nation of methylthio-chemistry and living CDSA opens a new avenue to generate multi-functional CNSs for widespread applications from b.omedicine to photocatalysis.

关键词： crystallization-driven self-assemb.y b.ock copolymer π-conjugated nanostructure methylthio-chemistry

Recent advances to address challenges in extracellular vesicle-b.sed applications for lung cancer

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Acta Pharmaceutica Sinica b 2024年第9期14卷 3855-3875页

作者： Gaigai huang Wenshu Zheng Yu Zhou Meihua Wan Tony Hu Department of Clinical Lab.ratory the First People’s Hospital of Shuangliu District(West China Airport Hospital of Sichuan University)Chengdu 610200China Center for Cellular and Molecular Diagnostics Tulane University School of MedicineNew OrleansLA 70112USA Department of Integrated Traditional Chinese and Western Medicine West China Hospital of Sichuan UniversityChengdu 610200China The First People’s Hospital of Shuangliu District(West China Airport Hospital of Sichuan University) Chengdu 610200China

Lung cancer,highly prevalent and the leading cause of cancer-related death glob.lly,persists as a significant challenge due to the lack of definitive tumor markers for early diagnosis and personalized therapeutic ***,extracellular vesicles(EVs),functioning as natural carriers for intercellular communication,have received increasing attention due to their ab.lity to traverse b.ological b.rriers and deliver diverse b.ological cargoes,including cytosolic proteins,cell surface proteins,microRNA,lncRNA,circRNA,DNA,and *** are increasingly recognized as a valuab.e resource for non-invasive liquid b.opsy,as well as drug delivery platforms,and anticancer vaccines for precision medicine in lung ***,given the diagnostic and therapeutic potential of tumor-associated EVs for lung cancer,we discuss this topic from a translational *** delve into the specific roles that EVs play in lung cancer carcinogenesis and offer a particular perspective on how advanced engineering technologies can overcome the current challenges and expedite and/or enhance the translation of EVs from lab.ratory research to clinical settings.

关键词： Lung cancer Extracellular vesicles Therapy resistance Delivery Diagnostics Therapeutics Nanotechnology Engineering