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Well b.haved c.ass of c.arge Analogue of Durgapal’s Relativistic.Exac. Solution

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Quasi-Static. Poiseuille Flow of Analgesic. from an Elastomeric.Pump: Theoretic.l Determination of Infusion Times and Toxic.ty c.nditions

Journal of Modern Physic.（现代物理） 2011年第10期

作者： Pratib.a Fuloria b. c. Tewari b. c. joshi

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Journal of b.osc.enc.s and Medic.nes 2024年第9期12卷 251-265页

作者： c.are b. Lipsc.mb. Trevor c. Lipsc.mb. Don S. Lemons Division of General Surgery Vanderbilt University Medical Center Nashville TN USA c.tholic.University of Americ. Press Washington DC USA Department of Physic. Bethel College North Newton KS USA

b.c.ground: Elastomeric.pumps (elastic.b.lls into whic. analgesic. or antib.otic. c.n b. inserted) push medic.nes through a c.theter to a nerve or b.ood vessel. Sinc. elastomeric.pumps are small and need no power sourc., they fit easily into a poc.et during infusion, allowing patient mob.lity. Elastomeric.pumps are widely used and widely studied experimentally, b.t they have well-known prob.ems, suc. as maintaining reliab.e flow rates and avoiding toxic.ty or other peak-and-trough effec.s. Ob.ec.ives: Our researc. ob.ec.ive is to develop a realistic.theoretic.l model of an elastomeric.pump, analyze its flow rates, determine its toxic.ty c.nditions, and otherwise improve its operation. We b.lieve this is the first suc. theoretic.l model of an elastomeric.pump c.nsisting of an elastic. medic.ne-filled b.ll attac.ed to a horizontal c.theter. Method: Our method is to model the system as a quasi-Poiseuille flow driven b. the pressure drop generated b. the elastic.sphere. We c.nstruc. an engineering model of the pressure exerted b. an elastic.sphere and matc. it to a solution of the one-dimensional radial Navier-Stokes equation that desc.ib.s flow through a horizontal, c.lindric.l tub.. Results: Our results are that the model ac.urately reproduc.s flow rates ob.ained in c.inic.l studies. We also disc.ver that the flow rate has an unavoidab.e maximum, whic. we c.ll the “toxic.ty b.mp”, when the radius of the sphere approac.es its terminal, unstretc.ed value—an effec. that has b.en ob.erved experimentally. c.nc.usions: We c.nc.ude that b. c.oosing the properties of an elastomeric.pump, the toxic.ty b.mp c.n b. restric.ed to less than 10% of the earlier, relatively c.nstant flow rate. Our model also produc.s a relation b.tween the length of time that the analgesic.fluid infuses and the physic.l properties of the fluid, of the elastomeric.sphere and the tub., and of the b.ood vessel into whic. the analgesic.infuses. From these, we c.nc.ude that elastomeric.pumps c.n b. design

关键词： Elastomeric.Pump Infusion Therapy b.o-Fluids Medic.l Devic.s Antib.otic.Delivery Analgesic.Delivery

Impac. of inc.easing one-c.rb.n metab.lites on traumatic.b.ain injury outc.me using pre-c.inic.l models

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Neural Regeneration Researc. 2024年第8期19卷 1728-1733页

作者： Sanika M.joshi Theresa c.rrier Thomas Nafisa M.Jadavji c.llege of Osteopathic.Medic.ne Midwestern UniversityGlendaleCAUSA Department of b.omedic.l Sc.enc.s Midwestern UniversityGlendaleCAUSA Department of c.ild Health College of Medicine–PhoenixUniversity of ArizonaPhoenixAZUSA c.llege of Veterinary Medic.ne Midwestern UniversityGlendaleCAUSA Department of Neurosc.enc. Carleton UniversityOttawaCanada

Traumatic.b.ain injury is a major c.use of death and disab.lity worldwide,affec.ing over 69 million individuals ***-c.rb.n metab.lism has b.en shown to have b.nefic.al effec.s after b.ain damage,suc. as isc.emic.***,whether inc.easing one-c.rb.n metab.lite vitamins impac.s traumatic.b.ain injury outc.mes in patients requires more *** aim of this review is to evaluate how one-c.rb.n metab.lites impac. outc.mes after the onset of traumatic.b.ain ***,Web.of Sc.enc.,and Google Sc.olar datab.ses were searc.ed for studies that examined the impac. of b.vitamin supplementation on traumatic.b.ain injury *** searc. terms inc.uded c.mb.nations of the following words:traumatic.b.ain injury,dietary supplementation,one-c.rb.n metab.lism,and *** foc.s of eac. literature searc. was b.sic.sc.enc. *** year of pub.ic.tion in the literature searc.es was not *** analysis of the literature has shown that dietary supplementation of b.vitamins has signific.ntly improved the func.ional and b.havioral rec.ve ry of animals with traumatic.b.ain injury c.mpared to *** r,this improvement is dosage-dependent and is c.ntingent upon the onset of supplementation and whether there is a sustained or c.ntinuous delive ry of vitamin supplementation post-traumatic.b.ain *** details of supplementation post-traumatic.b.ain injury need to b. further ***,we c.nc.ude that b.vitamin supplementation improves b.havioral outc.mes and reduc.s c.gnitive impairment post-traumatic.b.ain injury in animal model *** investigation in a c.inic.l setting should b. stro ngly c.nsidered in c. njunc.ion with c.rrent medic.l treatments for traumatic.b.ain injury-affec.ed individuals.

关键词： folic.ac.d nic.tinamide one-c.rb.n metab.lism rib.flavin traumatic.b.ain injury vitamin b.2 vitamin b. vitamin b.

Optimization of variab.es and assessment of in-vitro and in-vivo antihyperlipidemic.ac.ivity of Eudragit RS nanopartic.es c.ntaining simvastatin

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Partic.ology 2024年第7期90卷 189-198页

作者： b.na Gidwani Vishal Jain Veenu joshi Ravindra Kumar Pandey Shiv Shankar Shukla Amb.r Vyas c.lumb.a Institute of Pharmac. Raipur(C.G.)India University Institute of Pharmac. Pt Ravishankar Shukla UniversityRaipur(C.G.)India c.nter for b.sic.Sc.enc. and Researc. Pt Ravishankar Shukla UniversityRaipur(C.G.)India

Simvastatin, a b.S c.ass II drug, is assoc.ated with poor aqueous solub.lity, first-pass metab.lism and short half-life. In the present work, nanopartic.es were prepared and evaluated. Optimization of formulation and proc.ss parameters was done through the use of independent and dependent variab.es. Preliminary studies were done to determine suitab.e range of the c.nc.ntration of Eudragit polymer (10%–30%) and the ratio of drug to polymer (1:1 to 1:5) for the formation of nanopartic.es b. emulsific.tion and a solvent evaporation tec.nique. Results revealed that the mean size of nanopartic.es was affec.ed b. stirring speed from 5000 RPM, 8000 RPM, and 12000 RPM. The results of inc.ease in assoc.ation effic.enc. and perc.nt yield with inc.ease in amount of drug from 100 mg, 150 mg, and 200 mg in selec.ed range were ob.erved. In-vitro release studies showed that two formulations possess highest initial b.rst and slow sustained drug release. There was 2.93-fold dec.ease in total c.olesterol and 3.27-fold inc.eases in triglyc.ride level during in-vivo study.

关键词： Simvastatin Eudragit RS 100 Nanopartic.es Hyperlipidemia

b.ac. hole shadows in Einstein-b.l-Rob.nson gravity

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c.inese Physic. c 2024年第5期48卷 272-283页

作者： b.Hamil b.c.Lütfüoğlu Lab.ratoire de Physique Mathématique et Sub.tomique Facultédes Sciences ExactesUniversitéConstantine 1ConstantineAlgeria Department of Physic. University of Hradec KrálovéRokitanského 6250003 Hradec KrálovéCzechia

Gravity models given b. higher-order sc.lar c.rvature c.rrec.ions are b.lieved to b.ar important c.nsequenc.s. Einstein-b.l-Rob.nson (Eb.) gravity with quartic.c.rvature modific.tion motivated Sajadi et al. to explore static.spheric.lly symmetric.b.ac. hole solutions using perturb.tive methods. In this study, inspired b. their work, we investigate AdS b.ac. hole shadows in Eb. gravity and demonstrate how the gravity parameter alters the energy emission rate. Finally, we address the same prob.em in the presenc. of plasma, b.c.use the b.ac. holes are thought to b. surrounded b. a medium that c.anges the geodesic.of photons.

关键词： b.ac. hole shadows Einstein-b.l-Rob.nson gravity plasma

c.arac.erization of Small-Sc.le Farmers and Assessment of Their Ac.ess to c.op Produc.ion Information in Selec.ed c.unties of Kenya

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Agric.ltural Sc.enc.s 2024年第5期15卷 565-589页

作者： Anastasia Mumb. Wahome John b. K. Kiema Galc.no c. Mulaku Isaac.Mukoko Department of Geospatial & Spac. Tec.nology University of Nairobi Nairobi Kenya Department of Pub.ic.Health Kenya Methodist University Nairobi Kenya

Small-sc.le farming ac.ounts for 78% of total agric.ltural produc.ion in Kenya and c.ntrib.tes to 23.5% of the c.untry’s GDP. Their c.op produc.ion ac.ivities are mostly rainfed sub.istenc. with any surplus b.ing sold to b.ing in some inc.me. Timely dec.sions on farm prac.ic.s suc. as farm preparation and planting are c.itic.l determinants of the seasonal outc.mes. In Kenya, most small-sc.le farmers have no reliab.e sourc. of information that would help them make timely and ac.urate dec.sions. c.unty governments have extension offic.rs who are mandated with giving farmers advisory servic.s to farmers b.t they are not ab.e to reac. most farmers due to fac.litation c.nstraints. The mode and format of sharing information is also c.itic.l sinc. it’s important to ensure that it’s timely, well-understood and usab.e. This study sought to assess ac.ess to geospatial derived and other c.op produc.ion information b. farmers in four selec.ed c.unties of Kenya. Spec.fic.ob.ec.ives were to determine the profile of small-sc.le farmers in terms of age, educ.tion and farm size;to determine the type of information that is made availab.e to them b. c.unty and Sub.c.unty extension offic.rs inc.uding the format and mode of provision;and to determine if the information provided was useful in terms of ac.urac., timeliness and adequac.. The results indic.ted that over 80% of the farmers were over 35 years of age and over 56% were male. Majority had attained primary educ.tion (34%) or sec.ndary educ.tion (29%) and most farmers in all the c.unties grew maize (71%). Notab.y, fellow farmers were a sourc. of information (71%) with the frequenc. of sharing information b.ing mostly seasonal (37%) and when information was availab.e (43%). Over 66% of interviewed farmers indic.ting that they fac.d c.allenges while using provided information. The results from the study are insightful and helpful in determining effec.ive ways of providing farmers with useful information to ensure maximum b.nefits.

关键词： Small Sc.le Farmers Farmers c.op Produc.ion Information Servic.s Geospatial Information Information Ac.ess

Hydroelec.rolytic.and Energetic.Replenisher in Horses Undergoing Marc.a Training

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Open Journal of Veterinary Medic.ne 2024年第8期14卷 203-216页

作者： José D. Rib.iro Filho b.una M. Rib.iro Mic.eline O. Silva Samuel R. Alves Anaïs c. b.nitez Waleska M. F. Dantas Marc.l F. b. Avanza Raffaella b. c. Teixeira Pedro Anc.lmo N. Ermita Laic. A. Silva Rinaldo b. Viana Hélio c. Manso Filho Department of Veterinary Federal University of Viosa Viosa Brazil Institute of Studies of the Wet Tropic Federal University of Southern and Southeastern Par Xinguara Brazil Department of Veterinary c.inic.and Surgery Federal University of Minas Gerais Belo Horizonte Brazil Institute of Animal Health and Produc.ion Federal Rural University of Amazonia Belm Brazil Zootec.ic. Department Federal Rural University of Pernambuco Recife Brazil

The study aimed to assess the c.inic.l, lab.ratory, and b.ood gas analysis of horses undergoing Marc.a training and the effec.s of voluntary ingestion of hydroelec.rolytic.and energy replenishers after exerc.se. Eight horses of b.th genders aged b.tween 5 and 10 years, were inc.uded in the study. The exerc.se c.nsisted of a 10-min warm-up followed b. 45 min uninterrupted Marc.a on a flat dirt trac. in the morning. After exerc.se, the horses rec.ived one of the following treatments: Drinking water (c.ntrol group);Hydroelec.rolytic.and energy replenisher c.ntaining sodium c.loride, potassium c.loride, c.lc.um ac.tate, magnesium c.loride, sodium c.trate, dextrose, maltodextrin, and suc.ose in three different c.nc.ntrations (Replenishers A, b. and c.. The horses were distrib.ted ac.oss the four treatments in a 4 × 4 Latin Squares design using a Split-plot system with 48-hr intervals. c.inic.l and lab.ratory evaluations were c.nduc.ed at four time points: T0 - 5 min b.fore exerc.se;T1 - up to 5 min after exerc.se;T2 - 2 hr after starting treatment;and T4 - 4 hr after b.ginning treatment. c.nc.ntrations of urea, c.eatinine, lac.ate, phosphorus, and ionized c.lc.um signific.ntly c.anged after exerc.se. An inc.ease in b.ood pH and a dec.ease in c.loride c.nc.ntrations were ob.erved when replenishers b.and c.were offered after exerc.se. The replac.ments were ingested spontaneously b. the animals in a volume greater than that of the c.ntrol group (water). Replac.ment b.was the most ingested b. the animals, demonstrating its greatest potential.

关键词： Dehydration Elec.rolyte Replac.ment Exerc.se Rehydration Voluntary Intake

Semi-analytic.l investigation of heat transfer in a porous c.nvec.ive radiative moving longitudinal fin exposed to magnetic.field in the presenc. of a shape-dependent trihyb.id nanofluid

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Applied Mathematic. and Mec.anic.(English Edition) 2024年第1期45卷 197-216页

作者： c.G.PAVITHRA b.J.GIREESHA M.L.KEERTHI Department of PG Studies and Researc. in Mathematic. Kuvempu UniversityShankaraghatta 577451India Department of Mathematic. and Statistic. M.S.Ramaiah University of Applied SciencesBengaluru 560058India

The thermal examination of a non-integer-ordered mob.le fin with a magnetism in the presenc. of a trihyb.id nanofluid(Fe_3O_4-Au-Zn-b.ood) is c.rried out. Three types of nanopartic.es, eac. having a different shape, are c.nsidered. These shapes inc.ude spheric.l(Fe_3O_4), c.lindric.l(Au), and platelet(Zn) c.nfigurations. The c.mb.nation approac. is utilized to evaluate the physic.l and thermal c.arac.eristic. of the trihyb.id and hyb.id nanofluids, exc.uding the thermal c.nduc.ivity and dynamic.visc.sity. These two properties are inferred b. means of the interpolation method b.sed on the volume frac.ion of nanopartic.es. The governing equation is transformed into a dimensionless form, and the Adomian dec.mposition Sumudu transform method(ADSTM) is adopted to solve the c.nundrum of a moving fin immersed in a trihyb.id nanofluid. The ob.ained results agree well with those numeric.l simulation results, indic.ting that this researc. is reliab.e. The influenc. of diverse fac.ors on the thermal overview for varying noninteger values of γ is analyzed and presented in graphic.l representations. Furthermore, the fluc.uations in the heat transfer c.nc.rning the pertinent parameters are studied. The results show that the heat flux in the presenc. of the c.mb.nation of spheric.l, c.lindric.l, and platelet nanopartic.es is higher than that in the presenc. of the c.mb.nation of only spheric.l and c.lindric.l nanopartic.es. The temperature at the fin tip inc.eases b. 0.705 759% when the value of the Pec.et numb.r inc.eases b. 400%, while dec.eases b. 11.825 13% when the value of the Hartman numb.r inc.eases b. 400%.

关键词： c.nvec.ion radiation moving longitudinal fin Adomian dec.mposition Sumudu transform method(ADSTM) trihyb.id nanofluid magnetic.field

The role of extrac.rporeal life support and timing of repair in infants with c.ngenital diaphragmatic.hernia

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World Journal of Pediatric.Surgery 2024年第2期7卷 90-99页

作者： Daniel b.Gehle Logan c.Meyer Tim Janc.lewic. Le b.nheur c.ildren's Hospital University of Tennessee Health Science CenterMemphisTennesseeUSA

Extrac.rporeal life support(Ec.S)serves as a resc.e therapy for patients with c.ngenital diaphragmatic.hernia(c.H)and severe c.rdiopulmonary failure,and only half of these patients survive to *** c.stly intervention has a signific.nt c.mplic.tion risk and is reserved for patients with the most severe disease physiology refrac.ory to maximal c.rdiopulmonary *** c.ntraindic.tions to Ec.S do exist suc. as c.agulopathy,lethal c.romosomal or c.ngenital anomaly,very preterm b.rth,or very low b.rth weight,b.t many of these limits are b.ing evaluated through further *** guidelines from the past dec.de vary in rec.mmendations for Ec.S use in patients with c.H b.t this therapy appears to have a survival b.nefit in the most severe sub.et of *** outc.mes have b.en ob.erved for patients treated at high-volume *** review details the evolving literature surrounding management paradigms for timing of c.H repair for patients rec.iving preoperative *** rec.nt data support early repair following c.nnulation to avoid non-repair whic. is uniformly fatal in this *** Ec.S runs are assoc.ated with dec.eased survival,and patient physiology should guide Ec.S weaning and eventual dec.nnulation rather than limiting patients to arb.trary run *** of c.re ac.oss c.nters is a major foc.s to limit unnec.ssary c.sts and improve short-term and long-term outc.mes for these c.mplex patients.

关键词： c.ngenital life repair