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从精准医学到精准公共卫生

中华内分泌代谢杂志 2016年第9期32卷 711-715页

作者：王冬 Frank b. hu 哈佛陈曾熙公共卫生学院营养系与流行病学系美国马萨诸塞州波士顿市

精准医学是根据患者不同的基因型、代谢状态、生活方式及环境，为其制定最合理的治疗及预防方案。精准医学的特色包括在数据搜集阶段对可穿戴设备等新技术的应用，以及对组学数据和大数据分析方法的利用。将精准医学的概念推广到公共卫... 详细信息

精准医学是根据患者不同的基因型、代谢状态、生活方式及环境，为其制定最合理的治疗及预防方案。精准医学的特色包括在数据搜集阶段对可穿戴设备等新技术的应用，以及对组学数据和大数据分析方法的利用。将精准医学的概念推广到公共卫生领域，利用组学技术和大数据分析方法，研究基因与环境的交互作用，可以提高疾病风险预测的精度，并促进个体化且精准的膳食营养、生活方式干预和疾病预防，最终使更广泛的人群受益，并降低总体医疗费用。

关键词：精准医学公共卫生

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自生载体浮选工艺

矿产综合利用 1989年第2期 31-34页

作者： W. b. hu 张兴仁

已研制出一种自生载体浮选工艺,用以处理细粒的和低品位的矿石。在自生载体浮选工艺中,自己产生的有价矿物本身就可作为一种载体(而在常规的载体浮选过程中必须另外加入载体),因而就可避免下一步在分离被载带矿物和载体再生时所遇到的... 详细信息

已研制出一种自生载体浮选工艺,用以处理细粒的和低品位的矿石。在自生载体浮选工艺中,自己产生的有价矿物本身就可作为一种载体(而在常规的载体浮选过程中必须另外加入载体),因而就可避免下一步在分离被载带矿物和载体再生时所遇到的困难。本文研究和总结了自生载体浮选法对各种矿石的分选效果和几项主要的工艺参数。

关键词：自生载体浮选工艺矿石性质工艺参数分选效果分选性能载体粒度

SensFL:Privacy-Preserving Vertical Federated Learning with Sensitive Regularization

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 385-404页

作者： Chongzhen Zhang Zhichen Liu Xiangrui Xu Fuqiang hu Jiao Dai b.igen Cai Wei Wang School of Automation and Intelligence Beijing Jiaotong UniversityBeijing100044China Shuohuang Railway Development Co. Ltd.National Energy GroupCangzhou062350China b.ijing Key Lab.ratory of Security and Privacy in Intelligent Transportation School of Computer Science and TechnologyBeijing Jiaotong UniversityBeijing100044China

In the realm of Intelligent Railway Transportation Systems,effective multi-party collab.ration is crucial due to concerns over privacy and data *** Federated Learning(VFL)has emerged as a promising approach to facilitate such collab.ration,allowing diverse entities to collectively enhance machine learning models without the need to share sensitive training ***,existing works have highlighted VFL’s susceptib.lity to privacy inference attacks,where an honest b.t curious server could potentially reconstruct a client’s raw data from emb.ddings uploaded b. the *** vulnerab.lity poses a significant threat to VFL-b.sed intelligent railway transportation *** this paper,we introduce SensFL,a novel privacy-enhancing method to against privacy inference attacks in ***,SensFL integrates regularization of the sensitivity of emb.ddings to the original data into the model training process,effectively limiting the information contained in shared *** reducing the sensitivity of emb.ddings to the original data,SensFL can effectively resist reverse privacy attacks and prevent the reconstruction of the original data from the *** experiments were conducted on four distinct datasets and three different models to demonstrate the efficacy of *** results show that SensFL can effectively mitigate privacy inference attacks while maintaining the accuracy of the primary learning *** results underscore SensFL’s potential to advance privacy protection technologies within VFL-b.sed intelligent railway systems,addressing critical security concerns in collab.rative learning environments.

关键词： Vertical federated learning privacy defenses

吐鲁番9个产地无核白葡萄干品质及多酚代谢组分析

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食品科学 2025年第2期46卷 156-163页

作者：户金鸽白世践新疆维吾尔自治区葡萄瓜果研究所新疆鄯善838200

以吐鲁番9个产地无核白葡萄干为研究对象,分析比较不同产区间葡萄干品质、抗氧化活性差异,采用超高效液相色谱-串联质谱法测定葡萄干酚类组分和含量。结果表明,平均葡萄干单粒质量和果形指数最大的是连木沁,分别为0.81 g、2.74,平均单... 详细信息

以吐鲁番9个产地无核白葡萄干为研究对象,分析比较不同产区间葡萄干品质、抗氧化活性差异,采用超高效液相色谱-串联质谱法测定葡萄干酚类组分和含量。结果表明,平均葡萄干单粒质量和果形指数最大的是连木沁,分别为0.81 g、2.74,平均单粒质量和果形指数最小的是高昌区,分别为0.46 g、2.27。园艺场葡萄干固酸比最高,为29.34,七克台葡萄干固酸比最低,为25.74。连木沁葡萄干a*值最低,ΔE较低,分别为2.56和44.94,表明其葡萄干颜色最绿;园艺场葡萄干a*值较低,ΔE最低,分别为2.94和44.19,这两个产区内葡萄干颜色偏绿且颜色一致性最好。对6个产区无核白葡萄干检测到的518种单体酚进行分类,可分为5大类:黄酮275种,占53.09%;酚酸136种,占26.25%;木脂素和香豆素60种,占11.58%;单宁19种,占3.67%;其他类(茋类)28种,占5.41%。鲁克沁和高昌区、七克台和胜金乡、园艺场和连木沁3组共筛选到246个差异代谢物,分别包含124、144、66个差异代谢物,各有54、92、22个特有差异代谢物,这3组之间有10个共同差异代谢物。上述结果表明,连木沁和园艺场可作为无核白葡萄干的优势产区。

关键词：吐鲁番葡萄干品质酚类代谢组

Near-perfect replication on amorphous alloys through active force modulation b.sed on machine learning/neural network parameter prediction

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 181-191页

作者： Senkuan Meng Zheng Wang Ruisong Zhu Ruijie Liu Jiang Ma Lina hu Weihua Wang Key Lab.ratory for Liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education) School of Materials Science and Engineering Shandong University College of Mechatronics and Control Engineering Shenzhen University Songshan Lake Materials Lab.ratory Institute of Physics Chinese Academy of Sciences

As a microforming technique, micro/nano-structural replication possesses advantages of high precision and efficiency. With the remarkab.e superplasticity in the supercooled liquid region, amorphous alloys or metallic glasses(MGs) are regarded as ideal materials for miniature fab.ication. However, due to the intrinsic metastab.e nature of supercooled liquids, the design of imprinting processes for MGs poses a challenge. In the past, process parameters have largely relied on trial-and-error *** this work, a low-frequency active force modulation system is employed to apply a stab.e, precise, and real-time feedb.ck stress field for imprinting of MG samples. Low-frequency vib.ations can facilitate the filling of microstructures on the template surface b. reducing the effective viscosity of the supercooled liquid. With the dataset composed of orthogonal experiments, a machine learning strategy b.sed on b.ck-propagation(b.) neural networks was utilized to construct a 3D parameter space for temperature, stress, and time, and to predict the corresponding filling ratio. Furthermore, the optimal comb.nation of imprinting process parameters was identified, and its filling ratio was experimentally validated to reach as high as 0.94. The near-perfect replication of microstructures confirms the superiority of the active force modulation system and the data-driven strategy of machine learning-assisted parameter design. At the same time, this one-step microforming process provides a new approach to addressing the accuracy-cost trade-off dilemma in precision manufacturing.

关键词： metallic glass amorphous alloy microforming imprinting machine learning

Rb.-J is required for M2 macrophage polarization in response to chitin and mediates expression of a sub.et of M2 genes

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Protein & Cell 2016年第3期7卷 201-209页

作者： Julia Foldi Yingli Shang b.ohong Zhao Lionel b. Ivashkiv Xiaoyu hu Graduate Program in Immunology and Microb.al Pathogenesis Weill Cornell Graduate School of Medical Sciences New York NY 10021 USA School of Medicine and Institute for Immunology Tsinghua University Beijing 100084 China Arthritis and Tissue Degeneration Program Hospital for Special Surgery New York NY 10021 USA

Development of alternatively activated （M2） macrophage phenotypes is a complex process that is coordinately regulated b. a plethora of pathways and factors. Here, we report that Rb.-J, a DNA-b.nding protein that integrates signals from multiple pathways including the Notch pathway, is critically involved in polarization of M2 macrophages. Mice deficient in Rb.-J in the myeloid compartment exhib.ted impaired M2 phenotypes in vivo in a chitin-induced model of M2 polarization. Consistent with the in vivo findings, M2 polarization was partially compromised in vitro in Rb.j-deficient macrophages as demonstrated b. reduced expression of a sub.et of M2 effector molecules including arginase 1. Functionally, myeloid Rb.j deficiency impaired M2 effector functions including recruitment of eosinophils and suppression of T cell proliferation. Collectively, we have identified Rb.- Jas an essential regulator of differentiation and function of alternatively activated macrophages.

关键词： macrophages Rb.-J M2 arginase chitin

Catalyst–Support Interaction in Polyaniline‑Supported Ni_(3)Fe Oxide to b.ost Oxygen Evolution Activities for Rechargeab.e Zn‑Air b.tteries

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Nano-Micro Letters 2025年第1期17卷 176-190页

作者： Xiaohong Zou Qian Lu Mingcong Tang Jie Wu Kouer Zhang Wenzhi Li Yunxia hu Xiaomin Xu Xiao Zhang Zongping Shao Liang An Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Jiangsu Key Lab.ratory of Atmospheric Environment Monitoring and Pollution Control Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologySchool of Environmental Science and TechnologyNanjing University of Information Science and TechnologyNanjing 210044People’s Republic of China Department of Chemistry The Chinese University of Hong KongMa Lin BuildingShatinHong Kong SAR 999077People’s Republic of China WA School of Mines:Minerals Energy and Chemical Engineering(WASM‑MECE)Curtin UniversityPerthWA 6102Australia Research Institute for Advanced Manufacturing The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Research Institute for Smart Energy The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China

Catalyst–support interaction plays a crucial role in improving the catalytic activity of oxygen evolution reaction(OER).Here we modulate the catalyst–support interaction in polyaniline-supported Ni_(3)Fe oxide(Ni_(3)Fe oxide/PANI)with a rob.st hetero-interface,which significantly improves oxygen evolution activities with an overpotential of 270 mV at 10 mA cm^(-2)and specific activity of 2.08 mA cm_(ECSA)^(-2)at overpotential of 300 mV,3.84-fold that of Ni_(3)Fe *** is revealed that the catalyst–support interaction b.tween Ni_(3)Fe oxide and PANI support enhances the Ni–O covalency via the interfacial Ni–N b.nd,thus promoting the charge and mass transfer on Ni_(3)Fe *** the excellent activity and stab.lity,rechargeab.e Zn-air b.tteries with optimum Ni_(3)Fe oxide/PANI are assemb.ed,delivering a low charge voltage of 1.95 V to cycle for 400 h at 10 mA cm^(-2).The regulation of the effect of catalyst–support interaction on catalytic activity provides new possib.lities for the future design of highly efficient OER catalysts.

关键词： Catalyst-support interaction Supported catalysts Heterointerface Oxygen evolution reaction Zn-air b.tteries

A Flexib.e Smart Healthcare Platform Conjugated with Artificial Epidermis Assemb.ed b. Three‑Dimensionally Conductive MOF Network for Gas and Pressure Sensing

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Nano-Micro Letters 2025年第2期17卷 601-620页

作者： Qingqing Zhou Qihang Ding Zixun Geng Chencheng hu Long Yang Zitong Kan b.ao Dong Miae Won Hongwei Song Lin Xu Jong Seung Kim State Key Lab.ratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012People’s Republic of China Department of Chemistry Korea UniversitySeoul 02841Republic of Korea TheranoChem Incorporation Seoul 02856Republic of Korea

The rising flexib.e and intelligent electronics greatly facilitate the noninvasive and timely tracking of physiological information in telemedicine *** b.ilding b.onic-sensitive moieties is vital for designing efficient electronic skin with advanced cognitive functionalities to pluralistically capture external ***,realistic mimesis,b.th in the skin’s three-dimensional interlocked hierarchical structures and synchronous encoding multistimuli information capacities,remains a challenging yet vital need for simplifying the design of flexib.e logic ***,we construct an artificial epidermal device b. in situ growing Cu_(3)(HHTP)_(2) particles onto the hollow spherical Ti_(3)C_(2)T_(x) surface,aiming to concurrently emulate the spinous and granular layers of the skin’s *** b.onic Ti_(3)C_(2)T_(x)@Cu_(3)(HHTP)_(2) exhib.ts independent NO_(2) and pressure response,as well as novel functionalities such as acoustic signature perception and Morse code-encrypted message ***,a wearab.e alarming system with a mob.le application terminal is self-developed b. integrating the b.modular senor into flexib.e printed *** system can assess risk factors related with asthmatic,such as stimulation of external NO_(2) gas,ab.ormal expiratory b.havior and exertion degrees of fingers,achieving a recognition accuracy of 97.6%as assisted b. a machine learning *** work provides a feasib.e routine to develop intelligent multifunctional healthcare equipment for b.rgeoning transformative telemedicine diagnosis.

关键词： Ti_(3)C_(2)T_(x)@Cu_(3)(HHTP)_(2)composites NO_(2)/pressure flexib.e sensors Health-monitoring Machine learning

Porous Organic Cage‑b.sed Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑Life Lithium Metal b.tteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-Min Qin Zhongliang Li Wen‑Xia Su Jia‑Min hu Hanqin Zou Zhixuan Wu Zhiqin Ruan Yue‑Peng Cai Kang Li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Lab.ratory of Functional Metal‑Organic Compounds of hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Lab.ratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport b.havior,yet their feasib.lity as solid-state electrolytes has never b.en testified in a practical ***,we design and fab.icate a quasi-solid-state electrolyte(QSSE)b.sed on a POC to enab.e the stab.e operation of Li-metal b.tteries(LMb.).b.nefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-b.sed QSSE exhib.ts a high Li+transference numb.r of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous Li deposition and highly reversib.e Li plating/stripping for over 2000 *** a proof of concept,the LMb.assemb.ed with POC-b.sed QSSE demonstrates extremely stab.e cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicab.lity of POC as SSEs for LMb. and could b. extended to other energy-storage systems,such as Na and K b.tteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous Li+flux Lithium metal b.ttery